OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Neuropathologica is 40. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD	158
Macrophages and endothelial cells in the neurovascular unit	148
A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques	148
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy	139
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers	132
Wolframin is a novel regulator of tau pathology and neurodegeneration	107
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease	98
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis	95
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database	93
Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype	92
A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting	85
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry	83
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation	79
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair	72
SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility	66
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum	65
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma	64
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS	64
TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration	61
Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy	60
The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression	58
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges	58
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics	57
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2	55
Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2	52

Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma	51
TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia	51
Tau seeding in chronic traumatic encephalopathy parallels disease severity	50
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination	50
Jorge Cervós-Navarro 1930–2021	49
Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old	46
From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and oth	45
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis	45
Clinicopathological and molecular characterization of three cases classified by DNA-methylation profiling as “Glioneuronal Tumors, NOS, Subtype A”	44
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD	43
Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’	42
Clinical applicability of miR517a detection in liquid biopsies of ETMR patients	41
Variants in DTNA cause a mild, dominantly inherited muscular dystrophy	40
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism	40
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy	40
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a diseas	40
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau	40