OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Neuropathologica is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques	217
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers	199
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy	141
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database	131
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis	126
Macrophages and endothelial cells in the neurovascular unit	122
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease	103
Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype	87
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma	85
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair	85
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry	83
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum	81
A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting	80
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS	76
SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility	75
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation	73
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics	66
TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration	63
Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma	63
TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia	61
The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression	60
Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy	59
Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2	59
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges	55
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination	55

Jorge Cervós-Navarro 1930–2021	54
Variants in DTNA cause a mild, dominantly inherited muscular dystrophy	54
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2	54
Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’	54
From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and oth	52
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy	52
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau	51
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism	51
Clinicopathological and molecular characterization of three cases classified by DNA-methylation profiling as “Glioneuronal Tumors, NOS, Subtype A”	51
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis	50
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD	50
Clinical applicability of miR517a detection in liquid biopsies of ETMR patients	50
Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old	50
Neuropathologic scales of cerebrovascular disease associated with diffusion changes on MRI	49
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a diseas	49
CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease	47
A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease	47
Correction to: MET receptor serves as a promising target in melanoma brain metastases	47
Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 2204	46
Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations	46
Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses	46
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex	46