OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Neuropathologica is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques	235
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy	217
Macrophages and endothelial cells in the neurovascular unit	145
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis	142
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database	128
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers	111
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease	99
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation	97
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma	95
Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype	92
A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting	90
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry	83
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair	73
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS	72
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum	68
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2	67
TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration	67
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics	66
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges	64
Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma	64
TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia	64
Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy	62
Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2	62
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination	60
Clinicopathological and molecular characterization of three cases classified by DNA-methylation profiling as “Glioneuronal Tumors, NOS, Subtype A”	60

PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD	60
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy	58
Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’	57
Clinical applicability of miR517a detection in liquid biopsies of ETMR patients	56
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism	56
Variants in DTNA cause a mild, dominantly inherited muscular dystrophy	55
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau	54
From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and oth	54
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis	54
Correction to: MET receptor serves as a promising target in melanoma brain metastases	53
Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations	53
A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease	52
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a diseas	51
CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease	50
Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses	50
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions	50
Chronic traumatic encephalopathy in a female ex-professional Australian rules footballer	49
Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS	49
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex	49
Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 2204	49
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease	48
Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex	47
Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations	47