American Journal of Pathology

Article	Citations
Editorial Board	180
Microbiome and Inherited Retinal Degenerations	92
The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases	80
This Month in AJP	75
Crosstalk between Hepatic Stellate Cells and Hepatic Macrophages in Metabolic Dysfunction–Associated Steatohepatitis	62
The Circadian Clock of Müller Glia Is Necessary for Retinal Homeostasis and Neuronal Survival	61
Table of Contents	48
The Impact of Generative Artificial Intelligence in Scientific Content Synthesis for Authors	45
Development of CAR-T Therapies and Personalized Vaccines for the Treatment of Cholangiocarcinoma	44
Cullin 2 Elevates the Warburg Effect to Accelerate the Development of Hypoxic Pulmonary Hypertension	43
Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer Disease	40
Deep Learning–Based Stratification of Gastric Cancer Patients from Hematoxylin and Eosin–Stained Whole Slide Images by Predicting Molecular Features for Immunotherapy Response	39
The Gut Microbiome as a Possible Mediator in Autoimmunity and Cardiovascular Disease	39
Table of Contents	39
Delayed Bone Fracture Healing in Hybid (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization)–Deficient Mice	37
Defective Uterine Spiral Artery Remodeling and Placental Senescence in a Pregnant Rat Model of Polycystic Ovary Syndrome	35
Constitutive Hepatic mTORC1 Activation Aggravates Alcohol-Induced Liver Injury via Endoplasmic Reticulum Stress–Mediated Ferroptosis	35
Editorial Board	32
Super-Resolution Microscopy Reveals Alterations in Clathrin Structure in Human Cancer Tissue	32
Editorial Board	30
Location of Retinal Pigment Epithelial Cells in the Eye Is Critical to Their Function	30
This Month in AJP	30
Reviewer Acknowledgment	29
This Month in AJP	28
Evolution of Lymphoma Diagnosis in the Era of Personalized Medicine	28

Table of Contents	28
RNA Sequencing of Idiopathic Subglottic Stenosis Tissues Uncovers Putative Profibrotic Mechanisms and Identifies a Prognostic Biomarker	27
Table of Contents	27
Endothelial Cell Stimulator of Interferon Genes Regulates IL-6 Production and Is Required for Pathologic Cardiac Hypertrophy and Contractile Dysfunction in Experimental Heart Failure	26
Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients and Mice with Wilson Disease	26
Protein Kinase D2 and D3 Promote Prostate Cancer Cell Bone Metastasis by Positively Regulating Runx2 in a MEK/ERK1/2–Dependent Manner	26
Gut Microbiome and Bile Acid Interactions	26
Vitamin D and Microbiome	26
The Transcriptional Landscape of Coding and Noncoding RNAs in Recurrent and Nonrecurrent Colon Cancer	25
Hepatic Steatosis in the Mouse Model of Wilson Disease Coincides with a Muted Inflammatory Response	24
AMD3100-Mediated CXCR4 Inhibition Impairs Development of Primary Lymphoma of the Central Nervous System	24
Nuclear Control of Vascular Smooth Muscle Cell Plasticity during Vascular Remodeling	24
From Ulcerative Colitis to Metastatic Colorectal Cancer	24
Mechanistic Insights into Glucocorticoid-Induced Ocular Hypertension Using Differences in Mouse Strain Responsiveness	23
Collapsin Response Mediator Protein 1 (CRMP1) Is Required for High-Frequency Hearing	22
This Month in AJP	22
Authors’ Reply	22
Bringing Clarity to the Murky Problem of Cardiac Allograft Vasculopathy	22
Ablation of Dual-Specificity Phosphatase 6 Protects against Nonalcoholic Fatty Liver Disease via Cytochrome P450 4A and Mitogen-Activated Protein Kinase	22
The Microbial Metabolite δ-Valerobetaine Strengthens the Gut Epithelial Barrier	21
Adipose Triglyceride Lipase–Mediated Adipocyte Lipolysis Exacerbates Acute Pancreatitis Severity in Mouse Models and Patients	21
This Month in AJP	21
TGFβ1-Induced Fibrotic Responses of Conjunctival Fibroblasts through the Wnt/β-Catenin/CRYAB Signaling Pathway	21
Transcription Factor Forkhead Box O1 Mediates Transforming Growth Factor-β1–Induced Apoptosis in Hepatocytes	21
This Month in AJP	21
The mRNA Stability of PIEZO1, Regulated by Methyltransferase-Like 3 via N6-Methylation of Adenosine Modification in a YT521-B Homology Domain Family 2–Dependent Manner, Facilitates the Progression of	20
Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease	20
Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice	20
Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis	20
Resolvin E1 Reduces Tumor Growth in a Xenograft Model of Lung Cancer	20
Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology	20
Sex Differences in Impacts of Early Gestational and Peri-Adolescent Ozone Exposure on Lung Development in Rats	19
A Spatial Atlas of Wnt Receptors in Adult Mouse Liver	19
Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis	19
A Multiscale Connected UNet for the Segmentation of Lung Cancer Cells in Pathology Sections Stained Using Rapid On-Site Cytopathological Evaluation	19
Introducing the Ocular Pathobiology Topic Category in The American Journal of Pathology	19
Systemic Reduction of Glut1 Normalizes Retinal Dysfunction, Inflammation, and Oxidative Stress in the Retina of Spontaneous Type 2 Diabetic Mice	19
miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways	19
TRIM24 Up-Regulates ORM2 to Alleviate Abnormal Lipid Metabolism, Inflammation, and Oxidative Stress in Mice with Obstructive Sleep Apnea Syndrome and Metabolic Dysfunction–Associated Steatotic Liver D	19
Forkhead Box O Signaling Pathway in Skeletal Muscle Atrophy	19
Editorial Board	18
Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury	18
Editorial Board	18
This Month in AJP	18
Tumor Necrosis Factor α–Induced Protein 8–Like 1 Binds to Protein Arginine Methyltransferase 1 to Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral	18
ZNF33A Promotes Tumor Progression and BET Inhibitor Resistance in Triple-Negative Breast Cancer	17
Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization	17
The Proteostasis Network in Proteinopathies	17
Blowing Dust Off the Archives	17
The Unrecognized Role of Ninjurin 2 in Inflammation, Metabolism, and Pyroptosis	17

NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases	17
Paraoxonase 1 Ameliorates Renal Lipotoxicity by Activating Lipophagy and Inhibiting Pyroptosis	17
Murine Coronavirus Disease 2019 Lethality Is Characterized by Lymphoid Depletion Associated with Suppressed Antigen-Presenting Cell Functionality	17
Macrophage Activation in Synovitis and Osteoarthritis of Temporomandibular Joint and Its Relationship with the Progression of Synovitis and Bone Remodeling	17
Fibroblast Programmed Cell Death Ligand 1 Promotes Osteoclastogenesis in Odontogenic Keratocysts	17
Release of miR-29 Target Laminin C2 Improves Skin Repair	16
A Histopathologic Image Analysis for the Classification of Endocervical Adenocarcinoma Silva Patterns Depend on Weakly Supervised Deep Learning	16
Not Sure if You Are an Investigative Pathologist? Yes, You Are	16
Enhancement of Tumor Necrosis Factor-α–Mediated Hepatic Apoptosis and Liver Injury by Hepatitis B Virus Surface Antigen	16
Cholestasis in Alcohol-Associated Liver Disease	16
Human Kidney Organoids and Tubuloids as Models of Complex Kidney Disease	16
Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis	16
Alcohol-Associated Hepatocarcinogenesis	16
Hyperglycemia Induces Tear Reduction and Dry Eye in Diabetic Mice through the Norepinephrine–α1 Adrenergic Receptor–Mitochondrial Impairment Axis of Lacrimal Gland	16
Understanding How Alcohol Induces Human Acute Alcoholic Pancreatitis	15
Histopathologic Marks of Tongue in a Mouse Model of Oculopharyngeal Muscular Dystrophy Suggest Biomechanical Defects	15
Wnt-5a–Receptor Tyrosine Kinase-Like Orphan Receptor 2 Signaling Provokes Metastatic Colonization and Angiogenesis in Renal Cell Carcinoma, and Prunetin Supresses the Axis Activation	15
CDR1as Deficiency Prevents Photoreceptor Degeneration by Regulating miR-7a-5p/α-syn/Parthanatos Pathway in Retinal Detachment	15
Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2	15
Finding Your CAR	15
Small Nuclear Ribonucleoprotein Polypeptides B and B1 Promote Osteosarcoma Progression via Activating the Ataxia-Telangiectasia Mutated Signaling Pathway through Ribonucleotide Reductase Subunit M2	15
Increased Matrix Metalloproteinase-1 Activation Enhances Disruption and Regression of k-RasV12–Expressing Arteriovenous Malformation-Like Vessels	15
Editorial Board	15
Returning Individual Research Results to Vulnerable Individuals	15
Local Tetanus Begins with a Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release due to Cleavage of the Vesicle-Associated Membrane Protein	15
Hepatocyte-Specific Casein Kinase 1 Epsilon Ablation Ameliorates Metabolic Dysfunction–Associated Steatohepatitis by Up-Regulating Tumor Necrosis Factor Receptor–Associated Factor 3 in Mice	15
Medulloblastomas Initiated by Homologous Recombination Defects in Mice	15
This Month in AJP	15
DANCR Induces Cisplatin Resistance of Triple-Negative Breast Cancer by KLF5/p27 Signaling	14
Table of Contents	14
This Month in AJP	14
Involvement of Heat Shock Protein 47 in Osteophyte Formation of Knee Joint Osteoarthritis	14
Excess Growth Hormone Triggers Inflammation-Associated Arthropathy, Subchondral Bone Loss, and Arthralgia	14
Dynamic Angiopoietin-2 Serum Level as Endothelial Damage Marker and Potential Therapeutic Target	14
Editorial Board	14
Table of Contents	14
iPSC-Derived Neurons from Patients with POLG Mutations Exhibit Decreased Mitochondrial Content and Dendrite Simplification	14
Editorial Board	14
Table of Contents	14
Editorial Board	14
Mutation of TP53 Confers Ferroptosis Resistance in Lung Cancer Through the FOXM1/MEF2C Axis	13
Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice	13
Retraction Notice to “Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis” [Am J Pathol 191 (2021) 385–395]	13
Correction	13
Editorial Board	13
Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele	13
Editorial Board	13
Ferrostatin-1 Inhibits Toll-Like Receptor 4/NF-κB Signaling to Alleviate Intervertebral Disc Degeneration in Rats	13
A Newly Identified Protective Role of C5a Receptor 1 in Kidney Tubules against Toxin-Induced Acute Kidney Injury	13
Editorial Board	13
Editorial Board	13
Hypoxia-Inducible Factor-1α–Induced Astrocytic D-Dopachrome Tautomerase Activates Microglial Inflammatory Response following Spinal Cord Injury	13
P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers	13
Periostin Deletion Reduces Corneal Opacity and the Infiltration of Immune Cells	13
Progression of Arterial Vasa Vasorum from Regulator of Arterial Homeostasis to Promoter of Atherogenesis	13
Rat Model of Type 2 Diabetes Mellitus Recapitulates Human Disease in the Anterior Segment of the Eye	13
Scientific Integrity Policy	13
An Integrative Analysis Framework for Identifying the Prognostic Markers from Multidimensional RNA Data of Clear Cell Renal Cell Carcinoma	13
Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α–Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex	12
Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells	12
Transcriptome Analysis Identifies Oncogenic Tissue Remodeling during Progression from Common Nevi to Early Melanoma	12
Panic at the Bile Duct	12
Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages	12
Epidermal Potentiation of Dermal Fibrosis	12
Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts	12
This Month in AJP	12
The D2.B10-Dmd/J Mouse Model of Duchenne Muscular Dystrophy Exhibits a Severe Mitochondrial Deficiency Not Observed in the C57BL/10ScSn-Dmd/J Mouse	12
Current Therapeutic Targets for Alcohol-Associated Liver Disease	12
Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase A–Dependent Pathway	12
Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis	12
Emergent White Matter Degeneration in the rTg-DI Rat Model of Cerebral Amyloid Angiopathy Exhibits Unique Proteomic Changes	12
The Cellular, Molecular, and Pathologic Consequences of Stress on the Liver	11
Inorganic Pyrophosphate Deficiency Syndromes and Potential Treatments for Pathologic Tissue Calcification	11
Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy	11
This Month in AJP	11
Inhibition of Heat Shock Factor 1 Signaling Decreases Hepatoblastoma Growth via Induction of Apoptosis	11
Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model	11
Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney Repair and Suppresses Renal Fibrosis after Acute Kidney Injury	11
The Role of Twist1 in Chronic Pancreatitis–Associated Pancreatic Stellate Cells	11
From Disruption of Muscle Membrane to Muscle Membrane Repair	11

Emerging Mechanistic Roles of STING Signaling in Kidney Diseases	11
Decreased Proteasomal Function Exacerbates Endoplasmic Reticulum Stress-Induced Chronic Inflammation in Obese Adipose Tissue	11
Development of a New Murine Model of Type 2 Autoimmune Hepatitis Using a Human Liver Protein	11
Assessment of Skin Toxicity in an in Vitro Reconstituted Human Epidermis Model Using Deep Learning	11
The Angiofibrotic Switch in Retinal and Choroidal Vascular Diseases	10
PathViT	10
Transcription Factor YY2 Inhibits Tumor Cell Glutamine Catabolism by Regulating GLS1 RNA Splicing Isoform GAC	10
Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing through Transforming Growth Factor-β/Smad3 Signaling	10
TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease	10
Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis	10
Prediction of MET Overexpression in Lung Adenocarcinoma from Hematoxylin and Eosin Images	10
Genomic Characterization of Prostatic Basal Cell Carcinoma	10
Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis	10
Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease	10
Contribution of Hepatic Steatosis–Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice	10
Deep Learning of Rhabdomyosarcoma Pathology Images for Classification and Survival Outcome Prediction	10
Opioid Use in Murine Model Results in Severe Gastric Pathology that May Be Attenuated by Proton Pump Inhibition	10
Enhanced Pathology Image Quality with Restore–Generative Adversarial Network	10
FOXO3-Activated HOTTIP Sequesters miR-615-3p away from COL2A1 to Mitigate Intervertebral Disc Degeneration	10
Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury	9
A Complex Interplay between Notch Effectors and β-Catenin Signaling in Morular Differentiation of Endometrial Carcinoma Cells	9
Glycosylation Triggers Cathepsin D Maturation and Secretion to Promote Gastric Cancer Development	9
Author Index	9
Severe Acute Respiratory Syndrome Coronavirus 2 Vasculopathy in a Syrian Golden Hamster Model	9
Loss of Aquaporin-1 in Tumor Cells Fosters Intrahepatic Cholangiocarcinoma Progression	9
WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis	9
Table of Contents	9
Author Index	9
A Deep Learning–Based Assessment Pipeline for Intraepithelial and Stromal Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Carcinoma	9
Computer Vision Identifies Recurrent and Nonrecurrent Ductal Carcinoma in Situ Lesions with Special Emphasis on African-American Women	9
Single-Cell Sequencing Reveals the Palmitoylation Landscape in Lung Adenocarcinoma and Identifies ABHD17C as a Novel Biomarker	9
Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury	9
Whole-Slide Cytometric Feature Mapping for Distinguishing Tumor Genomic Subtypes in Head and Neck Squamous Cell Carcinoma Whole-Slide Images	9
A Core of Keratocan-Negative Cells Survives in Old Corneal Scars	9
This Month in AJP	9
Table of Contents	9
Liver X Receptor–Growth Differentiation Factor 15 Activation Drives Profibrotic Changes in the Aqueous Outflow Tract of Uveitic Glaucoma	9
Vision Transformers for Breast Cancer Human Epidermal Growth Factor Receptor 2 Expression Staging without Immunohistochemical Staining	9
Notch Signaling Aggravates Helicobacter pylori–Induced Inflammation by Promoting Macrophage Activation and Proinflammatory Th1/Th17 Responses	9
Table of Contents	8
Editorial Board	8
Weakly Supervised Framework for Cancer Region Detection of Hepatocellular Carcinoma in Whole-Slide Pathologic Images Based on Multiscale Attention Convolutional Neural Network	8
Identification of an Electrogenic 2Cl−/H+ Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis	8
A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Delta Isoform in Hepatocellular Proliferation	8
Renal Fibrosis Is Alleviated through Targeted Inhibition of IL-11–Induced Renal Tubular Epithelial-to-Mesenchymal Transition	8
Meeting Abstracts	8
Editorial Board	8
Correction	8
Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice	8
Role of HIF1α and HIF2α in Cre Recombinase–Induced Retinal Pigment Epithelium Pathology and Its Secondary Effect on Choroidal Neovascularization	8
Both Classical and Non-Classical Monocytes Patrol Glomerular Capillaries and Promote Acute Glomerular Inflammation	8
Table of Contents	8
Table of Contents	8
A Primer on BRIMR	8
Nonalcoholic Steatohepatitis Exacerbates Inflammatory Bone Destruction and Macrophage NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Ligature-Induced Periodontitis	8
Fusion Gene Detection in Prostate Cancer Samples Enhances the Prediction of Prostate Cancer Clinical Outcomes from Radical Prostatectomy through Machine Learning in a Multi-Institutional Analysis	8
Severe Acute Respiratory Syndrome Coronavirus 2, the Human Placenta, and Adverse Perinatal Outcomes	8
Machine Learning and Mendelian Randomization Reveal a Tumor Immune Cell Profile for Predicting Bladder Cancer Risk and Immunotherapy Outcomes	8
Title Page	8
Cholangiocarcinoma Targeted Therapies	8
EZH2 Promotes Cholangiocarcinoma Development and Progression through Histone Methylation and microRNA-Mediated Down-Regulation of Tumor Suppressor Genes	8
Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis	8
Authors' Reply	8
Table of Contents	8
Overexpression of Estrogen Receptor α in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor α–Positive Mammary Adenocarcinomas	8
Targeting Skeletal Muscle in Duchenne Muscular Dystrophy	8
The Pathobiology of IL-11 in Kidney Disease	8
Title Page	8
Table of Contents	8
Table of Contents	8
Lipid Droplet Dynamics in Alcoholic Steatohepatitis	8
Histopathologic Differential Diagnosis and Estrogen Receptor/Progesterone Receptor Immunohistochemical Evaluation of Breast Carcinoma Using a Deep Learning–Based Artificial Intelligence Architecture	8