OOIR: Observatory of International Research

Papers

(The H4-Index of Biochemical Pharmacology is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Verteporfin combined with ROCK inhibitor promotes the restoration of corneal endothelial cell dysfunction in rats	356
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	157
JOSD2 promotes breast cancer metastasis by deubiquitinating and stabilizing SMAD4	157
Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives	141
Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation	131
Multimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies	128
Tankyrase1/2 inhibitor XAV-939 reverts EMT and suggests that PARylation partially regulates aerobic activities in human hepatocytes and HepG2 cells	116
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies	114
The functional subclasses of AT1 receptor autoantibody in patients with coronary heart disease	106
Abscisic acid, an evolutionary conserved hormone: Biosynthesis, therapeutic and diagnostic applications in mammals	104
An inducible sphingosine kinase 1 in hepatic stellate cells potentiates liver fibrosis	103
Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation	95
Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis	95
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	89
Developing insulin-like peptide 5-based antagonists for the G protein-coupled receptor, RXFP4	88
Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans	84
Ganciclovir attenuates the onset and progression of experimental autoimmune uveitis by inhibiting infiltration of Th17 and inflammatory cells into the retina	82
M4IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells	80
miR-146a-5p/TXNIP axis attenuates intestinal ischemia-reperfusion injury by inhibiting autophagy via the PRKAA/mTOR signaling pathway	79
Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis	78
Interplay between purinergic signalling and extracellular vesicles in health and disease	74
Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells	72
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	71
Exosomes: Powerful weapon for cancer nano-immunoengineering	69
Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy	68

Adaptive changes in tumor cells in response to reductive stress	67
Ferroptosis resistance in cancer: recent advances and future perspectives	65
JAK inhibition as a new treatment strategy for patients with COVID-19	65
AMPKα2/HNF4A/BORIS/GLUT4 pathway promotes hepatocellular carcinoma cell invasion and metastasis in low glucose microenviroment	64
Corrigendum to “MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM Mice” [Biochem. Pharmacol. volume (230), Part 2, Published online October 23, 2024/116593]	64
The gut microbiota – A vehicle for the prevention and treatment of hepatocellular carcinoma	64
SIRT-2 inhibition by AK-7 orchestrates fibrotic cascades in airways through neuroimmune interaction via TRPA1, TRPM8 and TGF-β signalling	61
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	61
Corrigendum to “Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE -/- mice” [Biochem. Pharmacol. 223 (2024) 116170]	59
The combination of gemcitabine and albumin-bound paclitaxel effectively inhibits de novo lipogenesis in pancreatic cancer cells by targeting the AMPK/SREBP1 pathway	59
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	59
The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells	55
The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1	54
Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats	54
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity	54
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy	53
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice	51
SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy	50
Glycosylation in SARS-CoV-2 variants: A path to infection and recovery	50
miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer	50
Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology	48
Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells	48