Biochemical Pharmacology

Papers
(The median citation count of Biochemical Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Corrigendum to “Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells” [Biochem. Pharmacol. 176 (2020) 113902]212
Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells188
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase157
Editorial Board155
Corrigendum to “Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord” [Biochem. Pharmacol. 185 (2021) 114411]151
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis131
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis129
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies125
The potent role of Src kinase-regulating glucose metabolism in cancer120
PXR as the tipping point between innate immune response, microbial infections, and drug metabolism117
Sleep during COVID-19 lockdown: A cross-cultural study investigating job system relevance116
Corrigendum to “Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis” [Biochem. Pharmacol. 232 (2025) 116711]110
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy100
Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention97
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice93
Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation92
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway91
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models89
Metformin exhibits inhibitory effects on ferroptosis and alleviates chondrocyte metabolic imbalance in osteoarthritis models, as well as Erastin-induced ferroptosis, through the modulation of the P53/87
Diabetes and the fabkin complex: A dual-edged sword85
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease74
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases73
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies70
Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells70
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights69
Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release69
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect68
Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy67
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling66
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex65
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway64
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain64
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex62
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis60
Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis59
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease59
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy59
Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression58
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review55
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway55
Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation54
The relationship between tumor metabolism and 5-fluorouracil resistance53
Bile acids and bile acid activated receptors in the treatment of Covid-1953
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib52
Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans51
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models51
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis50
The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity49
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study49
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F147
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure46
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization46
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons46
Methionine cycle in nonalcoholic fatty liver disease and its potential applications45
The value of neck adipose tissue as a predictor for metabolic risk in health and type 2 diabetes45
Ammonium tetrathiomolybdate attenuates acetaminophen-induced acute liver failure by inhibiting the TRPV4/Calcium/NF-κB signaling pathway45
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products45
Potential small effector molecules restoring cellular defects due to sialic acid biosynthetic enzyme deficiency: Pathological relevance to GNE myopathy44
Carbon monoxide in cell signaling and potential therapeutics44
Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver43
Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas’ disease43
Mast cell activation induced by tamoxifen citrate via MRGPRX2 plays a potential adverse role in breast cancer treatment43
Knockdown of Galectin-9 alleviates rheumatoid arthritis through suppressing TNF-α-induced activation of fibroblast-like synoviocytes43
Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines42
LILRB4 as a novel immunotherapeutic target for multiple diseases42
GRHL3 drives radiotherapy resistance and blocks the anti-tumor response of NK and CD4+ T cells in lung squamous cell carcinoma via RNF242
DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca2+/calcineurin pathway42
SIS3 suppresses osteoclastogenesis and ameliorates bone loss in ovariectomized mice by modulating Nox4-dependent reactive oxygen species41
Targeting non-coding RNAs and N6-methyladenosine modification in hepatocellular carcinoma41
Rosavidin protects against PM2.5-induced lung toxicity via inhibition of NLRP3 inflammasome-mediated pyroptosis by activating the PI3K/AKT pathway40
Methyl-oxazolomycin A: A novel oxazolomycin analog with potent selective estrogen receptor degrading activity in breast cancer cells40
PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells40
Viral Vectors, Exosomes, and Vexosomes: Potential armamentarium for delivering CRISPR/Cas to cancer cells39
SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription39
Editorial Board38
Effect of pharmacological heart failure drugs and gene therapy on Danon's cardiomyopathy38
Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis38
Dexmedetomidine alleviates anxiety-like behavior in mice following peripheral nerve injury by reducing the hyperactivity of glutamatergic neurons in the anterior cingulate cortex38
Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson’s disease38
Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG138
Immunometabolic attributes and mitochondria-associated signaling of Tumor-Associated Macrophages in tumor microenvironment modulate cancer progression37
Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro37
Recent advances in studies on FtsZ inhibitors37
The role and regulation of Pnn in proliferative and non-dividing cells: Form embryogenesis to pathogenesis37
The dual targeting effects of KD025 on casein kinase 2 and ROCK2 in a mouse model of diet-induced obesity37
Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)37
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα37
Serum-derived extracellular vesicles mediate acquired multidrug resistance of MCF-7 breast cancer cells induced by chemotherapeutic drugs37
Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages36
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders36
ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma35
Dual-specificity tyrosine phosphorylation-regulated kinase 1A promotes the inclusion of amyloid precursor protein exon 735
Immunomodulatory effects of antiangiogenic tyrosine kinase inhibitors in renal cell carcinoma models: Impact on following anti-PD-1 treatments35
Exploring the glycation association with dyslipidaemia: Novel approach for diabetic nephropathy35
Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease34
FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression34
Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities33
UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder33
Sirtuin1-p53: A potential axis for cancer therapy33
Peroxisome proliferator-activated receptor (PPAR) agonists as a potential therapy for inherited metabolic disorders32
Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis32
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis32
Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice32
Physiological and pharmacological overview of the gonadotropin releasing hormone32
Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo32
The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding31
Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate31
Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension31
Corrigendum to “Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury“ [Biochem. Pharmacol. 63(1) (2002)31
Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance31
Itaconate alleviates β2-microglobulin-induced cognitive impairment by enhancing the hippocampal amino-β-carboxymuconate-semialdehyde-decarboxylase/picolinic acid pathway31
Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives31
Nodosin alleviates cholestatic liver injury by activation of SIRT1/FXR signaling pathway and inhibition of hepatic inflammation31
6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model31
KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP/PS1 mice by inhibiting PARP16 expression31
Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction31
Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation30
Ifosfamide alleviates autoimmune toxicity and enhances antitumor efficacy in melanoma immunotherapy30
Mitomycin induced the senescence of alveolar epithelial cells by targeting peroxiredoxin I30
Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology29
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities29
xCT/Slc7a11 promotes pulmonary arterial hypertension by disrupting AMPKα suppression of mTOR activation29
Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics29
Preclinical evaluation of new drug-drug interactions of lomitapide: A proposal for novel mechanism of interaction associated with lipid metabolic changes29
Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets29
PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction29
Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives28
Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies28
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 228
Detailed resume of S-methyltransferases: Categories, structures, biological functions and research advancements in related pathophysiology and pharmacotherapy28
Targeting fibroblast activation protein with chimeric antigen receptor macrophages28
CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis28
P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA28
BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury28
Cytarabine-induced destabilization of MCL1 mRNA and protein triggers apoptosis in leukemia cells28
Mitochondrial elongation confers protection against doxorubicin-induced cardiotoxicity28
TNFα blockade reverses vascular and uteroplacental matrix metalloproteinases imbalance and collagen accumulation in hypertensive pregnant rats28
Corrigendum to “DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages” [Biochem. Pharmacol. 184 (2021) 114399]27
A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine27
Macrophage-derived human resistin promotes perivascular adipose tissue dysfunction in experimental inflammatory arthritis27
Editorial Board27
Mithramycin suppresses tumor growth by regulating CD47 and PD-L1 expression27
Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators27
Corrigendum to “Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Ge27
Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles27
MiR-466b-3p/HDAC7 meditates transgenerational inheritance of testicular testosterone synthesis inhibition induced by prenatal dexamethasone exposure26
Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway26
Finding new analgesics: Computational pharmacology faces drug discovery challenges26
FGFR3 phosphorylates EGFR to promote cisplatin-resistance in ovarian cancer26
SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3)26
Positive programming of the GC-IGF1 axis mediates adult osteoporosis susceptibility in male offspring rats induced by prenatal dexamethasone exposure26
A rational foundation for micheliolide-based combination strategy by targeting redox and metabolic circuit in cancer cells26
Protein prenylation in islet β-cell function in health and metabolic stress26
Differential contribution of renal cytochrome P450 enzymes to kidney endothelial dysfunction and vascular oxidative stress in obesity26
Antibody-drug conjugates for non-small cell lung cancer: Advantages and challenges in clinical translation26
Ponatinib exacerbate renal injury in systemic lupus erythematosus mouse model through PDGFR-PI3K/AKT pathway26
IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation26
The critical roles of STING in mitochondrial homeostasis26
Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses26
Overview of the therapeutic strategies for ER positive breast cancer26
Therapeutic of a white adipose tissue-specific bivalent aptamer in obesity25
Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects25
Eicosatrienoic acid inhibits estradiol synthesis through the CD36/FOXO1/CYP19A1 signaling pathway to improve PCOS in mice25
Targeting regulated chondrocyte death in osteoarthritis therapy25
Editorial Board25
Corrigendum to “TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain” [Biochem. Pharmacol. 192 (2021) 125
Editorial Board25
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin25
Citrulline activates adenosine receptors: New insight into metabolic pathways interaction25
Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes24
Corrigendum to “Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics” [Biochem. Pharmacol. 24
Selpercatinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway24
Enhanced thermogenesis in PAS Kinase-deficient male mice24
Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis24
Sterol regulation of developmental and oncogenic Hedgehog signaling24
Glucocorticoids and natural killer cells: A suppressive relationship24
Azithromycin modulates Teff/Treg balance in retinal inflammation via the mTOR signaling pathway24
Pathogenic mitochondrial dysfunction and metabolic abnormalities24
Implication of Let7b/AhR/ARNT/HMGB1/RAGE cascade in neuroplasticity disturbances induced by glucocorticoids and the promising reversible effect of 3,3 diindolymethane: Bidirectional crosstalk of Aryl 24
miR-486-5p-rich extracellular vesicles derived from patients with olanzapine-induced insulin resistance negatively affect glucose-regulating function24
3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages24
Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer24
Mechanotransduction and the extracellular matrix: Key drivers of lung pathologies and drug responsiveness24
Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury24
Extracellular nucleotides in smooth muscle contraction24
The increasing role of pigment epithelium-derived factor in metastasis: from biological importance to a promising target24
An A-ring substituted evodiamine derivative with potent anticancer activity against human non-small cell lung cancer cells by targeting heat shock protein 7024
Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells24
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors24
CD146+Mesenchymal stem cells treatment improves vascularization, muscle contraction and VEGF expression, and reduces apoptosis in rat ischemic hind limb24
Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway24
Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR12023
A systematic review and meta-analysis of environmental contaminant exposure impacts on weight loss and glucose regulation during calorie-restricted diets in preclinical studies: Persistent organic pol23
Curing childhood cancer the “Natural” Way: Nature as the source of chemotherapy agents23
Delineating the tumour-regulatory roles of EYA423
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress23
Cardiac human bitter taste receptors contain naturally occurring variants that alter function23
CXCR2, a novel target to overcome tyrosine kinase inhibitor resistance in chronic myelogenous leukemia cells23
Is REM sleep a paradoxical state?: Different neurons are activated in the cingulate cortices and the claustrum during wakefulness and paradoxical sleep hypersomnia23
Redox regulation by carotenoids: Evidence and conflicts for their application in cancer23
Inhibition of soluble epoxide hydrolase relieves adipose inflammation via modulating M1/M2 macrophage polarization to alleviate airway inflammation and hyperresponsiveness in obese asthma23
The role of taurine through endoplasmic reticulum in physiology and pathology23
Activated microglia secretome and proinflammatory cytokines increase neuronal mu-opioid receptor signalling and expression23
Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate re23
Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies23
Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk23
Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis22
Calcium saccharate/DUSP6 suppresses renal cell carcinoma glycolytic metabolism and boosts sunitinib efficacy via the ERK-AKT pathway22
Cell-specific drug targeting in the lung22
Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice22
Editorial Board22
Cancer stem cells: Recent insights and therapies22
Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy22
Animal models of acute lymphoblastic leukemia: Recapitulating the human disease to evaluate drug efficacy and discover therapeutic targets22
AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review22
Canonical DDR activation by EMT inducing agent 5-Fluorouracil is modulated by a cannabinoid based combinatorial approach via inducing autophagy and suppression of vimentin expression22
Oridonin combined with cisplatin synergistically induces apoptosis by activating the NOXA-BCL2 axis in esophageal squamous cell carcinoma22
Spectral sensitivity of circadian phase resetting, melatonin suppression and acute alerting effects of intermittent light exposure22
FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy22
The relevance of daylight for humans22
PPARγ activation by fisetin mitigates vascular smooth muscle cell senescence via the mTORC2-FoxO3a-autophagy signaling pathway22
Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo21
Sonidegib potentiates the cancer cells’ sensitivity to cytostatic agents by functional inhibition of ABCB1 and ABCG2 in vitro and ex vivo21
Estrogen dampens central cannabinoid receptor 1-mediated neuroexcitation and pressor response in conscious female rats21
ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus21
Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging21
Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases21
Editorial Board21
Heat shock protein 90 inhibitor 17-AAG down-regulates thymidine phosphorylase expression and potentiates the cytotoxic effect of tamoxifen and erlotinib in human lung squamous carcinoma cells21
Selective stabilization of the intermediate inactivated Na+ channel by the new-generation anticonvulsant rufinamide21
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential21
Advancements in age-related macular degeneration treatment: From traditional anti-VEGF to emerging therapies in gene, stem cell, and nanotechnology21
Vitamin B12 reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats21
Acknowledgment21
Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats21
Corrigendum to “Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway” [Biochem. Pharmacol. 92 (2014) 484–493]21
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease21
Broad-spectrum hybrid antimicrobial peptides derived from PMAP-23 with potential LPS binding ability21
Corrigendum to “Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways” [Biochem. Pharmacol21
Isoliensinine suppresses bone loss by targeted inhibition of RANKL-RANK binding20
Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins20
Cardiometabolic effects of sacubitril/valsartan in a rat model of heart failure with preserved ejection fraction20
Untargeted metabolomics analysis of serum and urine unveils the protective effect of cilastatin on altered metabolic pathways during cisplatin-induced acute kidney injury20
Bisphenol-A analogs induce lower urinary tract dysfunction in male mice20
Activation of aryl hydrocarbon receptor by azatyrosine-phenylbutyric hydroxamide inhibits progression of diabetic retinopathy mice20
Pharmacological characterization of prostaglandin E2 EP2 and EP4 receptors in male rat locus coeruleus neurons ex vivo20
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury20
Nicotinamide riboside alleviates brain dysfunction induced by chronic cerebral hypoperfusion via protecting mitochondria20
AT1 receptors modulate ethanol-induced loss of anticontractile effect of perivascular adipose tissue20
Potential role of modulating autophagy levels in sensorineural hearing loss20
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