Biochemical Pharmacology

Article	Citations
Verteporfin combined with ROCK inhibitor promotes the restoration of corneal endothelial cell dysfunction in rats	356
JOSD2 promotes breast cancer metastasis by deubiquitinating and stabilizing SMAD4	157
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	157
Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives	141
Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation	131
Multimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies	128
Tankyrase1/2 inhibitor XAV-939 reverts EMT and suggests that PARylation partially regulates aerobic activities in human hepatocytes and HepG2 cells	116
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies	114
The functional subclasses of AT1 receptor autoantibody in patients with coronary heart disease	106
Abscisic acid, an evolutionary conserved hormone: Biosynthesis, therapeutic and diagnostic applications in mammals	104
An inducible sphingosine kinase 1 in hepatic stellate cells potentiates liver fibrosis	103
Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis	95
Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation	95
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	89
Developing insulin-like peptide 5-based antagonists for the G protein-coupled receptor, RXFP4	88
Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans	84
Ganciclovir attenuates the onset and progression of experimental autoimmune uveitis by inhibiting infiltration of Th17 and inflammatory cells into the retina	82
M4IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells	80
miR-146a-5p/TXNIP axis attenuates intestinal ischemia-reperfusion injury by inhibiting autophagy via the PRKAA/mTOR signaling pathway	79
Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis	78
Interplay between purinergic signalling and extracellular vesicles in health and disease	74
Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells	72
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	71
Exosomes: Powerful weapon for cancer nano-immunoengineering	69
Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy	68

Adaptive changes in tumor cells in response to reductive stress	67
JAK inhibition as a new treatment strategy for patients with COVID-19	65
Ferroptosis resistance in cancer: recent advances and future perspectives	65
Corrigendum to “MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM Mice” [Biochem. Pharmacol. volume (230), Part 2, Published online October 23, 2024/116593]	64
The gut microbiota – A vehicle for the prevention and treatment of hepatocellular carcinoma	64
AMPKα2/HNF4A/BORIS/GLUT4 pathway promotes hepatocellular carcinoma cell invasion and metastasis in low glucose microenviroment	64
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	61
SIRT-2 inhibition by AK-7 orchestrates fibrotic cascades in airways through neuroimmune interaction via TRPA1, TRPM8 and TGF-β signalling	61
The combination of gemcitabine and albumin-bound paclitaxel effectively inhibits de novo lipogenesis in pancreatic cancer cells by targeting the AMPK/SREBP1 pathway	59
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	59
Corrigendum to “Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE -/- mice” [Biochem. Pharmacol. 223 (2024) 116170]	59
The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells	55
Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats	54
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity	54
The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1	54
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy	53
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice	51
Glycosylation in SARS-CoV-2 variants: A path to infection and recovery	50
miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer	50
SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy	50
Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology	48
Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells	48
Lymph node metastasis and tumor-educated immune tolerance: Potential therapeutic targets against distant metastasis	46
miR-218-5p promotes hepatic lipogenesis through targeting Elovl5 in non-alcoholic fatty liver disease	45
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib	45
Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers	45
Tanshinone IIA acts as a regulator of lipogenesis to overcome osimertinib acquired resistance in lung cancer	45
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect	45
Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+ breast cancer cells	44
Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges	44
The magic of a methyl group: Biochemistry at the service of medicine	44
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux	43
Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma	43
From molecular pathogenesis to therapy: Unraveling non-coding RNAs/DNMT3A axis in human cancers	43
Diabetes and the fabkin complex: A dual-edged sword	42
Protein arginine methyltransferases (PRMTs): Orchestrators of cancer pathogenesis, immunotherapy dynamics, and drug resistance	42
G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis	42
Pharmacological options in the treatment of osteogenesis imperfecta: A comprehensive review of clinical and potential alternatives	41
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models	41
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure	41
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation	41
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5	40
Prostaglandin E2 EP receptors in cardiovascular disease: An update	40
Vitamin D and the risk for cancer: A molecular analysis	40
Long non-coding RNAs in gastrointestinal cancers: Implications for protein phosphorylation	40
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy	40
Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis	39
Targeting Wnt/β-catenin signaling by microRNAs as a therapeutic approach in chemoresistant osteosarcoma	39
Cellular senescence signaling in cancer: A novel therapeutic target to combat human malignancies	37
Editorial Board	37

Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress	37
EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis	37
Effect of 7-ketocholesterol incorporation on substrate binding affinity and turnover rate of the organic cation transporter 2 (OCT2)	37
Physiopathological mechanisms involved in the development of hypertension associated with gut dysbiosis and the effect of nutritional/pharmacological interventions	36
Editorial Board	36
Editorial Board	35
Editorial Board	35
Impact of endocrine disrupting chemicals on health and disease	35
Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability	35
Editor’s Note	35
Unlocking the protective potential of the angiotensin type 2 receptor (AT2R) in acute lung injury and age-related pulmonary dysfunction	35
The potent role of Src kinase-regulating glucose metabolism in cancer	35
Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity	34
Editorial Board	34
Acknowledgment	33
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo	33
Editorial Board	33
Editorial Board	33
The ‘ABC’ of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations	32
Unveiling the protective potential of mirabegron against thioacetamide-induced hepatic encephalopathy in rats: Insights into cAMP/PPAR-γ/p-ERK1/2/p S536 NF-κB p 65 and p-CREB/BDNF/TrkB in parallel wit	32
Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signal	32
Editorial Board	32
Ketamine – An Imperfect Wonder Drug?	32
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease	31
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis	31
Downregulation of RSAD2 ameliorates keratinocyte hyperproliferation and skin inflammation in psoriasis via the TAK1/NF-κB axis	31
An introduction to the special issue “9th International Conference on Relaxin and Related Peptides”	31
Small-molecule inhibitor BAY synergizes with gemcitabine through AHR inhibition in pancreatic cancer cells	31
Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule	31
Nanoengineered immune check point inhibitors delivery for targeted brain cancer treatment: Current status and future perspectives	31
Editorial Board	31
Spider and scorpion knottins targeting voltage-gated sodium ion channels in pain signaling	30
mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle – Roles of Rap1 geranylgeranylation and mitochondrial dysfunction	30
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases	30
The novel use of the CFTR corrector C17 in muscular dystrophy: pharmacological profile and in vivo efficacy	30
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex	30
Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention	30
A chemically adjustable BMP6-IL6 axis in mesenchymal stem cells drives acute myeloid leukemia cell differentiation	30
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation	30
Targeting cancer stem cells with antibiotics inducing mitochondrial dysfunction as an alternative anticancer therapy	30
Harringtonine: A more effective antagonist for Omicron variant	30
Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer	29
Early evolutionary history (from bacteria to hemichordata) of the omnipresent purinergic signalling: A tribute to Geoff Burnstock inquisitive mind	29
Kv7.4 channels regulate potassium permeability in neuronal mitochondria	29
Comments on “Clinically relevant therapeutic approaches against acetaminophen (APAP) hepatotoxicity and acute liver failure”	29
Bile acids and bile acid activated receptors in the treatment of Covid-19	28
SHU9119 and MBP10 are biased ligands at the human melanocortin-4 receptor	28
Exploration of the urocontrin A scaffold yields new urotensinergic system allosteric modulator and competitive antagonists	28
Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases	28
Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target	28
Induction of mitochondrial toxicity by non-steroidal anti-inflammatory drugs (NSAIDs): The ultimate trade-off governing the therapeutic merits and demerits of these wonder drugs	28
GPR56: A potential therapeutic target for neurological and psychiatric disorders	28
The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation	28
Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases	28
Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase	28
Sanggenol L induces ferroptosis in non-small cell lung cancer cells via regulating the miR-26a-1-3p/MDM2/p53 signaling pathway	28
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation	28
Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications	27
The contribution of the AT1 receptor to erythropoiesis	27
Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats	27
Cancer treatment-related cardiovascular disease: Current status and future research priorities	27
The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-κB signaling	27
Challenging and target-based shifting strategies for heart failure treatment: An update from the last decades	27
The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice	27
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo	27
A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo	27
Geniposide effectively safeguards HT22 cells against Aβ-induced damage by activating mitophagy via the PINK1/Parkin signaling pathway	27
TIPE2 ameliorates neuroinflammation and cognitive impairment in sepsis-associated encephalopathy through regulating RhoA/ROCK2–NF-κB signaling pathway	27
Protective effect of the sphingosine-1 phosphate receptor agonist siponimod on disrupted blood brain barrier function	27
Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications	26
KCNE4-dependent modulation of Kv1.3 pharmacology	26
IL-23p19 deficiency reduces M1 macrophage polarization and improves stress-induced cardiac remodeling by alleviating macrophage ferroptosis in mice	26
Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin	26
SKCa- and Kv1-type potassium channels and cancer: Promising therapeutic targets?	26
Circulating miRNAs in diabetic retinopathy patients: Prognostic markers or pharmacological targets?	26
Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy	26
Redox modulating small molecules having antimalarial efficacy	26
Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells	26
MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells	26
PCSK9 inhibitor attenuates cardiac fibrosis in reperfusion injury rat by suppressing inflammatory response and TGF-β1/Smad3 pathway	26

ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling	25
The C-terminal cleavage of angiotensin II and III is mediated by prolyl carboxypeptidase in human umbilical vein and aortic endothelial cells	25
Antisense drug discovery and development technology considered in a pharmacological context	25
Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles	25
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies	25
Adenosine A1 receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity	25
Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs	25
Use of knockout mice to explore CNS effects of adenosine	25
Eltrombopag inhibits Type I interferon-mediated antiviral signaling by decreasing cellular iron	25
Isopropyl 3-(3,4-dihydroxyphenyl) 2-hydroxypropanoate protects septic myocardial injury via regulating GAS6/Axl-AMPK signaling pathway	25
Introduction to the Special Issue “Angiotensin Receptors”	25
Sevelamer reverses liver fibrosis by deactivation of hepatic stellate cells	25
Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents – A randomized crossover trial	25
Expression and function of VISTA on myeloid cells	25
S100A16 induces epithelial-mesenchymal transition in human PDAC cells and is a new therapeutic target for pancreatic cancer treatment that synergizes with gemcitabine	24
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study	24
Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin	24
CaMK4: Structure, physiological functions, and therapeutic potential	24
Suppression of NSCLC progression via the co-administration of Danusertib, an AURK inhibitor, and KRIBB11, an HSF1 inhibitor	24
Pharmacogene expression during progression of metabolic dysfunction-associated steatotic liver disease: Studies on mRNA and protein levels and their relevance to drug treatment	24
Sleep during COVID-19 lockdown: A cross-cultural study investigating job system relevance	23
Increased uterine arterial tone, stiffness and remodeling with augmented matrix metalloproteinase-1 and -7 in uteroplacental ischemia-induced hypertensive pregnancy	23
Neratinib exerts dual effects on cartilage degradation and osteoclast production in Osteoarthritis by inhibiting the activation of the MAPK/NF-κB signaling pathways	23
Probiotics as a strategy for addressing helminth infections in low-income countries: Working smarter rather than richer	23
Paris saponins Ⅶ inhibits glycolysis of ovarian cancer via the RORC/ACK1 signaling pathway	23
Human P2X7 receptors – Properties of single ATP-gated ion channels	23
Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea	23
ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats	23
RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseases	23
Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2	23
A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease	23
Zoledronate repositioning as a potential trypanocidal drug. Trypanosoma cruzi HPRT an alternative target to be considered	23
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway	23
Metformin-conjugated micellar system with intratumoral pH responsive de-shielding for co-delivery of doxorubicin and nucleic acid	23
Design, synthesis and biological evaluation of novel curcumin-fluorouracil hybrids as potential anti-cancer agents	23
EYA4 reduces chemosensitivity of osteosarcoma to doxorubicin through DNA damage repair	23
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway	22
Mitochondria and the permeability transition pore in cancer metabolic reprogramming	22
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1	22
Unraveling HDAC11: Epigenetic orchestra in different diseases and structural insights for inhibitor design	22
Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists	22
P2X7 receptors in the central nervous system	22
Targeting the NLRP3 inflammasome in diabetic retinopathy: From pathogenesis to therapeutic strategies	22
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer	22
Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor	22
MicroRNA-15b promotes cardiac ischemia injury by the inhibition of Mitofusin 2/PERK pathway	22
Impact of the redox-active MnTnHex-2-PyP5+ and cisplatin on the metabolome of non-small cell lung cancer cells	22
Editorial Board	22
Regression of ovarian cancer xenografts by depleting or inhibiting RLIP	22
High-throughput screening identifies stevioside as a potent agent to induce apoptosis in bladder cancer cells	22
A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells	22
Circadian, sleep-wake dependent or both? A preface to the special issue “Circadian rhythm and sleep-wake dependent regulation of behavior and brain function”	22
Non-coding RNAs: Emerging from the discovery to therapeutic applications	22
The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity	21
Enhydrin suppresses the malignant phenotype of GBM via Jun/Smad7/TGF-β1 signaling pathway	21
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis	21
Attenuation of growth hormone production at the fetal stage is critical for dioxin-induced developmental disorder in rat offspring	21
Tetrahydroberberrubine exhibits preventive effect on obesity by activating PGC1α-mediated thermogenesis in white and brown adipose tissue	21
Reg2 treatment is protective but the induced Reg2 autoantibody is destructive to the islets in NOD mice	21
Mesenchymal stem cells loaded with oncolytic reovirus enhances antitumor activity in mice models of colorectal cancer	21
miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway	21
The aging brain: sleep, the circadian clock and exercise	21
Differential pattern of neurotoxicity induced by the gliadin peptides p31-43 and p57-68 in in vitro model of epilepsy	21
Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells	20
Characterization of a novel LTA/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae)	20
Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy	20
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization	20
Interfering with alternatively activated macrophages by CSF-1R inhibition exerts therapeutic capacity on allergic airway inflammation	20
Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition	20
Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial dysfunction	20
Activation of activator protein-1-fibroblast growth factor 21 signaling attenuates Cisplatin hepatotoxicity	20
Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)	20
Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis	20
Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats	20
A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo	20
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation patterns	20
Carbon monoxide and β-cell function: Implications for type 2 diabetes mellitus	20
Methionine cycle in nonalcoholic fatty liver disease and its potential applications	20
Phytochemicals modulate pancreatic islet β cell function through glucagon-like peptide-1-related mechanisms	20
Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status	20
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models	20
Exploring cell competition for the prevention and therapy of esophageal squamous cell carcinoma	19
Oncogenic FLT3 internal tandem duplication activates E2F1 to regulate purine metabolism in acute myeloid leukaemia	19
Long-term glucocorticoid exposure persistently impairs CD4+ T cell biology by epigenetically modulating the mTORC1 pathway	19
Preserved oxytocin-induced myometrium contraction and sensitivity to progesterone inhibition following rat uterus thermal insult. Impact on fertility	19
Necrosulfonamide ameliorates intestinal inflammation via inhibiting GSDMD-medicated pyroptosis and MLKL-mediated necroptosis	19
Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release	19
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex	19
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV pathogen box	19
Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere	19
Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Geraniol alleviate	19
Dahl salt-resistant rats are protected against angiotensin II-induced hypertension	19
PPARGC1A affects inflammatory responses in photodynamic therapy (PDT)-treated inflammatory bowel disease (IBD)	19
The role of Notch signaling pathway in metabolic bone diseases	19
Carbon monoxide mechanism of protection against renal ischemia and reperfusion injury	19