Biochemical Pharmacology

Article	Citations
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective	702
The growth of siRNA-based therapeutics: Updated clinical studies	254
Detection of Viral Infections by Innate Immunity	224
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine	137
Sleep timing, chronotype and social jetlag: Impact on cognitive abilities and psychiatric disorders	105
Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery	99
The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro	98
Targeting tumor-associated macrophages as an antitumor strategy	91
Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1	88
P2X7 receptor and the NLRP3 inflammasome: Partners in crime	85
Drug uptake-based chemoresistance in breast cancer treatment	85
Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease	84
SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management	79
Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action	78
Therapeutic potential of targeting mitochondrial dynamics in cancer	78
Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches	78
White adipose tissue dysfunction in obesity and aging	75
The relevance of daylight for humans	73
Polo-like kinase 1 (PLK1) signaling in cancer and beyond	72
Obesity II: Establishing causal links between chemical exposures and obesity	68
Mechanisms of ketamine and its metabolites as antidepressants	68
Obesity I: Overview and molecular and biochemical mechanisms	67
Minocycline promotes functional recovery in ischemic stroke by modulating microglia polarization through STAT1/STAT6 pathways	67
Ferroptosis and its potential as a therapeutic target	66
Recent progress on targeting ferroptosis for cancer therapy	65

Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition	63
Alzheimer’s disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?	63
Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer’s and Parkinson’s disease therapeutics	62
Circadian rhythm in pharmacokinetics and its relevance to chronotherapy	62
Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators	60
Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production, protecting against deoxynivalenol exposure in nude mice	59
Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction	58
Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance	56
Cisplatin in cancer treatment	54
Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside	53
Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms	53
New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers	52
Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease	51
Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development	50
PDE4 inhibition as a therapeutic strategy for improvement of pulmonary dysfunctions in Covid-19 and cigarette smoking	50
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective	50
Molecular pharmacology of P2Y receptor subtypes	50
COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials	49
Oroxylin A reduces osteoclast formation and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation	49
The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations	49
Applications and evolution of melittin, the quintessential membrane active peptide	49
Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat	48
The management of severe asthma in 2020	48
Antisense drug discovery and development technology considered in a pharmacological context	48
Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function	47
History of ectonucleotidases and their role in purinergic signaling	46
Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction	46
Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions	46
TGF-β1-activated cancer-associated fibroblasts promote breast cancer invasion, metastasis and epithelial-mesenchymal transition by autophagy or overexpression of FAP-α	45
Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities	45
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase	45
Targeting immunosuppression by TGF-β1 for cancer immunotherapy	44
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway	44
Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics	44
Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors	43
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer	43
Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients	43
Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes	43
Targeted therapy for breast cancer: An overview of drug classes and outcomes	42
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential	41
N6-methyladenosine RNA modification in cancer therapeutic resistance: Current status and perspectives	41
The therapeutic importance of acid-base balance	41
Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection	41
Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer	41
Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine	40
The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides	40
Vitamin D and the risk for cancer: A molecular analysis	40
Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression	39
Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists	39
Aryl hydrocarbon receptor: Its roles in physiology	39

Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response	38
Parathyroid hormone and its related peptides in bone metabolism	38
Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy	38
Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors	38
Porcine milk exosome miRNAs protect intestinal epithelial cells against deoxynivalenol-induced damage	38
Peripheral nitric oxide signaling directly blocks inflammatory pain	38
Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform	37
The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor	37
Resolvin E1 protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress, autophagy and apoptosis by targeting AKT/mTOR signaling	37
Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling	37
Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment	37
Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: Principles and application	37
AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication	37
Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs	36
Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention	36
Estrogen receptor-positive (ER+) breast cancer treatment: Are multi-target compounds the next promising approach?	36
Regulation of IRF3 activation in human antiviral signaling pathways	35
Epigenetics/epigenomics of triterpenoids in cancer prevention and in health	35
Amino acid metabolism, transport and signalling in the liver revisited	35
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer	35
Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system	34
ALKBH1 promotes lung cancer by regulating m6A RNA demethylation	34
OATP2B1 – The underrated member of the organic anion transporting polypeptide family of drug transporters?	34
Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?	34
Purinergic signaling in diabetes and metabolism	34
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression	34
Prediction of response to biological treatment with monoclonal antibodies in severe asthma	34
Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway	34
Snake antivenom: Challenges and alternate approaches	34
P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice	34
Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway	34
Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells	34
Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases	33
The impact of DAMP-mediated inflammation in severe COVID-19 and related disorders	33
Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways	33
Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors	33
Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators	33
Aryl hydrocarbon receptor (AHR)-mediated inflammation and resolution: Non-genomic and genomic signaling	33
Identification of psychedelic new psychoactive substances (NPS) showing biased agonism at the 5-HT2AR through simultaneous use of β-arrestin 2 and miniGαq bioassays	33
Progesterone: An enigmatic ligand for the mineralocorticoid receptor	33
Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression	33
A nine-lncRNA signature predicts distant relapse-free survival of HER2-negative breast cancer patients receiving taxane and anthracycline-based neoadjuvant chemotherapy	33
Procyanidin B1, a novel and specific inhibitor of Kv10.1 channel, suppresses the evolution of hepatoma	33
Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters	33
The role of clock genes in sleep, stress and memory	32
NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury	32
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1	31
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages	31
LncRNA regulation: New frontiers in epigenetic solutions to drug chemoresistance	31
Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-β/Smad signaling pathway	31
Dysregulation of iron metabolism in cardiovascular diseases: From iron deficiency to iron overload	31
B7-H3 augments the pro-angiogenic function of tumor-associated macrophages and acts as a novel adjuvant target for triple-negative breast cancer therapy	30
The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications	30
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway	30
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction	30
The role of epigenetics in the development of obesity	30
HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo	30
Nitric oxide and tumor metabolic reprogramming	30
“Selective” serotonin 5-HT2A receptor antagonists	30
Non-coding RNAs: Emerging from the discovery to therapeutic applications	30
Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost	29
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin	29
Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma	29
Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β	29
Targeting mitochondrial respiration for the treatment of acute myeloid leukemia	29
Sensitizing activities of nitric oxide donors for cancer resistance to anticancer therapeutic drugs	29
Melatonin improves cognitive function by suppressing endoplasmic reticulum stress and promoting synaptic plasticity during chronic cerebral hypoperfusion in rats	29
Tumor associated macrophages and ‘NO’	29
Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway	28
GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer’s disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway	28
Virotherapy: From single agents to combinatorial treatments	28
P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications	28
Maresin conjugates in tissue regeneration 1 prevents lipopolysaccharide-induced cardiac dysfunction through improvement of mitochondrial biogenesis and function	28
Dysfunctional cerebrovascular tone contributes to cognitive impairment in a non-obese rat model of prediabetic challenge: Role of suppression of autophagy and modulation by anti-diabetic drugs	28
Canagliflozin inhibits p-gp function and early autophagy and improves the sensitivity to the antitumor effect of doxorubicin	28
Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated	27
Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells	27
Targeting the spliceosome machinery: A new therapeutic axis in cancer?	27
Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets	27
Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics	27

The P2Y/P2X divide: How it began	27
Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway	27
The role of FUNDC1 in mitophagy, mitochondrial dynamics and human diseases	27
3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells	27
miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2	27
Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition	27
Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis	26
Celastrol ameliorates acute liver injury through modulation of PPARα	26
Assessment of biased agonism at the A3 adenosine receptor using β-arrestin and miniGαi recruitment assays	26
The multiple roles and therapeutic potential of HSP60 in cancer	26
Regulation of p53 stability as a therapeutic strategy for cancer	26
Promises and challenges of biologics for severe asthma	26
Polyphenols and taste 2 receptors. Physiological, pathophysiological and pharmacological implications	26
Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway	26
Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS	25
Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases	25
Historical origins of the discovery of mammalian nitric oxide (nitrogen monoxide) production/physiology/pathophysiology	25
The primary cilium: Its role as a tumor suppressor organelle	25
Short-chain free-fatty acid G protein-coupled receptors in colon cancer	25
Eosinophil diversity in asthma	25
Pharmacological inhibition of mitochondrial fission attenuates cardiac ischemia-reperfusion injury in pre-diabetic rats	25
Angiotensin II receptor type 1 – An update on structure, expression and pathology	25
Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation	25
The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes	25
Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature	25
Dipeptidyl peptidase 4 inhibitors: Applications in innate immunity?	25
Hepatocellular carcinoma: Gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450	24
Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study	24
Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases	24
Human gut bacterial β-glucuronidase inhibition: An emerging approach to manage medication therapy	24
Diphenyl diselenide alleviates diabetic peripheral neuropathy in rats with streptozotocin-induced diabetes by modulating oxidative stress	24
The role of P2Y receptors in regulating immunity and metabolism	24
Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention	24
Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2	23
Pyrvinium pamoate attenuates non-alcoholic steatohepatitis: Insight on hedgehog/Gli and Wnt/β-catenin signaling crosstalk	23
Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway	23
Perillaldehyde: A promising antifungal agent to treat oropharyngeal candidiasis	23
Regulation of membrane phospholipid biosynthesis in mammalian cells	23
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation	23
Cell adhesion molecule-mediated therapeutic strategies in atherosclerosis: From a biological basis and molecular mechanism to drug delivery nanosystems	23
Developmental exposure to phytoestrogens found in soy: New findings and clinical implications	23
Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells	23
Paracrine TGF-β1 from breast cancer contributes to chemoresistance in cancer associated fibroblasts via upregulation of the p44/42 MAPK signaling pathway	23
Inhibition of RUNX1 promotes cisplatin-induced apoptosis in ovarian cancer cells	23
Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II)	23
A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine	23
Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis	23
The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapy	23
Future prospects for mitosis-targeted antitumor therapies	23
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors	23
The metabolism and biotransformation of AFB1: Key enzymes and pathways	23
Pathogenic mitochondrial dysfunction and metabolic abnormalities	22
Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity	22
Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases	22
Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance	22
Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis	22
Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy	22
Sleep during COVID-19 lockdown: A cross-cultural study investigating job system relevance	22
Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy	22
Endothelial and vascular smooth muscle dysfunction in hypertension	22
A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells	22
Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway	21
TGF-β1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression	21
Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor	21
Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux	21
A novel oral glucagon-like peptide 1 receptor agonist protects against diabetic cardiomyopathy via alleviating cardiac lipotoxicity induced mitochondria dysfunction	21
HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis	21
Formation of eicosanoids and other oxylipins in human macrophages	21
A selective NaV1.1 activator with potential for treatment of Dravet syndrome epilepsy	21
Therapeutics on the clock: Circadian medicine in the treatment of chronic inflammatory diseases	21
β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance	21
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2	21
Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways	21
Receptor tyrosine kinases and heparan sulfate proteoglycans: Interplay providing anticancer targeting strategies and new therapeutic opportunities	21
DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages	21
Purinergic signalling in host innate immune defence against intracellular pathogens	21
Chemogenetics a robust approach to pharmacology and gene therapy	21
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization	21
The amino acid transporter SLC7A11-mediated crosstalk implicated in cancer therapy and the tumor microenvironment	21
Extracellular adenosine 5′-triphosphate in pulmonary disorders	21
A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis	21
The aging brain: sleep, the circadian clock and exercise	21
Dapagliflozin attenuates arrhythmic vulnerabilities by regulating connexin43 expression via the AMPK pathway in post-infarcted rat hearts	21
Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model	20
Metformin in Alzheimer’s disease: An overview of potential mechanisms, preclinical and clinical findings	20
The sodium-glucose cotransporter-2 (SGLT2) inhibitors synergize with nitric oxide and prostacyclin to reduce human platelet activation	20
Protective effect of the sphingosine-1 phosphate receptor agonist siponimod on disrupted blood brain barrier function	20
Our evolving understanding of how 27-hydroxycholesterol influences cancer	20
Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library	20
Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives	20
Targeting Akt-associated microRNAs for cancer therapeutics	20
Ischemic stroke and infection: A brief update on mechanisms and potential therapies	20
Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury	20
Circulating miRNAs in diabetic retinopathy patients: Prognostic markers or pharmacological targets?	20
Exosomes: Powerful weapon for cancer nano-immunoengineering	20