Biochemical Pharmacology

Papers
(The TQCC of Biochemical Pharmacology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)
ArticleCitations
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice374
Corrigendum to “Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells” [Biochem. Pharmacol. 176 (2020) 113902]188
Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells170
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase147
Editorial Board135
Corrigendum to “Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord” [Biochem. Pharmacol. 185 (2021) 114411]132
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights122
Sleep during COVID-19 lockdown: A cross-cultural study investigating job system relevance120
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis110
Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy108
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis106
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review103
Corrigendum to “Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis” [Biochem. Pharmacol. 232 (2025) 116711]102
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy93
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway88
Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention86
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons85
Methionine cycle in nonalcoholic fatty liver disease and its potential applications85
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib79
Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation78
Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation76
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway70
The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity69
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain68
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis67
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F167
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease67
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex67
Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis64
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis64
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy62
Bile acids and bile acid activated receptors in the treatment of Covid-1962
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure57
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models56
Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells56
Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans56
HDAC6 is involved in diabetic nephropathy by regulating TGFβ/Smads and NF-κB signaling pathways55
PXR as the tipping point between innate immune response, microbial infections, and drug metabolism55
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models53
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway53
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies52
Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release52
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study52
Diabetes and the fabkin complex: A dual-edged sword51
The relationship between tumor metabolism and 5-fluorouracil resistance51
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization50
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect50
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies50
The potent role of Src kinase-regulating glucose metabolism in cancer50
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex49
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases48
Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression48
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling47
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease46
Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension45
Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo45
KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP/PS1 mice by inhibiting PARP16 expression45
Sirtuin1-p53: A potential axis for cancer therapy45
Itaconate alleviates β2-microglobulin-induced cognitive impairment by enhancing the hippocampal amino-β-carboxymuconate-semialdehyde-decarboxylase/picolinic acid pathway44
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products43
The value of neck adipose tissue as a predictor for metabolic risk in health and type 2 diabetes43
Single bioengineered ncRNA molecule for dual-targeting toward the control of non-small cell lung cancer patient-derived xenograft tumor growth43
Potential small effector molecules restoring cellular defects due to sialic acid biosynthetic enzyme deficiency: Pathological relevance to GNE myopathy42
Carbon monoxide in cell signaling and potential therapeutics42
The role and regulation of Pnn in proliferative and non-dividing cells: Form embryogenesis to pathogenesis42
Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)42
Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas’ disease42
Knockdown of Galectin-9 alleviates rheumatoid arthritis through suppressing TNF-α-induced activation of fibroblast-like synoviocytes41
FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression41
Mast cell activation induced by tamoxifen citrate via MRGPRX2 plays a potential adverse role in breast cancer treatment41
Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver41
DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca2+/calcineurin pathway40
LILRB4 as a novel immunotherapeutic target for multiple diseases40
Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction39
GRHL3 drives radiotherapy resistance and blocks the anti-tumor response of NK and CD4+ T cells in lung squamous cell carcinoma via RNF239
Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines38
Targeting non-coding RNAs and N6-methyladenosine modification in hepatocellular carcinoma38
Effect of pharmacological heart failure drugs and gene therapy on Danon's cardiomyopathy38
Recent advances in studies on FtsZ inhibitors38
SIS3 suppresses osteoclastogenesis and ameliorates bone loss in ovariectomized mice by modulating Nox4-dependent reactive oxygen species38
Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson’s disease37
Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate37
SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription37
Editorial Board37
Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis36
Peroxisome proliferator-activated receptor (PPAR) agonists as a potential therapy for inherited metabolic disorders36
Viral Vectors, Exosomes, and Vexosomes: Potential armamentarium for delivering CRISPR/Cas to cancer cells36
Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice35
Rosavidin protects against PM2.5-induced lung toxicity via inhibition of NLRP3 inflammasome-mediated pyroptosis by activating the PI3K/AKT pathway35
Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG135
Physiological and pharmacological overview of the gonadotropin releasing hormone35
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders34
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα34
The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding34
Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages34
Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance34
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis34
Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities33
Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p33
Exploring the glycation association with dyslipidaemia: Novel approach for diabetic nephropathy33
ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma33
UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder33
Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives32
Dexmedetomidine alleviates anxiety-like behavior in mice following peripheral nerve injury by reducing the hyperactivity of glutamatergic neurons in the anterior cingulate cortex32
Dual-specificity tyrosine phosphorylation-regulated kinase 1A promotes the inclusion of amyloid precursor protein exon 732
Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease32
Immunometabolic attributes and mitochondria-associated signaling of Tumor-Associated Macrophages in tumor microenvironment modulate cancer progression32
6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model32
Immunomodulatory effects of antiangiogenic tyrosine kinase inhibitors in renal cell carcinoma models: Impact on following anti-PD-1 treatments32
PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells31
Targeting nucleolin by RNA G-quadruplex-forming motif31
Corrigendum to “Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury“ [Biochem. Pharmacol. 63(1) (2002)31
Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis31
Ponatinib exacerbate renal injury in systemic lupus erythematosus mouse model through PDGFR-PI3K/AKT pathway31
Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro31
Mitomycin induced the senescence of alveolar epithelial cells by targeting peroxiredoxin I31
Differential contribution of renal cytochrome P450 enzymes to kidney endothelial dysfunction and vascular oxidative stress in obesity30
Ifosfamide alleviates autoimmune toxicity and enhances antitumor efficacy in melanoma immunotherapy30
xCT/Slc7a11 promotes pulmonary arterial hypertension by disrupting AMPKα suppression of mTOR activation30
Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting30
Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation30
Targeting fibroblast activation protein with chimeric antigen receptor macrophages30
Preclinical evaluation of new drug-drug interactions of lomitapide: A proposal for novel mechanism of interaction associated with lipid metabolic changes29
Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology29
Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets29
P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA29
PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction29
TNFα blockade reverses vascular and uteroplacental matrix metalloproteinases imbalance and collagen accumulation in hypertensive pregnant rats28
Cytarabine-induced destabilization of MCL1 mRNA and protein triggers apoptosis in leukemia cells28
Editorial Board28
Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses28
Therapeutic of a white adipose tissue-specific bivalent aptamer in obesity28
Mithramycin suppresses tumor growth by regulating CD47 and PD-L1 expression28
Corrigendum to “Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Ge28
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities28
Detailed resume of S-methyltransferases: Categories, structures, biological functions and research advancements in related pathophysiology and pharmacotherapy28
Corrigendum to “DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages” [Biochem. Pharmacol. 184 (2021) 114399]28
IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation28
Overview of the therapeutic strategies for ER positive breast cancer27
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 227
Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies27
Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics27
A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine27
Finding new analgesics: Computational pharmacology faces drug discovery challenges27
Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives27
FGFR3 phosphorylates EGFR to promote cisplatin-resistance in ovarian cancer27
Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators27
Mitochondrial elongation confers protection against doxorubicin-induced cardiotoxicity26
SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3)26
Targeting regulated chondrocyte death in osteoarthritis therapy26
Positive programming of the GC-IGF1 axis mediates adult osteoporosis susceptibility in male offspring rats induced by prenatal dexamethasone exposure26
CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis26
Antibody-drug conjugates for non-small cell lung cancer: Advantages and challenges in clinical translation26
Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles26
Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway26
Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity26
BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury26
The critical roles of STING in mitochondrial homeostasis26
MiR-466b-3p/HDAC7 meditates transgenerational inheritance of testicular testosterone synthesis inhibition induced by prenatal dexamethasone exposure26
A rational foundation for micheliolide-based combination strategy by targeting redox and metabolic circuit in cancer cells26
Activated microglia secretome and proinflammatory cytokines increase neuronal mu-opioid receptor signalling and expression25
Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects25
Eicosatrienoic acid inhibits estradiol synthesis through the CD36/FOXO1/CYP19A1 signaling pathway to improve PCOS in mice25
Macrophage-derived human resistin promotes perivascular adipose tissue dysfunction in experimental inflammatory arthritis25
Editorial Board25
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin25
Corrigendum to “TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain” [Biochem. Pharmacol. 192 (2021) 125
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cel25
Editorial Board25
RNA therapeutics: From biochemical pharmacology to technology development and clinical applications25
Citrulline activates adenosine receptors: New insight into metabolic pathways interaction25
Corrigendum to “Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics” [Biochem. Pharmacol. 24
An A-ring substituted evodiamine derivative with potent anticancer activity against human non-small cell lung cancer cells by targeting heat shock protein 7024
Selpercatinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway24
Inhibition of soluble epoxide hydrolase relieves adipose inflammation via modulating M1/M2 macrophage polarization to alleviate airway inflammation and hyperresponsiveness in obese asthma24
Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes24
Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway24
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors24
The increasing role of pigment epithelium-derived factor in metastasis: from biological importance to a promising target24
Azithromycin modulates Teff/Treg balance in retinal inflammation via the mTOR signaling pathway24
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction24
Extracellular nucleotides in smooth muscle contraction24
Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies23
Enhanced thermogenesis in PAS Kinase-deficient male mice23
Spectral sensitivity of circadian phase resetting, melatonin suppression and acute alerting effects of intermittent light exposure23
Is REM sleep a paradoxical state?: Different neurons are activated in the cingulate cortices and the claustrum during wakefulness and paradoxical sleep hypersomnia23
Implication of Let7b/AhR/ARNT/HMGB1/RAGE cascade in neuroplasticity disturbances induced by glucocorticoids and the promising reversible effect of 3,3 diindolymethane: Bidirectional crosstalk of Aryl 23
Cardiac human bitter taste receptors contain naturally occurring variants that alter function23
Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis23
Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells23
Mechanotransduction and the extracellular matrix: Key drivers of lung pathologies and drug responsiveness23
Cell-specific drug targeting in the lung23
Sterol regulation of developmental and oncogenic Hedgehog signaling23
Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer23
PPARγ activation by fisetin mitigates vascular smooth muscle cell senescence via the mTORC2-FoxO3a-autophagy signaling pathway23
Pathogenic mitochondrial dysfunction and metabolic abnormalities23
Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate re23
Delineating the tumour-regulatory roles of EYA423
A systematic review and meta-analysis of environmental contaminant exposure impacts on weight loss and glucose regulation during calorie-restricted diets in preclinical studies: Persistent organic pol23
Glucocorticoids and natural killer cells: A suppressive relationship23
The role of taurine through endoplasmic reticulum in physiology and pathology23
Canonical DDR activation by EMT inducing agent 5-Fluorouracil is modulated by a cannabinoid based combinatorial approach via inducing autophagy and suppression of vimentin expression23
Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis22
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress22
miR-486-5p-rich extracellular vesicles derived from patients with olanzapine-induced insulin resistance negatively affect glucose-regulating function22
AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review22
Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR12022
Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury22
Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice22
Curing childhood cancer the “Natural” Way: Nature as the source of chemotherapy agents22
CXCR2, a novel target to overcome tyrosine kinase inhibitor resistance in chronic myelogenous leukemia cells22
CD146+Mesenchymal stem cells treatment improves vascularization, muscle contraction and VEGF expression, and reduces apoptosis in rat ischemic hind limb22
3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages22
Cancer stem cells: Recent insights and therapies22
Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk22
Editorial Board22
Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy22
Animal models of acute lymphoblastic leukemia: Recapitulating the human disease to evaluate drug efficacy and discover therapeutic targets22
Redox regulation by carotenoids: Evidence and conflicts for their application in cancer22
Editorial Board22
The relevance of daylight for humans22
Calcium saccharate/DUSP6 suppresses renal cell carcinoma glycolytic metabolism and boosts sunitinib efficacy via the ERK-AKT pathway22
FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy22
Corrigendum to “Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways” [Biochem. Pharmacol21
Flavokawain B is an effective natural peroxisome proliferator-activated receptor γ-selective agonist with a strong glucose-lowering effect21
Estrogen dampens central cannabinoid receptor 1-mediated neuroexcitation and pressor response in conscious female rats21
Sonidegib potentiates the cancer cells’ sensitivity to cytostatic agents by functional inhibition of ABCB1 and ABCG2 in vitro and ex vivo21
Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats21
ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus21
Detailed functional characterization of four nanobodies as positive allosteric modulators of the human calcium-sensing receptor21
Editorial Board21
Acknowledgment21
Antiplatelet drug ticagrelor suppresses triple negative breast cancer metastasis by targeting PI3K21
Selective stabilization of the intermediate inactivated Na+ channel by the new-generation anticonvulsant rufinamide21
Corrigendum to “Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway” [Biochem. Pharmacol. 92 (2014) 484–493]21
Suppression MGP inhibits tumor proliferation and reverses oxaliplatin resistance in colorectal cancer21
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease21
Intestinal guard: Human CXCL17 modulates protective response against mycotoxins and CXCL17-mimetic peptides development21
Heat shock protein 90 inhibitor 17-AAG down-regulates thymidine phosphorylase expression and potentiates the cytotoxic effect of tamoxifen and erlotinib in human lung squamous carcinoma cells21
Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo21
Activation of aryl hydrocarbon receptor by azatyrosine-phenylbutyric hydroxamide inhibits progression of diabetic retinopathy mice20
Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?20
Pharmacological characterization of prostaglandin E2 EP2 and EP4 receptors in male rat locus coeruleus neurons ex vivo20
TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion20
Targeting epigenetics as a promising therapeutic strategy for treatment of neurodegenerative diseases20
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury20
Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells20
Challenges and opportunities in gene editing of B cells20
Cardiometabolic effects of sacubitril/valsartan in a rat model of heart failure with preserved ejection fraction20
AT1 receptors modulate ethanol-induced loss of anticontractile effect of perivascular adipose tissue20
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