Biochemistry

Article	Citations
Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles	102
Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3	88
Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag	80
Modulating α-Synuclein Liquid–Liquid Phase Separation	68
Genetic Code Expansion: A Brief History and Perspective	65
Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies: Structurally Adaptable Allosteric Communication Hotspots Define Spike Si	63
Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates	62
Targeting Lipid Metabolism in Liver Cancer	59
Ligandability of E3 Ligases for Targeted Protein Degradation Applications	50
Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation	50
The Biochemical Landscape of Riboswitch Ligands	49
Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic	49
Principles Governing the Phase Separation of Multidomain Proteins	47
Exploring the Mechanism of Covalent Inhibition: Simulating the Binding Free Energy of α-Ketoamide Inhibitors of the Main Protease of SARS-CoV-2	47
Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity	45
Cryo-EM Structure of the Rhodobacter sphaeroides Light-Harvesting 2 Complex at 2.1 Å	42
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors	40
High-Throughput Screening at the Membrane Interface Reveals Inhibitors of Amyloid-β	39
How Do Branched Detergents Stabilize GPCRs in Micelles?	39
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation	37
Mechanism of Catalysis by l-Asparaginase	36
Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide	35
Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria	34
Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences	31
Improving the Treatment of Acute Lymphoblastic Leukemia	30

Solving the Conundrum: Widespread Proteins Annotated for Urea Metabolism in Bacteria Are Carboxyguanidine Deiminases Mediating Nitrogen Assimilation from Guanidine	29
Enzyme Stabilization by Virus-Like Particles	29
Bicarbonate-Mediated CO2 Formation on Both Sides of Photosystem II	29
Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists	29
Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases	29
Biosynthesis of Metal Nanoparticles from Leaves of Ficus palmata and Evaluation of Their Anti-inflammatory and Anti-diabetic Activities	29
Dimerization Induced by C-Terminal 14–3–3 Binding Is Sufficient for BRAF Kinase Activation	29
Hydration and Dynamics of Full-Length Tau Amyloid Fibrils Investigated by Solid-State Nuclear Magnetic Resonance	29
Fast and Specific Peroxygenase Reactions Catalyzed by Fungal Mono-Copper Enzymes	29
Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils	28
Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease	28
Effect of Molecular Crowding on the Stability of RNA G-Quadruplexes with Various Numbers of Quartets and Lengths of Loops	28
Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo	26
The Origin of Lipid Rafts	26
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function	26
The NBDY Microprotein Regulates Cellular RNA Decapping	26
Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry	25
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design	25
Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution	24
Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening	24
Direct Mapping of Higher-Order RNA Interactions by SHAPE-JuMP	24
Pulse EPR Spectroscopic Characterization of the S3 State of the Oxygen-Evolving Complex of Photosystem II Isolated from Synechocystis	24
Effect of Surface Modification with Hydrocarbyl Groups on the Exocytosis of Nanoparticles	24
Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity	24
Protein Substrates Engage the Lumen of O-GlcNAc Transferase’s Tetratricopeptide Repeat Domain in Different Ways	23
Understanding the Link between Lipid Diversity and the Biophysical Properties of the Neuronal Plasma Membrane	23
Midazolam as a Probe for Drug–Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation	22
Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes	22
Dynamic Connection between Enzymatic Catalysis and Collective Protein Motions	22
Energetics of Ionized Water Molecules in the H-Bond Network near the Ca2+ and Cl– Binding Sites in Photosystem II	22
Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum	22
Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension	22
Targeted Degradation of the Oncogenic Phosphatase SHP2	22
Global Profiling of Cellular Substrates of Human Dcp2	21
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode	21
Human γS-Crystallin–Copper Binding Helps Buffer against Aggregation Caused by Oxidative Damage	21
Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC	21
The Inflection Point Hypothesis: The Relationship between the Temperature Dependence of Enzyme-Catalyzed Reaction Rates and Microbial Growth Rates	21
Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life	21
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen	21
Probing the Conformational Changes Associated with DNA Binding to PARP1	20
Structural Studies of the Methylosinus trichosporium OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel	20
Reframing the Protein Folding Problem: Entropy as Organizer	20
Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery	20
HDAC6 ZnF UBP as the Modifier of Tau Structure and Function	20
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2	20
Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach	20
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates	19
Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway	19
The m6A Consensus Motif Provides a Paradigm of Epitranscriptomic Studies	19

The Structure of the Dimeric State of IscU Harboring Two Adjacent [2Fe–2S] Clusters Provides Mechanistic Insights into Cluster Conversion to [4Fe–4S]	19
Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3	19
Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force	19
Metal Sequestration and Antimicrobial Activity of Human Calprotectin Are pH-Dependent	19
Enhanced Cholesterol-Dependent Hemifusion by Internal Fusion Peptide 1 of SARS Coronavirus-2 Compared to Its N-Terminal Counterpart	18
A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster	18
Flexible Synthetic Carbohydrate Receptors as Inhibitors of Viral Attachment	18
The 2-Aminopyridine Nucleobase Improves Triple-Helical Recognition of RNA and DNA When Used Instead of Pseudoisocytosine in Peptide Nucleic Acids	18
Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors	18
Discovery of a New, Recurrent Enzyme in Bacterial Phosphonate Degradation: (R)-1-Hydroxy-2-aminoethylphosphonate Ammonia-lyase	18
Correlated Motions in Structural Biology	18
Polyamines Mediate Folding of Primordial Hyperacidic Helical Proteins	17
Engineering Fe(II)/α-Ketoglutarate-Dependent Halogenases and Desaturases	17
Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2	17
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases	17
Buffers, Especially the Good Kind	17
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain	17
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin	17
Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles	17
Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases	17
Can Selenoenzymes Resist Electrophilic Modification? Evidence from Thioredoxin Reductase and a Mutant Containing α-Methylselenocysteine	17
Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport	17
Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences	17
Mimicking Functions of Native Enzymes or Photosynthetic Reaction Centers by Nucleoapzymes and Photonucleoapzymes	16
Engineering of a Brighter Variant of the FusionRed Fluorescent Protein Using Lifetime Flow Cytometry and Structure-Guided Mutations	16
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease	16
An Ambidextrous Polyphenol Glycosyltransferase PaGT2 from Phytolacca americana	16
Mechanism of Oxygen Evolution and Mn4CaO5 Cluster Restoration in the Natural Water-Oxidizing Catalyst	16
Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin	16
Progress, Challenges, and Opportunities with Artificial Metalloenzymes in Biosynthesis	16
Protein Sequence Selection Method That Enables Full Consensus Design of Artificial l-Threonine 3-Dehydrogenases with Unique Enzymatic Properties	16
One-Enzyme Reverse Transcription qPCR Using Taq DNA Polymerase	16
Hidden Conformational States and Strange Temperature Optima in Enzyme Catalysis	16
Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity	16
Intermolecular and Intramolecular Interactions of the Arabidopsis Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker	16
Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction	16
The Interaction between PsbT and the DE Loop of D1 in Photosystem II Stabilizes the Quinone–Iron Electron Acceptor Complex	15
Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw	15
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1	15
Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products	15
Leveraging Peptide Sequence Modification to Promote Assembly of Chiral Helical Gold Nanoparticle Superstructures	15
Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition	15
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator	15
Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase	15
Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory	15
Lycopene-Family Carotenoids Confer Thermostability on Photocomplexes from a New Thermophilic Purple Bacterium	15
Residue-Specific Binding Mechanisms of Thioflavin T to a Surface of Flat β-Sheets within a Peptide Self-Assembly Mimic	15
Long-Acting Cabotegravir for HIV/AIDS Prophylaxis	14
Substrate-Dependent Mobile Loop Conformational Changes in Alkanesulfonate Monooxygenase from Accelerated Molecular Dynamics	14
A Chemoenzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir	14
Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni	14
X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10	14
Fatty Acid Photodecarboxylase Is an Interfacial Enzyme That Binds to Lipid–Water Interfaces to Access Its Insoluble Substrate	14
SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers	14
Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4-Kinase IIIβ	14
Targeted Protein Degradation via Lysosomes	14
An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways	14
Dried Protein Structure Revealed at the Residue Level by Liquid-Observed Vapor Exchange NMR	14
Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase	14
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications	14
Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin	14
Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets	13
Monitoring Protein–Protein Interactions in the Cyanobacterial Circadian Clock in Real Time via Electron Paramagnetic Resonance Spectroscopy	13
Polyanions Cause Protein Destabilization Similar to That in Live Cells	13
HD-[HD-GYP] Phosphodiesterases: Activities and Evolutionary Diversification within the HD-GYP Family	13
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, th	13
Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir	13
Structural Robustness Affects the Engineerability of Aminoacyl-tRNA Synthetases for Genetic Code Expansion	13
Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)	13
Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis	13
Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity	13
Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox	13
Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane–Membrane Interfaces	13
Biosynthesis of Oxetanocin-A Includes a B12-Dependent Radical SAM Enzyme That Can Catalyze both Oxidative Ring Contraction and the Demethylation of SAM	13
Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca2+Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic	13
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B	13
Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence	12
Live and Let Dye	12
On the Track of Long-Range Electron Transfer in B-Type Dye-Decolorizing Peroxidases: Identification of a Tyrosyl Radical by Computational Prediction and Electron Paramagnetic Resonance Spectroscopy	12
Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization	12

Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in Escherichia coli	12
The Siderophore Synthetase IucA of the Aerobactin Biosynthetic Pathway Uses an Ordered Mechanism	12
Structural Insights into Binding of Remdesivir Triphosphate within the Replication–Transcription Complex of SARS-CoV-2	12
Analysis of Tagged Proteins Using Tandem Affinity-Buffer Exchange Chromatography Online with Native Mass Spectrometry	12
PET Polymer Recycling	12
Structure and Role of BCOR PUFD in Noncanonical PRC1 Assembly and Disease	12
Convergent Evolution of Multiple Mutations Improves the Viral Fitness of SARS-CoV-2 Variants by Balancing Positive and Negative Selection	12
New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products	12
Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair	12
Cholesterol Asymmetrically Modulates the Conformational Ensemble of the Nucleotide-Binding Domains of P-Glycoprotein in Lipid Nanodiscs	12
Advances in the Treatment of Chronic Pain by Targeting GPCRs	12
Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase	12
De Novo-Designed β-Sheet Heme Proteins	12
Lifetimes of the Aglycone Substrates of Specifier Proteins, the Autonomous Iron Enzymes That Dictate the Products of the Glucosinolate-Myrosinase Defense System in Brassica Plants	12
Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions	12
Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzym	12
Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides	12
Water’s Variable Role in Protein Stability Uncovered by Liquid-Observed Vapor Exchange NMR	12
Danio rerio Oocytes for Eukaryotic In-Cell NMR	11
Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance	11
Insights into Cerebral Amyloid Angiopathy Type 1 and Type 2 from Comparisons of the Fibrillar Assembly and Stability of the Aβ40-Iowa and Aβ40-Dutch Peptides	11
Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid l-Dap in Capreomycin Biosynthesis	11
New Mechanism of Gemcitabine and Its Phosphates: DNA Polymerization Disruption via 3′–5′ Exonuclease Inhibition	11
Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides	11
Bioinformatic Expansion of Borosins Uncovers Trans-Acting Peptide Backbone N-Methyltransferases in Bacteria	11
The RNA Polymerase α Subunit Recognizes the DNA Shape of the Upstream Promoter Element	11
Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs)	11
Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane	11
The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through Its RGG and C-Terminal Domains	11
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?	11
Expression and In Vivo Characterization of the Antimicrobial Peptide Oncocin and Variants Binding to Ribosomes	11
The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme	11
Spectroscopic Investigation of Cysteamine Dioxygenase	11
How Sugars Protect Dry Protein Structure	11
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases	11
Epitope Mapping for a Preclinical Bevacizumab (Avastin) Biosimilar on an Extended Construct of Vascular Endothelial Growth Factor A Using Millisecond Hydrogen–Deuterium Exchange Mass Spectrometry	11
Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease	11
Light-Driven Catalytic Regulation of Enzymes at the Interface with Plasmonic Nanomaterials	11
The Zinc and Iron Binuclear Transport Center of ZupT, a ZIP Transporter from Escherichia coli	11
Structure of a Stable Interstrand DNA Cross-Link Involving a β-N-Glycosyl Linkage Between an N6-dA Amino Group and an Abasic Site	11
Long Range Communication between the Drug-Binding Sites and Nucleotide Binding Domains of the Efflux Transporter ABCB1	11
Thermodynamic and Kinetic Studies of the Interaction of Nuclear Receptor Coactivator-4 (NCOA4) with Human Ferritin	11
NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex	11
The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity	11
The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase	11
Ligand- and pH-Induced Structural Transition of Gypsy Moth Lymantria dispar Pheromone-Binding Protein 1 (LdisPBP1)	10
Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range	10
Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis	10
Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element	10
Origins of Ca2+ Imaging with Fluorescent Indicators	10
An Extended DNA Binding Domain of the Estrogen Receptor Alpha Directly Interacts with RNAs in Vitro	10
Kinetic and Spectroscopic Characterization of the Catalytic Ternary Complex of Tryptophan 2,3-Dioxygenase	10
Photoreaction Dynamics of a Full-Length Protein YtvA and Intermolecular Interaction with RsbRA	10
Hepatocellular Carcinoma and Statins	10
High-Affinity Binding of LDL Receptor-Related Protein 1 to Matrix Metalloprotease 1 Requires Protease:Inhibitor Complex Formation	10
Cytoskeletal Drugs Modulate Off-Target Protein Folding Landscapes Inside Cells	10
Local Electric Field Changes during the Photoconversion of the Bathy Phytochrome Agp2	10
PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments	10
Selection of High-Affinity RNA Aptamers That Distinguish between Doxycycline and Tetracycline	10
Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA	10
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity	10
The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam	10
Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins	10
Insights into Binding of Single-Stranded Viral RNA Template to the Replication–Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations	10
Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily	10
Variable Autoinhibition among Deafness-Associated Variants of Diaphanous 1 (DIAPH1)	10
Purification of Recombinant α-synuclein: A Comparison of Commonly Used Protocols	10
Remarkable Enhancement of Nucleotide Excision Repair of a Bulky Guanine Lesion in a Covalently Closed Circular DNA Plasmid Relative to the Same Linearized Plasmid	10
The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase	10
H1.0 C Terminal Domain Is Integral for Altering Transcription Factor Binding within Nucleosomes	10
ATR-FTIR Spectroelectrochemical Study on the Mechanism of the pH Dependence of the Redox Potential of the Non-Heme Iron in Photosystem II	10
Staphylococcus aureus Glucose-Induced Biofilm Accessory Protein A (GbaA) Is a Monothiol-Dependent Electrophile Sensor	10
Dynamics and Mechanism of Binding of Androstenedione to Membrane-Associated Aromatase	10
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay	10
Novel Mechanisms of Molecular Glue-Induced Protein Degradation	10
Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption	10
A Structural View of Alkyl-Coenzyme M Reductases, the First Step of Alkane Anaerobic Oxidation Catalyzed by Archaea	10
Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1	9
Global Mapping of Metalloproteomes	9
Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors	9
Design of a Superpositively Charged Enzyme: Human Carbonic Anhydrase II Variant with Ferritin Encapsulation and Immobilization	9
Metabolic Processing of Selenium-Based Bioisosteres of meso-Diaminopimelic Acid in Live Bacteria	9
Protonation State of a Key Histidine Ligand in the Iron–Quinone Complex of Photosystem II as Revealed by Light-Induced ATR-FTIR Spectroscopy	9
Peptide-Based Approach to Inhibition of the Multidrug Resistance Efflux Pump AcrB	9
New Light on the Mechanism of Phototransduction in Phototropin	9
Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP	9
Opposing Effects of PhoPQ and PmrAB on the Properties of Salmonella enterica serovar Typhimurium: Implications on Resistance to Antimicrobial Peptides	9
Bacterial Responses to Iron Withholding by Calprotectin	9
Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating N-d-Acetylglucosamine and d-Glucosamine	9
Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1	9
Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation	9
Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c	9
Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms	9
Comparison of the Forward and Reverse Photocycle Dynamics of Two Highly Similar Canonical Red/Green Cyanobacteriochromes Reveals Unexpected Differences	9
Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level	9