Biology of Reproduction

Article	Citations
ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis†	71
Metabolic changes in mouse sperm during capacitation†	50
Inflammation and reproductive function in women with polycystic ovary syndrome	47
Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality	42
The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization†	41
Cytoplasmic maturation in human oocytes: an ultrastructural study †	40
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†	35
In vitro models of the human endometrium: evolution and application for women’s health+	33
Epigenetic transgenerational inheritance, gametogenesis and germline development†	33
Macrophages: an indispensable piece of ovarian health	33
Role of zinc in female reproduction	32
Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct	31
Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells	31
In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables†	29
Microvesicles and exosomes released by amnion epithelial cells under oxidative stress cause inflammatory changes in uterine cells†	28
NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome‡	28
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis	27
Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility	27
The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications†	27
Dux facilitates post-implantation development, but is not essential for zygotic genome activation†	27
Developmental programming of the female reproductive system—a review	26
Mysteries and unsolved problems of mammalian fertilization and related topics	25
CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity	25
The effects of assisted reproduction technologies on metabolic health and disease†	25
Igf3: a novel player in fish reproduction	25

The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†	25
Progesterone receptor membrane components: key regulators of fetal membrane integrity	24
Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal	23
Engineering monoclonal antibody-based contraception and multipurpose prevention technologies†	23
MiRNA-155 regulates cumulus cells function, oocyte maturation, and blastocyst formation	23
AASRA: an anchor alignment-based small RNA annotation pipeline†	22
Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies	22
Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†	22
Maternal high fat diet-induced obesity affects trophoblast differentiation and placental function in mice†	22
Iodoacetic acid affects estrous cyclicity, ovarian gene expression, and hormone levels in mice	21
Generation and characterization of human Fetal membrane and Decidual cell lines for reproductive biology experiments	21
Pig conceptuses secrete interferon gamma to recruit T cells to the endometrium during the peri-implantation period	21
The PRAME family of cancer testis antigens is essential for germline development and gametogenesis	21
Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights	21
Single-cell RNA sequencing analysis of mouse follicular somatic cells	21
Male hybrid sterility in the cattle-yak and other bovines: a review	21
Bisphenol A and 17α-ethinylestradiol-induced transgenerational gene expression differences in the brain–pituitary–testis axis of medaka, Oryzias latipes†	20
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†	20
Peripheral action of kisspeptin at reproductive tissues—role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review	20
Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development	20
Retinoic acid receptor antagonists for male contraception: current status†	20
Comparing effects and action mechanisms of BPA and BPS on HTR-8/SVneo placental cells	19
Overview of extracellular vesicles in the pathogenesis of preeclampsia	19
Modeling human peri-implantation placental development and function	19
Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†	19
Effect of mitophagy in oocytes and granulosa cells on oocyte quality†	19
Impaired decidualization of human endometrial stromal cells from women with adenomyosis†	19
Experimentally Induced Endometritis Impairs the Developmental Capacity of Bovine Oocytes†	19
NOTCH signaling pathway is required for bovine early embryonic development	18
Hypoxia-inducible factor (HIF1alpha) inhibition modulates cumulus cell function and affects bovine oocyte maturation in vitro†	18
Severity of prepregnancy diabetes on the fetal malformations and viability associated with early embryos in rats†	18
Successful in vitro fertilization in the horse: production of blastocysts and birth of foals after prolonged sperm incubation for capacitation	18
Differences in the proteome of stallion spermatozoa explain stallion-to-stallion variability in sperm quality post-thaw†	17
Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells†	17
Early life stress affects the miRNA cargo of epididymal extracellular vesicles in mouse	17
Negative impact of high doses of follicle-stimulating hormone during superovulation on the ovulatory follicle function in small ovarian reserve dairy heifers	17
Loss of ITGB3 in ovine conceptuses decreases conceptus expression of NOS3 and SPP1: implications for the developing placental vasculature†	17
Endometrial Organoids: A New Model for the Research of Endometrial-Related Diseases†	17
Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy	16
Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†	16
The future of assessing bull fertility: Can the ‘omics fields identify usable biomarkers?	16
METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development‡	16
The influence of COVID-19 infection-associated immune response on the female reproductive system	15
Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy†	15
The anatomy, movement, and functions of human sperm tail: an evolving mystery	15
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth	15
The molecular mechanisms underlying acrosome biogenesis elucidated by gene-manipulated mice†	15
The effects of vitrification on oocyte quality	15
Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†	15
Toxicant effects on mammalian oocyte mitochondria†	15

Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation†	15
HOXA10 improves endometrial receptivity by upregulating E-cadherin	15
Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence	15
Role of DNA damage and repair mechanisms in uterine fibroid/leiomyomas: a review	15
Is there a definite relationship between placental mTOR signaling and fetal growth?	15
Nesfatin-1-like peptide suppresses hypothalamo–pituitary–gonadal mRNAs, gonadal steroidogenesis, and oocyte maturation in fish†	15
Metabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet	15
Seminal plasma AnnexinA2 protein is a relevant biomarker for stallions which require removal of seminal plasma for sperm survival upon refrigeration†	14
Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss	14
Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction	14
Extracellular vesicle research in reproductive science: Paving the way for clinical achievements	14
MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†	14
C1QTNF6 participates in the pathogenesis of PCOS by affecting the inflammatory response of granulosa cells	14
Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy	14
Conceptus interferon gamma is essential for establishment of pregnancy in the pig	14
Preclinical contraceptive development for men and women	14
Obesity alters the ovarian proteomic response to zearalenone exposure	14
Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis	14
Metabolo-epigenetics: the interplay of metabolism and epigenetics during early germ cells development†	14
Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish	13
Heritable consequences of paternal nicotine exposure: from phenomena to mechanisms†	13
Melatonin alleviates deoxynivalenol-induced apoptosis of human granulosa cells by reducing mutually accentuated FOXO1 and ER stress	13
Generation of chimeric mice with spermatozoa fully derived from embryonic stem cells using a triple-target CRISPR method forNanos3†	13
Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy	13
CCL20-CCR6 axis directs sperm–oocyte interaction and its dysregulation correlates/associates with male infertility‡	13
The effects of the phthalate DiNP on reproduction†	13
Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries†	13
The sperm-specific form of lactate dehydrogenase is required for fertility and is an attractive target for male contraception (a review)	13
Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage	13
Five questions toward mRNA degradation in oocytes and preimplantation embryos: when, who, to whom, how, and why?	13
Towards a roadmap to advance non-hormonal contraceptive multipurpose prevention technologies: strategic insights from key stakeholders†	13
The ruminant placental trophoblast binucleate cell: an evolutionary breakthrough	13
Roles of aryl hydrocarbon receptor in endothelial angiogenic responses†	13
The impact of bisphenol A on the placenta	13
Metabolomic signature of spermatozoa established during holding time is responsible for differences in boar sperm freezability	13
Multiomics analysis of male infertility	13
Ephrin and Eph receptor signaling in female reproductive physiology and pathology†	12
Igf3 is essential for ovary differentiation in zebrafish†	12
Progesterone receptor membrane component 1 is required for mammary gland development†	12
Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†	12
The new contraceptive revolution: developing innovative products outside of industry†,‡	12
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells	12
The microRNA-200 cluster on chromosome 23 is required for oocyte maturation and ovulation in zebrafish†	12
Self-renewal and differentiation of rat epididymal basal cells using a novel in vitro organoid model	12
Cross talk: trafficking and functional impact of maternal exosomes at the feto-maternal interface under normal and pathologic states	12
Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†	12
Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation	12
The alarmin S100A12 causes sterile inflammation of the human chorioamniotic membranes as well as preterm birth and neonatal mortality in mice	12
Present state and future outlook for the application of in vitro oocyte maturation in human infertility treatment	11
Phthalates and alternative plasticizers differentially affect phenotypic parameters in gonadal somatic and germ cell lines	11
Endometrial receptivity and embryo implantation in carnivores—commonalities and differences with other mammalian species	11
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells	11
The functions ofWt1in mouse gonad development and somatic cells differentiation	11
State of assisted reproduction technology in the coronavirus disease 2019 era and consequences on human reproductive system	11
SPP1 expression in the mouse uterus and placenta: implications for implantation†	11
The actions of resveratrol in decidualizing endometrium: acceleration or inhibition?†	11
Effects of LPXRFamide peptides on chub mackerel gonadotropin secretion	11
High-fat-diet induced obesity increases the proportion of linoleic acyl residues in dam serum and milk and in suckling neonate circulation	11
Current progress, challenges, and future prospects of testis organoids†	11
Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism†	11
Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress†	11
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†	11
Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy	11
Transforming growth factor beta signaling and decidual integrity in mice†	11
Differences in the sperm metabolomes of smoking and nonsmoking men	11
Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health	11
Novel mineral regulatory pathways in ovine pregnancy: I. phosphate, klotho signaling, and sodium-dependent phosphate transporters	11
Phosphorylation of Yes-associated protein impairs trophoblast invasion and migration: implications for the pathogenesis of fetal growth restriction†	10
Depletion of high-mobility group box 2 causes seminiferous tubule atrophy via aberrant expression of androgen and estrogen receptors in mouse testis	10
Chemerin as a modulator of angiogenesis and apoptosis processes in the corpus luteum of pigs: an in vitro study	10
Preserving Oocytes in Oncofertility	10
Conceptus metabolomic profiling reveals stage-specific phenotypes leading up to pregnancy recognition in cattle†	10
Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice	10
Ancestral smoking and developmental outcomes: a review of publications from a population birth cohort	10
Spatial transcriptomic profiles of mouse uterine microenvironments at pregnancy day 7.5	10
Melatonergic systems of AANAT, melatonin, and its receptor MT2 in the corpus luteum are essential for reproductive success in mammals†	10
Whole-exome sequencing reveals potential germline and somatic mutations in 60 malignant ovarian germ cell tumors	10
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice	10
Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats	10
Hyaluronidase-based swim-up for semen selection in patients with human papillomavirus semen infection	10

A central role for cAMP/EPAC/RAP/PI3K/AKT/CREB signaling in LH-induced follicular Pgr expression at medaka ovulation	10
Roles ofStra8andTcerg1lin retinoic acid induced spermatogonial differentiation in mouse	10
Spatial transcriptomics analysis of uterine gene expression in enhancer of zeste homolog 2 conditional knockout mice†	10
miR-26a-5p and miR-125b-5p affect trophoblast genes and cell functions important during early pregnancy	10
IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†	10
Long non-coding RNA NRSN2-AS1 facilitates tumorigenesis and progression of ovarian cancer via miR-744-5p/PRKX axis	10
Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage	10
Pleiotropic role of prokineticin 1 in the porcine endometrium during pregnancy establishment and embryo implantation †	9
Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression†	9
Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†	9
The enigmatic sperm proteins in mammalian fertilization: an overview†	9
Leptin and Its Signaling Are Not Involved in Zebrafish Puberty Onset	9
Novel mineral regulatory pathways in ovine pregnancy: II. Calcium-binding proteins, calcium transporters, and vitamin D signaling	9
Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm	9
Two distinct Sertoli cell states are regulated via germ cell crosstalk†	9
Germ cells of the mammalian female: A limited or renewable resource?	9
Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells	9
Chronic overload of concentration-dependent iron exerts different effects on ovarian function in C57BL/6J mice	9
Role of AMP-activated protein kinase during postovulatory aging of mouse oocytes†	9
Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface	9
Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications†	9
Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism	9
Exogenous sex steroids regulate genital epithelial barrier function in female rhesus macaques	9
Development of human ectocervical tissue models with physiologic endocrine and paracrine signaling†	9
Use of anti-inhibin monoclonal antibody for increasing the litter size of mouse strains and its application to in vivo-genome editing technology	9
Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats	9
Exposures during the prepuberty period and future offspring’s health: evidence from human cohort studies†	9
Attainment and maintenance of pubertal cyclicity may predict reproductive longevity in beef heifers	8
Neither gonadotropin nor cumulus cell expansion is needed for the maturation of competent porcine oocytes in vitro†	8
Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases	8
An evo-devo perspective of the female reproductive tract	8
Comparing mRNA and sncRNA profiles during the maternal-to-embryonic transition in bovine IVF and scNT embryos	8
Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice	8
Ovarian follicles are resistant to monocyte perturbations—implications for ovarian health with immune disruption	8
Prostaglandin I2 mediates weak vasodilatation in human placental microvessels	8
Effect of natural pre-luteolytic prostaglandin F2α pulses on the bovine luteal transcriptome during spontaneous luteal regression†	8
Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase/protein kinase B/matrix metallopeptidase 2 pathway†	8
Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†	8
Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries†	8
ESR1 mediates estrogen-induced feminization of genetic male Chinese soft-shelled turtle	8
Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism	8
Removal of peri-ovarian adipose tissue affects follicular development and lipid metabolism†	8
The placenta as a target of opioid drugs	8
Meiotic chromosome organization and crossover patterns	8
Regulation of the neuroendocrine axis in male rats by soy-based diets is independent of age and due specifically to isoflavone action†	8
Male fetal sex affects uteroplacental angiogenesis in growth restriction mouse model†	8
The rapamycin analog Everolimus reversibly impairs male germ cell differentiation and fertility in the mouse†	8
Characterization of transcriptional activity during ZGA in mammalian SCNT embryo	8
Sperm–oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site	8
Oocyte quality following in vitro follicle development	8
Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†	8
Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†	8
Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model	8
Low glucose and high pyruvate reduce the production of 2-oxoaldehydes, improving mitochondrial efficiency, redox regulation, and stallion sperm function†	8
Non-invasive oocyte quality assessment	8
MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy†	8
Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development†	8
The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques	8
MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis	8
Reversing complete mechanical transzonal projections disruption during mouse in vitro follicle culture with unaltered oocyte competence	8
Sex differences in microRNA expression in first and third trimester human placenta	8
Transcriptomic analysis of equine placenta reveals key regulators and pathways involved in ascending placentitis†	8
Glutamate can act as a signaling molecule in mouse preimplantation embryos	8
RNF8 is not required for histone-to-protamine exchange in spermiogenesis	7
Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling	7
Neuroanatomical basis of the nerve growth factor ovulation–induction pathway in llamas†	7
Evidence of intergenerational transmission of diethylstilbestrol health effects: hindsight and insight	7
Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis†	7
Epigenetic regulation of cell fate transition: learning from early embryo development and somatic cell reprogramming	7
Clonal gametogenesis is triggered by intrinsic stimuli in the hybrid’s germ cells but is dependent on sex differentiation	7
Lipid metabolism is altered in maternal, placental, and fetal tissues of ewes with small for gestational age fetuses†	7
Prolonging photoperiod promotes testosterone synthesis of Leydig cells by directly targeting local melatonin system in rooster testes	7
The mystery of the life tree: the placentas	7
Comparing the maternal-fetal microbiome of humans and cattle: a translational assessment of the reproductive, placental, and fetal gut microbiomes	7
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes	7
L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls	7
Zp4 is completely dispensable for fertility in female rats	7
Niclosamide’s potential direct targets in ovarian cancer	7
Distinct changes of in BTLA, ICOS, PD-1, and TIGIT expression on peripheral blood and decidual CD8+ T cells in women with unexplained recurrent spontaneous abortion†	7
An association study of polymorphisms in the H19 imprinted gene in an Iranian population with the risk of polycystic ovary syndrome	7
SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy	7
Galectin-1 induces gene and protein expression related to maternal-conceptus immune tolerance in bovine endometrium	7
The impact of perfluoroalkyl substances on pregnancy, birth outcomes, and offspring development: a review of data from mouse models	7
NEDD4-like ubiquitin ligase 2 protein (NEDL2) in porcine spermatozoa, oocytes, and preimplantation embryos and its role in oocyte fertilization	7
Berberine alleviates LPS-induced apoptosis, oxidation, and skewed lineages during mouse preimplantation development	7
Activation of bovine oocytes by protein synthesis inhibitors: new findings on the role of MPF/MAPKs†	7
Altrenogest affects the development and endocrine milieu of ovarian follicles in prepubertal and mature gilts†	7
Proteomic and metabolomic analyses uncover sex-specific regulatory pathways in mouse fetal germline differentiation†	7
Kisspeptin-54 injection induces a physiological luteinizing hormone surge and ovulation in mice	7
CXCR4 signaling at the fetal–maternal interface may drive inflammation and syncytia formation during ovine pregnancy†	7
The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero†	7
Insulin-like growth factor 2 is produced by antral follicles and promotes preantral follicle development in macaques†	7
Endometrial and luteal responses to a prostaglandin F2alpha pulse: a comparison between heifers and mares	7
Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory period	7
Vaginal microbiota differences associated with pelvic organ prolapse risk during late gestation in commercial sows	7