Biophysical Journal

Article	Citations
Identifying crucial E-protein residues responsible for unusual stability of Zika virus envelope	176
Protein target search diffusion-association/dissociation free energy landscape around DNA binding site with flanking sequences	148
Water-protein interactions as a driver of phase separation, biology, and disease	142
Unraveling the hydration dynamics of ACC1–13K24 with ATP: From liquid to droplet to amyloid fibril	140
Hyperactive deoxy-PIEZO1 shapes the circulatory life cycle of irreversibly sickled cells	103
Sensing membrane voltage by reorientation of dipolar transmembrane peptides	81
Quantitative insights into processivity of an Hsp100 protein disaggregase on folded proteins	78
FRETsael: Nanometer localization of biomolecular interactions using fluorescence lifetime imaging	70
Dry mass photometry of single bacteria using quantitative wavefront microscopy	63
Both the transcriptional activator, Bcd, and repressor, Cic, form small mobile oligomeric clusters	61
Molecular mechanism of regulation of RhoA GTPase by phosphorylation of RhoGDI	59
Escherichia coli JM109 in LB as a model bacterial system to study magnetic field effect in recombination of non-correlated pair of biologically relevant radicals nitric oxide and superoxide anion in h	58
Enhanced compaction and folding of RNAs in apolar chemical environments	58
LIS1, an RNA-binding protein, regulates the physical properties of embryonic stem cells	57
Rapid inducible decay of RNA (RIDR) reveals roles of processing bodies	55
Stem-loop II motif (s2m) structural and dynamical differences between SARS-CoV-2 and b.1.617.2 (Delta) variant	54
Molecular movements underlying voltage-dependent regulation of the CaV2.1 channel	53
Bioluminescent platform for tracking intercellular interactions	51
Fluorescence lifetime imaging microscopy (FLIM) for tracking RNA dynamics in live mammalian cells	48
Spatial parameterization of attachment processes in molecular motor-cargo systems	47
Dissecting the structural basis of Huntingtin pathogenesis: one molecule at the time	46
A proposed mechanism for Vibrio export monitoring polypeptide folding in the ribosome exit tunnel	43
The MIDAS domain of AAA mechanoenzyme MDN1 forms catch bonds with two different substrates	42
Kinetics and spatial organisation of the SRP pathway in live bacteria resolved by single-molecule tracking	41
Nobias: analyzing anomalous diffusion in single-molecule tracks with nonparametric Bayesian inference	41

Structural studies of human FIS1 reveal a dynamic region important for DRP1 recruitment and mitochondrial fission	39
Proline isomerization in molecular dynamics simulations of a proline-rich signaling peptide	39
Motor guidance by long-range communication through the microtubule highway	39
Cooperativity and competition in cortical actin wave formation	38
Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding	37
Mechanisms of dysfunction in patient-derived cardiomyocytes with the hypertrophic cardiomyopathy-myosin binding protein-C e258K mutation	36
Topologies of synthetic gene circuit for optimal fold change activation in bacterial biosensors	36
Changes in cell volume are drivers of plasticity in disordered proteins	35
Measuring the dynamics of glucose-stimulated oxygen consumption in individual pancreatic islets using islet-on-a-chip	35
pH-dependent compaction of intrinsically disordered poly-E motif in titin	34
Hypertrophic and dilated cardiomyopathy-associatedTNNT2 pathogenic variants induce nucleus remodeling in hiPSC-CM models	34
Direct visualization of TRPV2 intrinsic disordered regions and interactions with cannabinoids	34
Engineered heart tissues for studying twitch tension and inotropic pharmacological interventions	34
The molecular nature of temperature dependence of the TRPM2 channel	34
High-resolution cryo-EM structures of the magnesium-inhibited and calcium-inactivated RyR1	33
Elucidating bacterial lipid transport mechanisms by the envelope spanning LetAB complex	32
Biochemical and structural insight of regulation in yeast vacuolar ABC transporter Ycf1	32
A novel 3D spatial model of mouse sinoatrial node cells for investigating impact of microstructure changes on pacemaker activity	32
Magnesium increases the chemo-mechanical energy released by curling protofilaments during microtubule disassembly	32
Copper-dependent ATP7B N-terminal domain dynamics in two reaction-cycle intermediates	31
Using novel small molecules to alter cardiac thin filament function	31
Small molecule and antibody mediated inhibition of the aggregation of a tau fragment implicit in Alzheimer's disease	30
Generation and control of cellular protrusions	30
Ligand discovery for LAT1 with molecular dynamics simulation and virtual screening	30
The best defense is a cheap offense? How Gram-negative bacteria build their outer membranes and secrete toxins without typical sources of energy	30
Bis-coumarin homodimers—potential inhibitors of amyloid aggregation of globular and intrinsically disordered proteins	30
The E. coli outer membrane: what have we learned from molecular simulations?	29
Nucleosome chaperones facilitate both nucleosome assembly and disassembly	29
S-Acylation regulates store-operated calcium entry	28
Modulation of Kv1.5 channel expression and function by the sigma 1 receptor	28
Threading proteins at the speed limit of folding	27
Disparate effects of CaM N- and C-lobe CPVT-linked mutations on SK channel-CaM assembly	27
Role of cytoplasmic cap in determining the ion selectivity of P2X receptor channels	27
Different metabolic changes between fast- and slow-twitch skeletal muscle underlie impaired muscle fatigue resistance in chronic kidney disease	27
Probing unfolding barriers in high throughput	27
Using monoclonal antibody probes in a high throughput microplate assay and localized surface plasmon resonance (LSPR) analysis of allosteric conformations of troponin subunits	27
Structure and properties of the selectivity filter of homo- and hetero- tetrameres of plant ionotropic glutamate receptors: a modelling approach	27
Monitoring protein unfolding and DNA binding using protein charge transfer spectra	27
How does the 5-HT3 receptor MX helix modulate function?	26
Single-molecule dissection of coupling mechanisms between cofactor binding and folding of a complex protein	26
Validating Action-CSA approach for finding multiple protein folding pathways	26
Characterization of S100A1/N2A-IS interaction in titin	25
Exploring kinetically controlled protein solubility under physiologically relevant conditions	25
Desensitization and channel conductance of the GABA type A receptors depends on electrostatic interactions in the top part of the ion pore	25
Definition of the mechanokinetic parameters accounting for the functional diversity of slow and fast isoforms of skeletal muscle myosin with a synthetic nanomachine	25
Sweet and umami receptors are expressed in the heart and regulate contractility	25
Structural basis of the super-relaxed and hyper-relaxed state of myosin II	24
Mechanical stretching of muscle cells induces global gene expression and alternative splicing changes and alterations in SR proteins	24
Morphological and molecular diversity of human astrocytes in a cerebral organoid	23
Mechano-chemo-electric signaling in heart: how local blood flow is regulated	23

DNA tension probes show that cardiomyocyte maturation is sensitive to piconewton scale traction forces	23
Ion-specific partition energies in a heparan sulfate glycocalyx model	22
Analysis of PI(4,5)P2 metabolism from the perspective of different cell types	22
Oscillating membranes: autonomous shape-transforming sheets via chemo-mechanical “metabolism”	22
DNA origami cell sensors for real time probing of membrane interactions with biomolecules in extracellular matrix	22
Integrated light and electron microscopy continuum resolution imaging of 3D cell cultures	22
Using microresonators to simultaneously monitor mass and adhesion of single living cells	22
The multiple dimensions of lncRNAS: how 3D structure determines meg3 function	22
Combined use of serial block face SEM and focused ion beam SEM elucidates the 3D ultrastructure of blood platelets and thrombi	22
PrkC kinase modulates MreB filament and bacteria growth by monitoring cell wall precursor lipid II	22
A surface plasmon resonance database for better experimental planning and execution	21
How non-coding RNAs shape nuclear structure to regulate gene expression	21
Polymorphic interruption of molecular allosteric pathways in mitotic kinesin-5: comparison of experiment and algorithmic prediction	21
Distingushing positional isomers of posttranslationally modified peptides using a biological nanopore	21
Real-time simultaneous imaging of acidification and proteolysis in single phagosomes using bifunctional Janus particle probes	21
Utilizing correlation functions to develop a multistate model of P. denitrificans F1-ATPase and enhance single-molecule imaging resolution	21
Sizing up the challenge: The number of active dynein teams scales with organelle size	21
Elucidating the role of membrane tension in cellular processes using continuum modeling	21
In situ detection of single microRNA molecules by transient hybridization utilizing FRET-based probes	21
The effects of biomolecular crowding on the behaviour of polymyxin antibiotics within the E. coli cell envelope	20
Correlation between secondary structures and rheological properties of xanthan polymers	20
Many sequence-diverse domains switch between alpha-helix and beta-sheet folds	20
Fluid-gel coexistence in membranes under differential stress	20
Molecular dynamics modeling of polystyrene functionalized carbon nanotubes	20
Predicting spectroscopic properties of fluorescent proteins with a variational autoencoder	20
Classical molecular dynamics, transition path sampling, and umbrella sampling to investigate the structural, conformational, and proton transfer properties of glyonic liquids	20
Revisiting lipid II binding by teixobactin oligomers using membrane MD simulations	20
Determining explicit ion-lipid cross-terms for MD simulation using high-dimensional parameter search	20
Clinical biophysics: complex genetic diseases—inheritance, influence, and occurrence mechanisms of polygenic multifactorial diseases	20
Rivalry of cholesterol and antimicrobial peptides as seen by molecular simulations and NMR spectroscopy	20
Engineered nuclear import receptor karyopherin-B2 chaperones aberrant phase transitions of disease-associated cargo	20
A molecular dynamic study of an all-parallel-stranded G-quadruplex formed in the hTert core promoter	20
The influence of linker histones on chromatin dynamics and energetics	19
Chromatin unfolds and unwraps under tension and crowding	19
Entrenchment and evolution of drug resistance in HIV	19
Single molecule activity assay for SARS-CoV-2 RNA dependent RNA polymerase	19
Characterizing local conformations and conformational disorder near single-stranded (ss) - double stranded (ds) DNA replication junctions	19
Absolute quantitation of the yeast Whi5 transcriptional repressor during G1 phase growth	19
Physical descriptions of molecular and mesoscale organizations of proteins within condensates and at interfaces	19
Deep learning-based subcellular phenotyping of protrusion dynamics reveals fine differential drug responses at subcellular and single-cell levels	19
A thermodynamic model of bacterial transcription	19
Mechanism-driven approaches towards synthesis of highly pure RNA for a wide variety of applications	19
Development of a new automated platform for proteome-wide structural biology	18
Myosin off-on transition modulates the simple harmonic motion of tropomyosin coupling length-dependent activation and the actomyosin chemomechanical cycle	18
Overexpression of MCU vs. mito-ROS scavenging to attenuate proarrhythmic spontaneous Ca2+ release in diseased ventricular myocytes	18
Deciphering vimentin-microtubule interactions in cell polarity	18
Complete description of rapid single-molecule dynamics beyond instrument acquisition rate	18
Modeling contractility kit mediated mechanosensation and cytoskeletal network assembly	18
Polymerization of actin inside liquid-like protein droplets drives spontaneous actin bundling	18
Role of MICU1 in the control of the cardiac mitochondrial calcium uniporter	18
Measuring energy consumption through space and time in an active matter system of cytoskeletal motors and filaments	18
Measuring errors over time: towards a quantitative theory of chromosome segregation error correction	18
Machine learning model predicts the effects of tropomyosin rigidity on cardiac muscle contraction	18
Measuring the barrier function of skeletal muscle in individuals with muscular dystrophy	18
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks	18
Innovation by evolution: bringing new chemistry to life	18
Discoidin 1, a traditional lectin, acts within the cell non-traditionally	18
Phosphorylation of cardiac ryanodine receptor (RyR2): a structure-function study of phosphomimetic and phospho-null triple mutants	18
CaMKII signalling is reduced in the sinus node of a heart failure experimental model	18
Structural changes of Gap junction visualized in simulation utilizing a double membrane	17
Investigating the effects of alcohols and cholesterol manipulations on bovine aortic endothelial cell membrane properties using phasor analysis of laurdan fluorescence lifetime microscopy and spectral	17
Changes in the receptor-binding interface may cause immune evasion by the SARS-CoV-2 delta variant b.1.617.2	17
Low temperature and omecamtiv mecarbil affect the regulatory state of the thick filament of cardiac myocytes in diastole	17
Molecular mechanisms of the mitochondrial calcium uniporter part II: evidence against MICU1 as a uniporter potentiator	17
Effect of Sterols on the stability of bilayer lipid membranes	17
Nitrile IR intensities directly measure electric fields in protic and non-protic environments	17
Theoretical model for DNA looping by positively charged condensing agents	17
Amantadine preferential binding and disordering of phase separated membranes	17
A molecular dynamics exploration of the binding of phosphatidylinositol-4,5-bisphosphate to transient receptor potential canonical 3	17
Molecular dynamics simulations of the human VEGF promoter G-quadruplex	17
Morphologies and structure of brain lipid membrane dispersions	17
Using molecular dynamics simulations to characterize the structural/conformational effect of amino acid substitutions at the second position of the intrinsically disordered mitochondrial localization	17
HIV-1 nucleocapsid protein binds double stranded DNA in multiple modes for maximum density compaction	16
Super-resolved tracking	16
Accurate segmentation and tracking of single cells in complex 4D bacterial biofilms using machine learning	16
Acoustoplasma synthesis of silver nanoparticles with antibacterial properties	16
40S scanning unveiled by smFRET	16
Proteins mediating different DNA topologies block RNAP elongation with different efficiency	16
The phasor approach to histone FLIM-FRET microscopy maps nuclear wide heterochromatin structure at the level of nucleosome proximity in a living cell	16
From barnyard to bedside: using interspecies variants to inform the rational design of novel analogs of islet amyloid polypeptide	16

Tetra-gel expansion microscopy combined with superresolution imaging enables superior accuracy	16
Long-term 3D live cell tracking and morphological studies by telecentric digital holographic microscopy with digital focusing correction	16
Deciphering the interaction network of cytosolic type 3 secretion system proteins in living Yersinia enterocolitica	16
Kinetic mechanism of viral RNA selective packaging by HIV-1	16
Destabilizing tropomyosin-troponin I interactions increases calcium sensitivity	16
Unraveling the structural basis of selective inhibition of human cytochrome p450 3a5	15
Cell invasion involves membrane-active and calmodulin-binding properties of the CyaA toxin translocation domain	15
An adaptive approach to predicting antibody-antigen complex structures from sequence	15
Evaluation and design of conformationally stable halogen-substituted beta-hairpins using molecular simulation	15
The role of PTM crosstalks in Httex1 structure, aggregation and membrane interaction	15
Single-molecule investigation of product inhibition of Cel7 cellulase activity by cellobiose	15
Integrative structural dynamics of calmodulin showcases sequence-to-function	15
Structure, dynamics and nanomechanics of wild-type and alpha-variant SARS-CoV-2 virions	15
Direct visualization of the action of antimicrobial peptide ll37 on biofilms	15
Fibrillary ECM proteins contribute to tumor progression	15
QSAR investigation into SS peptides' interaction with lipid bilayers and their effects on transmembrane ion leakage in the presence of transmembrane potentials	15
Rapid identification of DNA fragments through direct sequencing with electro-optical zero-mode waveguides	15
Impact of mutations near the SARS-CoV-2 furin-cleavage site on viral infectivity	15
Pathological and protective isoforms of ApoE adopt distinct conformations in the presence of lipids	15
Molecular dynamics investigation of the ph-dependent influenza hemagglutinin conformational change	15
Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues	15
The Candida albicans virulence factor candidalysin must self-assemble in solution to form membrane pores	15
Orthogonal control of DNA nanoswitches with mixed physical and biochemical cues	15
Mixtures of curvature sensitive lipids in a GUV increase normal mode fluctuations	15
Multimodal characterization of live cancer cells using atomic force microscopy and Raman spectroscopy	15
Subunit conformation modulates the concentration of CO2 in the active site of the most efficient carboxylase	14
Distant electrostatic interactions dominate the dynamics of the disordered measles virus NTAIL	14
Truncated titin protein in dilated cardiomyopathy	14
Allosteric modulators of force production: towards precision medicine for different classes of heart diseases	14
Modeling area gain and loss during cytokinesis	14
Understanding ligand specificity through protein network dynamics	14
Dynamics of Syntaxin at sites of constitutive and stimulated fusion	14
Structural flexibility of FG-nucleoporins regulates the molecular transport through the nuclear pore complex	14
Phospholipid interaction sites in a ligand-gated ion channel from simulations and cryo-electron microscopy	14
When does Bell's model for unbinding kinetics fail?	14
Single-molecule view of slow and sequential conformational transitions of A2A adenosine receptor	14
Salt bridge formation by phthalate metabolites in PPAR-gamma nuclear receptor reveals a potential mode of toxicity	14
A computational insight into how human serum carnosinase 1 recognises carnosine and anserine	14
Regulation of cardiac action potential duration by neurotransmitters and co-transmitters	14
Comparison of left versus right ventricular contraction profile in failing and non-failing isolated human myocardium	14
Induced fit docking workflow based on charmm-gui modules: LBS Finder & Refiner and High-Throughput Simulator	14
Exploring the relationship between LC8 and viral phosphoproteins	14
Structure-Based discovery of actin-binding drugs	13
Quantifying variation in chromosome structural ensembles using statistical analysis of pairwise structure similarity matrices	13
Cav1.3 L-type Ca2+ channel modulates pancreatic β-cell electrical activity and survival	13
Functional effects of a lethal mutation (R1667P) in the voltage-sensing S4 α-helix of Repeat IV of CaV2.1	13
The discovery of antivirals and novel targets for SARS-CoV-2 and EV-A71	13
Investigating the effects of mutations in non-muscle myosin 2A LMM by circular dichroism and electron microscopy analysis	13
A simple and high-sensitive fluorescence polarization method for screening small molecule agonists of glucagon-like peptide-1 receptor	13
Proton-gated coincidence detection is a common feature of GPCR signaling	13
Promoting receptor protein tyrosine phosphatase activity by targeting transmembrane domain interactions	13
Skeletal, smooth and cardiac muscle myosin 2 are less sensitive for the chiral hydroxyl moiety of blebbistatin than that of non-muscle myosin 2 isoforms	13
Learning coevolutionary models for protein design	13
Visualizing disordered domain phase separation associated with ALS and cancers	13
Phosphomimetic mutations in the C-terminal basic region of troponin T increases actin filament activity	13
Genomic-locus tracking reveals the viscoelasticity of chromatin and its local environment in living cells	13
Superresolution imaging of native surface AMPA receptors in brain tissue	13
A digital feedback amplifier for oocyte ion channel measurements	13
Genetic- and diet-induced omega 3 fatty acid enrichment reduces TRPV4 desensitization in endothelial cells to enhance vasodilation	13
Impacts of mutations on electrostatic interactions in the lac repressor headpiece	13
Experimental studies of wild type A2A receptor and cholesterol-binding receptor variants support a model for cholesterol as an allosteric modulator of G protein coupling	13
Understanding the molecular basis of HCM-causing mutations in cardiac myosin and cardiac myosin binding protein-C	13
The role of electrostatic interactions in the stabilization of main functional states of the bacterial mechanosensitive channel MscS	13
Cryo-EM structure of the asynchronous flight muscle thick filament from the bumble bee, Bombus ignitius, at 6 Å resolution	13
Effect of cigarette smoke on immune response to pollen allergen in the lung	13
Examining enzyme active site dynamics using linear and nonlinear infrared spectroscopy: substrate orientation, cofactor composition, and solvent effects	13
Gaseous delivery of volatile anesthetics to a planar membrane	13
Site-search process for SfiI restriction enzyme characterized by time-lapse AFM	13
The voltage dependent structural rearrangements of the four voltage sensing domains of the human T-type Cav3.1 channel	13
Effects of charge on the interaction of the huntingtin N-terminal sequence with model cell membranes	13
Quantum entanglement effects in biomolecules	13
Development of an accelerated simulation technique for exploring protein transition pathways	13
Integration of IL-2 signalling at the immunological synapse	13
MDAnalysis 2.0 and beyond: fast and interoperable, community driven simulation analysis	13
Essential myosin light chain MLC-1sa decelerates actin and thin filament gliding on beta-myosin molecules	13
Untethering the Cav channel β2A subunit from the membrane: the role of depalmitoylases	13
Real time imaging of the trafficking of a Hedgehog pathway kinesin in the primary cilium	13
DNA base identification by enzyme-less stepping in a nanopore	13
Assessing structure and dynamics of AlphaFold2 prediction of GeoCas9	13
Predicting interfacial partitioning into zwitterionic and anionic membranes	13
Structural dynamics within the water and proton channels of Photosystem II	13
Trivalent lanthanides affect gating of the hERG potassium channel at low micromolar concentrations	12
Decoding gene network models and rates from smFISH data	12
Eosinophil phagocytosis of IgG-coated targets depends on the presence of serum	12
Multiscale simulations of the effects of 2’-deoxy-ATP and a myosin mutation on actomyosin interactions	12
Associated mRNAs coordinate biogenesis of functionally related ion channels	12
Electrical characterization of the short and long gamma subunit splice variants of human GABAA receptors	12
Direct RTK-integrin interactions universally modulate αvβ3 integrin-mediated cell adhesion	12
Kinetic analysis of group IIC RNP formation	12
Anti-virulence activity of plant-based antifungals through microtubule inhibition	12
Non-Uniform spatial distribution of protamine induced DNA looping	12
Comparing lipid packing between nanodiscs and native membranes	12
Mechanical stimulation of cerebral organoids toward understanding human neural response	12
Surface densities prewet a near critical membrane	12
Identification and validation of a nuclear localization sequence in the hERG1 potassium channel	12