OOIR: Observatory of International Research

Papers

(The H4-Index of Biotechnology and Bioengineering is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Concentration of clarified pool by single‐pass tangential flow filtration to improve productivity of protein A capture step: Impact of clarification strategies	67
Biotechnology and Bioengineering: Volume 122, Number 5, May 2025	66
	59
Optical discrimination of pathological red blood cells	57
	53
	53
Continuous low pH viral inactivation: Operation and scaling strategy informs viral clearance study	53
Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno‐associated virus gene therapy manufacturing	52
Elucidating the Interplay Between Resin Media, Feed Constituents, and Process Conditions in AAV Affinity Column Fouling With Confocal Microscopy	51
Biotechnology and Bioengineering: Volume 122, Number 12, December 2025	48
Application and progress of 3D tumor models in breast cancer	47
Effects of biofilm heterogeneity on the apparent mechanical properties obtained by shear rheometry	43
Current Advances and Future Prospects of Bulk and Microfluidic‐Enabled Electroporation Systems	43
Genetically Programmed Control of Overflow Metabolism	43
Dynamic D‐Allose Monitoring Via a Toggle‐Programmed Microbial Fluorescent Biosensor	42
An engineered ultrahigh affinity bi‐paratopic uPAR targeting agent confers enhanced tumor targeting	41
Constructing multi‐enzymatic cascade reactions for selective production of 6‐bromoindirubin from tryptophan in Escherichia coli	41
RSEA: A Web Server for Pathway Enrichment Analysis of Metabolic Reaction Sets	39
Engineering Plasmid‐Free Escherichia coli via Synergistic Metabolic Tuning and Fermentation Optimization for High‐Titer Salidroside Biosynthesis	39
Concentration‐dependent diffusion of unlabeled protein within an in vitro hyaluronic acid matrix	38
Dual‐targeting multifunctional hyaluronic acid ligand‐capped gold nanorods with enhanced endo‐lysosomal escape ability for synergetic photodynamic–photothermal therapy of cancer	35
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation	35
Engineered Stable, Antibiotic‐Free, High‐Level Protein Expression in the Probiotic Chassis Escherichia coli Nissle 1917	34
High‐throughput screening of optimal process conditions using model predictive control	34
Double‐reporter‐guided targeted activation of the oxytetracycline silent gene cluster in Streptomyces rimosus M527	34

Dual‐Stage Cross‐Flow Filtration: Integrated Capture and Purification of Virus‐Like Particles	33
Iron in blood cells: Function, relation to disease, and potential for magnetic separation	33
Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity of CHO stable pools	33
Expression of filaments of the Geobacter extracellular cytochrome OmcS in Shewanella oneidensis	33
Application of gas diffusion electrodes in bioeconomy: An update	33
Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics	33
Super7 passaging method to improve Chinese hamster ovary cell fed‐batch performance	32
Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell‐derived extracellular vesicles in stirred‐tank bioreactors	32
Phenazine‐Based Synthetic Biology to Signal Between Cells and Electrodes	32