OOIR: Observatory of International Research

Papers

(The H4-Index of Biotechnology and Bioengineering is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell‐derived extracellular vesicles in stirred‐tank bioreactors	129
Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity of CHO stable pools	54
Elucidating the Interplay Between Resin Media, Feed Constituents, and Process Conditions in AAV Affinity Column Fouling With Confocal Microscopy	54
Application and progress of 3D tumor models in breast cancer	54
Dynamic D‐Allose Monitoring Via a Toggle‐Programmed Microbial Fluorescent Biosensor	54
Biotechnology and Bioengineering: Volume 122, Number 5, May 2025	50
Dual‐Stage Cross‐Flow Filtration: Integrated Capture and Purification of Virus‐Like Particles	50
Constructing multi‐enzymatic cascade reactions for selective production of 6‐bromoindirubin from tryptophan in Escherichia coli	47
Concentration‐dependent diffusion of unlabeled protein within an in vitro hyaluronic acid matrix	47
Dual‐targeting multifunctional hyaluronic acid ligand‐capped gold nanorods with enhanced endo‐lysosomal escape ability for synergetic photodynamic–photothermal therapy of cancer	45
Heterologous Expression of Candida antarctica Lipase B in Aspergillus niger Using CRISPR/Cas9‐mediated Multi‐Gene Editing	44
Double‐reporter‐guided targeted activation of the oxytetracycline silent gene cluster in Streptomyces rimosus M527	44
	44
Super7 passaging method to improve Chinese hamster ovary cell fed‐batch performance	43
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation	43
Optical discrimination of pathological red blood cells	43
An engineered ultrahigh affinity bi‐paratopic uPAR targeting agent confers enhanced tumor targeting	43
	42
Continuous low pH viral inactivation: Operation and scaling strategy informs viral clearance study	40
Iron in blood cells: Function, relation to disease, and potential for magnetic separation	40
RSEA: A Web Server for Pathway Enrichment Analysis of Metabolic Reaction Sets	36
	36
Current Advances and Future Prospects of Bulk and Microfluidic‐Enabled Electroporation Systems	36
High‐throughput screening of optimal process conditions using model predictive control	36
Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno‐associated virus gene therapy manufacturing	35

pH Threshold Impacts Chalcopyrite Bioleaching Dynamics for the Extreme Thermoacidophile Sulfurisphaera ohwakuensis	35
Evaluating potential of tissue‐engineered cryogels and chondrocyte derived exosomes in articular cartilage repair	35
From spores to fungal pellets: A new high‐throughput image analysis highlights the structural development of Aspergillus niger	34
Expression of filaments of the Geobacter extracellular cytochrome OmcS in Shewanella oneidensis	34
Application of gas diffusion electrodes in bioeconomy: An update	34
Effects of biofilm heterogeneity on the apparent mechanical properties obtained by shear rheometry	34
Concentration of clarified pool by single‐pass tangential flow filtration to improve productivity of protein A capture step: Impact of clarification strategies	34
Comparative genomic and transcriptomic analysis guides to further enhance the biosynthesis of erythromycin by an overproducer	32
Enabling biocatalysis in high‐concentration organic cosolvent by enzyme gate engineering	32