British Journal of Pharmacology

Article	Citations
Pharmacogenomics	399
The pathogenesis and development of targeted drugs in acute T lymphoblastic leukaemia	339
Issue Information	317
Identification and pre‐clinical investigation of 3‐O‐cyclohexanecarbonyl‐11‐keto‐β‐boswellic acid as a drug for external use to treat psoriasis	213
Alpha 7‐nicotinic cholinoceptor regulation of pericyte‐containing retinal capillaries	198
Scientific integrity in the era of predatory journals: Insights from an editors in chief symposium	179
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Issue Information	144
The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine	140
Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock	123
Interactions between ADGRF1 (GPR110) and extracellular matrix proteins govern its effects on tumorigenesis in HER2‐positive breast cancer	118
A vitamin D‐based strategy overcomes chemoresistance in prostate cancer	115
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis	112
Ticagrelor inverse agonist activity at the P2Y12 receptor is non‐reversible versus its endogenous agonist adenosine 5´‐diphosphate	101
Heterogeneity in response to repeated intranasal oxytocin in schizophrenia and autism spectrum disorders: A meta‐analysis of variance	100
Opportunities of patient‐derived organoids in drug development	99
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	92
EXPRESSION OF CONCERN: Rosiglitazone and 15‐deoxy‐Δ12,14‐prostaglandin J2, ligands of the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), reduce ischaemia/reperfusion inju	88
RETRACTION: Cloricromene, a Coumarine Derivative, Protects Against Collagen‐induced Arthritis in Lewis Rats	87
A bio. tools collection of online resources for GPCR research	83
SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines	82
2‐Hydroxyl hispolon reverses high glucose‐induced endothelial progenitor cell dysfunction through the PI3K/Akt/eNOS and AMPK/HO‐1 pathways	81
Endothelium‐derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large‐conductance Ca2+‐activated K+ channels	76
Early erythroferrone levels can predict the long‐term haemoglobin responses to erythropoiesis‐stimulating agents	76

Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding	74
Targeting Na+/K+‐ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma	73
Compulsive alcohol seeking and relapse: Central role of conditioning factors associated with alleviation of withdrawal states by alcohol	72
Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study	70
Mitragynine (Kratom)—Withdrawal behaviour and cognitive impairments can be ameliorated by an epigenetic mechanism	66
The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors	66
Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome	66
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels	64
Asthma: role of the angiotensin‐(1‐7)/Mas (MAS1) pathway in pathophysiology and therapy	64
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	62
Pentoxifylline as a therapeutic option for pre‐eclampsia: a study on its placental effects	62
P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors	62
Issue Information	60
Withdrawal: Ham, H. J., Lee, Y. S., Lee, H. P., Cho, J., Ham, Y. W., Lee, K. S., Yun, J., Han, S. B. and Hong, J. T. G721‐0282 exerts anxiolytic‐like effects on chronic unpredictable mild stres	56
Assessment of Spinster homologue 2 (Spns2)‐dependent transport of sphingosine‐1‐phosphate as a therapeutic target	55
Advancing Alzheimer's disease pharmacotherapy: efficacy of glucocorticoid modulation with dazucorilant (CORT113176) in preclinical mouse models	54
The endocannabinoid anandamide mediates anti‐inflammatory effects through activation of NR4A nuclear receptors	53
Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2	53
Issue Information	53
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	52
Cross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons	52
NaHS alters synaptic plasticity proteins and enhances dendritic arborization to improve cognitive and motor deficits after traumatic brain injury in mice	50
S1P/S1PRs‐TRPV4 axis is a novel therapeutic target for persistent pain and itch in chronic dermatitis	49
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Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	48
Commentary on: Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain	47
Issue Information	45
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In vitro sepsis up‐regulates Nociceptin/Orphanin FQ receptor expression and function on human T‐ but not B‐cells	43
Issue Information	43
Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene‐related peptide responsive receptors	43
Issue Information	42
Insight into the regulatory mechanism of β‐arrestin2 and its emerging role in diseases	42
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Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms	41
Flucloxacillin worsens while imipenem–cilastatin protects against vancomycin‐induced kidney injury in a translational rat model	40
Novel therapeutic approaches to target neurodegeneration	40
Non‐neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats	39
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	37
Issue Information	37
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	37
Issue Information	37
Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice	36
Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT2A and 5‐HT1A receptors	36
Anti‐chitinase‐3‐like 1 antibody attenuated atopic dermatitis‐like skin inflammation through inhibition of STAT3‐dependent CXCL8 expression	35
Natural products targeting tumour angiogenesis	35
Discovery of a novel, potent and selective small‐molecule inhibitor of PD‐1/PD‐L1 interaction with robust in vivo anti‐tumour efficacy	34
Regulation of the ATP‐binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood–brain barrier endothelial cells	34
Issue Information	34
Inhibition of p38MAPK signalling pathway alleviates radiation‐induced testicular damage through improving spermatogenesis	34

Synergism between remdesivir and ribavirin leads to SARS‐CoV‐2 extinction in cell culture	33
Sex‐ and age‐specific respiratory alterations induced by prenatal exposure to the cannabinoid receptor agonist WIN 55,212‐2 in rats	33
Riboflavin protects against heart failure via SCAD‐dependent DJ‐1–Keap1–Nrf2 signalling pathway	33
Network medicine and systems pharmacology approaches to predicting adverse drug effects	33
Regulation of depressive‐like behaviours by palmitoylation: Role of AKAP150 in the basolateral amygdala	32
Paradoxical changes in brain reward status during oxycodone self‐administration in a novel test of the negative reinforcement hypothesis	32
GPR84 in physiology—Many functions in many tissues	31
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	31
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SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	31
Issue Information	30
Coronavirus disease 2019 and the revival of passive immunization: Antibody therapy for inhibiting severe acute respiratory syndrome coronavirus 2 and preventing host cell infection: IUPHAR review 31	30
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Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC1 receptor	28
pH‐dependent modulation of TRPV1 by modality‐selective antagonists	28
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	28
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Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor	28
Extent of foetal exposure to maternal elexacaftor/tezacaftor/ivacaftor during pregnancy	28
In vitro and in vivo anti‐epileptic efficacy of eslicarbazepine acetate in a mouse model of KCNQ2‐related self‐limited epilepsy	28
Issue Information	28
Glycyrrhetinic acid blocks SARS‐CoV‐2 infection by activating the cGAS‐STING signalling pathway	27
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Insights into the mechanisms underlying opioid use disorder and potential treatment strategies	27
The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions	27
Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle	27
Are insulin sensitizers the new strategy to treat Type 1 diabetes? A long‐acting dual amylin and calcitonin receptor agonist improves insulin‐mediated glycaemic control and controls body weight	27
Identifying the core concepts of pharmacology education: A global initiative	26
Scorpion venom heat‐resistant synthesized peptide ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: likely role of Nav1.6 inhibition in microglia	26
Basolateral amygdala astrocytes modulate diabetic neuropathic pain and may be a potential therapeutic target for koumine	26
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice	26
Ruthenium 360 and mitoxantrone inhibit mitochondrial calcium uniporter channel to prevent liver steatosis induced by high‐fat diet	26
Residency time of agonists does not affect the stability of GPCR–arrestin complexes	26
Complement component C3 as a new target to lower albuminuria in hypertensive kidney disease	26
Issue Information	25
Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders	25
Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability?	25
G protein‐coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex‐specific manner?	25
An optimised Bcl‐3 inhibitor for melanoma treatment	25
Bias translation: The final frontier?	25
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Memantine‐induced functional rewiring of the glutamate synapse in the striatum of dopamine transporter knockout rats	25
Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP)	25
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P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity	24
Animal models of diabetes‐associated vascular diseases: an update on available models and experimental analysis	24
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice	24
Issue Information	24
The search for anti‐oxytotic/ferroptotic compounds in the plant world	24
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases	24
How far are we from predicting multi‐drug interactions during treatment for COVID‐19 infection?	24
Tumour brain: Pretreatment cognitive and affective disorders caused by peripheral cancers	24
Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities	24
Structural and molecular determinants of mineralocorticoid receptor signalling	23
Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction	23
TLR2 activates AP‐1 to facilitate CTGF transcription and stimulate doxorubicin‐induced myocardial injury	23
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	23
Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues	23
Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide‐induced migration of primary macrophages	23
Actions of dexmedetomidine in regulating NLRP3 in postoperative cognitive dysfunction in aged mice via the autophagy–lysosome pathway	22
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl− concentration	22
Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy	22
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	22
Drug‐likeness evaluation and inhibitory mechanism of the emodin derivative on cardiac fibrosis based on metastasis‐associated protein 3	22
IDH2‐NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis	22
Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src‐YAP signalling axis	22
A comment on the interpretation of ligand binding experiments for agonists	22
PACAP‐38 related modulation of the cranial parasympathetic projection: A novel mechanism and therapeutic target in severe primary headache	22
Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature	22
Schwann cell TRPA1 elicits reserpine‐induced fibromyalgia pain in mice	21
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity	21
Epithelial deletion of the glucocorticoid receptor (Nr3c1) protects the mouse intestine against experimental inflammation	21

Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	21
β‐Arrestin1 and GPCR kinase2 play permissive roles in Src‐mediated endocytosis of α4β2 nicotinic ACh receptors	21
Issue Information	21
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	21
Metabolomics analysis of human plasma reveals decreased production of trimethylamine N‐oxide retards the progression of chronic kidney disease	21
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Role of NaV1.7 in action potential conduction along human bronchial vagal afferent C‐fibres	20
STAT1‐ and NFAT‐independent amplification of purinoceptor function integrates cellular senescence with interleukin‐6 production in preadipocytes	20
Unravelling G protein‐coupled receptor signalling networks using global phosphoproteomics	20
Issue Information	20
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	20
Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease	19
Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors	19
A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor	19
6‐Shogaol (enexasogoal) treatment improves experimental knee osteoarthritis exerting a pleiotropic effect over immune innate signalling responses in chondrocytes	19
The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing	19
Recent changes in the British Journal of Pharmacology: widening scope and improving author and editor experience	19
Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor–forkhead box subclass O transcription factor signalling axis	19
Single nucleotide variations encoding missense mutations in G protein‐coupled receptors may contribute to autism	19
A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins	19
Clinical applications for exosomes: Are we there yet?	19
The role of gut microbiota in cerebrovascular disease and related dementia	19
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Positive allosteric modulation of the cannabinoid CB1 receptor potentiates endocannabinoid signalling and changes ERK1/2 phosphorylation kinetics	18
The plant extract PNS mitigates atherosclerosis via promoting Nrf2‐mediated inhibition of ferroptosis through reducing USP2‐mediated Keap1 deubiquitination	18
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	18
Reinforcement‐based cognitive biases as vulnerability factors in alcohol addiction: From humans to animal models	18
Sub‐chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice	18
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	18
The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension	18
An agonist of the adenosine A2A receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signalling pathway	18
Issue Information	18
Genetic polymorphisms influencing antihypertensive drug responses	18
PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells	18
Role of LRP5/6/GSK‐3β/β‐catenin in the differences in exenatide‐ and insulin‐promoted T2D osteogenesis and osteomodulation	18
Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins	18
Targeting sphingosine kinase‐1 with the low MW inhibitor SKI‐5C suppresses the development of endometriotic lesions in mice	18
Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders	18
EXPRESSION OF CONCERN: Dose‐Dependent Biphasic Leptin‐Induced Proliferation is Caused by Non‐Specific IL‐6/NF‐κB Pathway Activation in Human Myometrial Cells	18
Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2	17
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker	17
The insulin‐like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis	17
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice	17
Molecular dynamic and pharmacological studies on protein‐engineered hirudin variants of Hirudinaria manillensis and Hirudo medicinalis	17
KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis	17
AhR–STAT3–HO‐1/COX‐2 signalling pathway may restrict ferroptosis and improve hMSC accumulation and efficacy in mouse liver	17
A plant‐derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy	17
Up‐regulation of hepatic CD36 by increased corticosterone/cortisol levels via GR leads to lipid accumulation in liver and hypertriglyceridaemia during pregnancy	17
Convallatoxin inhibits IL‐1β production by suppressing zinc finger protein 91 (ZFP91)‐mediated pro‐IL‐1β ubiquitination and caspase‐8 inflammasome activity	17
Optimization of cancer immunotherapy on the basis of programmed death ligand‐1 distribution and function	17
Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice	17
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non‐alcoholic fatty liver disease	16
Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post‐ischaemic blood flow recovery	16
Correction	16
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	16
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	16
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	16
Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translation	16
Bisphosphonates for delivering drugs to bone	16
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	16
Correction	16
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease	16
Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain	16
Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B	16
Withdrawn	16
Correction	16
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35	15
The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors	15
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Mechanopharmacology: in vitro techniques to advance drug discovery	15
Supersulfide biology and translational medicine for disease control	15
Modulation of interleukin‐36 based inflammatory feedback loop through the hepatocyte‐derived IL‐36R‐P2X7R axis improves steatosis in alcoholic steatohepatitis	15
The mineralocorticoid receptor in chronic kidney disease	15
A partial agonist of PPARγ prevents paclitaxel‐induced peripheral neuropathy in mice, by inhibiting neuroinflammation	15
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy	15
Tetrabenazine, a vesicular monoamine transporter 2 inhibitor, inhibits vesicular storage capacity and release of monoamine transmitters in mouse brain tissue	15
Resveratrol attenuates behavioural impairment associated with learning and memory in rats with diabetes induced by a high‐fat diet and streptozotocin	15
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?	15
Erratum	15
Issue Information	15
Correction to “Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis”	15
In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity	15
Osteosarcoma mechanobiology and therapeutic targets	14
Astrocyte‐derived lactoferrin reduces β‐amyloid burden by promoting the interaction between p38 kinase and PP2A phosphatase in male APP/PS1 transgenic mice	14
Activation of thyroid hormone receptor‐β improved disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis	14
The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders	14
β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma	14
Bruton's tyrosine kinase inhibition suppresses pathological retinal angiogenesis	14
The role of the mineralocorticoid receptor in immune cells in cardiovascular disease	14
Anti‐arrhythmic investigations in large animal models of atrial fibrillation	14
Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment	14
Intra‐articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice	14
Soluble GC stimulators and activators: Past, present and future	14
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR	14
Resveratrol, a novel inhibitor of fatty acid binding protein 5, inhibits cervical cancer metastasis by suppressing fatty acid transport into nucleus and downstream pathways	14