British Journal of Pharmacology

Article	Citations
Issue Information	437
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	328
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	239
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	184
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	181
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	173
Opportunities of patient‐derived organoids in drug development	153
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Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	131
GPR84 in physiology—Many functions in many tissues	128
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	122
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	118
Scorpion venom heat‐resistant synthesized peptide ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: likely role of Nav1.6 inhibition in microglia	117
Animal models of diabetes‐associated vascular diseases: an update on available models and experimental analysis	111
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice	110
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice	102
A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins	98
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice	96
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	85
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity	77
Novel therapeutic approaches to target neurodegeneration	74
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	74
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR	72

Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	72
Supersulfide biology and translational medicine for disease control	71
The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine	70
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	70
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	68
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	67
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	66
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity	62
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	62
Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway	61
Structural and molecular determinants of mineralocorticoid receptor signalling	57
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	55
Issue Information	55
Role of NaV1.7 in action potential conduction along human bronchial vagal afferent C‐fibres	55
Issue Information	54
Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor	52
Targeting mitochondrial proteases for therapy of acute myeloid leukaemia	50
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis	49
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway	48
Development of new Kir2.1 channel openers from propafenone analogues	47
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad	46
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation	45
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent	44
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities	43
Mineralocorticoid receptors in non‐alcoholic fatty liver disease	43
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial	43
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition	42
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19	41
Defining and unpacking the core concepts of pharmacology: A global initiative	41
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain	41
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice	39
Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837	39
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation	39
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice	37
Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours	37
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment	36
Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice	35
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate	35
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights	35
Exploring group size for statistical analysis of real‐time signalling experiments	35
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	34
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis	34
From mundane to classic: Sinomenine as a multi‐therapeutic agent	33
Fifty years with aspirin and platelets	33
Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy	33
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles	33
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential	33
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons	33
NRF2 signalling in cytoprotection and metabolism	32
Issue Information	32

Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes	32
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats	32
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Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells	31
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Proteinase‐activated receptor‐2 antagonist C391 inhibits Alternaria‐induced airway epithelial signalling and asthma indicators in acute exposure mouse models	31
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice	30
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BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus	30
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice	30
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq	30
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia	30
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Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV‐dependent and UV‐independent melanogenesis	29
Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.	29
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets	29
Gαq signalling from endosomes: A new conundrum	29
Effects of microsomal prostaglandin E synthase‐1 inhibition on resistance artery tone in patients with end stage kidney disease	29
Resolution pharmacology and the treatment of infectious diseases	29
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells	29
Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene‐related peptide family of peptides	28
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs	28
Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice	28
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol	28
Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels	28
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder	27
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor	27
A proposal for rational drug class terminology: A gastrointestinal perspective	27
Perspective article: A proposal for rational drug class terminology	27
Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?	27
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain	26
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets	26
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration	26
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors	26
Dual effects of mefenamic acid on the IKs molecular complex	26
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain	25
Nicotinic‐acid derivative BGP‐15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy	25
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function	25
R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases	25
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes	24
Natural products and cancer: From drug discovery to prevention and therapy	24
Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice	24
The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation	24
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Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease	24
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Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish	23
Hypothesis: Possible influence of antivector immunity and SARS‐CoV‐2 variants on efficacy of ChAdOx1 nCoV‐19 vaccine	23
Issue Information	23
Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase	23
Issue Information	23
EXPRESSION OF CONCERN: H2S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91phox Expression in Arterial Endothelial Cells: Role of Protein Kinases A and G	22
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma	22
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein	22
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation	22
Targeting noncoding RNAs to treat atherosclerosis	22
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia	22
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration	22
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19	21
Characterisation of agonist signalling profiles and agonist‐dependent antagonism at PACAP‐responsive receptors: Implications for drug discovery	21
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats	21
Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology	21
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration	21
Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout	21
Molecular basis for ligand modulation of the cannabinoid CB1 receptor	21
A GLP‐1/glucagon (GCG)/CCK2 receptors tri‐agonist provides new therapy for obesity and diabetes	21
The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells	21
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment	21
Linking drug and food addiction via compulsive appetite	21
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea	21
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels	20
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo	20
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Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling	20
Baclofen modulates the immune response after spinal cord injury with locomotor benefits	20
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34	20
Issue Information	20
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A	20

Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared with human receptors	20
Safety Toxicology	20
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation	20
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Correction	19
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?	19
Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation	19
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Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence	19
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth	19
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Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release	19
Molecular imaging of arterial and venous thrombosis	19
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel	18
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons	18
Chemistry/structural biology of psychedelic drugs and their receptor(s)	18
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats	18
Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis	18
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity	18
Quercetin relieves D‐amphetamine‐induced manic‐like behaviour through activating TREK‐1 potassium channels in mice	18
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors	18
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China	17
CORRECTION	17
Natural Products	17
Issue Information	17
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma	17
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive	17
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages	17
Mucin‐fused myeloid‐derived growth factor (MYDGF164) exhibits a prolonged serum half‐life and alleviates fibrosis in chronic kidney disease	17
Correction	17
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	17
Perivascular fat imaging by computed tomography (CT): a virtual guide	17
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis	17
Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity	17
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Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21	17
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity	17
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation	16
Blocking glutamate mGlu5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1G93A mouse model of amyotrophic lateral sclerosis	16
Sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain	16
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease	16
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis	16
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Building Bridges In Neuropharmacology: New therapeutic approaches for psychiatric and neurodegenerative disorders	16
Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition	16
Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling	16
The Australia story: Current status and future challenges for the clinical applications of psychedelics	16
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis	16
Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation	16
Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges	16
Genetic deletion or pharmacological blockade of nociceptin/orphanin FQ receptors in the ventral tegmental area attenuates nicotine‐motivated behaviour	16
Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’	16
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”	16
Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity	16
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy	15
RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats	15
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis	15
Bacterial growth dynamics and pharmacokinetic–pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice	15
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights	15
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia	15
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum	15
Evidence for 5‐HT1A receptor‐mediated antiallodynic and antihyperalgesic effects of apigenin in mice suffering from mononeuropathy	15
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The diverse effects of brain glucagon‐like peptide 1 receptors on ingestive behaviour	15
Pulmonary arterial hypertension: Sex matters	15
AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations	15
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy	14
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Issue Information	14
Sub‐chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice	14
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases	14
Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice	14
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl− concentration	14
Targeting sphingosine kinase‐1 with the low MW inhibitor SKI‐5C suppresses the development of endometriotic lesions in mice	14
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Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	14
Issue Information	14
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SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	14
Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	14
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	14
Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues	14
The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension	14
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Withdrawn	14
A comment on the interpretation of ligand binding experiments for agonists	14
D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection	14
The search for anti‐oxytotic/ferroptotic compounds in the plant world	14
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	14
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	14
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease	14
A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor	14
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Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice	13
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?	13