British Journal of Pharmacology

Article	Citations
Issue Information	460
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Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	220
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	213
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Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	172
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The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine	150
GPR84 in physiology—Many functions in many tissues	145
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	139
A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins	138
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity	135
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	124
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	121
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	119
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	116
Opportunities of patient‐derived organoids in drug development	103
Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors	100
The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment	86
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	84
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	81
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	80

Structural and molecular determinants of mineralocorticoid receptor signalling	77
Supersulfide biology and translational medicine for disease control	76
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice	75
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	75
Role of NaV1.7 in action potential conduction along human bronchial vagal afferent C‐fibres	75
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice	68
Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway	64
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity	62
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice	61
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	61
Novel therapeutic approaches to target neurodegeneration	60
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	55
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR	53
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	52
Targeting mitochondrial proteases for therapy of acute myeloid leukaemia	50
Issue Information	50
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation	49
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles	49
Fifty years with aspirin and platelets	48
Mineralocorticoid receptors in non‐alcoholic fatty liver disease	47
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential	46
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons	46
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis	45
Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours	43
From mundane to classic: Sinomenine as a multi‐therapeutic agent	41
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	41
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice	40
Development of new Kir2.1 channel openers from propafenone analogues	39
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent	39
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights	39
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment	38
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate	38
Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes	37
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad	36
Defining and unpacking the core concepts of pharmacology: A global initiative	36
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice	36
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats	35
Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling	35
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition	34
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis	34
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial	34
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice	34
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19	34
Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837	34
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation	33
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities	33
Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy	32
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain	32
NRF2 signalling in cytoprotection and metabolism	32
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway	32

Network‐based precision medicine and systems pharmacology	31
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Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol	30
R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases	30
Dual effects of mefenamic acid on the IKs molecular complex	30
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function	29
Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV‐dependent and UV‐independent melanogenesis	29
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Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice	27
Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy	27
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Resolution pharmacology and the treatment of infectious diseases	27
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain	26
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice	26
Gαq signalling from endosomes: A new conundrum	26
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration	26
Proteinase‐activated receptor‐2 antagonist C391 inhibits Alternaria‐induced airway epithelial signalling and asthma indicators in acute exposure mouse models	26
Perspective article: A proposal for rational drug class terminology	25
Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.	25
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs	25
Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells	25
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets	25
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets	24
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder	24
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq	24
Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease	24
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia	24
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells	24
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain	24
Effects of microsomal prostaglandin E synthase‐1 inhibition on resistance artery tone in patients with end stage kidney disease	24
BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus	24
Natural products and cancer: From drug discovery to prevention and therapy	24
A proposal for rational drug class terminology: A gastrointestinal perspective	23
Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice	23
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors	23
Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?	23
Nicotinic‐acid derivative BGP‐15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy	23
The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation	23
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes	23
Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice	23
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor	23
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration	22
Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene‐related peptide family of peptides	22
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Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology	22
Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels	22
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The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration	22
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Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase	22
Targeting noncoding RNAs to treat atherosclerosis	21
Linking drug and food addiction via compulsive appetite	21
A GLP‐1/glucagon (GCG)/CCK2 receptors tri‐agonist provides new therapy for obesity and diabetes	21
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment	21
EXPRESSION OF CONCERN: H2S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91phox Expression in Arterial Endothelial Cells: Role of Protein Kinases A and G	21
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma	21
Baclofen modulates the immune response after spinal cord injury with locomotor benefits	21
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation	21
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo	21
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34	21
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea	20
Advancing antihypertensive drug development	20
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation	20
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish	19
Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling	19
Characterisation of agonist signalling profiles and agonist‐dependent antagonism at PACAP‐responsive receptors: Implications for drug discovery	19
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein	19
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia	19
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels	19
Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout	19
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A	19
Opioid receptors in cardiovascular function	18
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats	18
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Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats	18

The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells	18
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Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth	18
Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery	18
Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared with human receptors	18
Safety Toxicology	18
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Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis	17
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons	17
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages	17
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Molecular imaging of arterial and venous thrombosis	17
Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib	17
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence	17
Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation	17
Mucin‐fused myeloid‐derived growth factor (MYDGF164) exhibits a prolonged serum half‐life and alleviates fibrosis in chronic kidney disease	17
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors	17
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis	17
Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies	17
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential	17
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Oral anticoagulants: A plausible new treatment for Alzheimer's disease?	17
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma	17
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer	17
In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by	17
Corticosteroid insensitivity in asthma associated with obstructive sleep apnoea: Role of oxidative stress and histone acetylation	17
Chemistry/structural biology of psychedelic drugs and their receptor(s)	16
Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release	16
Issue Information	16
CORRECTION	16
Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation	16
Perivascular fat imaging by computed tomography (CT): a virtual guide	16
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity	16
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive	16
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Correction	16
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	16
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel	16
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China	16
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity	16
Natural Products	16
Issue Information	16
Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges	15
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis	15
Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’	15
RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats	15
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia	15
AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations	15
Genetic deletion or pharmacological blockade of nociceptin/orphanin FQ receptors in the ventral tegmental area attenuates nicotine‐motivated behaviour	15
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Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease	15
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Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity	15
Pulmonary arterial hypertension: Sex matters	15
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation	14
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”	14
Sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain	14
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum	14
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Galangin alleviates vitiligo by targeting ANXA2 degradation in macrophages	14
Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition	14
Bacterial growth dynamics and pharmacokinetic–pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice	14
The Australia story: Current status and future challenges for the clinical applications of psychedelics	14
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis	14
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Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy	14
Building Bridges In Neuropharmacology: New therapeutic approaches for psychiatric and neurodegenerative disorders	14
Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21	14
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights	14
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ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis	14
The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension	13
Sub‐chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice	13
Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders	13
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	13
Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues	13
Non‐canonical PKG1 regulation in cardiovascular health and disease	13
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	13
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases	13
A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor	13
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl− concentration	13
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy	13
The plant extract PNS mitigates atherosclerosis via promoting Nrf2‐mediated inhibition of ferroptosis through reducing USP2‐mediated Keap1 deubiquitination	13
JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine	13
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P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	13
Molecular dynamic and pharmacological studies on protein‐engineered hirudin variants of Hirudinaria manillensis and Hirudo medicinalis	13
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease	13
A comment on the interpretation of ligand binding experiments for agonists	13
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	13
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Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease	12
Genetic polymorphisms influencing antihypertensive drug responses	12
The opioid partial agonist PPL‐138 reduces alcohol self‐administration in rats susceptible to post‐traumatic stress disorder	12