OOIR: Observatory of International Research

Papers

(The median citation count of Canadian Journal of Physiology and Pharmacology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Note of appreciation	31
Correction: Cardiac physiology and pathophysiology in pregnancy	31
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	20
Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model	20
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	19
Detection of joining points for genomic DNA circularization in cell culture	19
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	17
Sex-specific considerations in cardiovascular drug therapy	17
Different responses to homocysteine in primary endothelial cells and an immortalized endothelial cell line	17
The impact of ionizing radiation compared to drug-induced immunological changes	16
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	14
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	13
Preface to the special issue on the IACS-ES 2024 conference—Know the heart: novel insights into the prevention and treatment of heart disease to live and promote a healthy lifestyle	13
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	12
Next-generation therapeutics and renaissance of legacy drugs targeting the endothelin system	12
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	12
Canadian Society of Pharmacology and Therapeutics	12
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	11
Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	10
Cardiogenic shock—sex-specific risk factors and outcome differences	10
Sex-specific vascular effects of menthol: TRPM8- and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries	10
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	9
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	9

Endoplasmic reticulum stress, calcium homeostasis and the aging heart	9
Assessment of human placental microbial signatures in pre-eclampsia using shotgun metagenomics	9
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	9
Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system	8
Focus on aging, heart failure, regeneration, and cardiovascular medicine	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Clozapine and pharmacogenomics testing: opportunities and challenges for personalized treatment in schizophrenia	8
5 weeks of online resistance training with blood flow restriction increases sit-to-stand oxygen consumption in healthy older adults	8
Right ventricular dysfunction in preclinical models of type I and type II diabetes	8
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	8
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	8
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	7
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Abstracts for The 2025 Scientific Meeting of the Canadian Society of Pharmacology and Therapeutics	7
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	6
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Introduction—Unveiling gender disparity in heart disease	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Canadian Society of Pharmacology and Therapeutics	6
The transplacental transfer of NHC, the active metabolite of molnupiravir, in the ex vivo human placental perfusion model	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Effect of ostarine on glucose level, lipid profile, and osteoporosis in streptozotocin induced diabetic male rats	6
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Myotubularin related protein 7, a novel STIM1 binding protein	6
Potassium depolarized rat uterus in response to oxytocin and its structural analogues: kinetic analysis	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies	5
Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases	5
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	5
Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Deferoxamine alleviates brain ischemia/reperfusion injury through decreasing LAG-3 and α-Syn expression	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
Note of appreciation	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4

The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
Formation of a border ischemic zone depends on plasma potassium concentration	4
KCNQ3 activation by the naturally occurring phenol, eugenol	4
Untangling the heart–brain connection in Parkinson’s disease: emerging mechanisms and models	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	4
Editorial Expression of Concern: Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
High fructose consumption induces cardiac dysfunction and vascular abnormalities	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Opioid agonist treatment dispensing trends between 2018 and 2022 across six Canadian provinces	4
High-sensitivity troponin I-guided cardiovascular risk assessment in a general asymptomatic population: a cost-effectiveness analysis in 4000 adults	4
Coenzyme Q10 ameliorates hepatoprotective effect of metformin in experimentally-induced type 2 diabetes mellitus in rats: a functional and histological study	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats	3
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	3
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca²⁺ influx	3
Metabolic therapy for cardiovascular diseases with propionyl L-carnitine	3
Advances in Heart Preservation Techniques for Transplantation: An Updated Review	3
Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus	3
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	3
Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	3
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	3
Cardiovascular and physiological risk factors in women at mid-life and beyond	3
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	3
12th Annual Meeting of the North American Section of the International Academy of Cardiovascular Sciences (IACS-NAS)	3
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension	3
Microemboli model of vascular cognitive impairment/dementia (VCID) presents with long-term brain tissue hypoxia: relevance to the endothelin (ET) system	3
Impact of biological sex on valvular heart disease, interventions, and outcomes	3
In memoriam: Morley D. Hollenberg (1944–2025), scientist, artist, mentor, and friend	3
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	3
Cardioprotective effects of losartan and diminazene against the ischemia/reperfusion injury in hyperthyroidism rats	3
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity	3
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission	3
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy	2
Impact of inhalational anesthetics on neurodegeneration in Alzheimer’s disease: current evidence and potential implications	2
Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect	2
Considerations for choosing an optimal animal model of cardiovascular disease	2
Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba	2
White matter microglia morphological changes with aging in guinea pig offspring born growth restricted	2
Protective effects of Melissa officinalis ethanolic extract on doxorubicin-induced cardiotoxicity in a rat model	2
Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy	2
Celebrating the life and legacy of Dr. Gary D. Lopaschuk (1955–2025)	2
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart	2
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure	2
Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice	2
Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture	2
A review of the common causes of acute coronary syndrome (ACS) in females, and the role of estrogen on its pathologies and risk factors—review article	2
Correction: Polygenic scores of obesity in childhood based on summary statistics from adults versus children	2
SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression	2
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report	2
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients	2
Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro	2
Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	2
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	2
Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52	2
Nampt: a new therapeutic target for modulating NAD⁺ levels in metabolic, cardiovascular, and neurodegenerative diseases	2
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels	2
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications	2
Correction: Deciphering MMP9’s dual role in regulating SOD3 through protein–protein interactions	2
Role of endogenous incretin hormones, GLP-1 and GIP, in cardiovascular physiology	2
Lysophosphatidic acid metabolism and signaling in heart disease	2
The impact of different energy sources on redox balance during endometriotic cyst laparoscopy	2
Low-fat cheese ameliorates glucose intolerance and normalizes insulin secretion in a rat model of type 2 diabetes by promoting β-cell recovery	2
Systematic review of Health Canada approved clinical therapeutic trials for the treatment or prevention of coronavirus disease 2019 (COVID-19)	2
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model	2
The Seventeenth International Conference on Endothelin (ET-17)	2
Placental hypoxia and oxidative stress responses to smokeless tobacco use in Alaska Native participants in the MAW study	2
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally	2