Canadian Journal of Physiology and Pharmacology

Article	Citations
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	24
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa	21
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	21
Correction: Cardiac physiology and pathophysiology in pregnancy	20
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	18
Sex-specific considerations in cardiovascular drug therapy	18
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	16
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	16
Detection of joining points for genomic DNA circularization in cell culture	16
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K+ channel pathway	15
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	15
Note of appreciation	15
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	14
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	14
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	14
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	14
The impact of ionizing radiation compared to drug-induced immunological changes	14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	13
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	12
Canadian Society of Pharmacology and Therapeutics	12
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	11
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	11
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	11
Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11

Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	11
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	11
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	10
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	10
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	10
Cardiogenic shock—sex-specific risk factors and outcome differences	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	10
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	10
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	9
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	9
Gender-specific side effects of chemotherapy in pancreatic cancer patients	9
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	9
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	9
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	9
Right ventricular dysfunction in preclinical models of type I and type II diabetes	9
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	9
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	8
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	8
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	8
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	8
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	8
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	8
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	7
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	7
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	7
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	7
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	7
Association of blood pressure and BMI to corrected QT interval in young adults	7
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	7
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol	6
The addictive process of opioids: current and novel interventions in opioid use disorder	6
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	6
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	6
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	6
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	6
Myotubularin related protein 7, a novel STIM1 binding protein	6
The S1PR1 agonist SEW2871 promotes the survival of skin flap	6
Introduction—Unveiling gender disparity in heart disease	6

Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	6
Canadian Society of Pharmacology and Therapeutics	6
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	5
Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center	5
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	5
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	5
Note of appreciation	5
Formation of a border ischemic zone depends on plasma potassium concentration	5
KCNQ3 activation by the naturally occurring phenol, eugenol	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
Epigenetic regulation of sex dimorphism in cardiovascular health	5
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	5
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	5
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	5
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling	5
Paradoxical effects of acidosis on the noradrenaline-induced and neurogenic constriction of the rat tail artery at low temperatures	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	5
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	5
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A	5
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	5
Post hoc assessment of the relationship among coronary stenosis, electrocardiography, and ventricular function in patients with heart disease	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4
Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position	4
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	4
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission	4
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	4
Cardiovascular and physiological risk factors in women at mid-life and beyond	4
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca2+ influx	4
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	4
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats	4
Nanoparticle-eluting stents for coronary intervention: formulation, characterization, and in vitro evaluation	4
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation	4
Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review	4
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity	4
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	4
Impact of biological sex on valvular heart disease, interventions, and outcomes	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
β-elemene relieves neuropathic pain in mice through the regulation on C-X-C motif chemokine receptor 3 and GABAA receptor	3
Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy	3
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation	3
Cardioprotective effects of losartan and diminazene against the ischemia/reperfusion injury in hyperthyroidism rats	3
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat – high sucrose feeding	3
Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases	3
Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect	3
Potential role of d-chiro-inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome	3
White matter microglia morphological changes with aging in guinea pig offspring born growth restricted	3
Endothelial colony forming cells’ tetrahydrobiopterin level in coronary artery disease patients and its association with circulating endothelial progenitor cells	3
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report	3
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	3
Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba	3
Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	3
Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen–progestin contraceptive-induced hyperinsulinemic female rats	3
Transgenerational impact of topical steroid application on superoxide dismutase activities of hypothalamus-pituitary-adrenal axis in rats	3
Considerations for choosing an optimal animal model of cardiovascular disease	3
Aprocitentan and the endothelin system in resistant hypertension	3
The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes	3
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	3
Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus	3
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension	3
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	3
Lysophosphatidic acid metabolism and signaling in heart disease	3
The correlation between the expression of ATF4 and procalcitonin combined with the detection of RET mutation and the pathological stage and clinical prognosis of medullary thyroid carcinoma	3
Low-fat cheese ameliorates glucose intolerance and normalizes insulin secretion in a rat model of type 2 diabetes by promoting β-cell recovery	3
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients	3

SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression	3
Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy	2
The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52	2
Knockdown of lysyl oxidase like 1 inhibits the proliferation and pro-fibrotic effects of transforming growth factor-β1-induced hypertrophic scar fibroblasts	2
Mental health in COVID-19 Delta variant survivors and healthcare workers during the 2021 outbreak in Nanjing, China: a cross-sectional study	2
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels	2
TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia	2
Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	2
The Seventeenth International Conference on Endothelin (ET-17)	2
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model	2
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway	2
Systematic review of Health Canada approved clinical therapeutic trials for the treatment or prevention of coronavirus disease 2019 (COVID-19)	2
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications	2
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	2
A novel regulatory network of linc00174/miR-150-5p/VEGFA modulates pathological angiogenesis in diabetic retinopathy	2
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy	2
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart	2
Effect of soya phosphatidylcholine and possible underlying mechanism on ischemia/reperfusion injury in isolated perfused rat heart: an experimental and computational study	2
Azilsartan prevents muscle loss and fast- to slow-twitch muscle fiber shift in natural ageing sarcopenic rats	2
Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells	2
Suppression of protein kinase RNA-like endoplasmic reticulum kinase by probiotics circumvents cardiovascular risk profile in experimentally induced PCOS model	2
Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury	2
Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	2
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally	2
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	2
A review of the common causes of acute coronary syndrome (ACS) in females, and the role of estrogen on its pathologies and risk factors—review article	2
Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture	2
New approaches to the design of analgesic medicinal substances	2
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure	2
Psychological interventions targeting mental health and stress among females with cardiac disease: a scoping review	2
Celebrating the life and legacy of Dr. Gary D. Lopaschuk (1955–2025)	2
NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell	2
Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury	2
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	2
The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway	2
Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice	2
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis	2
Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro	2