Canadian Journal of Physiology and Pharmacology

Article	Citations
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	23
Note of appreciation	23
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa	20
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	19
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	17
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	17
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	16
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	16
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K+ channel pathway	16
Correction: Cardiac physiology and pathophysiology in pregnancy	15
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	15
Sex-specific considerations in cardiovascular drug therapy	14
Detection of joining points for genomic DNA circularization in cell culture	14
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	14
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	13
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	13
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	13
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	13
The impact of ionizing radiation compared to drug-induced immunological changes	13
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	13
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	12
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	12
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	11
Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11

Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	11
Canadian Society of Pharmacology and Therapeutics	10
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	10
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	10
Cardiogenic shock—sex-specific risk factors and outcome differences	10
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	9
Gender-specific side effects of chemotherapy in pancreatic cancer patients	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	9
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	9
Right ventricular dysfunction in preclinical models of type I and type II diabetes	9
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	9
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	9
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	9
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	8
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	8
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	8
Association of blood pressure and BMI to corrected QT interval in young adults	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	7
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	6
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	6
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	6
Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression	6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	6
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	6
Canadian Society of Pharmacology and Therapeutics	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A	5
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5

Time to treat the climate and nature crisis as one indivisible global health emergency	5
The S1PR1 agonist SEW2871 promotes the survival of skin flap	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	5
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	5
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	5
Myotubularin related protein 7, a novel STIM1 binding protein	5
Effects of physical exercise on baroreflex sensitivity and renal sympathetic nerve activity in chronic nicotine-treated rats	5
Note of appreciation	5
Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Renal expression and urinary excretion of aquaporin-2 in postobstructive uropathy in rats	5
Formation of a border ischemic zone depends on plasma potassium concentration	5
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	5
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	5
Introduction—Unveiling gender disparity in heart disease	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center	4
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling	4
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	4
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Post hoc assessment of the relationship among coronary stenosis, electrocardiography, and ventricular function in patients with heart disease	4
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Paradoxical effects of acidosis on the noradrenaline-induced and neurogenic constriction of the rat tail artery at low temperatures	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	4
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	4
Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review	4
Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position	4
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation	3
Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation	3
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	3
Nanoparticle-eluting stents for coronary intervention: formulation, characterization, and in vitro evaluation	3
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat – high sucrose feeding	3
Considerations for choosing an optimal animal model of cardiovascular disease	3
Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy	3
Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba	3
Lysophosphatidic acid metabolism and signaling in heart disease	3
Cardioprotective effects of losartan and diminazene against the ischemia/reperfusion injury in hyperthyroidism rats	3
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report	3
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity	3
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	3
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	3
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca2+ influx	3
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	3
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	3
Transgenerational impact of topical steroid application on superoxide dismutase activities of hypothalamus-pituitary-adrenal axis in rats	3
SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression	3
White matter microglia morphological changes with aging in guinea pig offspring born growth restricted	3
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats	3
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	3
Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	3
The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes	3
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension	3
Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus	3
Impact of biological sex on valvular heart disease, interventions, and outcomes	3
Cardiovascular and physiological risk factors in women at mid-life and beyond	3
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	3
The correlation between the expression of ATF4 and procalcitonin combined with the detection of RET mutation and the pathological stage and clinical prognosis of medullary thyroid carcinoma	3
β-elemene relieves neuropathic pain in mice through the regulation on C-X-C motif chemokine receptor 3 and GABAA receptor	3
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients	3
Aprocitentan and the endothelin system in resistant hypertension	3
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro	3

Protective effect of sitagliptin and whole-body γ-irradiation in diabetes-induced cardiac injury	3
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission	3
Endothelial colony forming cells’ tetrahydrobiopterin level in coronary artery disease patients and its association with circulating endothelial progenitor cells	3
TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia	2
The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52	2
Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro	2
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model	2
New approaches to the design of analgesic medicinal substances	2
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	2
Low-fat cheese ameliorates glucose intolerance and normalizes insulin secretion in a rat model of type 2 diabetes by promoting β-cell recovery	2
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis	2
Potential role of d-chiro-inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome	2
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels	2
Effect of soya phosphatidylcholine and possible underlying mechanism on ischemia/reperfusion injury in isolated perfused rat heart: an experimental and computational study	2
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	2
Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Preventative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives (N-functional group loading) on MPTP-induced parkinsonism in mice	2
Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture	2
NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell	2
Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells	2
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart	2
Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury	2
Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect	2
Mental health in COVID-19 Delta variant survivors and healthcare workers during the 2021 outbreak in Nanjing, China: a cross-sectional study	2
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications	2
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure	2
Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases	2
The Seventeenth International Conference on Endothelin (ET-17)	2
A review of the common causes of acute coronary syndrome (ACS) in females, and the role of estrogen on its pathologies and risk factors	2
Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice	2
Systematic review of Health Canada approved clinical therapeutic trials for the treatment or prevention of coronavirus disease 2019 (COVID-19)	2
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway	2
Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	2
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy	2
Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	2
A novel regulatory network of linc00174/miR-150-5p/VEGFA modulates pathological angiogenesis in diabetic retinopathy	2
The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway	2
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy	2
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally	2
Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen–progestin contraceptive-induced hyperinsulinemic female rats	2
Knockdown of lysyl oxidase like 1 inhibits the proliferation and pro-fibrotic effects of transforming growth factor-β1-induced hypertrophic scar fibroblasts	2
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	2