OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity — a preliminary report	51
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro	37
Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease	36
Butyrate improves cardiac function and sympathetic neural remodeling following myocardial infarction in rats	30
After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease	24
Rhein attenuates lipopolysaccharide-primed inflammation through NF-κB inhibition in RAW264.7 cells: targeting the PPAR-γ signal pathway	21
Vascular smooth muscle remodeling in health and disease	19
Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line	19
Stimulation of the endogenous hydrogen sulfide synthesis suppresses oxidative–nitrosative stress and restores endothelial-dependent vasorelaxation in old rats	18
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment	17
Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke	16
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro	16
Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage	15
Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients	15
Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p	15
Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway	15
p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway	13
The possible protective effect of colchicine against liver damage induced by renal ischemia–reperfusion injury: role of Nrf2 and NLRP3 inflammasome	13
Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?	13
Inhibition of autophagy improves resistance and enhances sensitivity of gastric cancer cells to cisplatin	13
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	13
Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice	12
miR-142-5p and miR-212-5p cooperatively inhibit the proliferation and collagen formation of cardiac fibroblasts by regulating c-Myc/TP53INP1	12
Cyanidin-3-O-glucoside attenuates high glucose–induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway	12
Blockade of IL-6 alleviates bone loss induced by modeled microgravity in mice	12

Astragaloside IV relieves gestational diabetes mellitus in genetic mice through reducing hepatic gluconeogenesis	12
Effect of high-intensity interval training and high-intensity resistance training on irisin and fibroblast growth factor 21 in men with overweight and obesity	12
Quercetin modulates NRF2 and NF-κB/TLR-4 pathways to protect against isoniazid- and rifampicin-induced hepatotoxicity in vivo	12
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways	12
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	12
A novel regulatory network of linc00174/miR-150-5p/VEGFA modulates pathological angiogenesis in diabetic retinopathy	11
Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	11
Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4	11
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	11
Mechanisms of action of SGLT2 inhibitors and their beneficial effects on the cardiorenal axis	11
Aprocitentan and the endothelin system in resistant hypertension	11
Hyperhomocysteinemia: an instigating factor for periodontal disease	11
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	10
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	10
Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats	10
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	10
Caffeic acid phenethyl ester attenuates changes in pancreatic tissue damage biomarkers induced by cisplatin	9
Gut microbiota and the periodontal disease: role of hyperhomocysteinemia	9
Dual mechanism of modulation of Na_V1.8 sodium channels by ouabain	9
High-methionine diet in skeletal muscle remodeling: epigenetic mechanism of homocysteine-mediated growth retardation	9
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	9
Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice	9
Combined treatment of menadione and calcitriol increases the antiproliferative effect by promoting oxidative/nitrosative stress, mitochondrial dysfunction, and autophagy in breast cancer MCF-7 cells	9
Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles	8
Circulating endothelial cell derived microvesicles are elevated with hypertension and associated with endothelial dysfunction	8
Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production	8
S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway	8
Long noncoding RNA GAS5 ameliorates chronic constriction injury induced neuropathic pain in rats by modulation of the miR-452-5p/CELF2 axis	8
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	8
Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model	8
α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts	8
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	8
Long non-coding RNA H19 acts as a microRNA-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts	8
Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence	8
Hypoxia-driven secretion of extracellular matrix proteins in the exosomes reflects the asymptomatic pathology of rotator cuff tendinopathies	8
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults	8
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	8
Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury	8
The impact of sex and gender on heart–brain axis dysfunction: current concepts and novel perspectives	8
Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway	7
Anisomycin inhibits angiogenesis, growth, and survival of triple-negative breast cancer through mitochondrial dysfunction, AMPK activation, and mTOR inhibition	7
Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes	7
Comparative protective effects of N-acetylcysteine and melatonin against obesity-induced testicular dysfunction in rats	7
Pharmacokinetic profile of the selective 5-HT₃ receptor antagonist ondansetron in the rat: an original study and a minireview of the behavioural pharmacological literature in the rat	7
Folic acid affects cardiometabolic, oxidative stress, and immunohistochemical parameters in monocrotaline-induced rat heart failure	7
Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	7
Participation of the opioid receptor – nitric oxide – cGMP – K⁺channel pathway in the peripheral antinociceptive effect of nalbuphine and buprenorphine in rats	7
Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF/eNOS signaling	7
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats	7
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	7

New approaches to the design of analgesic medicinal substances	7
Hepatoprotective effect of linagliptin against liver fibrosis induced by carbon tetrachloride in mice	7
Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells	7
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	7
Loss of endothelin type B receptor function improves insulin sensitivity in rats	7
Two-month administration of methylphenidate improves olfactory sensitivity and suppresses appetite in individuals with obesity	6
Effects of oleuropein on rat’s atria and thoracic aorta: a study of antihypertensive mechanisms	6
Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro	6
Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1	6
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	6
The effect of gender and ABCB1 gene polymorphism on the pharmacokinetics of azithromycin in healthy male and female Pakistani subjects	6
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model	6
Anti-cancer potential of cannabis terpenes in a Taxol-resistant model of breast cancer	6
Chondroitin sulfate mediates liver responses to injury induced by dual endothelin receptor inhibition	6
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	6
Regulatory role of cardiomyocyte metabolism via AMPK activation in modulating atrial structural, contractile, and electrical properties following atrial fibrillation	6
Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1	6
Redox and apoptotic potential of novel ruthenium complexes in rat blood and heart	6
The effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerve	6
Current therapies under investigation for COVID-19: potential COVID-19 treatments	6
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line	6
Fibroblast growth factor 21 improves lipopolysaccharide-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation	6
COVID-19 and the cardiovascular system: insights into effects and treatments	6
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway	6
Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability	6
Meclizine ameliorates memory deficits in streptozotocin-induced experimental dementia in mice: role of nuclear pregnane X receptors	6
Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions	6
Long-term survival outcome for pre-capillary pulmonary hypertension at a Japanese single center	5
Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats	5
Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia	5
Role of 7-chloro-4-(phenylselanyl) quinoline in the treatment of oxaliplatin-induced hepatic toxicity in mice	5
Expression of cholinesterases and their anchoring proteins in rat heart	5
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	5
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1	5
Gestational postprandial insulin sensitivity in the Sprague Dawley rat: the putative role of hepatic insulin sensitizing substance in glucose partitioning in pregnancy	5
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis	5
Endothelin receptor heteromerization inhibits β-arrestin function in HEK293 cells	5
Protecting the aging eye with hydrogen sulfide	5
Gender-specific side effects of chemotherapy in pancreatic cancer patients	5
Galectin-3 mediates high-glucose-induced cardiomyocyte injury by the NADPH oxidase/reactive oxygen species pathway	5
MicroRNA regulation of vascular smooth muscle cells and its significance in cardiovascular diseases	5
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	5
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	5
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	5
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	5
7-Chloro-4-(phenylselanyl) quinoline reduces renal oxidative stress induced by oxaliplatin in mice	5
Clinical study of pulmonary CT lesions and associated bronchiectasis in 115 convalescent patients with novel coronavirus pneumonia (COVID-19) in China	5
Exercise training suppresses Mst1 activation and attenuates myocardial dysfunction in mice with type 1 diabetes	5
The intervention oftert-butylhydroquinone protects ethanol-induced gastric ulcer in type II diabetic rats: the role of Nrf2 pathway	5
Melatonin modulates acute cardiac muscle damage induced by carbon tetrachloride — involvement of oxidative damage, glutathione, and arginine and nitric oxide metabolism	5
Possible cardioprotective role of NaHS on ECG and oxidative stress markers in an unpredictable chronic mild stress model in rats	5
Protective effects of selenium in tacrolimus-induced lung toxicity: potential role of heme oxygenase 1	5