Canadian Journal of Physiology and Pharmacology

Papers
(The TQCC of Canadian Journal of Physiology and Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria24
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia21
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa21
Correction: Cardiac physiology and pathophysiology in pregnancy20
Sex-specific considerations in cardiovascular drug therapy18
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia18
Detection of joining points for genomic DNA circularization in cell culture16
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals16
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats16
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy15
Note of appreciation15
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K+ channel pathway15
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway14
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition14
The impact of ionizing radiation compared to drug-induced immunological changes14
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats14
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats13
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney13
Canadian Society of Pharmacology and Therapeutics12
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 312
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart11
Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats11
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats11
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis11
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation11
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats11
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments10
Cardiogenic shock—sex-specific risk factors and outcome differences10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats10
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats10
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis10
Engaging women in decision-making about their heart health: a literature review with patients’ perspective10
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation10
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation9
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma9
Right ventricular dysfunction in preclinical models of type I and type II diabetes9
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes9
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels9
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury9
Gender-specific side effects of chemotherapy in pancreatic cancer patients9
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia9
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis8
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress8
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats8
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells8
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction8
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative8
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats8
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study7
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels7
Association of blood pressure and BMI to corrected QT interval in young adults7
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model7
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice7
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets7
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease7
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells6
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension6
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide6
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells6
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study6
Myotubularin related protein 7, a novel STIM1 binding protein6
The S1PR1 agonist SEW2871 promotes the survival of skin flap6
Introduction—Unveiling gender disparity in heart disease6
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes6
Canadian Society of Pharmacology and Therapeutics6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat6
Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol6
The addictive process of opioids: current and novel interventions in opioid use disorder6
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice6
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration6
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals5
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery5
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats5
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation5
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury5
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa5
Note of appreciation5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model5
Epigenetic regulation of sex dimorphism in cardiovascular health5
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice5
Paradoxical effects of acidosis on the noradrenaline-induced and neurogenic constriction of the rat tail artery at low temperatures5
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats5
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects5
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas5
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling5
Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center5
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors5
Formation of a border ischemic zone depends on plasma potassium concentration5
KCNQ3 activation by the naturally occurring phenol, eugenol5
Time to treat the climate and nature crisis as one indivisible global health emergency5
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics5
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