OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	23
Note of appreciation	23
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	20
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	19
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	17
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	17
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	16
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K⁺ channel pathway	16
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	16
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	15
Correction: Cardiac physiology and pathophysiology in pregnancy	15
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	14
Sex-specific considerations in cardiovascular drug therapy	14
Detection of joining points for genomic DNA circularization in cell culture	14
The impact of ionizing radiation compared to drug-induced immunological changes	13
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	13
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	13
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	13
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	13
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	13
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	12
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	12
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	11
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	11

Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Canadian Society of Pharmacology and Therapeutics	10
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	10
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	10
Cardiogenic shock—sex-specific risk factors and outcome differences	10
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	9
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	9
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	9
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	9
Gender-specific side effects of chemotherapy in pancreatic cancer patients	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	9
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	9
Right ventricular dysfunction in preclinical models of type I and type II diabetes	9
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	8
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	8
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	8
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Association of blood pressure and BMI to corrected QT interval in young adults	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	7
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	6
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	6
Canadian Society of Pharmacology and Therapeutics	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	6
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	6
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	6
Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression	6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Effects of physical exercise on baroreflex sensitivity and renal sympathetic nerve activity in chronic nicotine-treated rats	5
Note of appreciation	5
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	5
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	5
Myotubularin related protein 7, a novel STIM1 binding protein	5
Role of the NO-cGMP-K⁺ channels pathway in the peripheral antinociception induced by α-bisabolol	5

Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Formation of a border ischemic zone depends on plasma potassium concentration	5
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
Renal expression and urinary excretion of aquaporin-2 in postobstructive uropathy in rats	5
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	5
Introduction—Unveiling gender disparity in heart disease	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A	5
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	5
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
The S1PR1 agonist SEW2871 promotes the survival of skin flap	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	5