OOIR: Observatory of International Research

Papers

(The TQCC of Chemical & Pharmaceutical Bulletin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Development of Ethylcellulose Microparticles for Taste Masking of Fexofenadine	52
Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences	34
Rapid Determination of Dapagliflozin in Rat Plasma by UHPLC-Q-Orbitrap MS and Its Application to a Pharmacokinetic Study	21
Concise and Highly Stereoselective Synthesis of <i>β</i>,<i>β</i>-Disubstituted <i>α</i>,<i>β</i>-Unsaturated Esters	20
Foreword	18
Clinical Pipelines for Alzheimer’s Disease Psychosis and Agitation	18
Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway	18
Errata for Chemical and Pharmaceutical Bulletin	17
CBDPS 1.0: A Python GUI Application for Machine Learning Models to Predict Bitter-Tasting Children’s Oral Medicines	16
<i>In Vitro</i> and <i>in Silico</i> Studies of Potential Coronavirus-Specific 3C-Like Protease Inhibitors	16
Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction	15
Protective Effect of Apple Polyphenols on H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Damage in Human Colon Adenocarcinoma Caco-2 Cells	15
Syntheses of Aryl Thioethers <i>via</i> Aromatic Substitution of Aryl Halides at 0 to 25 °C	14
Photoinduced Atom Transfer Radical Addition Reaction of Olefins with α-Bromo Carbonyls	14
Design, Synthesis and Radioprotective Activity Evaluation of Novel <i>N</i>-Phenyl-2<i>H</i>-chromene-3-carboxamides Derived from Ex-RAD	13
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity	12
2-Azanorbornane-Based Amino Amide Organocatalysts for Asymmetric Michael Addition of <i>β</i>-Keto Esters with Nitroolefins	12
Development of Efficient Synthetic Reactions Using Enamines and Enamides Carrying Oxygen Atom Substituent on Nitrogen Atom	11
Teleocidin Analogs Isolated from <i>Streptomyces eurocidicus</i> as Membrane-Vesicle-Regulated Natural Products	11
Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation <i>via</i> Attachment of <i>N</i>-Methylpyrrole at the 2-Position	11
Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA	11
<i>In Vitro</i> Study on Combined Effect of Drugs for Hyperphosphatemia on Phosphorus Adsorption Capacity	11
Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups	11
Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>	10
Optimization and Advantages of Molded Tablets Using Trehalose as a Binder	10

Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture	10
Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity	10
Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library	9
Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)	9
Molecular Modeling, Synthesis, and Preliminary Cytotoxicity Evaluation of New Indole-Based Molecules as Possible Sirtuin Inhibitors	9
Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine	9
Anti-hepatitis C Virus Activity of Juglorubin Derivatives	9
Bromine K-Edge X-Ray Absorption Near-Edge Structure Analysis on Hydrobromide-Salt Crystals and the Solid Dispersion of Active Pharmaceutical Ingredients	9
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels	9
Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis	9
Functions, Structures, and Engineering of the Teleocidin Biosynthetic Enzymes	9
Synthesis of 2-Substituted Indoles <i>via</i> Migration Reaction of 3-Substituted Indoles with Triflic Acid	9
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster	8
The Effect of Iontophoresis with and without Electroporation on the Penetration of High Molecular Compounds into the Stratum Corneum	8
Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser	8
Evaluation of the Mechanism of Phosphate Removal Using Oyster Shell Powder in Aqueous Environments	8
Development of Low Molecular Weight Ligands for Integrin α<sub>v</sub>β<sub>3</sub>	8
Liquid Chromatographic Determination of <i>o</i>-Phosphoethanolamine in Human Plasma Using Fluorescent Derivatization	8
Solid Fat Content and Relaxation Time Measurement of Petrolatum Using Time-Domain NMR, and the Correlation with Viscosity and Crystallinity	8
<i>p</i>-Methoxy- and 2,4-Dimethoxybenzyl <i>N</i>-Acetylcarbamate Potassium Salts: Versatile Reagents for <i>N</i>-Alkylacetamide and <i>p</i>-Methoxy-	8
Estimation for Raw Material Plants of a Henna Product Using LC-High Resolution MS and Multivariate Analysis	7
Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides	7
Theoretical Study of the Mechanism of Ribosomal Peptide Bond Formation Using the ONIOM Method	7
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence	7
Total Synthesis of (+)-Silybin A	7
Chlorocyclization of Alkenoic Thioester	7
Two New Halimanes with a <i>γ</i>-Lactone from <i>Croton argyratus</i>	7
Organocatalyzed Amine-Free <i>O</i>-Phosphorylation of Alcohols with 4-Methylpyridine <i>N</i>-Oxide	7
Enteric Microcapsules Encapsulation of Roxithromycin-PVP Composite Core Particles to Inhibit Drug Crystallization upon Fluidized Bed Method for Oral Administration	7
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite	7
Transport Characteristics of Placenta-Derived Extracellular Vesicles and Their Relevance to Placenta-to-Maternal Tissue Communication	7
Effects of Physicochemical Properties of Constituent Ions of Ionic Liquid on Its Permeation through a Silicone Membrane	7
8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine	7
Tantalum-Catalyzed Peptide Elongation of Unprotected Amino Acids Using <i>N</i>-Trimethylsilylimidazole	7
Dynamic Dialysis Method for Characterizing Ammonia-Driven Drug Release from Liposomal Doxorubicin: Applicability and Kinetic Modeling	7
Emerging Separation Techniques in Supercritical Fluid Chromatography	7
Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction	7
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine	7
Optimization of the Hydrothermal Activation Treatment with Sodium Hydroxide Solution for the Conversion of Coal Fly Ash to Zeolite and Its Adsorption Capability of Lead (II) Ions from the Liquid Phase	7
Toward the Synthesis of Strychnos Alkaloids: Effective Construction of Fused Cyclohexane and Pyrrolidine Portion of the Strychnos Skeleton <i>via</i> Domino Intermolecular and Intramolecul	6
Magnetic Field-Responsive Pulsatile Drug Release Using A Magnetic Fluid	6
Antiproliferative Activities of Diterpenes from Leaves of <i>Isodon trichocarpus</i> against Cancer Stem Cells	6
Theoretical Study of the Substituent Effect on the Diradical Character of <i>α</i>-Substituted <i>α</i>,3-Didehydrotoluenes	6
Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells	6
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity	6
A Review on the Foodomics Based on Liquid Chromatography Mass Spectrometry	6
Identification of a Functionally Efficient and Thermally Stable Outward Sodium-Pumping Rhodopsin (<i>Be</i>NaR) from a Thermophilic Bacterium	6
C21 Steroidal Glycosides from the Roots of <i>Oxypetalum caeruleum</i>	6
Novel Pharmaceutical Cocrystals and Solvate Crystals of Nobiletin, a Citrus Flavonoid with Potent Pharmacological Activity	6
Foreword	6

Application of Quantitative NMR (qHNMR) towards Establishment of Pharmaceutical Reference Standard; A Case of a Ticagrelor Process Impurity	6
<i>N</i>-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride	6
Simultaneous Overcoming Approach for Poor Wettability and Low Stability in Stomach by Simple Methods; Formulation Design and Development of Monoacylglycerol Acyltransferase 2 Inhibitor, S-309309	6
Self-assembly of Urea Derivatives into Supramolecular Gels	6
Site-Selective Molecular Transformation: Acylation of Hydroxy Groups and C–H Amination	6
A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus <i>Curvularia aeria</i>	6
Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group	6
New Candidate Preservative in Ophthalmic Solution Instead of Benzalkonium Chloride: 1,3-Didecyl-2-methyl Imidazolium Chloride	5
Comparison of Phosphate and Bicarbonate Buffer Solutions as Dissolution Test Media for Predicting Bioequivalence of Febuxostat Formulation	5
Errata for Chemical and Pharmaceutical Bulletin	5
Comparison of Growth in <i>Hydrangea macrophylla</i> var. <i>thunbergii</i> Grown in Different Soil pH and Quantitative Analysis of Its Sweetness-Related Constituents	5
Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	5
Guided Isolation of Isopentenyl Flavonoids from <i>Daphne giraldii</i> Based on the Combination of GNPS and SMART	5
Design, Synthesis and Cytotoxicity Evalufation of Substituted Benzimidazole Conjugated 1,3,4-Oxadiazoles	5
Selective Synthesis of the Aminobutadiene Intermediate and Mechanistic Analysis of 1,4-Dihydropyridine Formation Reaction in Water	5
Errata for Chemical and Pharmaceutical Bulletin	5
Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation	5
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton	5
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities	5
Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root	5
C–H▪▪▪S Hydrogen Bonds in Ampicillin and Amoxicillin Crystals Investigated by Sulfur K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and Single-Crystal X-Ray Structure Analysis	5
Remarkable Solvent Effect of Fluorinated Alcohols on Azo–Ene Reactions	5
Effects of Membrane Cholesterol on Stability of Transmembrane Helix Associations	5
Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous	5
First Total Syntheses of Natural Phenanthrene Alkaloids, Uvariopsamine, Noruvariopsamine, 8-Hydroxystephenanthrine, 8-Methoxyuvariopsine, Thalihazine, and Secophoebine, and Their Potential as Antimala	5
Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers	5
Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent	5
Lewis Acid-Conjugated Pyrene Photoredox Catalyst Promoting the Addition Reaction of α-Silyl Amines with Benzalmalononitriles	5
μ-Oxo-Hypervalent-Iodine-Catalyzed Oxidative C–H Amination for Synthesis of Benzolactam Derivatives	5
Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography	4
Effect of Equipment Parameters on Amount and Dispersion of Wetting Liquid in Planetary Centrifugal Granulation	4
Effect of Particle Size of Powdered Cellulose Nanofibers as an Additive in the Production of Orally Disintegrating Mini-Tablets by Direct Powder Compression	4
2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors	4
Bivalent β-Carbolines Inhibit Colorectal Cancer Growth through Inducing Autophagy	4
Determination of the Absolute Configuration of 2′-Amino-3′-methylacetophenone Based on the Modified Mosher and Microcrystal Electron Diffraction Methods	4
Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge <i>Psammocinia</i> sp.	4
Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral <i>N</i>-(Anthracen-9-yl)methyl-<i>N</i>,<i>N</i>-bis(2-picolyl)amine and Evaluation of DNA P	4
Preparation and <i>in Vitro</i> Evaluation of Osmotic-Pump Lorcaserin-hydrochloride Controlled-Release Tablets	4
Formulation of Biopharmaceutical Dry Powder Inhaler Using the Void Forming Index (VFI) to Detect and Avoid Powder Caking in Dry Powder Inhaler Formulations	4
Synthesis and Evaluation of Quinone Derivatives for Activity against <i>Trypanosome cruzi</i>	4
The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors	4
Dissolution Profiles of Oral Disintegrating Tablet with Taste Masking Granule Polymer Coating in Biorelevant Bicarbonate Buffer	4
Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality	4
Triflimide-Promoted Nucleophilic <i>C</i>-Arylation of Halopurines to Access <i>N</i><sup>7</sup>-Substituted Purine Biaryls	4
Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor <i>via</i> NAD(P)H Oxidase	4
Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site	4
Chemical Components in <i>Hedera rhombea</i> Leaves and Their Cytotoxicity	4
Construction of <i>N</i>-Heterocycles Fused with a Highly Substituted Benzene Ring by a Benzyne-Mediated Cyclization/Functionalization Cascade Reaction and Its Application to the Total Syn	4
Synthesis of Formononetin Derivatives and Cardioprotective Effects	4
Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents	4
Electrochemical Characterization of a Novel Organoelectrocatalyst, 7-Azabicyclo[2.2.1]heptan-7-ol (ABHOL), and Its Application to Electrochemical Sensors	4
Protein Chemical Modification Using Highly Reactive Species and Spatial Control of Catalytic Reactions	4
Application of Quantitative NMR Spectroscopy to the Quality Evaluation of Diclofenac Gargles as Hospital Preparations	4
Structure–Activity Relationships of UTX-121 Derivatives for the Development of Novel Matrix Metalloproteinase-2/9 Inhibitors	4
Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from <i>Streptomyces niveoruber</i>	4
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery	4
Uric Acid as a Photosensitizer in the Reaction of Deoxyribonucleosides with UV Light of Wavelength Longer than 300 nm: Identification of Products from 2′-Deoxycytidine	4
Novel Strategies for Enantio- and Site-Selective Molecular Transformations	4
Effect of Sample Concentration on Nanoparticle Tracking Analysis of Small Extracellular Vesicles and Liposomes Mimicking the Physicochemical Properties of Exosomes	4
A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity	4
Exploring the Effectiveness of Carboxymethylated and Crosslinked <i>Albizia procera</i> Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis	4
Importance of the Azole Moiety of Cimetidine Derivatives for the Inhibition of Human Multidrug and Toxin Extrusion Transporter 1 (hMATE1)	4
Synthesis of Novel Pseudo-Enantiomeric Phase-Transfer Catalysts from <i>Cinchona</i> Alkaloids and Application to the Hydrolytic Dynamic Kinetic Resolution of Racemic 3-Phenyl-2-oxetanone	4
Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)	4
Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying	4
Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-1	4
Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain	4
An Update Mini-Review on the Progress of Azanucleoside Analogues	4
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication <i>via</i> Inflammation and Fibrosis Inhibition in Mice	4
Shanpanootols G and H, Diterpenoids from the Rhizomes of <i>Kaempferia pulchra</i> Collected in Myanmar and Their Vpr Inhibitory Activities	4
Quantification of Risperidone Contained in Precipitates Produced by Tea Catechins Using Nuclear Magnetic Resonance	4
GMP-Compliant Automated Radiolabeling and Quality Controls of [<sup>68</sup>Ga]Ga-FAPI-46 for Fibroblast Activation Protein-Targeted PET Imaging in Clinical Settings	4
Structure–Activity Relationships of Thiophene Carboxamide Annonaceous Acetogenin Analogs: Shortening the Alkyl Chain in the Tail Part Significantly Affects Their Growth Inhibitory Activity against Hum	4
Aqueous Dispersion Polymerization for the Development of Lamivudine-Polyacrylonitrile Nanoparticles through Quality by Design Approach	4
Development and Validation of an LC–MS/MS-Based Method for Quantifying Urinary Endogenous 6-Hydroxymelatonin	4