Chemico-Biological Interactions

Article	Citations
Roles of flavonoids against coronavirus infection	236
Essential metals in health and disease	211
Mechanism and regulation of pyroptosis-mediated in cancer cell death	164
High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms	121
Nuclear factor-kappa B and its role in inflammatory lung disease	115
Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways	87
Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties	85
Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish	82
Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice	77
Triaryl dicationic DNA minor-groove binders with antioxidant activity display cytotoxicity and induce apoptosis in breast cancer	66
Cytochrome P450 2E1 and its roles in disease	62
Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis	61
Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications	60
Colon cancer and colorectal cancer: Prevention and treatment by potential natural products	57
Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis	52
Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19	49
Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics	48
Exploring the binding mechanism and adverse toxic effects of persistent organic pollutant (dicofol) to human serum albumin: A biophysical, biochemical and computational approach	47
Transforming growth factor-β signaling: From tissue fibrosis to therapeutic opportunities	46
In silico analysis of selected alkaloids against main protease (Mpro) of SARS-CoV-2	45
Molecular and cellular basis of the anticancer activity of the prenylated flavonoid icaritin in hepatocellular carcinoma	45
Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells	44
Alcohol consumption and risk of stomach cancer: A meta-analysis	42
Galangin as an inflammatory response modulator: An updated overview and therapeutic potential	41
Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells	41

Modulation of TRPV1 channel function by natural products in the treatment of pain	41
Alcohol consumption. A leading risk factor for cancer	41
Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective	40
Neuroprotective effects of protocatechuic acid on sodium arsenate induced toxicity in mice: Role of oxidative stress, inflammation, and apoptosis	39
Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway	39
Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer	38
Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular regeneration	38
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer	38
Erythrocytes as model cells for biocompatibility assessment, cytotoxicity screening of xenobiotics and drug delivery	37
Effects of low-level imidacloprid oral exposure on cholinesterase activity, oxidative stress responses, and primary DNA damage in the blood and brain of male Wistar rats	36
Nuclear factor-κB signaling inhibitors revert multidrug-resistance in breast cancer cells	36
Cytotoxicity of a naturally occuring spirostanol saponin, progenin III, towards a broad range of cancer cell lines by induction of apoptosis, autophagy and necroptosis	36
Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis	36
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines	35
2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease	34
Aptamer-conjugated carbon-based nanomaterials for cancer and bacteria theranostics: A review	34
2D materials, synthesis, characterization and toxicity: A critical review	34
Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress	33
Potent toxic effects of Taroxaz-104 on the replication of SARS-CoV-2 particles	33
Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses	33
Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation	33
Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome	32
Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and RAW 264.7 macrophages via Nrf2/HO-1 and NF-κB pathways	32
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes	32
GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction	32
Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation	32
Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway	32
Graphene oxide enhances β-amyloid clearance by inducing autophagy of microglia and neurons	32
Novel benzimidazole derivatives: Synthesis, in vitro cytotoxicity, apoptosis and cell cycle studies	32
In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view	31
The newly synthesized compounds (NCHDH and NTHDH) attenuates LPS-induced septicemia and multi-organ failure via Nrf2/HO1 and HSP/TRVP1 signaling in mice	31
Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor	30
The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis	30
Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice	30
Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence	30
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer	30
Cytotoxicity of juglone and thymoquinone against pancreatic cancer cells	29
3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere	29
Metabolic reprograming confers tamoxifen resistance in breast cancer	28
Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454–3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC	28
Promoted inhibition of TLR4/miR-155/ NFkB p65 signaling by cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide	27
Artificial neural networks in contemporary toxicology research	27
Gallic acid and ferulic acid protect the liver from thioacetamide-induced fibrosis in rats via differential expression of miR-21, miR-30 and miR-200 and impact on TGF-β1/Smad3 signaling	27
Interplay between reactive oxygen and nitrogen species in living organisms	27
Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation	27
Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1/Ca2+ pathway	27
Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma	27
Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation	27
Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling	26
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells	26

Multidrug resistant tuberculosis – Diagnostic challenges and its conquering by nanotechnology approach – An overview	26
Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway	26
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation	26
The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway	25
Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases	25
Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways	25
Role of phytoconstituents in the management of COVID-19	25
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells	25
The anti-Zika virus and anti-tumoral activity of the citrus flavanone lipophilic naringenin-based compounds	25
Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis	25
Anticancer peptides mechanisms, simple and complex	24
Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contami	24
Naphthoquinones and derivatives as potential anticancer agents: An updated review	24
Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators	24
Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral	23
Protein and peptide delivery to lungs by using advanced targeted drug delivery	23
ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice	23
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p	23
Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway	22
Melatonin regulates the expression of inflammatory cytokines, VEGF and apoptosis in diabetic retinopathy in rats	22
mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test	22
Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells	22
Development of a conduit of PLGA-gelatin aligned nanofibers produced by electrospinning for peripheral nerve regeneration	22
Silver nanoparticles instigate physiological, genotoxicity, and ultrastructural anomalies in midgut tissues of beetles	22
Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora	22
Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat	22
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation	22
Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis	22
Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals	22
Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases	21
Advances in designing of polymeric micelles for biomedical application in brain related diseases	21
Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes	21
Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3	21
Plant defence mechanisms against mycotoxin Fumonisin B1	21
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway	21
Immunosuppressive role of Benzo[a]pyrene in induction of lung cancer in mice	21
TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway	20
A review on genotoxicity in connection to infertility and cancer	20
1H-benzimidazole-2-yl hydrazones as tubulin-targeting agents: Synthesis, structural characterization, anthelmintic activity and antiproliferative activity against MCF-7 breast carcinoma cells and mole	20
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line	20
An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy	20
Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model	20
Roles of peroxisome proliferator-activated receptor α in the pathogenesis of ethanol-induced liver disease	20
Label-free identification and differentiation of different microplastics using phasor analysis of fluorescence lifetime imaging microscopy (FLIM)-generated data	20
Tempol reduces inflammation and oxidative damage in cigarette smoke-exposed mice by decreasing neutrophil infiltration and activating the Nrf2 pathway	20
TRP channels in COVID-19 disease: Potential targets for prevention and treatment	20
Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells	19
Application of artificial intelligence for detection of chemico-biological interactions associated with oxidative stress and DNA damage	19
Understanding immune-modulatory efficacy in vitro	19
Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice	19
Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice	19
Ellagic acid blocks RANKL–RANK interaction and suppresses RANKL-induced osteoclastogenesis by inhibiting RANK signaling pathways	19
Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs	19
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity	19
Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway	19
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds	18
Elucidating of oxidative distress in COVID-19 and methods of its prevention	18
Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism	18
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues	18
Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes	18
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracell	18
Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats	18
Synthesis, characterization, DFT calculation, antioxidant activity, ADMET and molecular docking of thiosemicarbazide derivatives and their Cu (II) complexes	18
The protective effects of dulaglutide against advanced glycation end products (AGEs)-induced degradation of type Ⅱ collagen and aggrecan in human SW1353 chondrocytes	18
Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology	18
Effects of high-dose uric acid on cellular proteome, intracellular ATP, tissue repairing capability and calcium oxalate crystal-binding capability of renal tubular cells: Implications to hyperuricosur	18
The emerging potential of SIRT-3 in oxidative stress-inflammatory axis associated increased neuroinflammatory component for metabolically impaired neural cell	18
Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress	17
Knockdown of TRIM26 inhibits the proliferation, migration and invasion of bladder cancer cells through the Akt/GSK3β/β-catenin pathway	17
Control of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives	17
Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy	17
Biological activities of pyrazoline-indole based Re(I) carbonyls: DNA interaction, antibacterial, anticancer, ROS production, lipid peroxidation, in vivo and in vitro cytotoxicity studies	17
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication	17
Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response	17
PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway	17
Selenite induced breast cancer MCF7 cells apoptosis through endoplasmic reticulum stress and oxidative stress pathway	17
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro	16
β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways	16
The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy	16
Promises of phytochemical based nano drug delivery systems in the management of cancer	16

Systematic review of the scientific evidence on ethylene oxide as a human carcinogen	16
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury	16
The multifaceted role of ferroptosis in kidney diseases	16
E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice	16
Sphingolipids and the link between alcohol and cancer	16
Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis	16
Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): Mechanistic insight into cellular energy sensors, lipid accumulation and immune modulation	16
Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation	16
Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway	16
Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives	16
Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway	16
Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cyt	16
IL-33 regulates M1/M2 chemokine expression via mitochondrial redox-related mitophagy in human monocytes	15
Exposure to zinc oxide nanoparticles (ZnO-NPs) induces cardiovascular toxicity and exacerbates pathogenesis – Role of oxidative stress and MAPK signaling	15
Taurine loaded chitosan-pectin nanoparticle shows curative effect against acetic acid-induced colitis in rats	15
A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice	15
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced kidney damage in mice	15
Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance	15
Dental resin monomers induce early and potent oxidative damage on human odontoblast-like cells	15
Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways	15
Improved skin decontamination efficacy for the nerve agent VX	15
Thresholds for carcinogens	15
Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics	15
Hypoxia increases the apoptotic response to betulinic acid and betulin in human non-small cell lung cancer cells	15
Nitric oxide and Ca2+-activated high-conductance K+ channels mediate nothofagin-induced endothelium-dependent vasodilation in the perfused rat kidney	15
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer	15
AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway	15
STIP1 knockdown suppresses colorectal cancer cell proliferation, migration and invasion by inhibiting STAT3 pathway	15
A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for COVID-19: A combined hyperactive immune modulation and diagnostics	14
3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole ameliorates long-lasting depression- and anxiogenic-like behaviors and cognitive impairment in post-septic mice: Involvement of neuroimmune and oxidative	14
Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases	14
Gamabufotalin suppressed osteosarcoma stem cells through the TGF-β/periostin/PI3K/AKT pathway	14
Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review	14
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems	14
Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases	14
Harnessing the therapeutic potential of fisetin and its nanoparticles: Journey so far and road ahead	14
Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, induces apoptosis in melanoma cells	14
Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells	14
Sevoflurane reduces inflammatory factor expression, increases viability and inhibits apoptosis of lung cells in acute lung injury by microRNA-34a-3p upregulation and STAT1 downregulation	14
Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice	14
Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma	14
Linear non-threshold (LNT) fails numerous toxicological stress tests: Implications for continued policy use	14
Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague–Dawley rats	14
Geraniol isolated from lemon grass to mitigate doxorubicin-induced cardiotoxicity through Nrf2 and NF-κB signaling	14
Diphenyl diselenide ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats via suppressing oxidative stress and inflammation	14
Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach	14
Therapeutic potential of beta-caryophyllene against aflatoxin B1-Induced liver toxicity: biochemical and molecular insights in rats	14
Dietary vitamin D equilibrium in serum ameliorates direct bilirubin associated diabetes mellitus	14
MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke	14
Carvedilol attenuates l-arginine induced acute pancreatitis in rats through modulation of oxidative stress and inflammatory mediators	14
Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent	14
Bisphenol A and genistein have opposite effects on adult chicken ovary by acting on ERα/Nrf2-Keap1-signaling pathway	14
Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt/mTORC1/S6K1 signaling axis	13
Evaluation of acacetin inhibition potential against cytochrome P450 in vitro and in vivo	13
Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model	13
Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma	13
Neuropharmacological effect of risperidone: From chemistry to medicine	13
Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway	13
Therapeutic potential of marine macrolides: An overview from 1990 to 2022	13
Anticancer and antibacterial potential of robust Ruthenium(II) arene complexes regulated by choice of α-diimine and halide ligands	13
Long non-coding RNAs: A double-edged sword in aging kidney and renal disease	13
Critical discovery and synthesis of novel antibacterial and resistance-modifying agents inspired by plant phytochemical defense mechanisms	13
A novel glyceroglycolipid from brown algae Ishige okamurae improve photoaging and counteract inflammation in UVB-induced HaCaT cells	13
Triterpenoids with modified A-ring as modulators of P-gp-dependent drug-resistance in cancer cells	13
Natural alkaloids targeting EGFR in non-small cell lung cancer: Molecular docking and ADMET predictions	13
Dapagliflozin attenuates diabetic cardiomyopathy through erythropoietin up-regulation of AKT/JAK/MAPK pathways in streptozotocin-induced diabetic rats	13
Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations	13
Interaction of silver nanoparticles with plasma transport proteins: A systematic study on impacts of particle size, shape and surface functionalization	13
3,3′,5,5′-tetramethoxybiphenyl-4,4′diol induces cell cycle arrest in G2/M phase and apoptosis in human non-small cell lung cancer A549 cells	13
Harnessing the dual role of polysaccharides in treating gastrointestinal diseases: As therapeutics and polymers for drug delivery	13
BAY60-2770 attenuates doxorubicin-induced cardiotoxicity by decreased oxidative stress and enhanced autophagy	13
Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC)	13
Blood-brain barrier integrity is the primary target of alcohol abuse	13
Xanthosine, a purine glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/ FoxO1/AKT/GSK3β signaling cascade	13
Cyclosporine A induces testicular injury via mitochondrial apoptotic pathway by regulation of mir-34a and sirt-1 in male rats: The rescue effect of curcumin	13
A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways	13
Dual role of eugenol on chronic gastric ulcer in rats: Low-dose healing efficacy and the worsening gastric lesion in high doses	13
Hormesis and dental apical papilla stem cells	12
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis	12
Numb ameliorates necrosis and inflammation in acute kidney injury induced by cisplatin	12
Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells	12
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level	12
Antioxidation, anti-hyperlipidaemia and hepatoprotection of polysaccharides from Auricularia auricular residue	12
Differential mutation profile of SARS-CoV-2 proteins across deceased and asymptomatic patients	12
Triazole based novel molecules as potential therapeutic agents: Synthesis, characterization, biological evaluation, in-silico ADME profiling and molecular docking studies	12
Long-term administration of low-dose selenium nanoparticles with different sizes aggravated atherosclerotic lesions and exhibited toxicity in apolipoprotein E-deficient mice	12
Impact of prenatal arsenic exposure on the testes and epididymides of prepubertal rats	12
Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19	12
Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats	12
Decreasing sperm quality in mice subjected to chronic cannabidiol exposure: New insights of cannabidiol-mediated male reproductive toxicity	12
The chemical composition of ethanolic extracts from six genotypes of medical cannabis (Cannabis sativa L.) and their selective cytotoxic activity	12
Glycyrrhizic acid suppresses early stage of adipogenesis through repression of MEK/ERK-mediated C/EBPβ and C/EBPδ expression in 3T3-L1 cells	12
Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice	12
A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway	12
Lysionotin induces apoptosis of hepatocellular carcinoma cells via caspase-3 mediated mitochondrial pathway	12