Chemistry of Heterocyclic Compounds

Article	Citations
3-Nitro-1,2,4-triazol-5-one (NTO): High Explosive Insensitive Energetic Material	35
Biologically active compounds and drugs in the tetrazole series	35
Recent advances on heterocyclic compounds with antiviral properties	33
Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds	30
Antiviral nucleoside analogs	28
The main directions and recent trends in the synthesis and use of isoxazoles	23
Isomerization and changes of the properties of spiropyrans by mechanical stress: advances and outlook	22
Good pyridine hunting: a biomimic compound, a modifier and a unique pharmacophore in agrochemicals	21
Favipiravir – a Modern Antiviral Drug: Synthesis and Modifications	19
Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy	18
On the influence of weak intermolecular interactions on the molecular crystal density of 1,3,5-triazine trinitroalkyl derivatives	16
Antiviral activity of 1,2,4-triazole derivatives (microreview)	15
Methods of Synthesis for the Azolo[1,2,4]Triazines	14
Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use	13
Cage-Like Amines in the Green Protocol of Transannular Thieno[2,3-d]Pyrimidinone Formation as Promising Anticancer Agents	13
Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction	12
Metal-Free Functionalization of Azine N-Oxides with Electrophilic Reagents	12
Synthesis of biologically active derivatives of 2-aminobenzothiazole	12
Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells	12
Synthetic strategies for pyrrolo[2,1-f][1,2,4]triazine: the parent moiety of antiviral drug remdesivir	12
Hypervalent iodine in the structure of N-heterocycles: synthesis, structure, and application in organic synthesis	11
Spiropyrans: molecules in motion	11
2H-Azirines in medicinal chemistry	11
Indole Derivatives of Fusidane Triterpenoids: Synthesis and the Antibacterial Activity	11
Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole Units	11

Two approaches toward the regio- and stereoselective synthesis of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro-[chromeno[3,4-c]pyrrolidine-1,3'-oxindoles]	10
Regioisomeric 3,5-di(nitropyrazolyl)-1,2,4-oxadiazoles and their energetic properties	10
Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity	10
Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component domino reaction and evaluation of their cytotoxic activity	10
Thematic issue “Heterocyclic Compounds in Medicinal Chemistry”	10
Photochemical synthesis of novel naphtho[1,2-b]benzofuran derivatives from 2,3-disubstituted benzofurans	9
Nucleoside Analogs with Fleximer Nucleobase	9
Acyclic Enaminodiones in the Synthesis of Heterocyclic Compounds	9
Synthesis of 5-arylmethylidene-3-(arylmethylideneamino)thiazolidine-2,4-diones via triazine ring cleavage of tetrahydroimidazothiazolotriazinediones and their reactions with azomethine ylides	9
Synthesis and Evaluation of the Cytotoxicity of Indeno[1,2-c]Isoquinoline Derivatives Bearing Ester Functional Group and 1,2,3-Triazole Moiety	9
Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines	9
3-Nitro-2-phenyl-2-trifluoromethyl-2H-chromenes in reactions with azomethine ylides from isatins and (thia)proline: synthesis of spiro[chromeno(thia)pyrrolizidine-11,3'-oxindoles]	9
Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins	8
N-Propargylation and Copper(I)-Catalyzed Azide-Alkyne Cycloaddition as a Convenient Strategy for Directed Post-Synthetic Modification of 4-Oxo-1,4-Dihydrocinnoline Derivatives	8
Reactions of naphthalen-2-ol Mannich bases with β-aminoacrylonitriles and methyl 3-morpholinoacrylate	8
Iodine Acetate as a Mild Selective Agent for the Wagner–Meerwein Rearrangement in 3a,6-Epoxyisoindoles	8
Recent Advances in the Synthesis and Biological Applications of Nortopsentin Analogs	8
Synthesis and stability of thermally labile 1,2-oxaphosphetane 2-oxides and 1,2-thiaphosphetane 2-sulfides (microreview)	8
Study of the methylation reaction of 2,4-dinitroimidazole and potassium 2,4,5-trinitroimidazol-1-ide with dimethyl sulfate	8
Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides	8
Reactions of perfluoroacylchromenes with aromatic amines: synthesis of perfluoroalkylchromene carbaldehydes	8
3-Cyanoazolo[5,1-c][1,2,4]triazines: synthesis and antiviral activity	8
Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine	7
Regio- and Stereoselective 1,3-dipolar Cycloaddition of Azomethine Ylides Based on Isatins and (thia)proline to 3-nitro-2-(trifluoro(trichloro)methyl)-2H-chromenes: Synthesis and Cytotoxic Activity of	7
Highly efficient phosphine-catalyzed routes to α-imidoacrylates and 2,3-diimidopropanoates	7
Unsaturated carboxylic acids in the one-pot synthesis of novel derivatives of 3,4-dihydro-2H-thiopyran	7
Synthesis and analgesic activity of 1-[(1,2,3-triazol-1-yl)methyl]quinolizines based on the alkaloid lupinine	7
The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines – Structural Analogs of Antiviral Compounds	7
Methods for the Preparation of 3-Nitrobenzofurans	7
An efficient one-pot synthesis of indolyl-4H-chromene derivatives	7
Synthesis of unsymmetrical cage phosphonates from heterocyclic systems based on 2H-1,2-benzoxaphosphinine	7
Electrophile-Induced Reactions of Cross-Conjugated Enynones in the Synthesis of Heterocycles	7
Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity	7
Synthesis and Antiviral Activity of N-Heterocyclic Hydrazine Derivatives of Camphor and Fenchone	7
New methods for the synthesis of phosphono-δ-lactones (microreview)	6
Application of BF3·Et2O in the synthesis of cyclic organic peroxides (microreview)	6
Highly diastereoselective four-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines	6
Reactions of β-Carbonyl-Substituted 4H-chromenes and 1H-benzo[f]Chromenes with 5-aminopyrazoles	6
Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles	6
8-Ethynylxanthines as promising antiproliferative agents, angiogenesis inhibitors, and calcium channel activity modulators	6
Synthesis, Biological Activity and Photophysical Studies of Ellipticine and its Derivatives: State of the Art	6
Microwave-assisted synthesis of pyrazolo[3,4-b]pyridine derivatives (microreview)	6
Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties	6
Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles	6
Imidazo[A]Quinoxalines: New Approaches to Synthesis and Biological Activity	6
Stepwise, zwitterionic course of hetero-Diels–Alder reaction between 1,2,4-triazine molecular systems and 2-cyclopropylidene-1,3-dimethylimidazoline	6
Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives	6
Synthesis of new 2-substituted 6,8-dinitro[1,2,4]triazolo[1,5-a]pyridines	6
Synthesis of Sulfur-Containing Heterocycles by Electrophilic Addition Reactions of Disulfur Dichloride	6
Reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide	6

Synthesis and photophysical properties of 2-azolyl-6-piperidinylpurines	6
Conformations of saturated five-membered heterocycles evaluated by MP2 calculations	6
Synthesis, Cytotoxicity, and α-glucosidase Inhibitory Activity of Triterpenic and Sitosterol Tetrazole Derivatives	6
Benzobischalcogenadiazoles: synthesis and applications (microreview)	6
Nucleophilic Dearomatization of 3-nitrobenzofurans by the Action of 2-(1-arylethylidene)Malononitriles	6
Three-component condensation of cyclic 1,3-dicarbonyl compounds, N-phenacylpyridinium salts, and isatins or aromatic aldehydes as a method for the synthesis of novel condensed 2-aroyl-2,3-dihydrofuran	6
Synthesis of cyclic D-(+)-camphoric acid imides and study of their antiviral activity	6
Synthesis of tetrazole derivatives through conversion of amide and thioamide functionalities	6
A three-component condensation of cyclic enamino ketones, phenylglyoxal hydrate, and ethyl cyanoacetate	6
Tandem Reactions of Thermolysis and [3+2] Cycloaddition in the Synthesis of 3-Hetaryl-4-Nitrofuroxans from 4-Nitrofuroxannitrolic Acid	6
Aryltellurium Trihalides in the Synthesis of Heterocyclic Compounds (Microreview)	5
Transformations of 1-[2-(Adamantan-1-Yl)-2-Hydroxyethyl]-1,2,3,6-Tetrahydropyridines by the Action of Trifluoromethanesulfonic Acid	5
Synthesis via the Mannich Reaction and Biological Activity of Novel Fluorinated Camptothecin Derivatives	5
Reactions of thiiranes with NH-heterocycles 1. An investigation of the reaction of 2-chloromethylthiirane with 3,5-dibromo-4-nitropyrazole	5
Group-assisted purification chemistry principles to access highly substituted zwitterionic furans via fast, concise, and efficient one-pot three-component assembly	5
α-Functionalized ketene N,S-acetals as two-carbon synthons in the reaction with 1,2-naphthoquinone 1-methide. Synthesis of 3-amino-1H-benzo[f]chromenes	5
Synthesis and Biological Activities of 4H-3,1-Benzothiazin-4-Ones	5
Synthesis of 1,2-azole derivatives on the basis of α,β-unsaturated triterpene aldehydes	5
Synthesis and fungicidal activity of novel 6H-benzimidazo[1,2-c][1,3]benzoxazin-6-ones	5
NaSCN–(NH4)2Ce(NO3)6 system in heterocycle thiocyanation: synthesis of novel highly potent broad-spectrum fungicides for crop protection	5
Electrocatalytic tandem assembly of aldehydes with 2-thiobarbituric acid into 5,5'-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) and evaluation of their interaction with catalases	5
Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity	5
Synthesis and chemical properties of 3-alkoxycarbonylchromones and 3-alkoxalylchromones	5
Synthesis of 4,4'-Bis[3-(Fluorodinitromethyl)-1H-1,2,4-triazol-5-Yl]azofurazan	5
Synthesis of 1,8-naphthyridines: a recent update (microreview)	5
3-Amino-4-(1-amino-2-cyanovinyl)furazans: synthesis and cyclization	5
Synthesis of functionalized azolo(azino)quinazolines by electrophilic cyclization (microreview)	5
Synthesis of 2H-pyrano[3,2-g]quinolin-2-ones containing a pyrimidinone moiety and characterization of their anticoagulant activity via inhibition of blood coagulation factors Xa and XIa	5
Imidazolone-activated donor-acceptor cyclopropanes with a peripheral stereocenter. A study on stereoselectivity of cycloaddition with aldehydes	5
Electrophilic Fluorination of Heterocyclic Compounds with NF Reagents in Unconventional Media	5
Synthesis and application of haloisoxazoles	5
3-Hetarylisocoumarins in the synthesis of 1-functionalized 3-hetarylisoquinolines	5
Synthesis of Novel 3-(Pyridin-4-yl)-1,2,4-Triazines, their Analogs and Study of the Activity Against Vaccinia Virus	5
Alkaloid-like annulated pyrano[4,3-b]pyrroles: antiviral activity and hydrolysis	5
Coumarin synthesis via Pechmann condensation: toward a greener era (microreview)	5
Quadruple Bond Forming Multicomponent Approach to 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines and Its Interaction with the Neuropeptide Y1 Receptor	5
6-Nitro-4,7-dihydroazolo [1,5-a]pyrimidines: an alternative mechanism of formation and studies of alkylation	5
Green synthesis of novel phosphonate derivatives using ultrasonic irradiation	5
Synthesis, X-ray and DFT Studies of 6-halo-3-(hydroxymethyl)cinnolin-4(1H)-ones	5
Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives	5
Synthesis of five-membered heterocycles by [3+2] cycloaddition reactions of sulfur-containing 3,3,3-trifluoropropene derivatives	5
Heterocycles Based on 1-((Z)-1,4-dibromobut-2-en-2-yl)adamantane	5
Synthesis of novel γ-butyrolactone-based phenazine compounds via microwave-assisted multicomponent domino reactions	5
Construction and Characterization of 3,7-Dichloro-N-(2,6-Diethylphenyl)-N-(2-Propoxyethyl)Quinolone-8-Carboxamide: A Potential Novel Pesticide Compound	5
Facile Synthesis and Spectral Properties of Novel Isomeric Nitrile-Rich Bipyridine Derivatives	5
Regio- and stereoselectivity of [3+2] cycloaddition reactions between (Z)-1-(anthracen-9-yl)-N-methyl nitrone and analogs of trans-β-nitrostyrene on the basis of MEDT computational study	5
Synthesis and photophysical investigation of AIEgen dyes bearing quinoline and BODIPY scaffolds	5
Cycloaddition of nitrones to 1,3-diarylpropenones and subsequent transformations of the resulting isoxazolidines	5
Synthesis, structure, and antiviral properties of novel 2-adamantyl-5-aryl-2H-tetrazoles	5
Michael Adducts of Levoglucosenone with α-Ethoxycarbonyl- and α-Nitrocyclododecanones: Transformation into Chiral Macrolides	5
Synthesis of 1,2-Dihydroisoquinoline-1-Carboxylates Under Cobalt Catalysis	5
Heterocyclic analogs of 5,12-naphthacenequinone 16*. Synthesis and properties of new DNA ligands based on 4,11-diaminoanthra[2,3-b]thiophene-5,10-dione	5
Palladium-catalyzed amino group arylation of 1,3-disubstituted 1H-pyrazol-5-amine based on Buchwald–Hartwig reaction	5
Design, synthesis, and anti-breast-cancer activity evaluation of pyrrolo(pyrido)[2,3-d]pyrimidine derivatives	5
Oxaborine Derivatives: Synthesis and Therapeutic Potential	5
The Nenitzescu Reaction in the Synthesis of New Abietane Diterpene Indoles	5
A Beckmann rearrangement initiated by trifluoromethanesulfonic anhydride in the synthesis of compounds containing a new pyrazolo[3',4':5,6]pyrido[3,2-b]azepine heterocyclic system	4
Modified synthesis and structural features of 2-benzylidene-4-nitro-2,5-dihydrothiophene 1,1-dioxides	4
Imidazothiazoles and their Hydrogenated Analogs: Methods of Synthesis and Biomedical Potential	4
Formation of five- and six-membered nitrogen-containing heterocycles on the basis of hydrazones derived from α-dicarbonyl compounds (microreview)	4
Synthesis of isoxazolylpyrrolones by three-component reaction of α-ketoglutaric acid or its diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes	4
Atom-efficient synthesis of hybrid molecules combining fragments of triazolopyrimidines and 3-ethoxycarbonyl-1-ethyl-6-fluoroquinolin-4(1H)-one through 1,2,3-triazole linker	4
Synthesis of spiro[imidazole-4,3'-quinolin]ones from [2-(dimethylamino)benzylidene]-2-(methylsulfanyl)imidazolones	4
Synthesis of 2-aminopyridopyrimidinones and their plasmepsin I, II, IV inhibition potency	4
Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring	4
Synthesis of imidazo[2,1-b][1,3]thiazoles – potential anticancer agents derived from γ-bromodipnones	4
The Dimroth rearrangement of 5-amino-1-aryl-1,2,3-triazole-4-carbothioamides	4
Synthesis of pyrazoles from α-diazo-β-ketosulfones and α-diazo-β-ketophosphonates	4
Synthesis of Fluorinated Octahydro-2H-Chromenes in the Presence of the BF3·Et2O–H2O Catalytic System	4
Synthesis of new pyrido[2,3-d]pyrimidin-5-one, pyrido[2,3-d]pyrimidin-7-one, and pyrimidino[4,5-d][1,3]oxazine derivatives from 5-acetyl-4-aminopyrimidines	4
Synthesis of 2H-thiochromene derivatives (microreview)	4
Effective Synthesis of Hard-To-Reach 3,4-Disubstituted Thiophene Derivatives Based on bis(2-chloropropenyl) Sulfide	4
Formation of five-membered nitrogen-containing heterocycles based on 1-bromo-1-nitroalkenes (microreview)	4
N-Alkylation of Nitrogen Heterocycles with α-Diazocarbonyl Compounds	4
Recent synthetic approaches to 1H- and 2H-indazoles (microreview)	4
Synthesis of 3-substituted tetrahydroindol-4-one	4
Improved Synthesis and Thermochemical Properties of Amino- and Hydrazino-1,2,4,5-Tetrazines	4
Synthesis of new pyrido[2,3-d]pyrimidin-5-ones and pyrido[2,3-d]pyrimidin-7-ones functionalized at position 4 from 5-acetyl-6-amino-4-methylsulfanyl-2-phenylpyrimidine	4
Synthesis of azidopropargylamino-substituted 1,3,5-triazines – novel monomers for the production of energetic polymers	4
о-Aminopyrimidine Aldehydes and Ketones: Synthesis and use as Precursors to Fused Pyrimidines	4

Nitrolysis of N-alkylurotropinium Salts	4
Synthesis of 3-Amino-6,7-Dihydroferroceno[a]Quinolizin-4-One Derivatives via the Reaction of 3,4-Dihydroferroceno[c]Pyridines with Azlactones	4
Diazapyrenes: interaction with nucleic acids and biological activity	4
Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts	4
Recent developments in the synthesis of piperazines (microreview)	4
Cyclic Isothiourea in Drug Design	4
Ring-closure reactions of functionalized vinyl sulfonamides (microreview)	4
Synthesis of 3-Silylated 3-Sulfolenes from Propargylsilanes and their Reductive Desulfitation	4