OOIR: Observatory of International Research

Papers

(The TQCC of Circulation Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System	1384
Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19	749
Obesity Phenotypes, Diabetes, and Cardiovascular Diseases	741
Epidemiology of Atrial Fibrillation in the 21st Century	632
COVID-19 and the Heart	522
Cardiac Energy Metabolism in Heart Failure	456
Metabolic Inflammation and Insulin Resistance in Obesity	447
Gut Microbiota and Cardiovascular Disease	439
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications	434
Epidemiology of Heart Failure	392
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis	390
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19	363
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2	295
Basic Mechanisms of Diabetic Heart Disease	288
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics	287
Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice	269
Obesity, Adipose Tissue and Vascular Dysfunction	257
Basic and Therapeutic Aspects of Angiogenesis Updated	255
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease	245
COVID-19 and Cardiovascular Disease	231
Arterial Stiffness and Cardiovascular Risk in Hypertension	228
Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy	227
Social Determinants of Cardiovascular Disease	222
Epidemiology of Peripheral Artery Disease and Polyvascular Disease	214
Post-Stroke Cognitive Impairment and Dementia	211

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas	205
Myofibroblasts and Fibrosis	195
Oxidative Stress and Hypertension	193
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF	192
In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid	173
The Impact of Sex and Gender on Stroke	164
Adiponectin, Leptin and Cardiovascular Disorders	163
Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation	153
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury	153
From Systemic Inflammation to Myocardial Fibrosis	137
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression	135
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis	130
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions	129
Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure	129
SARS-CoV-2 Initiates Programmed Cell Death in Platelets	128
Pathophysiology of Hypertension	121
Arterial Stiffness Preceding Diabetes	119
Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction	116
Genetics of Atrial Fibrillation in 2020	114
Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women	110
Hypertension in Low- and Middle-Income Countries	108
S100A9 Links Inflammation and Repair in Myocardial Infarction	106
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity	105
Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification	105
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a	104
Hypertension	101
NAD ⁺ Repletion Reverses Heart Failure With Preserved Ejection Fraction	99
Inflammation, Infection and Venous Thromboembolism	99
Immune Cells and Immunotherapy for Cardiac Injury and Repair	97
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis	95
Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation	93
Genetic Basis and Therapies for Vascular Anomalies	92
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss	92
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway	89
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies	89
The Gut Microbiome in Hypertension	89
Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease	88
Molecular Genetic Basis of Hypertrophic Cardiomyopathy	87
Cerebral Cavernous Malformation: From Mechanism to Therapy	87
AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration	86
miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases	86
Metabolomics and Proteomics in Type 2 Diabetes	85
tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke	84
Gene Therapy for the Heart Lessons Learned and Future Perspectives	84
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation	82
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension	82
Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD	82
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes	81
New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease	81
Animal Models of Atrial Fibrillation	81

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis	79
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke	78
Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling	74
Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo	74
The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction	73
Advances in Acute Ischemic Stroke Therapy	71
Endothelial S1P ₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke	71
Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling	69
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci	68
Sex Differences in Peripheral Artery Disease	67
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas	66
Response by Zhang et al to Letter Regarding Article, “Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With H	66
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure	65
Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis	64
Racial and Ethnic Disparities in Peripheral Artery Disease	63
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease	63
Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair	62
Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury	62
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability	62
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function	62
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells	62
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart	62
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis	62
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation	62
Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation	62
Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes	61
Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction	61
Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability	61
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy	60
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation	60
Hypertension, a Moving Target in COVID-19	59
Population-Based Screening for Atrial Fibrillation	58
Hypoalbuminemia, Coagulopathy, and Vascular Disease in COVID-19	58
Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease	58
Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients	57
Contemporary Medical Management of Peripheral Artery Disease	57
Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health	57
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT	56
Sex Differences in Myocardial and Vascular Aging	56
Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia	56
Guideline-Driven Management of Hypertension	56
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure	55
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism	53
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity	53
Inflammation Resolution: Implications for Atherosclerosis	53
CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke	52
Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis	52
Emerging Technologies for Identifying Atrial Fibrillation	52
The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy	50
Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy	50
Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries	49
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells	49
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies	49
Unveiling Complexity and Multipotentiality of Early Heart Fields	49
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice	49
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke	48
Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure	48
Emerging Technologies for Pulmonary Vein Isolation	48
Gut Microbiome and Neuroinflammation in Hypertension	48
Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy	48
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca ²⁺ Leak	48
Machine Learning in Arrhythmia and Electrophysiology	48
Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis	48
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium	47
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca ²⁺ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca ²⁺	46
LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase	46
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk	46
Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation	46
Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection	45
Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy	45
COVID-19, Myocarditis and Pericarditis	45
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19	45
Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity	45
Sex Differences and Similarities in Valvular Heart Disease	45
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts	45
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies	44
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis	44
A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling	44
Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models	44
Advances in Lymphedema	43

Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome	43
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice	43
Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles	43
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension	42
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts	42
EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases	42
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals	41
Cardiac Tissues From Stem Cells	41
Lipid Profiles and Heart Failure Risk	41
Live Imaging of Intracranial Lymphatics in the Zebrafish	41
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease	40
Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD	40
Intracellular β ₁ -Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility	40
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis	40
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure	39
Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis	39
Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term	39
Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease	39
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart	38
CRISPR Modeling and Correction of Cardiovascular Disease	38
Association Between Atrial Fibrillation and Sudden Cardiac Death	38
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis	38
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism	38
MCUb Induction Protects the Heart From Postischemic Remodeling	38
Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion	38
Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post–Cardiac Arrest	38
Reverse Remodeling With Left Ventricular Assist Devices	38
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia	38
Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells	37
Adrenergic Ca _V 1.2 Activation via Rad Phosphorylation Converges at α _1C I-II Loop	37
Nutrition, Thrombosis, and Cardiovascular Disease	37
Preclinical Models of Cancer Therapy–Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association	37
Treatment of Obesity in Mitigating Metabolic Risk	37
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis	37
Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Inflammation	37
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension	36
Association of Habitual Physical Activity With Cardiovascular Disease Risk	36
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function	36
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix	36
Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope	36
Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death	36
How Will Machine Learning Inform the Clinical Care of Atrial Fibrillation?	35
Periostin	35
Platelets and COVID-19	35
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity	35
Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver	34
Effects of Atrial Fibrillation on the Human Ventricle	34
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition	34
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury	34
Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction	33
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis	33
Sex-Specific Cardiovascular Risks of Cancer and Its Therapies	33
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart	33
Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway	33
Eosinophils Protect Mice From Angiotensin-II Perfusion–Induced Abdominal Aortic Aneurysm	33
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart	33
Somatic Mutations in Cardiovascular Disease	32
Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine	32
Sex Differences in Cardiac Rehabilitation Outcomes	32
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes	32
CaMKIIδC Drives Early Adaptive Ca ²⁺ Change and Late Eccentric Cardiac Hypertrophy	32
Heart Failure With Targeted Cancer Therapies	32
Device Therapy of Hypertension	32
Randomized Trial of Etelcalcetide for Cardiac Hypertrophy in Hemodialysis	32
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease	32
Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration	32
Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation	32
Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease	31
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress	31
Identification of Functional Variant Enhancers Associated With Atrial Fibrillation	31
Mitochondrial H ₂ S Regulates BCAA Catabolism in Heart Failure	31
Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification	31
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis	31
Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome	31
Cardiovascular Disease Screening in Women: Leveraging Artificial Intelligence and Digital Tools	30
Cellular and Engineered Organoids for Cardiovascular Models	30
Heart Failure Subtypes and Cardiomyopathies in Women	30
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages	30
Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries	30
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis	30
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype	29
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters	29
MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury	29
Role of the Peroxisome Proliferator Activated Receptors in Hypertension	29
Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy	28
Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia	28
PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy	28
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury	28
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes	28
Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis	28
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function	28
Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure	28
Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade	28
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self	28
Renin Cells, the Kidney, and Hypertension	28