Clinica Chimica Acta

Article	Citations
Evaluating the clinical effectiveness of cardiovascular precision diagnostics	248
Performance evaluation and validation of high-performance liquid chromatography method for the quantification vitamins A and E	232
How did the COVID-19 pandemic impact drug trends?	154
Assessment of an analysing system for the determination of NA+, K+, CL- and CA2+	103
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in blood samples of rats using GC-MS/MS	93
Effects of obesity on liver function in children	88
The increased sensitivity of the Xpert® Xpress assay in detecting SARS-COV-2, compared to the COBAS® assay, can be attributed to the nucleocapsid gene target	83
Interference of hemolysis in urgent clinical biochemistry examinations analyzed on DxC 700 AU and access 2	82
Pre-analytical issues in haemostasis	74
Performance evaluation of the architect hepatitis c core antigen assay vs roche HCV DUO	67
Laboratory-based study of newborn with intrauterine growth restriction	59
Exploring artificial intelligence techniques for morphological analysis of digital images of peripheral blood cells: MC-80 versus HemaVision	58
New insights in the newborn screening for methylmalonic aciduria in the Balearic Islands: Surprisingly high prevalence of CD320 gene mutation (transcobalamin receptor)	55
Indeterminate results in quantiferon-TB gold plus testing: Possible explanation and predictive parameters	51
Hypocalcemia and hypomagnesemia among patients with depression attending KFMMC-Dhahran-KSA	50
Association of miRNA-126 cycle threshold values with the blood glucose concentration	48
Treating red blood cells with dithiothreitol can help eliminate daratumumab interference in blood compatibility tests (pretransfusion testing)	46
The effect of calcium chloride on the release of platelet-derived growth factor-BB in the platelet-rich plasma products	44
Improving of test utilization through modification of the electronic ordering system for blood zinc level	42
Real-world data shows the effectiveness of a tetravalent vaccine against human papilloma virus types 16 and 18 in Chilean women	42
Evaluation of beta glucan test using kinetic turbidimetric method on toxinometer MT-6500 for detection of invasive fungal infections in hospitalized patients	40
Evaluation of pre-analytical quality indicators by six sigma principle: Experience at a tertiary care hospital	38
Unveiling liquid markers: The diagnostic revolution in early detection of pancreatic cancer through liquid biopsy	38
Evaluation OF FGF-23 as a marker of mineral bone disease among newly diagnosed chronic kidney disease patients in a Nigerian hospital	38
Immunoglobulin fragmentation challenges the interpretation of capillary protein electrophoresis results	37

Seroprevalence and risk factors of toxoplasmosis among pregnant women in the M’saken region (Tunisia)	37
Evaluation of metabolic and endocrine profiles in the elderly	36
Association of ECM remodelling marker gene polymorphisms and their serum levels in acute and recurrent myocardial infarction	35
Association of single nucleotide polymorphisms in eNOS gene with development of diabetic nephropathy: A case control study	34
“Revolutionizing emergency care: A comparative analysis of comprehensive point-of-care test panels vs conventional laboratory processes in the critical care& emergency medicine”	33
Exploring the potency of Lamiaceae essential oils: Chemical composition and antibacterial efficacy against multidrug-resistant bacteri	33
Estimation of glomerular filtration rate with cystatin C in the evaluation of cardiovascular risk	32
Stability of arterial and venous gas samples stored for 20, 40 and 60 minutes after collection	31
A variant reclassification of SLC12A3 of Gitelman syndrome	31
Why do scientists call for action against vitamin D deficiency and what is behind the scene?	30
Uric acid lithiasis in southern Tunisia	30
Study of the association between vitamin D and anti-mullerian hormone (AMH)	29
Not one-size-fits-all: The types and varieties of dtc tests and their potential harms	29
Principle of flow cytometry and issues in diagnosis	28
Testosterone II (TSTII) and dimension VISTA® LOCI total testosterone (TTST) immunoassays meet the CDC host certification requirements for more than four years	28
A system troubleshooting for HIV-1 drug resistance genotyping amplification rate failure at Ethiopian public health institute HIV laboratory	28
Cardiorenal syndrome and diabetes mellitus in indonesian population	28
The reality of antimicrobial resistance (AMR) in Palestine and its impact on health and economy: A cross-sectional study in West Bank, Palestine	28
Strategy to improve the turn around time (TAT) for stat samples in clinical laboratories	28
Raman spectroscopic analysis of urine combined with machine learning identifies life-threatening inborn errors of metabolism	27
Detection of mycobacterium tuberculosis and rifampicin resistance with Xpert® MTB/RIF analysis in a tertiary hospital	27
Next step in predictive medicine: New serum biomarkers to predict acute stroke mortality	27
Changes in nonalcoholic fatty liver disease and M2BPHI due to lifestyle intervention in primary healthcare	27
Thyroid profile abnormalities among patients tested at the Nairobi Hospital Laboratory, Kenya	27
Antibiotic resistance profile of enterobacteriaceae isolated from infected hemodialysis catheters	27
Editorial Board	26
Aptamer-based electrochemical biosensors for progesterone detection: Advancing point-of-care diagnostics	26
Editorial Board	25
Integrating multiplex PCR in fever clinics for acute respiratory pathogen-specific diagnosis	25
Identification of cell cycle-related hub genes HMMR AND CDC25C for prognosis of head and neck squamous cell carcinoma through co-expression network analysis	24
Hematological malignancies: Analysis of complete blood count (CBC) and myelogram results in the Hematology Laboratory of Hedi Chaker Hospital Sfax (South Tunisia)	24
Comparison of various E-GFR equations in estimating glomerular filtration rate in Indians	24
Editorial Board	24
Interference in the detection of HBA1C: Detection of abnormal HB presence	24
Targeted plasma proteomic analysis uncovers a high-performance biomarker panel for early diagnosis of gastric cancer	23
Assay-Dependent Effects of EDTA Contamination on Magnesium and Iron	23
Metabolomics identifies metabolite markers in plasma and extracellular vesicles within plasma in patients with asthma	23
An accurate measurement method for serum homocysteine measurement by ID-LC/MS/MS and the application of external quality assessment	23
Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth	23
Identification of a novel plasma metabolite panel as diagnostic biomarker for hepatocellular carcinoma	23
Urinary iodine testing practices in China: Results of the 5-year external quality assessment program	23
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report	22
Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When “wrong” matrix is the right choice	22
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer	22
Potentiometric urea biosensors	22
Exosome biosensors for detection of liver cancer	22
Resistin and omentin in breast cancer: A systematic review and meta-analysis	22
M085 Determinants of systemic immunity to invasive salmonella infection in endemic settings	21
Quantitative analysis of soluble costimulatory molecules as potential diagnostic biomarkers for rheumatoid arthritis using LC-MS/MS in MRM mode	21
T274 Natural killer cell subsets and phenotypic expression of markers of activation, maturation and associated with slow progression of HIV in HAART naïve HIV patients in Addis Ababa, Ethiopia	21

T134 Establishment of algorithms and threshold of thyroid stimulating immunoglobulin for diagnosis of Graves’ disease by data mining: A Chinese multicenter study	21
Quantification of choline in serum and plasma using a clinical nuclear magnetic resonance analyzer	21
The pentraxin family in autoimmune disease	21
W058 Salmonella infection among the suspected enteric fever patients	21
Evaluation of thrombin generation assay in factor XI deficiency	21
T287 The change for qualitative balance of vascular endothelial growth factor-a may contribute to therapeutic efficacy for an anti-neutrophil cytoplasmic antibody associated vasculitis subtypes	21
W089 Emerging threat of biofilm producing MDR acinetobactercalcoaceticusbaumanniicomplex clinical isolates causing healthcare associated infections in a teaching hospital in Nepal	20
Evaluation of a batched-extraction method for measurement of sirolimus, tacrolimus, and cyclosporine on the Architect i2000SR	20
M251 Potential reference measurement procedure— Determination of c-reactive protein in serum by isotope dilution mass spectrometry based on enzyme digestion	20
T223 Validation and clinical application of a novel platelet function analyzer (ANYSIS 200) in cardiology patients	20
Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia	20
W080 Nanoparticle-enhanced digitof for detection of e. coli directly from urine	20
Plasma lipidomics reveals potential lipid markers for the prediction of delayed neurocognitive recovery after cardiac surgery with cardiopulmonary bypass	20
Development of exploratory algorithms to aid in risk of malignancy prediction of indeterminate pulmonary nodules	20
Serum Gas6 contributes to clinical outcome after aneurysmal subarachnoid hemorrhage: A prospective cohort study	20
W090 Effect of carbapenemase, qace, qace⊗1, and cepa genes on chlorhexidine sensitivity in clinical isolates of gram-negative bacteria with multiple resistance	20
Biological variation of thyroid function biomarkers over 24 hours	20
W139 Molecular characterization of glucose 6-phosphate dehydrogenase deficiency among selected populations in malaria endemic area of Ethiopia	20
T052 Tumor marker study in pleural fluid and tumor heterogeneity	20
M003 Cytogenetic mechanisms of the aortic coarctation formation and their relationship with late postoperative complications	19
T040 Micrornas stimulate prostate cancer stem cell expansion by targeting genes of the apoptotic pathway	19
Functional characterization of novel variants found in patients with suspected Fabry disease	19
Untargeted metabolomics analysis of the plasma metabolic signature of moderate-to-severe acne	19
W163 Effects of cassava processing methods on insulin index, glyceamic profile, glyceamic load and index of cassava (manihot esculeuta) meals in type 2 diabetes mellitus patients seen in Benue State U	19
Comparative study of plasma clearance of iohexol at different injection doses	19
T124 Hormonal biomarkers associated with in-hospital mortality in therapeutic hypothermia after cardiac arrest: A case series	19
T258 Investigation of genetic biomarkers associated with low platelet count in normal karyotype acute myeloid leukemia	19
T022 The role of antioxidant therapy in the symptomatic treatment of pancreatic cancer patients	19
Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test	19
M208 Pakistan inherited metabolic disorders network (PAK-IMD-NET): Breaking silos and bringing synergies	19
Editorial board member, Aims and Scope, Publication Info.	18
M080 Tinea unguium, tinea cruris and tinea corporis caused by trichophyton rurbum in HIV patient: A case report	18
M102 Laboratory errors in clinical biochemistry: The quality of laboratory testing in B.P. Koirala institute of health sciences, Nepal	18
Identification of of a PAX2 mutation from maternal mosaicism causes recurrent renal disorder in siblings	18
GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity	18
Analysis of the diagnostic and prognostic value of serum PAD2 in patients with sepsis in the intensive care unit	18
T215 About a case: Crioaglutinine disease	18
T195 Plasma creatinine measurement in diabetic patients. Should we advocate the enzymatic method?	18
W264 A survey on RBC transfusion practice in Korea	18
MicroRNA regulators of vascular pathophysiology in chronic kidney disease	18
Lipocalin2 as a useful biomarker for risk stratification in patients with acute cholangitis: A single-center prospective and observational study	17
Boron-doped diamond electrochemical biosensors	17
Epigenetics of Diabetes: A bioinformatic approach	17
“Extracellular Vesicle DNA: Advances and Applications as a Non-Invasive Biomarker in Disease Diagnosis and Treatment”	17
Diagnosis of patients with mucopolysaccharidosis type II via RNA sequencing	17
Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk	17
Electrochemical biosensors for enhanced detection of diabetes mellitus	17
Similar Ferroportin Q248H polymorphism prevalence in patients with Plasmodium falciparum malaria and control subjects in the low-endemic setting of Botswana	17
M062 Identification of biomarkers in patients with colorectal cancer in Kazakh population	17
Evaluation of a rapid immunochromatographic diagnostic test for heparin-induced thrombocytopenia: validation of delayed test and whole blood test	17
Non-coding RNA biomarkers in Alzheimer’s disease	17
Serum metabolomic profile of myasthenia gravis and potential values as biomarkers in disease monitoring	17
The value of serum glial fibrillary acidic protein as a biomarker of astrogliosis in different neurological diseases	16
Development and application of a novel aldehyde nanoparticle-based amplified luminescent proximity homogeneous assay for rapid quantitation of pancreatic stone protein	16
Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study	16
Seroprevalence of antinuclear antibodies in patients with Hepatitis B	16
Correlation between the levels of serum C-reactive protein and plasma glycated HbA1c in diabetic patients and non-diabetic individuals in the western parts of Nepal	16
The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases	16
Blood biomarkers for Alzheimer’s disease with the Lumipulse automated platform: Age-effect and clinical value interpretation	16
miRNA-based electrochemical biosensors for ovarian cancer	16
Biological variation of methylmalonic acid in urine in spanish population	16
Serum concentration of placental growth factor in pregnancy screening for placental dysfunction and low molecular weight heparin treatment	16
Nanoparticle electrochemical biosensors for virus detection	16
The value of serum tumor-associated autoantibodies in screening and diagnosis of gastric cancer	16
Simultaneous determination of multiple urine biomarkers for kidney injury using SPE combined with LC-MS/MS	16
Recent advances in lateral flow assays for MicroRNA detection	16
Comment on ‘The diagnostic value of interleukin-36 cytokines in pleural effusions of varying etiologies’	16
The biomarkers of oxidative stress – An effective tool for diagnosing COVID-19 patients and convalescents	16
Deficiency or sufficiency? A five-year analysis of calcidiol levels across age groups in the Spanish population	16
Irisin in atherosclerosis	16
Laboratory medicine residents in France − highly qualified, scarcely mobile	15
Clinical and genetic investigation in patients with permanent congenital hypothyroidism	15
T257 Blood coagulation testing and hematological features of thalassemia carriers in pregnant	15
Evaluation of iron metabolism in hospitalized COVID-19 patients	15
Validation of a liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantification of tryptophan and 10 key metabolites of the kynurenine pathway in plasma and urine: App	15
Editorial board member, Aims and Scope, Publication Info.	15
A novel KCNQ2 missense variant in non-syndromic intellectual disability causes mild gain-of-function of Kv7.2 channel	15
T021 Nagalase – New laboratory test for the discovery of malignancy and some serious viral diseases	15
TQ-Oxime derivative: A promising therapeutic agent for U87 glioma cells assessment of cytotoxic and apoptotic properties	15
T129 Stability of arterial blood gases (ABG)	15

Evaluating the efficacy of a long-read sequencing-based approach in the clinical diagnosis of neonatal congenital adrenocortical hyperplasia	15
Association of lipoprotein(a) with left ventricular hypertrophy in patients with new-onset acute myocardial infarction: A large cross-sectional study	15
T170 Three cases of endocrine immune-related adverse events caused by immune checkpoint inhibitor therapy	15
A multi-test planning model for risk based statistical quality control strategies	15
T104 An accuracy of blood glucose obtained from glucose meter [LDQUO]Standard Gluconavii® GDH Blood Glucose Meter[RDQUO] by testing with arterial and neonatal blood samples	15
Stool antigen testing and serology’s accuracy in identifying helicobacter pylori infections in suspected patients	15
Neonatal myofibrillar myopathy type II associated with biallelic UNC-45B gene novel mutation and perinatal myasthenia as the core phenotype: A case report	15
Exploring the key factors of schizophrenia relapse by integrating LC-MS/1H NMR metabolomics and weighted correlation network analysis	15
Use of point of care (POCT) c-reactive protein (CRP) to support antibiotic prescribing in primary care – Are they good enough? A review of performance on the Weqas POCT CRP programme	15
LIS requirements for laboratory management	15
M200 Evaluation of eight commercially available clinical chemistry assays on the ALINITY® C system	15
Editorial Board	15
W055 Serum erythroferrone in chronic kidney disease patients	14
Risk stratification and predictive value of serum sodium fluctuation for adverse prognosis in acute coronary syndrome patients	14
T079 High sensitive troponin assays in differentiating acute coronary syndrome from healthy individuals	14
W014 About a case of rhabdomyolysis in a 7 year-old child secondary to a deficiency of very long-chain acyl-coa dehydrogenase (VLCAD)	14
T201 The liver enzymes in patients with cirrhosis and hepatocellular carcinoma (HCC)	14
Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spect	14
W226 NGS-based pipeline for routine non-invasive preimplantation genetic assessment in IVF	14
W157 Prostaglandin-D-synthase levels in cerebrospinal fluid associated with altered tau proteins in patients with suspected Alzheimer’s disease	14
HDL subfractions determined by microfluidic chip electrophoresis predict the vulnerability of intracranial plaque: A HRMRI study	14
W224 Is there a relationship between seminal zinc concentration and sperm quality in overweight men?	14
M122 Sample rejection of mixed body fluids for CSF identification – The utility of fluid protein concentration	14
T017 Analytical and clinical assessment of prostate specific antigen by chemiluminescence HISCL-5000 immunoassay	14
T181 Establishment of influence factors and ageing models for thyroid hormones in the elderly using real-world big data	14
Emergency severity level-3 patient flow based on point-of-care testing improves patient outcomes	14
M052 Evaluation of extracellular fatty acid synthase and copeptin in obesity induced insulin resistance and metabolic syndrome	14
The role of laboratory diagnostics in determining the physical health of psychiatric inpatients	13
Overweight and obesity: The weight of genes	13
Pediatric reference values of NT-proBNP and Galectin-3 based on a French cohort	13
Analysis of gene mutation characteristics and its correlation with prognosis in patients with myelodysplastic syndromes	13
Sclerostin in ankylosing spondylitis: A meta-analysis	13
Quality management, ethical considerations, and emerging challenges in genomics and biobanking: A comprehensive review	13
Non-invasive fetal RHD genotyping in d- (RH:-1) patients with RHD genomic sequences: retrospective study over 11 years	13
Liaison MeMed BV: A new approach for a quicker diagnosis between viral and bacterial infections in a cohort of pediatric patients	13
Distance changes of lymphocyte quantity and function in patients with COVID-19	13
Leveraging machine learning to improve current diagnostic algorithms and laboratory stewardship	13
Lean adolescents with insulin resistance display higher angiopoietin like protein 3, ApoC-III and chylomicron remnant dyslipidemia	13
Procalcitonin and transferrin as a survival markers of patients with COVID-19	13
Clinical implications of opioid parent-metabolite ratios	13
Cytomegalovirus antigen-specific multi-cytokine immune responses in patients with rheumatic diseases under different cytomegalovirus infection status: A case-control study	13
Advantages of the implementation of a second-tier test strategy in the newborn screening	13
The association of siMS and siMS risk scores with risk factors for cardiovascular events in university students with metabolic syndrome	13
Evaluating the utility of using glycated albumin in diagnosing dysglycemia among Saudis- A pilot study	13
Enhancing breast cancer treatment through pharmacogenomics: A narrative review	13
Large-scale retrospective analyses of the effect of iron deficiency anemia on hemoglobin A1c concentrations	13
Expanding the clinical utility of reporter gene assay to infliximab biosimilars	13
Relationships among maternal monosomy X mosaicism, maternal trisomy, and discordant sex chromosome aneuploidies	13
Application of neutrophil-to-lymphocyte ratio in the diagnosis of complicated pediatric appendicitis	13
Mild-to-moderate COVID-19 may affect nervous system function in convalescents	13
Evaluation of the performance of biochemical ratios and albumin’s gradient in the etiological exploration of ascitic fluid	12
Artificial intelligence in the clinical laboratory	12
Study of the impact of ClinGen Revisions on ACMG/AMP variant semi-automatic classification for Rare Diseases diagnosis	12
Corrigendum to “The impact of triadimenol on male fertility: An in vitro study and molecular docking examination” [Reprod. Toxicol. 132 (2025) 108861]	12
Challenges with sweat testing – A quality improvement initiative	12
Clinical performance evaluation of smartchek SARS-COV-2 detection kit and smartchek SARS-COV-2 fast detection kit for detection of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in saliv	12
Waste management in clinical laboratories	12
Enhancing enteric pathogen detection: implementation and impact of multiplex PCR for improved diagnosis and surveillance	12
Performance verification and reference interval establishment of serum/plasma aldosterone by a novel “sandwich” chemiluminescent immunoassay	12
Brucella outbreak linked to ice cream: A Lebanese case series	12
Noninvasive fecal testing for colorectal cancer	12
Comparison of clot waveform analysis with or without adjustment between prothrombin time and activated partial thromboplastin time assays to assess in vitro effects of direct oral anticoagulants	12
The association between the PON1 genes rs662 and rs854560 and the metabolic syndrome in patients with obesity	12
MicroRNA biomarkers for predicting treatment response and resistance to bevacizumab in cancer	12
Strategic collaboration to address nitrous oxide challenges: Establishment of an international consortium of experts	12
Apolipoprotein C-III mucin core 2 O-Linked glycoforms: Hiding in plain sight	12
Serologic profile of individuals who contracted COVID-19 despite triple vaccination	12
Bacteriological profile and antimicrobial susceptibility patterns of organisms responsible for blood stream infections in intensive care unit patients	12
Revolutionizing cell-based analyses: An electrochemical analysis platform with integrated incubator capabilities	12
Association of HIV-1 Nef polymorphisms with coronary artery disease in HIV-positive patients	12
Associations between polycythemia and cardiometabolic risk factors in middle-aged men	12
Surface plasmon resonance: A promising approach for label-free early cancer diagnosis	12
Estimation of FGF-23 level in patients with chronic kidney disease with or without vitamin D supplementation	12
Impact of CSF collection volume in the accuracy of Alzheimer’s disease biomarker results	12
Study of teratozoospermia in our population through analysis of seminal fluid in the assisted human reproduction unit of a Spanish referral hospital	12
Novel biomarkers to improve diagnosis and monitor prognosis	12
Utility of serum indices for predicting liver fibrosis	12
The clinical validation of a dried blood spot method for simultaneous measurement of cyclosporine A, tacrolimus, creatinine, and hematocrit	11
Targeting tumour markers in ovarian cancer treatment	11
Biosensors and lateral flow immunoassays: Current state and future prospects	11
Incorporating measurement uncertainty into free valproic acid monitoring: estimation and clinical impact for therapeutic drug monitoring	11
Electrochemical biosensors in early leukemia detection	11
Non-coding RNA biomarkers in cardiovascular disease	11
Plasma cellular prion protein concentrations correlate with severity and prognosis of aneurysmal subarachnoid hemorrhage	11
Proteomics of neuropsychiatric disorders	11
Fragmentation of human cardiac troponin T after acute myocardial infarction	11
A critical appraisal of the role of metabolomics in breast cancer research and diagnostics	11
Limitations of hemolysis-based correction for potassium measurement in hemolyzed whole blood samples	11
The assessment of endocannabinoids and N-acylethanolamines in human hair: Associations with sociodemographic and psychological variables	11
A retrospective analysis of 1600 infertility patients with azoospermia and severe oligozoospermia	11
At-admission HbA1c levels in hospitalized COVID-19 participants with and without known diabetes	11
Metabolomic profiling of serum and tongue coating of pregnant women with intrahepatic cholestasis in pregnancy	11
A new pitfall in potassium testing: A case series of false elevation of hemolysis index in the presence of monoclonal protein	11
A novel variant of the POLR3A gene in a patient with hypomyelinating POLR3-related leukodystrophy	11
MicroRNA and cyclooxygenase-2 in breast cancer	11