Clinica Chimica Acta

Article	Citations
External quality assessment for molecular detection of Ureaplasma urealyticum in China	184
Development and application of a novel aldehyde nanoparticle-based amplified luminescent proximity homogeneous assay for rapid quantitation of pancreatic stone protein	128
The value of serum tumor-associated autoantibodies in screening and diagnosis of gastric cancer	121
PIWI-interacting RNA biomarkers in gastrointestinal disease	119
Serum levels of visfatin and vaspin in healthy and complicated pregnancies and their association with anthropometric measures of their offspring	91
Elevated neurofilament light chain associated with cobalt/chromium metal neurotoxicity in a patient with a failed hip implant	88
Evaluation of thrombin generation assay in factor XI deficiency	77
A comprehensive molecular approach in fish allergy: Usefulness in daily clinical practice	75
Monocyte distribution width and the fighting action to neutralize sepsis (FANS) score for sepsis prediction in emergency department	75
Comparability of the LDH measurement and analysis based on external quality assessment	74
Diagnostic value of three urine miRNAs composite score in BK virus nephropathy	66
Defining age-specific reference intervals for biomarkers distinguishing bacterial from viral infection in paediatrics	64
Coagulation factors VIII and factors IX testing practices in China: Results of the 5-year external quality assessment program	63
Fatty acid binding protein as a new age biomarker	60
Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study	59
An accurate measurement method for serum homocysteine measurement by ID-LC/MS/MS and the application of external quality assessment	53
Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms	52
Clinical utility of expanded carrier screening in the preconception and prenatal population: A Chinese cohort study	50
Circular RNAs in glioblastoma	50
Biosensors for autoimmune diseases	48
Metabolomics identifies metabolite markers in plasma and extracellular vesicles within plasma in patients with asthma	48
Tandem mass spectrometry-based assay for heparan-N-sulphatase in paediatric CSF: A potential pharmacodynamic biomarker for mucopolysaccharidosis type IIIA therapy	47
“Urinary tract infection: Conventional testing to developing Technologies”	42
Heptaminol hair testing to highlight octodrine contamination in supplements, responsible for a doping adverse analytical finding	41
Moving metabolomics into the routine of clinical laboratories: A forward-thinking strategy	40

Blood biomarkers for Alzheimer’s disease with the Lumipulse automated platform: Age-effect and clinical value interpretation	40
Intra- and inter-day variations in oral metabolites from mouth-rinsed water determined using capillary electrophoresis–mass spectrometry metabolomics	40
Osteopontin in rheumatic diseases: A systematic review and meta-analysis	39
Clinical application of bile acid profile combined with lipid indices in metabolic dysfunction-associated steatotic liver disease	39
Exosome biosensors for detection of liver cancer	37
Acute kidney injury and energy metabolism	37
Pathogenicity analysis of ATP7B in pediatric patients with Wilson’s disease and functional verification of alternative splice variants	36
Editorial Board	35
Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis	35
Effects of blood-processing protocols on cell-free DNA fragmentomics in plasma: Comparisons of one- and two-step centrifugations	35
Exploring optimization algorithms for establishing patient-based real-time quality control models	34
Circulating HPV DNA in HPV-associated cancers	34
The clinical value of rapidly detecting urinary exosomal lncRNA RMRP in bladder cancer with an RT-RAA-CRISPR/Cas12a method	34
Editorial Board	34
Prediction of acute kidney injury after total aortic arch replacement with serum cystatin C and urine N-acetyl-β-d-glucosaminidase: A prospective observational study	34
CRISPR-Cas12a-based detection and differentiation of Mycobacterium spp	33
Evidence of ostarine excretion in oral fluid after a single controlled oral administration	33
Breast cancer stem cells as novel biomarkers	33
Quality control frequency: Unleashing the truth	32
Recent advances in lateral flow assays for MicroRNA detection	32
A novel method for simultaneous detection of hematological tumors and infectious pathogens by metagenomic next generation sequencing of plasma	32
The potential of circulating free DNA of methylated IGFBP as a biomarker for type 2 diabetes Mellitus: A Comprehensive review	31
Editorial Board	29
Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease	29
Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis	29
Functions of nuclear receptors SUMOylation	29
Value of urine/serum Neutrophil gelatinase-associated lipocalin ratio in distinguishing acute kidney injury from chronic kidney disease	29
Extracellular vesicle-transferred long noncoding RNAs in bladder cancer	28
Biological variation of cardiovascular biochemical markers in patients with Type 2 Diabetes Mellitus	28
Circulating microparticles as indicators of cardiometabolic risk in PCOS	27
Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When “wrong” matrix is the right choice	26
Reference interval establishment and correlation research of urine thromboxane metabolites: Unveiling new possibilities in platelet activation	26
Detection of mutation profiles and tumor mutation burden of cerebrospinal fluid circulating DNA by a cancer genomic panel sequencing in glioma patients	25
Editorial Board	25
Comparative study of plasma clearance of iohexol at different injection doses	25
Diagnostic potential of vitreoretinal lymphoma by detection of gene mutations with NGS in 25 Chinese patients	25
Genetic architecture of preeclampsia	25
Changes in plasma level of endocrine hormones in lepromatous leprosy patients	24
First case of 5-oxoprolinuria with two homozygous mutations in GSS and OPLAH genes: A case with neonatal presentation and rapid fatal outcome	24
An atypical finding on serum immunofixation in free light chain multiple myeloma: A case report	24
Quantification of serum gp210 and sp100 antibodies in diagnosis of primary biliary cholangitis	23
Carbapenem-resistant Enterobacteria at the hospital of Monastir	23
Pre-analytical issues in haemostasis	23
“Revolutionizing emergency care: A comparative analysis of comprehensive point-of-care test panels vs conventional laboratory processes in the critical care& emergency medicine”	23
Does long term PPI use cause vitamin B12 deficiency ?	23
MMP-26 potential utility as a marker for differentiating serous ovarian cancer from serous cystadenomas	23
Unveiling liquid markers: The diagnostic revolution in early detection of pancreatic cancer through liquid biopsy	22
Cell-free DNA bearing p53 mutation (R248) as non-invasive biomarker in patients with head and neck squamous cell carcinoma	22
Assessment of serum osteopontin, osteoprotegerin and bone-specific alp as markers of bone turnover in patients with disorders of thyroid function in Ile-Ife, Nigeria	22
Novel prediction model of early screening lung adenocarcinoma with pulmonary fibrosis based on haematological index	22

Using big data analytics to measure the multi-year consistency of sigma metrics for vitros cardiac assays	22
Overweight and insulin resistance in Algerian adolescent	22
Impact of laboratory accreditation on the performance of quality indicators in an international indicator benchmarking program	22
Availability of ionized magnesium active form depends on kidney function and albumin levels	22
In-vitro and in-vivo studies of M. oliefera derived compounds as a promising therapeutic target in breast cancer progression and metastasis	22
Association of single nucleotide polymorphisms in eNOS gene with development of diabetic nephropathy: A case control study	22
Performance of laboratory services and systems in laboratory of a hospital in Nepal	22
Implementation of first coagulation total laboratory automation system in Taiwan – An experience from a 3000-beds medical center	22
Adoption and barriers to participation in a comparison program of core laboratory quality indicators among hospitals in Toronto, Canada	22
Total lab automation validation/verification: First step of process excellence journey in smart core lab	22
Calculated LDL cholesterol (freidwald, martin johns and Sampson) comparison of retrospective data with direct LDL cholesterol and hypertriglyceridaemia	22
Platelet volume indices and their association with atherogenic index of plasma in type 2 diabetes mellitus patients	21
Evaluation of the current status of the vitamin D assay standardization in China	21
Advanced oxidation protein products and catalase activity in patients with psoriasis	21
Performance of laboratory services and systems in laboratory of a hospital in Nepal	20
Antibiotic resistance profile of enterobacteriaceae isolated from infected hemodialysis catheters	20
Diagnostic pitfalls in ANCA testing by ANA patterns and titers	20
The connection of Vitamin D concentration with hematological parameters in patients with COVID-19	20
Review on the most important methylated genes in circulatory tumor DNA of brain tumor patients: Novel horizon towards early diagnosis and therapeutic follow up	20
Transferability and degree of harmonization of an LC-MS based reference measurement procedure for apolipoproteins in a network of calibration laboratories	20
Evaluation of interleukin-4, micro-albumin, and creatinine in students exposed to short-term formal in Nnewi	19
Failure to diagnose factor X deficiency in patient treated with anticoagulant therapy: A fatal case	19
Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in breast cancer risk in Mali: A case–control study	19
Changes in nonalcoholic fatty liver disease and M2BPHI due to lifestyle intervention in primary healthcare	19
Evaluation OF FGF-23 as a marker of mineral bone disease among newly diagnosed chronic kidney disease patients in a Nigerian hospital	19
Can lipid mediators be useful biomarkers in schizophrenia?	19
Differentiation of HbD and HbG-philadelphia by HbA concentration during neonatal screening	19
Accurate correction model of blood potassium concentration in hemolytic specimens	18
Treating red blood cells with dithiothreitol can help eliminate daratumumab interference in blood compatibility tests (pretransfusion testing)	18
Exploring artificial intelligence techniques for morphological analysis of digital images of peripheral blood cells: MC-80 versus HemaVision	18
The biochemical and cytological examination of the cerebrospinal fluid (CSF) and the number of erythrocytes	18
Faecal calprotectin as a potential biochemical marker of ulcerative colitis activity stratification	18
The influence of thyroid autoantibodies on depression severity	17
Raman spectroscopic analysis of urine combined with machine learning identifies life-threatening inborn errors of metabolism	17
Anti-diabetic and anti-inflammatory properties of some selected plant leaves: A transcriptomic approach	17
Earthquakes, wars and emerging infectious disease	17
Possibility of using erythrocyte indexes to predict clinical outcome in patients with burn injury	17
Evaluation of the management of infectious risk at the laboratories of the Yaounde University Teaching Hospital	17
Beyond direct methods: Establishing vitamin d reference intervals using real-world data	17
Detection of hotspot PIK3CA mutations in primary tumors and plasma-cfDNA of breast cancer patients using a novel highly sensitive CE-IVD KIT	17
Serum adenosine deaminase as breast and colorectal cancer progression biomarker	17
Association between serum lipid profile and clinicopathological features in breast cancer patients	17
Cardiorenal syndrome and diabetes mellitus in indonesian population	17
The relationship between disorders of the plasma and platelet components of hemostasis with the severity and timing of coronavirus infection in patients with chronic coronary syndromes	16
Myo-inositol: A novel biomarker for kidney disease	16
Evaluation of phosphocalcic metabolism and vitamin d status in renal transplant patients at military hospital of Oran, Algeria	16
Investigating the long-term effects of lung-specific autoantibodies post-COVID-19 following thoracic surgery	16
Strategy to improve the turn around time (TAT) for stat samples in clinical laboratories	16
An estimation of fructosamine threshold values for the diagnosis of diabetes in a Tunisian population	16
Heavy-light chain pairs as an alternative method to monitor isatuximab-based treatment responses in multiple myeloma patients	16
Hemolysis index measured on Cobas Pro is a good surrogate to plasmatic hemoglobin measurement in clinical pratice	16
Viscoelastic blood tests use in adult cardiac surgery	16
Mid-Regional proadrenomedullin (MR-PROADM) may be a new marker of severity status of patient with systemic inflammatory response-pilot project	16
Verification of equimolar peptide release in a mass spectrometry-based reference measurement procedure for quantification of Apolipoprotein(A)	16
Escherichia coli nissle (E.COLI NISSLE) modulated in colon cancer therapy	15
Comparison of demographical features and chemical composition in patients with renal stones in a tertiary care center	15
Results of 2023 national external quality assessment of hemostasis testing in medical laboratories of the Republic of Belarus	15
Follow-up of the TG and ANTI-TG in patient with differentiated thyroid cancer by two different analytical methods	15
The essential role of volunteer biologists in Lebanon’s COVID-19 pandemic management efforts	15
COVID-19 infection: a review of hematological and morphological features	15
Effects of vitamin D supplementation in neonates and infant	15
The management of heart failure patients in a value-based healthcare system: The role of cardiac biomarkers	15
The role of unsaturated iron binding capacity (UIBC) in the diagnosis of anemia	14
Serum concentration of asymmetrical dimethylarginine and protein carbonyl in patients with cardiovascular diseases	14
Management of discrepancies between immunocap specific IgE and the two multiplex test platforms immunocap ISAC and MADx ALEX 2 in a pediatric patient with anaphylaxis	14
Imiquimod-loaded chitosan-decorated di-block and tri-block polymeric nanoparticles gel for the management of human cervical intraepithelial neoplasia	14
Large-scale analysis reveals splicing biomarkers for tuberculosis progression and prognosis	14
Stability of arterial and venous gas samples stored for 20, 40 and 60 minutes after collection	14
Validating urinary orotic acid through high-pressure liquid chromatography (HPLC): Insights from a specialized biochemical genetics laboratory in Pakistan	14
Plasma levels of matrix metalloproteinases in patients with breast cancer as a potential marker of cardiotoxicity associated with doxorubicin therapy	14
Biological investigation of oxalocalcic lithiasis: Contribution of morphoconstitutional analysis and metabolic assessment	13
Evaluation of the diagnostic efficacy of hepatitis C virus infection in our healthcare area	13
Clinical validation in multiple sclerosis of the lumipulse immunoassay for plasma neurofilament light chain	13
Extensive molecular heterogeneity and transcriptomic signatures of circulating tumour cells are potential predictors of oral squamous cell carcinoma	13
Laboratory indicators of inflammation in the development of cytokine storm in patients with COVID-19	13
Clinical significance of medical leadership and laboratory management: Challenges and perspectives	13
Fcm in characterizing acute leukemic disorders	13
A study of c-reactive protein in breast cancer: Risk factor and prognostic	13
Determination of direct oral anticoagulant in the emergency laboratory: The experience in pandemic and post-pandemic period	13
Laboratory-based study of newborn with intrauterine growth restriction	13

Stiff person syndrome (SPR): A case report	13
Real-world data shows the effectiveness of a tetravalent vaccine against human papilloma virus types 16 and 18 in Chilean women	13
Electrophoretic profiles of patients with different types of hemoglobinopathies in south Tunisia	13
Exploring the relationship between Oxysperm and Sperm DNA Fragmentation Index (DFI) in the context of fertility potential	13
Unmanned high speed aerial vehicles in medical logistics: A comparative analysis of blood sample transportation with weather variability	13
Evaluation of beta glucan test using kinetic turbidimetric method on toxinometer MT-6500 for detection of invasive fungal infections in hospitalized patients	13
The increased sensitivity of the Xpert® Xpress assay in detecting SARS-COV-2, compared to the COBAS® assay, can be attributed to the nucleocapsid gene target	13
Indeterminate results in quantiferon-TB gold plus testing: Possible explanation and predictive parameters	13
Rotational thromboelastometry (CLORPRO) profiling of COVID-19 patients	13
Data science, digital health, big data and smart technologies to support biotechnology – Current perspectives and future challenges	13
Profile of soluble MER (sMER) and ADAM17 in relation to waist circumference range: Analyzing efferocytosis signaling in men with central obesity	13
The importance of determining hepcidines and soluble transferrin receptor (STFR) in haemodialysis patients	13
Evaluation of pre-analytical quality indicators by six sigma principle: Experience at a tertiary care hospital	13
Circulating miRNAs associated with physical performance in elderly subjects	12
N-Terminal pro-b-type natriuretic peptide, iron status and red cell distribution width in suspected heart failure patients	12
Blood donation and hepatitis seroprevalence transfusion medicine: A solution or a risk in a Palestinian perspective	12
Still’s syndrome. A case study	12
Escherichia coli in urine: Sensitivity to first-line molecules	12
Le Mans Protocol – Evidence-based approach to proof your choice of production concept	12
Molecular characterization of vibrio parahaemolyticus isolated from coastal environment in Eastern Province of Saudi Arabia	12
Principle of flow cytometry and issues in diagnosis	12
Using a diagnostic panel to determine predisposition to the development of disorders of the thyroid system	12
Atherogenic indices among women with benign and malignant breast lesions in Ile-Ife, Nigeria	12
Interference of hemolysis in urgent clinical biochemistry examinations analyzed on DxC 700 AU and access 2	12
Association of single nucleotide polymorphism of KCNJ11 (rs 5219) with type 2 diabetes mellitus in north Indian population	12
Frequency of occurrence of zoonotic tick-borne pathogens in ticks – Latvian 2023 year experience	12
Enhancing the sensitivity of rapid antigen detection test (RADT) of different SARS-COV-2 variants and lineages using fluorescence-labeled antibodies and a fluorescent meter	12
Six sigma improves the performance of quality control, financial and operation efficiency in a nationwide laboratory network in Mexico	12
About a case “a precocious puberty in A 10-month-old infant”	12
A variant reclassification of SLC12A3 of Gitelman syndrome	12
Effect of Candida auris secretions on monocyte-derived macrophages	12
Quantitative stool culture in hospitalized neonates: Microbiological analysis, antibiotic resistance patterns, and clinical management implications	12
Isolation, cloning, and sequencing the codiaeum variegatum GAPC gene	12
Interference in the determination of glycosylated hemoglobin caused by a hemoglobonipathy: A case report	12
Diabetes related foot infections: Bacterial epidemiology and antibiotic susceptibility profiling	12
Genotypic characterization of autosomal dominant polycystic kidney disease (ADPKD) in Indian population: A pilot study	12
Creating hemolysates using whole blood, are EDTA tubes the right choice?	11
Path to lab accreditation and improvements	11
Identification of immunoreactive COVID-19 epitopes based on M13 phage display library	11
Apolipoprotein B and its correlation with dyslipidemia in Type 2 Diabetes Mellitus	11
HDL functionality assessments and its relevance to the cardiovascular endpoints; Mashad cohort study over 10 years	11
Next step in predictive medicine: New serum biomarkers to predict acute stroke mortality	11
Assessment of vitamin D intake and supplementation in non-dialysis chronic kidney disease patients	11
Sickle cell crisis vs thrombotic microangiopathy secondary to neoplastic process: The clinical laboratory in differential diagnosis	11
Effect of bilirubin assays on treatment decision in neonatal jaundice: Past and present using Dutch external quality assessment results	11
Unraveling mechanisms regulating erythroid iron metabolism	11
Incidental diagnosis of aneuploidy of the sex chromosomes in a neuropaediatric patient	11
Prevalence of serum CEA and CA 19-9 elevation in patients with colorectal cancers at The Nairobi Hospital, Kenya	11
Testosterone II (TSTII) and dimension VISTA® LOCI total testosterone (TTST) immunoassays meet the CDC host certification requirements for more than four years	11
Biomarker panels: Analytical and clinical validation against clinically relevant reference standards	11
The technology for clinical laboratories in 21st century: Challenges and opportunitie	11
Acarbose a promising inhibitor of 17®-hydroxysteroid dehydrogenase type 1 as a potential candidate for anticancer therapy	11
Assessment of MSTN and CYP2D6 polymorphisms and physical performance in a population of athletes from Western Mexico	11
Machine learning-based prediction of intensive care during hospitalization for COVID-19 using laboratory test results at admission	11
Prediction of atherosclerosis in severe COVID-19 patients with CD16 and CD18 markers and inflammatory factors	11
Analysis of thicknesses of blood collection needle by scanning electron microscopy reveals wide heterogeneity	11
The reality of antimicrobial resistance (AMR) in Palestine and its impact on health and economy: A cross-sectional study in West Bank, Palestine	11
Why do scientists call for action against vitamin D deficiency and what is behind the scene?	11
Antibiotic susceptibility of bacteria isolated in pediatric settings during bacteremia	11
Intake of selected fat-soluble vitamins and trace elements on selected parameters of skin condition	11
Detection of mycobacterium tuberculosis and rifampicin resistance with Xpert® MTB/RIF analysis in a tertiary hospital	11
Uric acid lithiasis in southern Tunisia	11
Effect of cucumber supplementation on blood pressure, plasma lipid profile and some apolipoproteins in older adults in Nnewi, Nigeria	11
Seroprevalence and risk factors of toxoplasmosis among pregnant women in the M’saken region (Tunisia)	11
Green laboratory medicine in Africa: What is the contribution to environmental toxicity and how prepared is the continent for sustainable laboratory medicine?	11
Phosphatidylethanol in patients with liver diseases of different etiologies: Analysis of six homologues and comparison with other alcohol markers	10
The value of lipid metabolites 9,10-DOA and 11,12-EET in prenatal diagnosis of fetal heart defects	10
Resolving DOAC interference on antithrombin activity testing on a FXa based method by the use of activated carbon	10
Editorial Board	10
FIB-4 index: The importance of including pyridoxal-5-phosphate in alt and AST methods	10
Serum anti-oxLDL antibodies in patients with angiographically confirmed coronary artery disease	10
Altered bile metabolome and its diagnostic potential for biliopancreatic malignancies	10
Hypomethylation of RPTOR in peripheral blood is associated with very early-stage lung cancer	10
Additive value of bioclinical risk scores to high sensitivity troponins-only strategy in acute coronary syndrome	10
Resistin and omentin in breast cancer: A systematic review and meta-analysis	10
Early elevated NT-proBNP but not troponin I is associated with severe bronchiolitis in infants	10
Feasibility of the ALEX multiplex platform in the diagnosis of nut allergy from a Mediterranean population	10
Effects of obesity on liver function in children	10
Complete blood count parameters in CKD patients compared to healthy subjects	10
The clinical value of artificial intelligence in laboratory medicine	10
Superfluous amylase and lipase testing	10
“Extracellular Vesicle DNA: Advances and Applications as a Non-Invasive Biomarker in Disease Diagnosis and Treatment”	10
Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type	10
Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer’s disease	10
Non-coding RNAs as biomarkers of myocardial infarction	10
Kappa free light chains: Diagnostic performance in multiple sclerosis and utility in a clinical laboratory	10
Laboratory evaluation of RBC transfusion in patients with coronary artery disease	10
A diagnostic dilemma of TSHoma in a clinically euthyroid patient	10
Risk assessment for patient by centrifugation of samples on the DxA 5000 fit Beckman Coulter automated system	10
Profiling of circulating-MicroRNAs’ signatures in pre-diabetic versus diabetic patients	10
Serum metabolomics study of anxiety disorder patients based on LC-MS	10
Advances in the identification of calcium carbonate urinary crystals	10
W087 Seroprevalence of influenza a virus (H1N1) IGM in patients attending CMC-TH and its association with liver function test	9
W090 Effect of carbapenemase, qace, qace⊗1, and cepa genes on chlorhexidine sensitivity in clinical isolates of gram-negative bacteria with multiple resistance	9
A patient with severe congenital neutropenia harbors a missense ELANE mutation due to paternal germline mosaicism	9