OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Immunology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts	68
Issue Information	68
Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis	63
The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome	58
The PPAR-γ agonist pioglitazone exerts proinflammatory effects in bronchial epithelial cells during acute Pseudomonas aeruginosa pneumonia	49
Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures	48
Issue Information	47
Correction to: Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells	44
Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma	41
Identification of ANXA2 on epithelial cells as a new receptor for secretory IgA using immunoprecipitation and mass spectrometry	40
Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis	39
Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes	37
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK	35
Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis	35
Extracellular vesicles containing PD-L1 contribute to CD8+ T-cell immune suppression and predict poor outcomes in small cell lung cancer	35
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies	34
Diagnostic accuracy of saliva-based testing as a Vibrio cholerae surveillance tool among naturally infected patients	33
Cytokine production by human B cells: role in health and autoimmune disease	33
C/EBPε and its acetylation in PMN enhance the tolerance to trauma	31
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerbate DSS-induced inflammatory bowel disease	31
Molecular neuroimaging of inflammation in HIV	30
IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ	30
IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease	30
Heterosubtypic, cross-reactive immunity to human Cytomegalovirus glycoprotein B	29
Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset	29

Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals	28
Differentiating between activation via the lectin or the classical complement pathway in patients with systemic lupus erythematosus	26
The effect of immunomodulatory therapy with recombinant human interferon alpha-2β on blood cytokine levels in children with recurrent episodes of acute obstructive bronchitis	26
Periapical lesion following Cnm-positiveStreptococcus mutanspulp infection worsens cerebral hemorrhage onset in an SHRSP rat model	26
Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever	25
Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns	24
Reduced response to SARS-CoV-2 vaccination is associated with impaired immunoglobulin class switch recombination in SLE patients	22
Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer	22
Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide	22
The B-cells paradigm in systemic sclerosis: an update on pathophysiology and B-cell-targeted therapies	22
Human genetics of responses to vaccines	21
Exosomal PD-L1 predicts response with immunotherapy in NSCLC patients	21
Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors	20
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Clinical and neuroimaging findings in MOGAD–MRI and OCT	20
Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity	18
Inborn errors of immunity-related immunological mechanisms and pharmacological therapy alternatives in periodontitis	18
Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity	18
Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice	18
Clinical significance of differential serum-signatures for early prediction of severe dengue among Eastern Indian patients	17
NK-cell receptor modulation in viral infections	17
The CXCL10-CXCR3 axis plays an important role in Kawasaki disease	17
Introducing our new series: Clinical and Experimental Treatment of…	17
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway	17
A single-center pilot study in Malaysia on the clinical utility of whole-exome sequencing for inborn errors of immunity	17
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic varia	16
Regulatory T cells in autoimmune primary adrenal insufficiency	15
Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry–based peptide-MHC class-II tetramer staining	15
Impaired function of PD-1+ follicular regulatory T cells in systemic lupus erythematosus	15
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis	15
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions	15
Identifying platelet-derived factors as amplifiers ofB. burgdorferi-induced cytokine production	15
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren’s syndrome	14
Inborn errors of immunity: the Goldilocks effect—susceptibility to disease due to a little too much or a little too little	14
A study of changes in hematologic parameters in patients with migraine	14
Serum and urine free light chains measurements in patients with systemic sclerosis: novel biomarkers for disease activity	14
Pneumococcal serotype-specific antibodies in children with recurrent oto-sinopulmonary infections	14
Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease	14
16α-Bromoepiandrosterone as a new candidate for experimental diabetes–tuberculosis co-morbidity treatment	13
Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjögren’s syndrome	13
Exposure to gestational diabetes mellitus increases subclinical inflammation mediated in part by obesity	13
The role of extracellular vesicle immune checkpoints in cancer	13
The effect of short-chain fatty acids on M2 macrophages polarizationin vitroandin vivo	12
A close-up on the expanding landscape of CD21–/low B cells in humans	12
Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling	12
Identification of angiogenesis-related genes and molecular subtypes for psoriasis based on random forest algorithm	12
Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer	12
The pathogenesis of multiple sclerosis: a series of unfortunate events	12
Cytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy	12
Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients	12

Increased levels of pathogenic Th17 cells and diminished function of CD69+ Treg lymphocytes in patients with overweight	12
Time to treat the climate and nature crisis as one indivisible global health emergency	12
Droplet digital PCR for identifying copy number variations in patients with primary immunodeficiency disorders	12
	12
Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis	11
Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA	11
Effects of mesenchymal stem cells on Treg cells in rats with colitis	11
Increased expression of CXCL10 and CCL3 salivary gland chemokines in primary Sjögren’s syndrome detected and systematically quantified using RNAscope®in situ hybridization	11
Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis	11
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Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights	11
Diagnostic markers and potential therapeutic agents for Sjögren’s syndrome screened through multiple machine learning and molecular docking	11
Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth	11
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation	11
The Pathophysiology of Hemophagocytic lympho-histiocytosis (HLH) syndrome and insights from animal models	11
Harnessing the power of memory-like NK cells to fight cancer	11
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis	11
Induction of memory-like CD8+ T cells and CD4+ T cells from human naive T cells in culture	11
Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions	11
Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis	11
Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults	10
HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients	10
Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow-up of two randomized controlled trials	10
Tocilizumab suppresses NF-kappa B activation via toll-like receptor 9 signaling by reducing cell-free DNA in rheumatoid arthritis	10
Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases	10
Distinctive TCR repertoire in PIMS-TS/MIS-C patients: possible thymus involvement	10
Innate stimulation of B cells ex vivo enhances antibody secretion and identifies tumour-reactive antibodies from cancer patients	10
2B4: A potential target in Staphylococcus aureus associated allergic inflammation	10
Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion	10
Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis	10
Response to Letter to the Editor: Type 2 diabetes is associated with the accumulation of senescent T cells	10
Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1	10
The TOX subfamily: all-round players in the immune system	9
The immune landscape of the inflamed joint defined by spectral flow cytometry	9
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans	9
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway	9
Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender	9
Complement factors as biomarkers in ANCA-associated vasculitis in remission	9
Follow-up of immune response in patients with common variable immunodeficiency following SARS-CoV-2 vaccination	9
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway	9
CD4+LAG-3+ T cells are decreased in active psoriatic arthritis patients and their restorationin vitrois mediated by TNF inhibitors	9
COVID-19 infection and vaccination in immunodeficiency	9
Leptin-reactive antibodies are distinctly correlated with body composition parameters and metabolic risk indexes in children and adolescents	9
Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction	9
Parallel origins and functions of T cells and ILCs	9
Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas	8
PMA induces the differentiation of monocytes into immunosuppressive MDSCs	8
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome	8
Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation	8
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease	8
A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose	8
Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis	8
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications	8
SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis	8
The prevalence of anti-neurofascin-155 antibodies in patients with neuromyelitis optica spectrum disorders	8
Improved function and balance in T cell modulation by endothelial cells in young people	8
What do we know about co-stimulatory and co-inhibitory immune checkpoint signals in ankylosing spondylitis?	8
MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy:in vitroandex vivoevidence	8
Seroconversion following COVID-19 vaccination: can we optimize protective response in CD20-treated individuals?	8
Clinical features and nasal inflammation in asthma and allergic rhinitis	8
Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection	8
Unveiling WHIM syndrome: Mavorixafor’s emerging role in immune restoration and therapy	8
Dynamic mRNA expression of donor-derived activating KIR genes and their significant effects on clinical outcome after haematopoietic stem cell transplantation	8
Investigating Concomitant RAG-2 and LRBA Mutations in SCID and Autoimmunity	8
Engaging PD-1 rescues regulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis	8
Genetic correlation between thyroid hormones and Parkinson’s disease	8
Human FCHO1 deficiency: review of the literature and additional two cases	8
Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes	8
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease	8
My highlights as Editor-in-Chief of Clinical & Experimental Immunology, 2017–2024	8