OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Immunology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts	75
The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome	51
Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis	51
The PPAR-γ agonist pioglitazone exerts proinflammatory effects in bronchial epithelial cells during acute Pseudomonas aeruginosa pneumonia	48
Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures	45
Identification of ANXA2 on epithelial cells as a new receptor for secretory IgA using immunoprecipitation and mass spectrometry	42
Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis	40
Cytokine production by human B cells: role in health and autoimmune disease	38
Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes	37
Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma	36
Extracellular vesicles containing PD-L1 contribute to CD8+ T-cell immune suppression and predict poor outcomes in small cell lung cancer	36
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies	35
Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis	33
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK	33
Correction to: Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells	33
HLA-DR expressing lymph node fibroblasts maintain FoxP3+ regulatory T cells and are reduced in rheumatoid arthritis	31
IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease	31
Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset	29
IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ	29
Heterosubtypic, cross-reactive immunity to human Cytomegalovirus glycoprotein B	29
Molecular neuroimaging of inflammation in HIV	29
The effect of immunomodulatory therapy with recombinant human interferon alpha-2β on blood cytokine levels in children with recurrent episodes of acute obstructive bronchitis	28
Periapical lesion following Cnm-positiveStreptococcus mutanspulp infection worsens cerebral hemorrhage onset in an SHRSP rat model	28
Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever	26
Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide	25

Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns	25
Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals	24
Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer	23
Exosomal PD-L1 predicts response with immunotherapy in NSCLC patients	23
The B-cells paradigm in systemic sclerosis: an update on pathophysiology and B-cell-targeted therapies	22
Human genetics of responses to vaccines	21
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerbate DSS-induced inflammatory bowel disease	21
Diagnostic accuracy of saliva-based testing as a Vibrio cholerae surveillance tool among naturally infected patients	20
C/EBPε and its acetylation in PMN enhance the tolerance to trauma	20
Reduced response to SARS-CoV-2 vaccination is associated with impaired immunoglobulin class switch recombination in SLE patients	20
Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors	19
Differentiating between activation via the lectin or the classical complement pathway in patients with systemic lupus erythematosus	19
Clinical significance of differential serum-signatures for early prediction of severe dengue among Eastern Indian patients	18
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The CXCL10-CXCR3 axis plays an important role in Kawasaki disease	18
Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity	18
Introducing our new series: Clinical and Experimental Treatment of…	18
Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity	17
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic varia	17
Correction to: Discrepancy in clinical and laboratory profiles of NMOSD patients between AQP4 antibody positive and negative: can NMOSD be diagnosed without AQP4 antibody?	17
Inborn errors of immunity-related immunological mechanisms and pharmacological therapy alternatives in periodontitis	16
NK-cell receptor modulation in viral infections	16
Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice	16
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway	16
Regulatory T cells in autoimmune primary adrenal insufficiency	15
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions	15
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis	15
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren’s syndrome	15
Identifying platelet-derived factors as amplifiers ofB. burgdorferi-induced cytokine production	15
Inborn errors of immunity: the Goldilocks effect—susceptibility to disease due to a little too much or a little too little	15
Increased levels of pathogenic Th17 cells and diminished function of CD69+ Treg lymphocytes in patients with overweight	14
Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients	14
Exposure to gestational diabetes mellitus increases subclinical inflammation mediated in part by obesity	14
The effect of short-chain fatty acids on M2 macrophages polarizationin vitroandin vivo	14
Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry–based peptide-MHC class-II tetramer staining	14
The role of extracellular vesicle immune checkpoints in cancer	14
Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjögren’s syndrome	13
A study of changes in hematologic parameters in patients with migraine	13
The pathogenesis of multiple sclerosis: a series of unfortunate events	13
A close-up on the expanding landscape of CD21–/low B cells in humans	13
Identification of angiogenesis-related genes and molecular subtypes for psoriasis based on random forest algorithm	13
Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease	13
Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer	13
Pneumococcal serotype-specific antibodies in children with recurrent oto-sinopulmonary infections	13
Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions	12
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation	12
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Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis	12
Droplet digital PCR for identifying copy number variations in patients with primary immunodeficiency disorders	12
Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis	12

Diagnostic markers and potential therapeutic agents for Sjögren’s syndrome screened through multiple machine learning and molecular docking	12
Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis	12
Time to treat the climate and nature crisis as one indivisible global health emergency	12
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis	12
Increased expression of CXCL10 and CCL3 salivary gland chemokines in primary Sjögren’s syndrome detected and systematically quantified using RNAscope®in situ hybridization	12
Harnessing the power of memory-like NK cells to fight cancer	12
The pathophysiology of hemophagocytic lympho-histiocytosis (HLH) syndrome and insights from animal models	12
Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion	11
Innate stimulation of B cells ex vivo enhances antibody secretion and identifies tumour-reactive antibodies from cancer patients	11
Induction of memory-like CD8+ T cells and CD4+ T cells from human naive T cells in culture	11
2B4: A potential target in Staphylococcus aureus associated allergic inflammation	11
HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients	11
Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth	11
Tocilizumab suppresses NF-kappa B activation via toll-like receptor 9 signaling by reducing cell-free DNA in rheumatoid arthritis	11
Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults	11
Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA	11
The immune landscape of the inflamed joint defined by spectral flow cytometry	10
Parallel origins and functions of T cells and ILCs	10
The TOX subfamily: all-round players in the immune system	10
Complement factors as biomarkers in ANCA-associated vasculitis in remission	10
Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights	10
Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow-up of two randomized controlled trials	10
Distinctive T-cell receptor repertoire in paediatric inflammatory multisystem syndrome temporally associated with coronavirus disease 2019/multisystem inflammatory syndrome in children patients: possi	10
Effects of mesenchymal stem cells on Treg cells in rats with colitis	10
CD4+LAG-3+ T cells are decreased in active psoriatic arthritis patients and their restorationin vitrois mediated by TNF inhibitors	10
Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases	10
Improved function and balance in T cell modulation by endothelial cells in young people	9
Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1	9
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans	9
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome	9
Engaging PD-1 rescues regulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis	9
Response to Letter to the Editor: Type 2 diabetes is associated with the accumulation of senescent T cells	9
COVID-19 infection and vaccination in immunodeficiency	9
Follow-up of immune response in patients with common variable immunodeficiency following SARS-CoV-2 vaccination	9
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway	9
Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas	9
Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis	9
Leptin-reactive antibodies are distinctly correlated with body composition parameters and metabolic risk indexes in children and adolescents	9
What do we know about co-stimulatory and co-inhibitory immune checkpoint signals in ankylosing spondylitis?	9
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway	9
Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction	9
Per a 5-derived T-cell peptides modulate NF-kB signalling to ameliorate allergic inflammation systemically in murine model of cockroach allergic hyper-reactivity	8
Unveiling WHIM syndrome: Mavorixafor’s emerging role in immune restoration and therapy	8
Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation	8
SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis	8
MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy:in vitroandex vivoevidence	8
Seroconversion following COVID-19 vaccination: can we optimize protective response in CD20-treated individuals?	8
sB7-H4 is a diagnostic biomarker in epithelial ovarian cancer and correlates to platinum resistance	8
Human cytomegalovirus seropositivity and its influence on oral rotavirus vaccine immunogenicity: a specific concern for HIV-exposed-uninfected infants	8
Practical challenges for functional validation of STAT1 gain of function genetic variants	8
Investigating Concomitant RAG-2 and LRBA Mutations in SCID and Autoimmunity	8
Human FCHO1 deficiency: review of the literature and additional two cases	8
PMA induces the differentiation of monocytes into immunosuppressive MDSCs	8
Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis	8
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease	8
A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose	8
Metabolites as drivers and targets in rheumatoid arthritis	8
Neutrophil depletion attenuates antibody-mediated rejection in a renal transplantation mouse model	8
Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes	8
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease	8
My highlights as Editor-in-Chief of Clinical & Experimental Immunology, 2017–2024	8
Genetic correlation between thyroid hormones and Parkinson’s disease	8
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications	8
Organoids as a tool to study homeostatic and pathological immune–epithelial interactions in the gut	8
From acute lung injury to cerebral ischemia: a unified concept involving intercellular communication through extracellular vesicle-associated miRNAs released by macrophages/microglia	8
Clinical features and nasal inflammation in asthma and allergic rhinitis	8