Clinical Biochemistry

Papers
(The median citation count of Clinical Biochemistry is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Editorial Board83
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity75
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”32
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value29
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions27
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?26
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer25
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?24
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve23
Comparison of two (data mining) indirect approaches for between-subject biological variation determination23
Establishing age-stratified red blood cell fatty acid reference ranges using model-based clustering and iterative application of the harris-boyd method22
Comparison of laboratory results and pain perception in self-sampled capillary blood versus venous blood sampling: a systematic review and meta-analysis22
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine21
Hydroxocobalamin does not interfere with high-sensitivity cardiac troponin T assay21
Editorial Board20
Clinical efficacy of thyroid-stimulating immunoglobulin detection for diagnosing Graves’ disease and predictors of responsiveness to methimazole20
Editorial Board19
Defining blood gas analysis stability limits across five sample types18
Limited incremental value of growth differentiation factor 15 in the initial evaluation of low and intermediate risk acute chest pain patients18
Reducing AST orders by reviewing test panels18
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies17
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency17
Canadian Society of Clinical Chemists (CSCC) consensus guidance for testing, selection and quality management of SARS-CoV-2 point-of-care tests17
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study17
Novel threshold value of midnight serum cortisol for diagnosis of hypercortisolism using the Roche Cortisol II assay16
Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review16
Explainable artificial intelligence for LDL cholesterol prediction and classification15
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico15
Accuracy-based proficiency testing for estradiol measurements15
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study14
Integrating quality control and external quality assurance14
Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories14
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters14
Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces?13
Reference intervals for preterm thyroid function during the fifth to seventh day of life13
Assessment of accuracy, clinical validity, and analytical linearity in point-of-care glucose monitoring devices for diabetes mellitus: A systematic review and meta-analysis13
Editorial Board12
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice12
Editorial Board12
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub12
Editorial Board12
The impact of environmental factors on external and internal specimen transport11
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis11
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 8511
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer11
NT-proBNP in young healthy adults undergoing non-cardiac surgery11
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing11
Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results11
External quality assessment in the absence of proficiency testing: A split-sample testing program experience10
Combination of antibody tests against SARS-CoV-2 for health care workers after vaccination10
Editorial Board10
Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal cancer10
14–3-3 η ETA protein as a potential marker of joint damage in gout10
Editorial Board10
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays10
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions10
Urine toxicology screening by liquid chromatography time-of-flight mass spectrometry in a quaternary hospital setting10
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke10
Laboratory reporting of framingham risk score increases statin prescriptions in at-risk patients9
Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study9
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort9
Serum biotin interference: A troublemaker in hormone immunoassays9
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease9
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria9
The case of a bloody mess – Bictegravir/emtricitabine/tenofovir alafenamide induced colitis9
Green laboratory practice: Top 2 environmental recommendations for clinical laboratories9
Biological testing during acute psychological stress: A hindrance or an opportunity?9
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis9
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report9
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry9
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS9
Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes8
Methods for determining clinical utility8
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial8
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays8
Vascular endothelial growth factor A, a potential non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease progression8
2024 CSCC / SQBC Joint AnnualConference8
Estimation formulas for ionized magnesium in critically ill children8
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting8
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected8
Using quantitative immunoprecipitation mass spectrometry (QIP-MS) to identify low level monoclonal proteins8
Editorial Board8
Editorial Board8
Editorial Board8
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease8
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?8
Reducing unnecessary free thyroid hormone testing by the reinforcement of a reflexive algorithm in an outpatient environment8
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria8
Detection of Vitamin D Metabolites in Breast Milk: Perspectives and challenges for measurement by Liquid Chromatography Tandem-Mass Spectrometry7
Biomarker profiling for infection diagnosis in emergency departments: A diagnostic study evaluating C-reactive protein, procalcitonin, Club Cell Protein 16, interleukin-6, chitinase-like protein, and 7
Autoverification-based algorithms to detect preanalytical errors: Two examples7
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α7
Editorial Board7
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis7
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies7
Impact of lot-to-lot variation in absolute neutrophil count measured by a point-of-care device in patients receiving clozapine treatment7
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer7
Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders7
Clinical concordance assessment should be an integral component of laboratory method comparison studies: A regression transference of routine clinical data approach7
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma7
Canadian guidance for diagnosis and management of acute hepatic porphyrias7
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment7
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China7
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study7
Pediatric ionized calcium reference intervals from archived radiometer data7
Biotinidase activity is affected by both seasonal temperature and filter collection cards6
Less is more: minimum sample volume for the free phenytoin assay on the Roche Cobas c503 analyzer6
Editorial Board6
A new assay falsely increases lactate dehydrogenase in plasma but not in serum6
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum6
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey6
Establishing sustainable quality improvement in the clinical laboratory: Redesign of the total testing process and digital transformation of routine quality assurance activities6
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories6
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer6
In vivo and in vitro relationship between ionized magnesium and ionized calcium6
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis6
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays6
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia6
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease6
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction6
Innovations in infectious disease diagnostics6
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation6
Clinical chemistry score misses fewer deaths as compared to troponin T alone in a United States emergency department population6
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis6
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy6
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients6
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion6
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?6
Minimal mathematical model for glycation of albumin6
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots6
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment6
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs6
Characterizing M-protein light chain glycosylation via mass spectrometry6
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients6
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus5
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction5
Implementing minimal request intervals for laboratory tests: a utilization management study across eight hospitals in South Iran5
MELAS a clinically and genetically heterogeneous syndrome5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype5
Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke5
Two SARS-CoV-2 serology assays detect antibodies in the sera of individuals diagnosed with SARS-CoV-2 Omicron variant5
Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 20235
CYB5R3 homozygous pathogenic variant as a rare cause of cyanosis in the newborn5
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis5
Primer Part 1 − Preparing a laboratory quality improvement project5
Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies5
Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage5
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy5
Rapid COVID-19 testing: Speed, quality and cost. Can you have all three?5
Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®5
More about the random uncertainty of photometric determination of hemolysis index on the Abbott Alinity c platform5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E5
Dose optimization and target attainment of vancomycin in children5
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests5
Advances in molecular infectious diseases testing in the time of COVID-195
Therapeutic drug monitoring of levetiracetam – Is dried blood spot sampling suitable?5
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future5
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation5
Letter to the Editor: On moving average and internal quality control5
A novel and robust analytical method for the quantification of perospirone in human plasma using an LC–MS/MS system with self-internal standard calibration5
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China5
Editorial Board5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?5
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature5
The 10 most frequently requested blood tests in the Capital Region of Denmark, 2010–2019 and simulated effect of minimal retesting intervals5
Incidence and status of insulin secretion in pregnant women with flat plasma glucose profiles during oral glucose tolerance test4
Lipidomic profiling in patients with familial hypercholesterolemia: Abnormalities in glycerolipids and oxysterols4
Outcomes of Infliximab-Treated inflammatory bowel disease patients undergoing therapeutic drug monitoring with two different assays4
Non-invasive prenatal screening for foetal trisomy: An assessment of reliability and reporting4
Lessons learned: A look back at the performance of nine COVID-19 serologic assays and their proposed utility4
Assessing the predictive value of elevated triglycerides, triglyceride-glucose index (TyG), and TG/HDL ratios for cardiovascular disease and mortality during 20 years of follow-up: Tehran lipid and gl4
Application of Abbott ID NOW in the emergency department for SARS-CoV-2 detection: A medical center’s perspective4
What factors are associated with improvements in productivity in clinical laboratories in the Asia Pacific Region?4
Editorial Board4
Evaluation of BD Barricor™ and PST™ blood collection tubes compared to serum for testing 11 therapeutic drugs on a Roche Cobas® 8000 platform4
KNG1 mutations (c.618 T > G and c.1165C > T) cause disruption of the Cys206-Cys218 disulfide bond and truncation of the D5 domain leading to hereditary high molecular weight kininogen deficiency4
Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases4
CA19-9, CEA and PIVKA-Ⅱ as a novel panel of serum markers for diagnosis of pancreatic cancer4
Storage conditions, sample integrity, interferences, and a decision tool for investigating unusual high-sensitivity cardiac troponin results4
Comparison of different equations for renal function evaluation as proxies for antibiotic drug clearance: The examples of amoxicillin and cloxacillin4
Clinical features and capillary zone electrophoresis analysis of 10 patients with extremely elevated serum IgG4 levels4
Performance and reliability of two frequently used point-of-care blood gas analyzers at 423 and 4,559 m4
Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?4
Homozygous familial lipoprotein lipase deficiency without obvious coronary artery stenosis4
Editorial Board4
Independent origin for m.3243A>G mitochondrial mutation in three Venezuelan cases of MELAS syndrome4
Kinetics of d-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia4
Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening4
Hydroxocobalamin infusion in a patient monitored for plasma free hemoglobin levels4
Inter-laboratory variation for urine albumin among laboratories in a Swedish external quality assessment scheme 2005–20234
Performance of the Siemens’ thyroid stimulating immunoglobulin assay in the diagnosis of hyperthyroidism: Prospective cohort study4
The impact of different calibration matrices on the determination of insulin-like growth factor 1 by high-resolution-LC-MS in acromegalic and growth hormone deficient patients4
Comparison of three different cystatin C measurement procedures in a pediatric chronic kidney disease cohort: Calibration for longitudinal measurements and implications for clinical estimation of GFR4
New prognostic markers in pulmonary arterial hypertension: CRP to albumin ratio and uric acid4
Age- and sex-specific 99th percentile upper reference limits for high-sensitivity cardiac troponin T in Chinese older people: Real-world data mining4
Preanalytical stability of vitamins A and E in whole blood4
Effect of sodium–chloride ion difference on pH regulation4
New Psychoactive Substances: A Canadian perspective on emerging trends and challenges for the clinical laboratory4
Enhanced detection and Characterization of M-proteins in multiple myeloma patients using An Agilent AssayMAP Bravo liquid handling system coupled to an LC-QTOF4
Factor XII deficiency evaluated by thrombin generation assay4
Linking gestational RBP4 to bone resorption via postprandial glycemic pathways: A cross-sectional mediation analysis4
A review of temperature-related challenges and solutions for the Abbott i-STAT and Siemens Healthineers epoc devices3
The diagnosis and molecular analysis of a novel 27.2 kb deletion causing α0-thalassemia3
Long time monitoring of serum lithium results using patient median values show stable test results over a time period of more than 20 years3
Circulating plasma RNY1 as a potential biomarker of breast cancer: a case-control study3
Complex biological patterns of soluble cytokines and CD163 in childhood necessitating age-specific reference intervals for evidence-based clinical interpretation3
Significance of SDC2 and NDRG4 methylation in stool for colorectal cancer diagnosis3
The changing landscape of autoantibody testing in myasthenia gravis in the setting of novel drug treatments3
Serum levels of advanced glycation end products negatively correlates with activity of Paraoxonase1 and Lecithin-Cholesterol Acyltransferase in diabetic retinopathy; A cross-sectional case-control stu3
Clinical impact of PTEN rs701848 as a predictive marker for breast cancer3
Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease3
Clinical significance of elevated serum IL-36γ levels in patients with early-stage Hashimoto's thyroiditis3
Low concentration of serum vitamin B12 may be a strong predictor of large-artery atherosclerosis stroke: A case-control study3
Primer part 2 - implementing a laboratory quality improvement project3
Novel proposed cutoff values for anatabine and anabasine in differentiating smokers from non-smokers3
Association between circulating asprosin levels and carotid atherosclerotic plaque in patients with type 2 diabetes3
Establishment and application of an immunoassay for the simultaneous detection of IgG and its subtype IgG4 autoantibodies against M-type phospholipase A2 receptor3
Continuous reference intervals for 21 biochemical and hematological analytes in healthy Chinese children and adolescents: The PRINCE study3
Evaluation of serum YKL-40 level among clinical risk scores for early mortality in acute pulmonary thromboembolism3
CXCL5 as a biomarker for early diagnosis and prognosis of sepsis: A comprehensive clinical evaluation3
Comparison of capillary and venous blood sampling for routine coagulation assays3
A comparison of SARS-CoV-2 nucleocapsid and spike antibody detection using three commercially available automated immunoassays3
Dealing with redundant gamma glutamyl transpeptidase in primary care, when requested along with alkaline phosphatase3
Development of nation-wide reference intervals using an indirect method and harmonized assays3
Systemic evaluation of lymphocyte-bound C4d and immunoglobulins for diagnosis and activity monitoring of systemic lupus erythematosus3
Deteriorated thiol-disulphide and oxidized-reduced glutathione status in blood in Alzheimer’s disease3
Ex vivo hemolysis: Three cases demonstrating mechanically-induced hemolysis from the extracorporeal circuit during hemodialysis3
Heart failure biomarkers and prediction of early left ventricle remodeling after acute coronary syndromes3
Shortcoming of serum B-cell maturation antigen measurement by enzyme-linked immunosorbent assay in one laboratory’s experience: Unsatisfactory assay reproducibility3
Statistical issues on evaluating agreement between two different analytical platforms for assessing quantification of urinary albumin and -creatinine3
Analytical evaluation of a direct ion-selective-based analyser: Still gaps to close3
The expression of canopy FGF signaling regulator 2 serves as a diagnostic and prognostic indicator for NSCLC3
Oral glucose tolerance test to diagnose gestational diabetes mellitus: Impact of variations in specimen handling3
Application of the Hoffmann, Bhattacharya, nonparametric test, and Q-Q plot methods for establishing reference intervals from laboratory databases3
Impact of blood volume, air exposure duration, transport duration, and testing delay on plasma total carbon dioxide in simulated open collections using microtainers3
Variation in processes and reporting of cerebrospinal fluid oligoclonal banding and associated tests and calculated indices across Canadian clinical laboratories3
Circulating miRNA and circulating tumor DNA application as liquid biopsy markers in gastric cancer3
A call-to-action for energy conservation and sustainability in the clinical laboratory: Experiences from the University of Padova3
High serum levels of galectins 1 and 4 in osteoarthritis patients3
Do not report estimated average glucose (eAG) from HbA1c: Evidence is emerging3
Comparison of blood collection tubes for 29 biochemical analytes in pediatric patients with central venous catheters3
The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity3
ROC of SII and FIB-4 index for predicting mortality in idiopathic pulmonary fibrosis patients3
Quantitative abnormalities in the β-region of the electrophoretic profile of serum proteins as predictive markers of monoclonality: Machine learning for monoclonality prediction3
Serum matrix metalloproteinase-9 (MMP9) and amyloid-beta protein precursor (APP) as potential biomarkers in children with Fragile-X syndrome: A cross sectional study3
Longitudinal changes in plasma Cystatin C and all-cause mortality risk among the middle-aged and elderly Chinese population3
High triglyceride-glucose index and HOMA-IR are associated with different cardiometabolic profile in adults from the ELSA-Brasil study2
Reference intervals for serum immunoglobulin A, G, and M in a Danish paediatric population-based cohort2
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