Clinical Biochemistry

Article	Citations
Editorial Board	79
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity	71
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”	32
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value	28
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions	26
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer	24
Comparison of laboratory results and pain perception in self-sampled capillary blood versus venous blood sampling: a systematic review and meta-analysis	24
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?	24
Comparison of two (data mining) indirect approaches for between-subject biological variation determination	22
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?	22
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve	21
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine	21
Hydroxocobalamin does not interfere with high-sensitivity cardiac troponin T assay	21
Clinical efficacy of thyroid-stimulating immunoglobulin detection for diagnosing Graves’ disease and predictors of responsiveness to methimazole	21
Establishing age-stratified red blood cell fatty acid reference ranges using model-based clustering and iterative application of the harris-boyd method	21
Editorial Board	20
Editorial Board	20
Defining blood gas analysis stability limits across five sample types	19
Reducing AST orders by reviewing test panels	19
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency	18
Limited incremental value of growth differentiation factor 15 in the initial evaluation of low and intermediate risk acute chest pain patients	18
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study	17
Canadian Society of Clinical Chemists (CSCC) consensus guidance for testing, selection and quality management of SARS-CoV-2 point-of-care tests	17
Novel threshold value of midnight serum cortisol for diagnosis of hypercortisolism using the Roche Cortisol II assay	16
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	16

Explainable artificial intelligence for LDL cholesterol prediction and classification	16
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico	16
Integrating quality control and external quality assurance	15
Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review	15
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study	14
Accuracy-based proficiency testing for estradiol measurements	14
Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories	14
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters	14
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice	13
Assessment of accuracy, clinical validity, and analytical linearity in point-of-care glucose monitoring devices for diabetes mellitus: A systematic review and meta-analysis	13
Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces?	13
Reference intervals for preterm thyroid function during the fifth to seventh day of life	13
Editorial Board	12
Editorial Board	12
Editorial Board	12
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub	12
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing	11
NT-proBNP in young healthy adults undergoing non-cardiac surgery	11
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis	11
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 85	11
Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results	11
14–3-3 η ETA protein as a potential marker of joint damage in gout	10
Combination of antibody tests against SARS-CoV-2 for health care workers after vaccination	10
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions	10
Green laboratory practice: Top 2 environmental recommendations for clinical laboratories	10
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer	10
Urine toxicology screening by liquid chromatography time-of-flight mass spectrometry in a quaternary hospital setting	10
Editorial Board	10
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS	10
Editorial Board	10
The impact of environmental factors on external and internal specimen transport	10
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry	10
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke	10
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays	10
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	9
Reply to Letter to Editor Diagnostic significance of uncommon antinuclear antibodies	9
The case of a bloody mess – Bictegravir/emtricitabine/tenofovir alafenamide induced colitis	9
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report	9
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort	9
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis	9
External quality assessment in the absence of proficiency testing: A split-sample testing program experience	9
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease	9
Biological testing during acute psychological stress: A hindrance or an opportunity?	9
Serum biotin interference: A troublemaker in hormone immunoassays	9
Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study	9
Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal cancer	9
Laboratory reporting of framingham risk score increases statin prescriptions in at-risk patients	9
Editorial Board	9
Using quantitative immunoprecipitation mass spectrometry (QIP-MS) to identify low level monoclonal proteins	8
Reducing unnecessary free thyroid hormone testing by the reinforcement of a reflexive algorithm in an outpatient environment	8

Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes	8
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α	8
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial	8
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays	8
Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders	8
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria	8
Editorial Board	8
Methods for determining clinical utility	8
Editorial Board	8
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China	8
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected	8
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting	8
2024 CSCC / SQBC Joint AnnualConference	8
Vascular endothelial growth factor A, a potential non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease progression	8
Estimation formulas for ionized magnesium in critically ill children	8
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease	8
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?	8
Editorial Board	7
Diagnostic significance of uncommon antinuclear antibodies	7
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies	7
Detection of Vitamin D Metabolites in Breast Milk: Perspectives and challenges for measurement by Liquid Chromatography Tandem-Mass Spectrometry	7
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia	7
Canadian guidance for diagnosis and management of acute hepatic porphyrias	7
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma	7
Clinical concordance assessment should be an integral component of laboratory method comparison studies: A regression transference of routine clinical data approach	7
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer	7
Donor-specific ELISPOT assay for predicting acute rejection and allograft function after kidney transplantation: A systematic review and meta-analysis	7
Impact of lot-to-lot variation in absolute neutrophil count measured by a point-of-care device in patients receiving clozapine treatment	7
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion	7
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study	7
Pediatric ionized calcium reference intervals from archived radiometer data	7
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis	7
Autoverification-based algorithms to detect preanalytical errors: Two examples	7
Biomarker profiling for infection diagnosis in emergency departments: A diagnostic study evaluating C-reactive protein, procalcitonin, Club Cell Protein 16, interleukin-6, chitinase-like protein, and	7
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	7
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories	6
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer	6
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients	6
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients	6
Biotinidase activity is affected by both seasonal temperature and filter collection cards	6
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis	6
Editorial Board	6
Innovations in infectious disease diagnostics	6
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	6
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs	6
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease	6
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis	6
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?	6
In vivo and in vitro relationship between ionized magnesium and ionized calcium	6
Less is more: minimum sample volume for the free phenytoin assay on the Roche Cobas c503 analyzer	6
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	6
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment	6
Minimal mathematical model for glycation of albumin	6
Characterizing M-protein light chain glycosylation via mass spectrometry	6
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment	6
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy	6
Mid-regional pro-atrial natriuretic peptide levels before and after hemodialysis predict long-term prognosis	6
A new assay falsely increases lactate dehydrogenase in plasma but not in serum	6
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction	6
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey	6
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus	6
Two SARS-CoV-2 serology assays detect antibodies in the sera of individuals diagnosed with SARS-CoV-2 Omicron variant	5
CYB5R3 homozygous pathogenic variant as a rare cause of cyanosis in the newborn	5
Dose optimization and target attainment of vancomycin in children	5
Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023	5
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests	5
Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage	5
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction	5
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum	5
Implementing minimal request intervals for laboratory tests: a utilization management study across eight hospitals in South Iran	5
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China	5
Letter to the Editor: On moving average and internal quality control	5
Rapid COVID-19 testing: Speed, quality and cost. Can you have all three?	5
Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®	5
More about the random uncertainty of photometric determination of hemolysis index on the Abbott Alinity c platform	5
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy	5
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature	5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E	5
The 10 most frequently requested blood tests in the Capital Region of Denmark, 2010–2019 and simulated effect of minimal retesting intervals	5

MELAS a clinically and genetically heterogeneous syndrome	5
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation	5
Primer Part 1 − Preparing a laboratory quality improvement project	5
Establishing sustainable quality improvement in the clinical laboratory: Redesign of the total testing process and digital transformation of routine quality assurance activities	5
Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening	5
Evaluation of BD Barricor™ and PST™ blood collection tubes compared to serum for testing 11 therapeutic drugs on a Roche Cobas® 8000 platform	5
A novel and robust analytical method for the quantification of perospirone in human plasma using an LC–MS/MS system with self-internal standard calibration	5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?	5
Editorial Board	5
Advances in molecular infectious diseases testing in the time of COVID-19	5
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis	5
Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke	5
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation	5
Therapeutic drug monitoring of levetiracetam – Is dried blood spot sampling suitable?	5
Clinical chemistry score misses fewer deaths as compared to troponin T alone in a United States emergency department population	5
Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies	5
The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective	5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy	5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype	5
Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases	5