Clinical Biochemistry

Article	Citations
Editorial Board	95
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity	84
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”	77
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value	66
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions	30
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?	26
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer	23
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?	23
Comparison of two (data mining) indirect approaches for between-subject biological variation determination	22
Hydroxocobalamin does not interfere with high-sensitivity cardiac troponin T assay	21
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve	21
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine	21
Establishing age-stratified red blood cell fatty acid reference ranges using model-based clustering and iterative application of the harris-boyd method	21
Editorial Board	20
Clinical efficacy of thyroid-stimulating immunoglobulin detection for diagnosing Graves’ disease and predictors of responsiveness to methimazole	20
Reducing AST orders by reviewing test panels	19
Accuracy-based proficiency testing for estradiol measurements	19
Defining blood gas analysis stability limits across five sample types	19
Editorial Board	19
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency	18
Limited incremental value of growth differentiation factor 15 in the initial evaluation of low and intermediate risk acute chest pain patients	18
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study	17
Canadian Society of Clinical Chemists (CSCC) consensus guidance for testing, selection and quality management of SARS-CoV-2 point-of-care tests	17
Explainable artificial intelligence for LDL cholesterol prediction and classification	16
Novel threshold value of midnight serum cortisol for diagnosis of hypercortisolism using the Roche Cortisol II assay	16

Integrating quality control and external quality assurance	16
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	16
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico	16
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters	15
Reference intervals for preterm thyroid function during the fifth to seventh day of life	15
Assessment of accuracy, clinical validity, and analytical linearity in point-of-care glucose monitoring devices for diabetes mellitus: A systematic review and meta-analysis	15
Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review	15
Urine toxicology screening by liquid chromatography time-of-flight mass spectrometry in a quaternary hospital setting	15
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice	14
Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces?	14
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 85	13
Editorial Board	13
Editorial Board	13
Editorial Board	13
Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results	13
Editorial Board	13
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub	13
Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories	12
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis	12
NT-proBNP in young healthy adults undergoing non-cardiac surgery	12
Automatic reflex addition of serum magnesium determination to samples with severe hypocalcemia is an effective tool to detect and treat hypomagnesemia	11
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer	11
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study	11
14–3-3 η ETA protein as a potential marker of joint damage in gout	11
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing	11
The impact of environmental factors on external and internal specimen transport	11
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	10
The case of a bloody mess – Bictegravir/emtricitabine/tenofovir alafenamide induced colitis	10
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis	10
Editorial Board	10
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke	10
Reply to Letter to Editor Diagnostic significance of uncommon antinuclear antibodies	10
Biological testing during acute psychological stress: A hindrance or an opportunity?	10
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease	10
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS	10
Editorial Board	10
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions	10
Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study	10
External quality assessment in the absence of proficiency testing: A split-sample testing program experience	10
Combination of antibody tests against SARS-CoV-2 for health care workers after vaccination	10
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry	10
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report	9
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays	9
Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes	9
Editorial Board	9
Laboratory reporting of framingham risk score increases statin prescriptions in at-risk patients	9
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort	9
Editorial Board	9
Serum biotin interference: A troublemaker in hormone immunoassays	9
Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal cancer	9

Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria	9
Using quantitative immunoprecipitation mass spectrometry (QIP-MS) to identify low level monoclonal proteins	8
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting	8
Donor-specific ELISPOT assay for predicting acute rejection and allograft function after kidney transplantation: A systematic review and meta-analysis	8
Pediatric ionized calcium reference intervals from archived radiometer data	8
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study	8
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?	8
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial	8
2024 CSCC / SQBC Joint AnnualConference	8
Vascular endothelial growth factor A, a potential non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease progression	8
Diagnostic significance of uncommon antinuclear antibodies	8
Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders	8
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease	8
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α	8
Editorial Board	8
Methods for determining clinical utility	8
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China	8
Hempseed (Cannabis sativa) offers effective alternative over statins in ameliorating hypercholesterolemia associated nephropathy	8
Editorial Board	8
Clinical concordance assessment should be an integral component of laboratory method comparison studies: A regression transference of routine clinical data approach	8
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays	8
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected	8
Reducing unnecessary free thyroid hormone testing by the reinforcement of a reflexive algorithm in an outpatient environment	8
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis	7
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma	7
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia	7
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease	7
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy	7
Detection of Vitamin D Metabolites in Breast Milk: Perspectives and challenges for measurement by Liquid Chromatography Tandem-Mass Spectrometry	7
Autoverification-based algorithms to detect preanalytical errors: Two examples	7
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies	7
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	7
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer	7
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion	7
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer	7
Canadian guidance for diagnosis and management of acute hepatic porphyrias	7
In vivo and in vitro relationship between ionized magnesium and ionized calcium	7
Biotinidase activity is affected by both seasonal temperature and filter collection cards	7
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients	7
Innovations in infectious disease diagnostics	6
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	6
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey	6
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum	6
Characterizing M-protein light chain glycosylation via mass spectrometry	6
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?	6
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs	6
The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard	6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	6
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories	6
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis	6
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis	6
Minimal mathematical model for glycation of albumin	6
Editorial Board	6
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus	6
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation	6
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction	6
A new assay falsely increases lactate dehydrogenase in plasma but not in serum	6
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment	6
Mid-regional pro-atrial natriuretic peptide levels before and after hemodialysis predict long-term prognosis	6
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients	6
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment	6
Enhanced detection and Characterization of M-proteins in multiple myeloma patients using An Agilent AssayMAP Bravo liquid handling system coupled to an LC-QTOF	5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy	5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype	5
Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke	5
Implementing minimal request intervals for laboratory tests: a utilization management study across eight hospitals in South Iran	5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?	5
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis	5
Editorial Board	5
CYB5R3 homozygous pathogenic variant as a rare cause of cyanosis in the newborn	5
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China	5
Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage	5
Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies	5
Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023	5
KNG1 mutations (c.618 T > G and c.1165C > T) cause disruption of the Cys206-Cys218 disulfide bond and truncation of the D5 domain leading to hereditary high molecular weight kininogen deficiency	5
Letter to the Editor: On moving average and internal quality control	5
Rapid COVID-19 testing: Speed, quality and cost. Can you have all three?	5
The 10 most frequently requested blood tests in the Capital Region of Denmark, 2010–2019 and simulated effect of minimal retesting intervals	5
Kinetics of d-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia	5
Dose optimization and target attainment of vancomycin in children	5

Two SARS-CoV-2 serology assays detect antibodies in the sera of individuals diagnosed with SARS-CoV-2 Omicron variant	5
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy	5
A novel and robust analytical method for the quantification of perospirone in human plasma using an LC–MS/MS system with self-internal standard calibration	5
Establishing sustainable quality improvement in the clinical laboratory: Redesign of the total testing process and digital transformation of routine quality assurance activities	5
Clinical chemistry score misses fewer deaths as compared to troponin T alone in a United States emergency department population	5
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	5
Advances in molecular infectious diseases testing in the time of COVID-19	5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E	5
Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening	5
Evaluation of BD Barricor™ and PST™ blood collection tubes compared to serum for testing 11 therapeutic drugs on a Roche Cobas® 8000 platform	5
Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases	5
Primer Part 1 − Preparing a laboratory quality improvement project	5
Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®	5
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature	5
More about the random uncertainty of photometric determination of hemolysis index on the Abbott Alinity c platform	5
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests	5
MELAS a clinically and genetically heterogeneous syndrome	5
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction	5
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation	5
Therapeutic drug monitoring of levetiracetam – Is dried blood spot sampling suitable?	5