Computers in Biology and Medicine

Article	Citations
Editorial Board	437
Diffuse tumors: Molecular determinants shared by different cancer types	389
Identifying indications for novel drugs using electronic health records	337
Carotid single- and dual-layer stents reduce the wall adhesion of platelets by influencing flow and cellular transport	313
Pathogenicity classification of missense mutations based on deep generative model	298
Pedicle drilling force control of a robotic surgical system via spine-soft tissue coupling model and parameters optimization	293
A partially shared joint clustering framework for detecting protein complexes from multiple state-specific signed interaction networks	282
Contrastive learning based method for X-ray and CT registration under surgical equipment occlusion	280
Development and validation of a neutrophil extracellular traps-related gene signature for lower-grade gliomas	278
Multiscale differential geometry learning of networks with applications to single-cell RNA sequencing data	263
Eye movement analysis for real-world settings using segmented linear regression	255
Advances in disease detection through retinal imaging: A systematic review	249
Longitudinal dementia trajectories for Alzheimer’s Disease characterization and prediction	248
Graph neural network-based subgraph analysis for predicting adverse drug events	230
Pharmacophore-guided computational modeling of quinolone-ATPase conjugate inhibitors targeting DNA GyrB subunit of Staphylococcus aureus	230
Molecular modelling and experimental validation identified a new therapeutic inhibitor of toxoplasmosis	223
Discrepancy-based diffusion models for lesion detection in brain MRI	212
Beyond accuracy: The need for explainable AI in biomedical voice technology	210
A novel Harris Hawks Optimization-based clustering method for elucidating genetic associations in osteoarthritis and Diverse Cancer Types	204
D-glucose-conjugated thioureas containing 2-aminopyrimidine as potential multitarget inhibitors for type 2 diabetes mellitus: Synthesis and biological activity study	201
A novel hybrid ViT-LSTM model with explainable AI for brain stroke detection and classification in CT images: A case study of Rajshahi region	189
Discrete element method-based simulation system for predicting natural stone evacuation pathways in patients with urolithiasis	186
Prediction of lung cancer metastasis by gene expression	175
A deep learning based model using RNN-LSTM for the Detection of Schizophrenia from EEG data	174
Single-channel EEG based insomnia detection with domain adaptation	171

Class-Specific Distribution Alignment for semi-supervised medical image classification	171
REDDA: Integrating multiple biological relations to heterogeneous graph neural network for drug-disease association prediction	165
How CLSPN could demystify its prognostic value and potential molecular mechanism for hepatocellular carcinoma: A crosstalk study	155
DRBpred: A sequence-based machine learning method to effectively predict DNA- and RNA-binding residues	154
The role and potential of computer-aided drug discovery strategies in the discovery of novel antimicrobials	153
GasHisSDB: A new gastric histopathology image dataset for computer aided diagnosis of gastric cancer	152
Temporal relative transformer encoding cooperating with channel attention for EEG emotion analysis	152
Extinction and stationary distribution of a stochastic COVID-19 epidemic model with time-delay	152
A robust drug recall supply chain management system using hyperledger blockchain ecosystem	152
An improved RIME optimization algorithm for lung cancer image segmentation	147
Classical Simulations on Quantum Computers: Interface-Driven Peptide Folding on Simulated Membrane Surfaces	145
Deriving a suitable schedule through robust H	144
Context encoder transfer learning approaches for retinal image analysis	143
A systematic review on the state-of-the-art strategies for protein representation	142
Efficient sleep apnea detection using single-lead ECG: A CNN-Transformer-LSTM approach	140
Structure, sensing and control of pneumatic upper limb rehabilitation system: Review and prospect	139
A deep learning model combining convolutional neural networks and a selective kernel mechanism for SSVEP-Based BCIs	138
Dynamical pattern of successive bits to predict the outcomes of the SSRI and rTMS depression therapies using EEG signals	137
IVD fibrosis and disc collapse comprehensively aggravate vertebral body disuse osteoporosis and zygapophyseal joint osteoarthritis by posteriorly shifting the load transmission pattern	137
Enhancing targeted tumor treatment: A novel fuzzy logic framework for precision drug delivery strategy selection	136
Artificial intelligence for identification of candidates for device-aided therapy in Parkinson's disease: DELIST-PD study	133
Visual prior-based cross-modal alignment network for radiology report generation	133
The role of the extracellular matrix in the reduction of lateral force transmission in muscle bundles: A finite element analysis	130
Unraveling the complexities of pathological voice through saliency analysis	129
Improved predictive diagnosis of diabetic macular edema based on hybrid models: An observational study	127
Two-stage error detection to improve electron microscopy image mosaicking	124
JoCoRank: Joint correlation learning with ranking similarity regularization for imbalanced fetal brain age regression	123
Editorial Board	122
Prediction of colorectal cancer based on taxonomic levels of microorganisms and discovery of taxonomic biomarkers using the Grouping-Scoring-Modeling (G-S-M) approach	121
Corrigendum to “Unraveling the molecular landscape of non-small cell lung cancer: Integrating bioinformatics and statistical approaches to identify biomarkers and drug repurposing” [Comput. Biol. Med.	121
Insights from explainable AI in oesophageal cancer team decisions	120
Disclosing neonatal pain in real-time: AI-derived pain sign from continuous assessment of facial expressions	119
LSDVvac: An immunoinformatics database for vaccine design against lumpy skin disease virus	119
Enhancing and advancements in deep learning for melanoma detection: A comprehensive review	119
Semi-empirical Anticoagulation Model (SAM): Dose prediction during warfarin therapy	119
SSMT-PANBERT: A single-stage multitask model for phenotype extraction and assertion negation detection in unstructured clinical text	117
Prediction of protein N-terminal acetylation modification sites based on CNN-BiLSTM-attention model	116
Enhancing cell instance segmentation in scanning electron microscopy images via a deep contour closing operator	116
Automatic segmentation of intraluminal thrombosis of abdominal aortic aneurysms from CT angiography using a mixed-scale-driven multiview perception network (M2Net) model	116
Integrating CNN and Bi-LSTM for protein succinylation sites prediction based on Natural Language Processing technique	115
Non-same-scale feature attention network based on BPD for medical image segmentation	115
You get the best of both worlds? Integrating deep learning and traditional machine learning for breast cancer risk prediction	115
MulStack: An ensemble learning prediction model of multilabel mRNA subcellular localization	114
An efficient model for extracting respiratory and blood oxygen saturation data from photoplethysmogram signals by removing motion artifacts using heuristic-aided ensemble learning model	113
Data-driven discovery of sparse dynamical model of cardiovascular system for model predictive control	113
AIScholar: An OpenFaaS-enhanced cloud platform for intelligent medical data analytics	112
Artificial vascular image generation using blood vessel texture maps	110
Stack-AAgP: Computational prediction and interpretation of anti-angiogenic peptides using a meta-learning framework	109
Reversing skin cancer adversarial examples by multiscale diffusive and denoising aggregation mechanism	109
Deep learning and machine learning approaches to classify stomach distant metastatic tumors using DNA methylation profiles	109

Hybrid offline and self-knowledge distillation for acute ischemic stroke lesion segmentation from non-contrast CT scans	107
FCSU-Net: A novel full-scale Cross-dimension Self-attention U-Net with collaborative fusion of multi-scale feature for medical image segmentation	107
Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics	106
Predictive modeling for early detection of biliary atresia in infants with cholestasis: Insights from a machine learning study	106
Dynamic Statistical Attention-based lightweight model for Retinal Vessel Segmentation: DyStA-RetNet	104
Exploring the spike glycoprotein-encoding gene of SARS-CoV-2 using multifractal analysis: Unveiling structural complexity and implications for viral transmission	103
Identifying potent natural inhibitors of the hepatitis C virus NS3 protein using multiple computational and molecular approaches	103
Automated mitral valve segmentation in PLAX-view transthoracic echocardiography for anatomical assessment and risk stratification	103
M3-Net++: A multi-scale, multi-level, multi-stream network for nuclei segmentation in breast cancer histopathology using hierarchical context extraction and hybrid loss optimization	101
KC-UNIT: Multi-kernel conversion using unpaired image-to-image translation with perceptual guidance in chest computed tomography imaging	99
Optimization of deep learning models for inference in low resource environments	99
Anemia prediction using gene expression programming (GEP) and explainable artificial intelligence approaches	99
KS-TMIL: A K-Stage Transformer approach with multiple instance learning model for ovarian cancer subtype classification	98
Automated mitral inflow Doppler peak velocity measurement using deep learning	97
SURVS: A Swin-Unet and game theory-based unsupervised segmentation method for retinal vessel	96
Counting on AR: EEG responses to incongruent information with real-world context	96
Deep-learning-based real-time individualization for reduce-order haemodynamic model	96
Synergistic eigenanalysis of covariance and Hessian matrices for enhanced binary classification on health datasets	96
Triage and monitoring of COVID-19 patients in intensive care using unsupervised machine learning	95
A novel mobile phone and tablet application for automatized calculation of pain extent	95
Hemodynamic alternations following stent deployment and post-dilation in a heavily calcified coronary artery: In silico and ex-vivo approaches	94
Dynamic topography analysis of the cornea and its application to the diagnosis of keratoconus	94
Hierarchical cumulative network for unsupervised medical image registration	92
A computational model of the effects of macronutrients absorption and physical exercise on hormonal regulation and metabolic homeostasis	92
Identification of JUN as determinant of osteoarthritis and its inhibition by the Chinese herbal formulae Zhuanggu Huoxue Tang	90
Towards a better understanding of TF-DNA binding prediction from genomic features	89
Causal relationship between slow waves of arterial, intracranial pressures and blood velocity in brain	85
Identification of anti-cancer organometallic compounds by inhibition of BCL-2/Bax interactions	85
Editorial Board	85
Dual-Stream Subspace Clustering Network for revealing gene targets in Alzheimer's disease	85
Computer models evaluating hand tremors in Parkinson's disease patients	84
Functional identification and prediction of lncRNAs in esophageal cancer	84
Electroanatomical mapping of the stomach with simultaneous biomagnetic measurements	84
MCA-net: A multi-task channel attention network for Myocardial infarction detection and location using 12-lead ECGs	84
DE-JANet: A unified network based on dual encoder and joint attention for Alzheimer’s disease classification using multi-modal data	84
CARES: A Corpus for classification of Spanish Radiological reports	84
ILSHIP: An interpretable and predictive model for hypothyroidism	83
Enhanced depression detection from speech using Quantum Whale Optimization Algorithm for feature selection	83
Gene-related Parkinson's disease diagnosis via feature-based multi-branch octave convolution network	83
EpiTEAmDNA: Sequence feature representation via transfer learning and ensemble learning for identifying multiple DNA epigenetic modification types across species	83
AGNet: Automatic generation network for skin imaging reports	83
Simulated annealing aided genetic algorithm for gene selection from microarray data	83
DrugormerDTI: Drug Graphormer for drug–target interaction prediction	83
Computational prediction of protein folding rate using structural parameters and network centrality measures	82
Automatic eczema classification in clinical images based on hybrid deep neural network	82
Vectorial-based analysis of dual-tracer PET imaging: A proof of concept	82
A self-supervised COVID-19 CT recognition system with multiple regularizations	82
Automated identification of patient subgroups: A case-study on mortality of COVID-19 patients admitted to the ICU	81
Artificial intelligence techniques for prediction of drug synergy in malignant diseases: Past, present, and future	81
A mask R-CNN based automatic assessment system for nail psoriasis severity	81
Multi-constraint point set registration with redundant point removal for the registration of coronary arteries	80
Context-aggregator: An approach of loss- and class imbalance-aware aggregation in federated learning	79
In silico evaluation of lattice designs for additively manufactured total hip implants	79
Insights into potential mechanisms of asthma patients with COVID-19: A study based on the gene expression profiling of bronchoalveolar lavage fluid	79
Identifying fetal status with fetal heart rate: Deep learning approach based on long convolution	78
S2FLNet: Hepatic steatosis detection network with body shape	78
Evaluation of the mechanical behaviour of the expandable wedge locked nail fixation in retrograde use: A finite element study	78
Multi-label classification of fundus images with graph convolutional network and LightGBM	77
Uniqueness of inspiratory airflow patterns in a realistic rat nasal cavity	77
CauDR: A causality-inspired domain generalization framework for fundus-based diabetic retinopathy grading	77
A general sample-weighted framework for epileptic seizure prediction	76
Mapping synthetic binding proteins epitopes on diverse protein targets by protein structure prediction and protein-protein docking	76
A Three-branch Jointed Feature and Topology Decoder guided by game-theoretic interactions for temporomandibular joint segmentation	75
ST-SRPerf: Continuous spatiotemporal representation for perfusion MRI super-resolution through neural ODE and implicit neural representation	75
Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study	75
Development of closed-loop modelling framework for adaptive respiratory pacemakers	75
Drug repositioning for rosacea disease: Biological TARGET identification, molecular docking, pharmacophore mapping, and molecular dynamics analysis	74
Integrating biocomputational techniques for Breast cancer drug discovery via the HER-2, BCRA, VEGF and ER protein targets	74
Identification of potential agonist-like molecules for α2-adrenergic receptor by multi-layer virtual screening to combat sinusitis	74
Adaptive nonlinear filtering algorithms for removal of non-stationary noise in electronystagmographic signals	74
HOTGpred: Enhancing human O-linked threonine glycosylation prediction using integrated pretrained protein language model-based features and multi-stage feature selection approach	73
Analysis of domain shift in whole prostate gland, zonal and lesions segmentation and detection, using multicentric retrospective data	73
DeepSMR: Decoding high-complex motor imagery via subject-dependent multi-feature refinement in deep convolutional networks	72
A method for predicting linear and conformational B-cell epitopes in an antigen from its primary sequence	72
Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics	72
Novel ensemble of optimized CNN and dynamic selection techniques for accurate Covid-19 screening using chest CT images	72
Predicting diameter and tensile strength of electrospun fibers for biomedicine: A comparison of Box-Behnken design, traditional machine learning and deep learning	72
Conditional GAN based augmentation for predictive modeling of respiratory signals	71
Performance optimization of differential evolution with slime mould algorithm for multilevel breast cancer image segmentation	71
Mass diffusion in multi-layer systems: an electrical analogue modelling approach	71

Thyroid region prior guided attention for ultrasound segmentation of thyroid nodules	71
Prostate158 - An expert-annotated 3T MRI dataset and algorithm for prostate cancer detection	71
A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis	71
Structure-based design of promising natural products to inhibit thymidylate kinase from Monkeypox virus and validation using free energy calculations	71
Detecting IDH and TERTp mutations in diffuse gliomas using 1H-MRS with attention deep-shallow networks	71
Emotion recognition in EEG signals using deep learning methods: A review	70
Effect of tumor heterogeneity on enhancing drug delivery to vascularized tumors using thermo-sensitive liposomes triggered by hyperthermia: A multi-scale and multi-physics computational model	70
KNU-DTI: KNowledge United Drug-Target Interaction prediction	70
Identification of lncRNA associated with the SERPINE1 gene in colorectal cancer through TGF-β pathway	70
A transformer-based deep neural network for arrhythmia detection using continuous ECG signals	69
Performance of multilabel machine learning models and risk stratification schemas for predicting stroke and bleeding risk in patients with non-valvular atrial fibrillation	69
Automated tool detection with deep learning for monitoring kinematics and eye-hand coordination in microsurgery	69
Predicting lung cancer survival based on clinical data using machine learning: A review	69
Quantitative computed tomography imaging-based classification of cement dust-exposed subjects with an artificial neural network technique	69
An efficient image segmentation method for skin cancer imaging using improved golden jackal optimization algorithm	69
Modelling of thrombus formation, growth and embolisation in the left atrial appendage under atrial fibrillation	69
A review of deep learning-based information fusion techniques for multimodal medical image classification	69
Quantifying the influence of combined lung and kidney support using a cardiovascular model and sensitivity analysis-informed parameter identification	67
Numerical analysis of coil designs to expedite fracture healing using dielectrophoresis with S method	67
The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia	67
Wearable-based human flow experience recognition enhanced by transfer learning methods using emotion data	67
Sparse Dynamic Volume TransUNet with multi-level edge fusion for brain tumor segmentation	66
Fine-grained food image classification and recipe extraction using a customized deep neural network and NLP	66
AELGNet: Attention-based Enhanced Local and Global Features Network for medicinal leaf and plant classification	66
Interplay of mutations, alternate mechanisms, and treatment breaks in leukaemia: Understanding and implications studied with stochastic models	65
Transcriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells	65
Molecular hybridization assisted multi-technique approach for designing USP21 inhibitors to halt catalytic triad-mediated nucleophilic attack and suppress pancreatic ductal adenocarcinoma progression:	65
COVID-19 diagnosis using state-of-the-art CNN architecture features and Bayesian Optimization	65
Validation of fluid-structure interaction simulations of the opening phase of phantom mitral heart valves under physiologically inspired conditions	65
Exploring molecular mechanisms of diazinon toxicity in HT22 hippocampal neurons through integrated miRNA and mRNA profiling	65
FIM: A fatigued-injured muscle model based on the sliding filament theory	64
PNMC: Four-dimensional conebeam CT reconstruction combining prior network and motion compensation	64
Identification of a novel gene signature for the prognosis of sepsis	64
Ce	63
Deep learning image registration for cardiac motion estimation in adult and fetal echocardiography via a focus on anatomic plausibility and texture quality of warped image	63
Characterizing patients at higher cardiovascular risk for prescribed stimulants: Learning from health records data with predictive analytics and data mining techniques	63
Two-stage data augmentation for improved ASR performance for dysarthric speech	62
DNA protein binding recognition based on lifelong learning	62
Medical application of deep-learning-based head pose estimation from RGB image sequence	62
Three-dimensional morphology scoring of hepatocellular carcinoma stratifies prognosis and immune infiltration	62
Torque modulation mechanism of the knee joint during balance recovery	62
SPMLD: A skin pathological image dataset for non-melanoma with detailed lesion area annotation	62
Automatic segmentation and classification of Papanicolaou-stained cells and dataset for oral cancer detection	61
Lightweight triangular mesh deformable reconstruction for low quality 3D organ models: Thickness noise and uneven topology	61
Enhanced single-cell RNA-seq embedding through gene expression and data-driven gene-gene interaction integration	61
Enhancing nuclei segmentation in breast histopathology images using U-Net with backbone architectures	61
Design and hierarchical analysis of magnetic actuated robot: A governing equation based approach	61
Enhancing search strategies for systematic reviews on drug Harms: An evaluation of the utility of ChatGPT in error detection and keyword generation	60
Spatiotemporal modeling of host–pathogen interactions using level-set method	60
GeneDX-PBMC: An adversarial autoencoder framework for unlocking Alzheimer's disease biomarkers using blood single-cell RNA sequencing data	59
Repeated measures analysis for steady-state evoked potentials	59
An automated parametric ear model to improve frugal 3D scanning methods for the advanced manufacturing of high-quality prosthetic ears	59
An adaptive language model-based intelligent medication assistant for the decision support of antidepressant prescriptions	59
Automated engineered-stone silicosis screening and staging using Deep Learning with X-rays	59
NIMEQ-SACNet: A novel self-attention precision medicine model for vision-threatening diabetic retinopathy using image data	58
Multilevel threshold image segmentation for COVID-19 chest radiography: A framework using horizontal and vertical multiverse optimization	58
CFD simulations of inhalation through a subject-specific human larynx – Impact of the unilateral vocal fold immobility	58
PEA-Net: A progressive edge information aggregation network for vessel segmentation	58
DYNAFormer: Enhancing transformer segmentation with dynamic anchor mask for medical imaging	57
An unsupervised image registration method employing chest computed tomography images and deep neural networks	57
Smoke veil prior regularized surgical field desmoking without paired in-vivo data	57
A response-threshold method for early cancer diagnosis and monitoring via swarms of nanorobots	57
A multiwavelet-based sparse time-varying autoregressive modeling for motor imagery EEG classification	57
CISCA and CytoDArk0: A cell instance segmentation and classification method for histo(patho)logical image Analyses and a new, open, Nissl-stained dataset for brain cytoarchitecture studies	57
A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach	57
Artificial intelligence derived categorizations significantly improve HOMA IR/β indicators: Combating diabetes through cross-interacting drugs	57
Cross attention guided multi-scale feature fusion for false-positive reduction in pulmonary nodule detection	56
Joint cardiac tissue conductivity and activation time estimation using confirmatory factor analysis	56
A regularization method to improve adversarial robustness of neural networks for ECG signal classification	56
Forecasting COVID-19 recovered cases with Artificial Neural Networks to enable designing an effective blood supply chain	56
Intelligent tuberculosis activity assessment system based on an ensemble of neural networks	56
Editorial Board	56
Genetic algorithm based image reconstruction applying the digital holography process with the Discrete Orthonormal Stockwell Transform technique for diagnosis of COVID-19	56
Biochemical reaction network topology defines dose-dependent Drug–Drug interactions	56
A fully-convolutional residual encoder-decoder neural network to localize breast cancer on histopathology images	55
Lupus nephritis diagnosis using enhanced moth flame algorithm with support vector machines	55
Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study	55
A lightweight convolutional neural network hardware implementation for wearable heart rate anomaly detection	55
Identification of telomere-associated gene signatures to predict prognosis and drug sensitivity in glioma	55
A novel multi-objective metaheuristic algorithm for protein-peptide docking and benchmarking on the LEADS-PEP dataset	55
Pathological prognosis classification of patients with neuroblastoma using computational pathology analysis	55
A bidirectional registration neural network for cardiac motion tracking using cine MRI images	55
Estimation of potassium levels in hemodialysis patients by T wave nonlinear dynamics and morphology markers	55
Lung nodule diagnosis and cancer histology classification from computed tomography data by convolutional neural networks: A survey	55
Characterization of cancer subtypes associated with clinical outcomes by multi-omics integrative clustering	55
A novel mTOR-associated gene signature for predicting prognosis and evaluating tumor immune microenvironment in lung adenocarcinoma	55
Immunoinformatics-driven In silico vaccine design for Nipah virus (NPV): Integrating machine learning and computational epitope prediction	54
Bone marrow sparing oriented multi-model image registration in cervical cancer radiotherapy	54
Cancer-inspired genomics mapper model for the generation of synthetic DNA sequences with desired genomics signatures	54
A sleep staging model on wavelet-based adaptive spectrogram reconstruction and light weight CNN	54
Systematic comparison of genome information processing and boundary recognition tools used for genomic island detection	54
Prediction of drug-target interactions via neural tangent kernel extraction feature matrix factorization model	54
A multimodal deep learning framework for enzyme turnover prediction with missing modality	54
Radiology report generation using automatic keyword adaptation, frequency-based multi-label classification and text-to-text large language models	54
Enclosing 95% confidence area and volume to center of pressure and center of mass in posturography using optimization algorithm and coordinate ascent methods	54