Epilepsia

Article	Citations
	526
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	524
	275
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	223
	171
Erratum	159
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	139
Thank you to our Reviewers	132
Role of cholesterol in modulating brain hyperexcitability	101
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	99
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	94
Neurocardiac pathologies associated with potassium channelopathies	93
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	88
Levetiracetam dosing in patients receiving continuous renal replacement therapy	87
Self‐esteem mediates mental health outcomes in young people with epilepsy	84
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy	81
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	80
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	77
Comment on: Failure to use new breakthrough treatments for epilepsy	76
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	75
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	73
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	70
Optimizing external validation of deep neural networks for interictal discharge detection	70
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	69
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	67

Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures	64
Prediction of long‐term unprovoked seizures after status epilepticus	64
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	61
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	60
Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor	57
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	56
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	55
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	55
Decision‐making in stereotactic epilepsy surgery	54
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	54
Sleep, oscillations, and epilepsy	54
Issue Information	53
Epilepsia – January 2023 – Announcements	53
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	52
Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	52
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	49
Increasing challenges to trial recruitment and conduct over time	48
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	48
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	47
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	47
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	46
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	46
Effect of levetiracetam on the gene expression of placental transporters in a murine model	46
Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function	45
Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy	44
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	43
Cognitive phenotypes in frontal lobe epilepsy	43
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	43
The nuances of immunotherapy for NORSE/FIRES	42
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	42
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	42
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	41
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	41
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	40
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	40
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	40
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	40
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	39
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	39
Long‐term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: Open‐label extension of a randomized clinical study	39
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	38
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	38
	37
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy	37
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	36
Perampanel as precision therapy in rare genetic epilepsies	36
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique	36
Long‐term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program	36
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	36
Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	35

Author Index	34
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	34
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	34
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	34
High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study	34
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	34
Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study	34
An interview with Margherita Contento, 2022 Epilepsia Prize winner for clinical research	33
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	33
Toward personalized machine learning approaches in care of patients with epilepsy	33
Reproduction and genetic causal attribution of epilepsy	31
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings	31
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	31
Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment?	31
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	31
Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy	31
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	30
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	30
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	30
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	30
Cenobamate efficacy in specific populations	30
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	30
Issue Information	30
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	30
Corrigendum	29
Quantitative EEG biomarkers for STXBP1‐related disorders	29
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	29
Issue Information	28
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	28
Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	28
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	28
Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?	28
Long‐term seizure outcomes in patients with hypothalamic hamartoma treated by stereotactic radiofrequency thermocoagulation	28
Metabolomic changes in adults with status epilepticus: A human case–control study	27
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	27
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	27
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	27
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	27
Efficacy, tolerability, and retention of fenfluramine for the treatment of seizures in patients with Dravet syndrome: Compassionate use program in Germany	27
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways	27
Fully automated detection of focal cortical dysplasia: Comparison of MPRAGE and MP2RAGE sequences	26
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	26
Understanding cardiovascular disease in older adults with epilepsy	26
Carbon emission savings and short‐term health care impacts from telemedicine: An evaluation in epilepsy	26
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	26
Epilepsia – October 2021 – Announcements	25
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	25
Issue Information	25
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	25
Epilepsia—October 2023—Announcements	25
Epilepsia – September 2021 – Announcements	25
Epilepsia – January 2025 Announcements	25
Vitamin D prophylaxis in persons with epilepsy?	24
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	24
	24
An interview with Shruthi Iyer, 2021 Epilepsia Prize Winner for Basic Science Research	24
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	24
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	24
Understanding long‐term changes in patient identity 15–20 years after surgery for temporal lobe epilepsy	24
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	23
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	23
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	23
Farewell from the Editor‐in‐Chief	23
Latent class analysis of eHealth behaviors among adults with epilepsy	23
Early alterations of the neuronal network processing whisker‐related sensory signal during absence epileptogenesis	23
Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions	23
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	23
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	23
Creating rare epilepsy cohorts using keyword search in electronic health records	23
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	23
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	23
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	23
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	22
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	22
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	22
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	22
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	22
Gut microbiota modulates seizure susceptibility	22
Lacosamide decreases neonatal seizures without increasing apoptosis	22
Learning to generalize seizure forecasts	22

Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	21
Early life seizures and epileptic spasms in STXBP1‐related disorders	21
Epileptic heart: A clinical syndromic approach	21
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A systematic review and meta‐analysis	21
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	21
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	21
Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	21
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Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	21
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	21
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	21
Issue Information	21
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	21
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	20
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	20
Satellite Symposium	20
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	20
Epilepsia – June 2024 Announcements	20
Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials	20
	20
Epilepsia – May 2023 – Announcements	20
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	20
Issue Information	20
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	20
Drug resistance in epilepsy: A reappraisal of the definition is needed	19
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	19
Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review	19
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	19
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	19
Status epilepticus suspected autoimmune: Neuronal surface antibodies and main clinical features	19
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	19
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	19
Anticonvulsant dopamine type 2 receptor agonist activates inhibitory parvalbumin interneurons	19
Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy	19
Antiseizure medications in the World Health Organization list of “essential medicines”	19
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	18
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	18
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	18
Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force	18
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	18
Putative roles for homeostatic plasticity in epileptogenesis	18
Brain molecular mechanisms in Rasmussen encephalitis	18
Quantitative analysis of visually reviewed normal scalp EEG predicts seizure freedom following anterior temporal lobectomy	18
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	18
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	18
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	18
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	18
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	18
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	18
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	18
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	18
Epilepsia – September 2023 – Announcements	17
Electroconvulsive therapy for super refractory status epilepticus: A scoping review	17
Seizures and stigmas: Double burden on transgender health	17
Telemedicine as a path to bridging inequities in patients with epilepsy	17
Sudden unexpected death in epilepsy during cenobamate clinical development	17
Epilepsia – February 2022 – Announcements	17
Differential functional connectivity of amygdala in drug‐resistant temporal lobe epilepsy	17
Issue Information	17
Automated detection of interictal epileptiform discharges with few electroencephalographic channels	17
Practical considerations in epilepsy neurostimulation	17
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	17
Fast activity chirp patterns in focal seizures from patients and animal models	17
Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy	17
Epilepsia – December 2021 – Announcements	17
Insights from stereoelectroencephalography in KCNT1‐related focal epilepsy suggest a multifocal and migrating epileptogenic network	17
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions	17
Introduction to the epilepsy syndrome papers	17
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	17
Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry	17
Reappraisal of the Medical Research Council Antiepileptic Drug Withdrawal Study: Contamination‐adjusted and dose‐response re‐analysis	16
A national study of epilepsy‐related deaths in Scotland: Trends, mechanisms, and avoidable deaths	16
Substantial early changes in bone and calcium metabolism among adult pharmacoresistant epilepsy patients on a modified Atkins diet	16
Disrupting the epileptogenic network with stereoelectroencephalography‐guided radiofrequency thermocoagulation	16
Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula	16
Utility of 18F‐fluorodeoxyglucose positron emission tomography in presurgical evaluation of patients with epilepsy: A multicenter study	16
Seizures in anti‐Hu–associated extra‐limbic encephalitis: Characterization of a unique disease manifestation	16
Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system	16
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti‐seizure medications	16
Seizure‐onset zone lateralization in temporal lobe epilepsy using 7T rs‐fMRI: Direct comparison with 3T rs‐fMRI	16
Stereo‐EEG–based ictal functional connectivity in patients with periventricular nodular heterotopia–related epilepsy	16
Cross‐cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE)	16
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy	16
Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study	16
An interview with Riccardo De Feo, 2023 Epilepsia Prize winner for Basic Science Research	16
Long‐term intellectual and developmental outcomes after pediatric epilepsy surgery: A systematic review and meta‐analysis	16
Insights into familial adult myoclonus epilepsy pathogenesis: How the same repeat expansion in six unrelated genes may lead to cortical excitability	16
Prediction of epilepsy after stroke: Proposal of a modified SeLECT 2.0 score based on posttreatment stroke outcome	16
Association between pediatric traumatic brain injury and epilepsy at later ages in Finland: A nationwide register‐based cohort study	16
A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam	16
Prediction of seizure recurrence risk following discontinuation of antiepileptic drugs	16
Assessing seizure burden in pediatric epilepsy using an electronic medical record–based tool through a common data element approach	16
From theory to practical fundamentals of electroencephalographic source imaging in localizing the epileptogenic zone	16
Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study	16
Seizure detection using wearable sensors and machine learning: Setting a benchmark	15