Epilepsia

Article	Citations
	585
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	576
	302
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	233
Erratum	185
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy	181
Thank you to our Reviewers	152
Role of cholesterol in modulating brain hyperexcitability	142
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	110
Decision‐making in stereotactic epilepsy surgery	106
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	102
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	96
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	94
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	88
Neurocardiac pathologies associated with potassium channelopathies	84
Comment on: Failure to use new breakthrough treatments for epilepsy	84
Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures	82
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	81
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	79
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	74
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	74
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	73
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	73
Prediction of long‐term unprovoked seizures after status epilepticus	72
The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment	71

Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	66
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	60
Sleep, oscillations, and epilepsy	60
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	60
Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia	59
Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor	59
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	58
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	56
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	56
Optimizing external validation of deep neural networks for interictal discharge detection	54
Epilepsia – January 2023 – Announcements	52
Issue Information	51
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	49
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	49
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	48
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	48
Altered thalamic connectivity patterns in pediatric temporal lobe epilepsy: A gradient mapping study	48
Increasing challenges to trial recruitment and conduct over time	46
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	45
Effect of levetiracetam on the gene expression of placental transporters in a murine model	44
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	43
Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function	43
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	43
The nuances of immunotherapy for NORSE/FIRES	42
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	41
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	40
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	40
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	40
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	40
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique	40
Cognitive phenotypes in frontal lobe epilepsy	40
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	40
	40
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	38
Phase 1 study of ABI‐009 (nab‐rapamycin) for surgically refractory epilepsy (RaSuRE)	38
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	38
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	38
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	37
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	36
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	36
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities	36
Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults	35
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	34
Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome	33
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	32
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy	32
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	32
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	32
Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	32
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	32

Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	32
Long‐term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program	31
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	31
Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy	31
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	31
Perampanel as precision therapy in rare genetic epilepsies	31
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	30
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	30
Reproduction and genetic causal attribution of epilepsy	30
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	30
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	30
Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment?	30
An interview with Margherita Contento, 2022 Epilepsia Prize winner for clinical research	30
Author Index	30
Toward personalized machine learning approaches in care of patients with epilepsy	30
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings	30
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	29
Corrigendum	29
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	29
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	29
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	29
Cenobamate efficacy in specific populations	29
Issue Information	29
Issue Information	28
Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?	28
Quantitative EEG biomarkers for STXBP1‐related disorders	28
Metabolomic changes in adults with status epilepticus: A human case–control study	28
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	27
Fully automated detection of focal cortical dysplasia: Comparison of MPRAGE and MP2RAGE sequences	27
Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study	27
Carbon emission savings and short‐term health care impacts from telemedicine: An evaluation in epilepsy	27
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	27
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	27
Extracting epilepsy‐related information from unstructured clinic letters using large language models	27
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	26
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	26
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	26
Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy	26
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	26
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	26
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	26
High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study	26
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways	26
Efficacy, tolerability, and retention of fenfluramine for the treatment of seizures in patients with Dravet syndrome: Compassionate use program in Germany	26
Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study	26
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	26
Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study	25
Epilepsia – October 2021 – Announcements	25
Epilepsia – January 2025 Announcements	25
Long‐term seizure outcomes in patients with hypothalamic hamartoma treated by stereotactic radiofrequency thermocoagulation	25
Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	25
Issue Information	25
Epilepsia—October 2023—Announcements	25
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	25
Splicing variants in DEPDC5‐related epilepsies: From functional characterization to correction	25
Epilepsia – September 2021 – Announcements	25
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	24
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	24
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	24
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	24
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Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	23
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	23
Early life seizures and epileptic spasms in STXBP1‐related disorders	23
Learning to generalize seizure forecasts	23
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	23
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	23
Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	23
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	23
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	23
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study	22
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	22
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	22
Understanding long‐term changes in patient identity 15–20 years after surgery for temporal lobe epilepsy	22
Creating rare epilepsy cohorts using keyword search in electronic health records	22
Latent class analysis of eHealth behaviors among adults with epilepsy	22
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	22
Farewell from the Editor‐in‐Chief	22
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	22
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	21

Early alterations of the neuronal network processing whisker‐related sensory signal during absence epileptogenesis	21
Vitamin D prophylaxis in persons with epilepsy?	21
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	21
Lacosamide decreases neonatal seizures without increasing apoptosis	21
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	20
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	20
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	20
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Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	20
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	20
Role of vitamin D supplementation and vitamin D receptor in drug‐resistant epilepsy: A double‐blind placebo‐controlled trial conducted in India	20
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	20
Epilepsia – May 2023 – Announcements	20
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	20
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	20
Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	20
Issue Information	20
Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force	19
	19
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions	19
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	19
Fast activity chirp patterns in focal seizures from patients and animal models	19
Issue Information	19
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A systematic review and meta‐analysis	19
Telemedicine as a path to bridging inequities in patients with epilepsy	19
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	19
Introduction to the epilepsy syndrome papers	19
Satellite Symposium	19
Status epilepticus suspected autoimmune: Neuronal surface antibodies and main clinical features	19
Brain molecular mechanisms in Rasmussen encephalitis	19
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	19
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	19
Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials	18
Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review	18
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	18
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	18
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	18
Epilepsia – June 2024 Announcements	18
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	18
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	18
Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy	18
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	18
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	18
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	18
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	18
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	18
Sudden unexpected death in epilepsy during cenobamate clinical development	18
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	17
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	17
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	17
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	17
Practical considerations in epilepsy neurostimulation	17
Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy	17
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	17
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	17
Drug resistance in epilepsy: A reappraisal of the definition is needed	17
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	17
Epilepsia – February 2022 – Announcements	17
Epilepsia – September 2023 – Announcements	17
Antiseizure medications in the World Health Organization list of “essential medicines”	17
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	17
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	17
Putative roles for homeostatic plasticity in epileptogenesis	17
Quantitative analysis of visually reviewed normal scalp EEG predicts seizure freedom following anterior temporal lobectomy	17
Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry	17
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	17
An interview with Riccardo De Feo, 2023 Epilepsia Prize winner for Basic Science Research	16
Pharmacokinetics and 180‐day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2–5 years	16
Disrupting the epileptogenic network with stereoelectroencephalography‐guided radiofrequency thermocoagulation	16
Seizure outcomes after resection of temporal encephalocele in patients with drug‐resistant epilepsy: A systematic review and meta‐analysis	16
Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study	16
Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system	16
Development and validation of machine learning models for prediction of seizure outcome after pediatric epilepsy surgery	16
Association between pediatric traumatic brain injury and epilepsy at later ages in Finland: A nationwide register‐based cohort study	16
Variants in CSMD2 and CSMD3, genes involved in synaptogenesis, are associated with epilepsies	16
Substantial early changes in bone and calcium metabolism among adult pharmacoresistant epilepsy patients on a modified Atkins diet	16
Seizures in anti‐Hu–associated extra‐limbic encephalitis: Characterization of a unique disease manifestation	16
Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile	16
Issue Information	16
Sustainability of seizure reduction and seizure control with adjunctive cenobamate: Post hoc analysis of a phase 3, open‐label study	16
Stereo‐EEG–based ictal functional connectivity in patients with periventricular nodular heterotopia–related epilepsy	16
Epilepsia – December 2021 – Announcements	16
Prediction of epilepsy after stroke: Proposal of a modified SeLECT 2.0 score based on posttreatment stroke outcome	16
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti‐seizure medications	16
Incidence of sudden unexpected death in epilepsy in New Zealand: A prospective population‐wide, 2‐year study	15
Identification of a new retigabine derivative with improved photostability for selective activation of neuronal Kv7 channels and antiseizure activity	15
Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula	15
Electroconvulsive therapy for super refractory status epilepticus: A scoping review	15
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy	15
Cross‐cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE)	15
Seizure‐onset zone lateralization in temporal lobe epilepsy using 7T rs‐fMRI: Direct comparison with 3T rs‐fMRI	15
Long‐term intellectual and developmental outcomes after pediatric epilepsy surgery: A systematic review and meta‐analysis	15
Reappraisal of the Medical Research Council Antiepileptic Drug Withdrawal Study: Contamination‐adjusted and dose‐response re‐analysis	15
A national study of epilepsy‐related deaths in Scotland: Trends, mechanisms, and avoidable deaths	15
Automated detection of interictal epileptiform discharges with few electroencephalographic channels	15