European Journal of Clinical Investigation

Article	Citations
	158
Elevated factor XIa as a modulator of plasma fibrin clot properties in coronary artery disease	108
ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function	89
Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review	83
Combination therapy with an SGLT‐2 inhibitor and finerenone in DKD: Are we there yet?	78
Effects of glucagon‐like PEPTIDE‐1 receptor agonists on incidence of hepatocellular carcinoma and liver decompensation in patients with diabetes: A systematic review and META‐analysis	51
Progress and challenges in the symbiosis of AI with science and medicine	45
Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion	45
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study	45
Human blood metabolites and risk of severe COVID‐19: A Mendelian randomization study	43
New insights into Covid‐19 disease. Apo‐A1 antibodies are generated after mRNA Covid‐19 vaccination and after Covid‐19 infection	40
Clinical predictors of late SARS‐CoV‐2 positivity in Italian internal medicine wards	40
Hydrogen sulphide: Diabetic cardiomyopathy as the paradigm of its pleiotropic function	38
Effects of pharmacological inhibition of hyaluronic acid synthesis on experimental endometriosis	37
Does hospitalisation improve oral anticoagulant optimisation in patients with atrial fibrillation?	37
Issue Information	34
rFVIII‐Fc in severe haemophilia A: The incentive switch in case of high risk of joint bleedings	34
Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus	32
Impact of sirolimus on long‐term adverse cardiovascular outcomes in kidney transplant recipients: A nationwide cohort study	31
Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease	31
Correction to ‘Association Between Exposure to Air Pollution and Blood Lipids in the General Population of Spain’	30
Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants	29
Issue Information	29
Social determinants of health and cardiovascular outcomes in patients with heart failure	28
Adipocyte maturation impacts daunorubicin disposition and metabolism	28

Glucagon and glucagon‐like peptide‐1 dual agonist therapy: A possible future towards fatty kidney disease	28
The use of the Crohn's disease exclusion diet (CDED) in adults with Crohn's disease: A randomized controlled trial	27
The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections	27
The glucagon‐like peptide‐1 receptor agonist semaglutide in diabetic kidney disease: A new kid on the block to afford maximal kidney protection	26
Blood pressure measurement for prediction of chronic pressure overload and cardiovascular events	26
Mineralocorticoid receptor antagonists in kidney transplantation	25
Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta‐analysis	25
Short‐ and long‐term risk stratification in acutely ill medical patients by implementing ankle‐brachial index and pulse wave velocity in the emergency setting	25
Prognostic significance of echocardiographic deformation imaging in adult congenital heart disease	25
A precise review on NAATs‐based diagnostic assays for COVID‐19: A motion in fast POC molecular tests	24
The hinge‐1 domain of Flna is not necessary for diverse physiological functions in mice	24
MyofAPPcial: Construct validity of a novel technological aid for improving clinical reasoning in the management of myofascial pain syndrome	23
Markedly elevated serum preoperative thyroglobulin predicts radioiodine‐refractory thyroid cancer	23
Automatic reorientation algorithm for myocardial perfusion SPECT using segmentation	23
Mental stress as a trigger of cardiovascular events: A narrative review	22
Carcinoembryonic antigen‐related cell adhesion molecule 1 in cancer: Blessing or curse?	22
Incretin system and glucagon secretion in patients with chronic pancreatitis	21
Impaired fibrin clot lysis is associated with increased mortality in patients after coronary artery bypass grafting: A long‐term follow‐up study	21
BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis	21
Cardiac proteomic profiling suggests that hypertrophic and dilated cardiomyopathy share a common pathogenetic pathway of the calcium signalling pathway	21
Concerns regarding interpretation in systematic review of exercise and endothelial glycocalyx	20
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Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non‐alcoholic steatohepatitis	20
Refining the role of presurgical PET/4D‐CT in a large series of patients with primary hyperparathyroidism undergoing [18F]Fluorocholine PET/CT	20
Deep brain stimulation of fornix in Alzheimer's disease: From basic research to clinical practice	20
ALKBH1 contributes to renal cell carcinoma progression by reducing N6‐methyladenine of GPR137	20
No evidence linking sleep traits with white blood cell counts: Multivariable‐adjusted and Mendelian randomization analyses	19
Coronary artery calcium score and its association with stroke: A systematic review and meta‐analysis	19
Type 2 diabetes and chronic kidney disease as long‐term predictors of cardiovascular events in patients with coronary artery disease	19
Osteopontin is associated with neutrophil extracellular trap formation in elderly patients with severe sepsis	19
The sodium–chloride difference: A marker of prognosis in patients with acute myocardial infarction	19
Issue Information	19
ELOVL2‐methylation and renal and cardiovascular event in patients with chronic kidney disease	19
The role of mean platelet volume in metabolic dysfunction associated steatotic liver disease	18
Issue Information	18
Associations of 50 modifiable risk factors with atrial fibrillation using Mendelian randomization analysis	18
The ABCG8 polymorphism increases the risk of gallbladder cancer in the general population and gallstones in obese patients from Poland	18
Age‐related differences in cardiogenic shock secondary to Takotsubo syndrome	18
Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions	17
Elevated factor XI is associated with recurrent left ventricular thrombus of unknown origin	17
Differential utility of various frailty diagnostic tools in non‐geriatric hospital departments of several countries: A longitudinal study	17
What determines health professionals’ COVID‐19 vaccine hesitancy? A nationwide study	17
The urotensin‐II receptor: A marker for staging and steroid outcome prediction in ulcerative colitis	17
Cardiovascular benefits of early rhythm control and healthy lifestyle in young atrial fibrillation	17
Focal high‐intensity focused ultrasound therapy for localized prostate cancer: An interim analysis of the multinational FASST study	17
The influence of hypoxia‐mediated CEACAM6 upregulation on epithelial cell and macrophage response in the context of gastric cancer	17
Percutaneous coronary revascularization versus medical therapy in chronic coronary syndromes: An updated meta‐analysis of randomized controlled trials	17
Off‐label underdosing of four individual NOACs in patients with nonvalvular atrial fibrillation: A systematic review and meta‐analysis of observational studies	17
Cognitive impairment and endothelial dysfunction in convalescent COVID‐19 patients undergoing rehabilitation	17
Temporal trends of gender disparities in oral anticoagulant use in patients with atrial fibrillation	17

Statin treatment reduces protein carbonylation in patients with COPD: A randomized controlled study	16
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Issue Information	16
Author index	16
Serum fibulin‐1 levels and target organ damage in patients at high cardiovascular risk: A prospective observational study	16
Fatigue and itch severity in patients with PBC and PSC: Prospective analysis of two large cohorts	16
Constructive and obsessive criticism in science	16
Association between CMR‐derived hepatic T1‐time, tricuspid regurgitation and survival	16
Novel cutting edge nano‐strategies to address old long‐standing complications in cardiovascular diseases. A comprehensive review	15
Risk of gonadotoxicity with immunotherapy and targeted agents remains an unsolved but crucial issue	15
The association between the basal metabolic rate and cardiovascular disease: A two‐sample Mendelian randomization study	15
Cystatin C‐estimated GFR correlates with endothelial function improvements following bariatric surgery	15
Targeting the SPHK1/S1P/S1PR2 axis ameliorates GH‐secreted pituitary adenoma progression	15
Artificial‐intelligence‐based decision support tools for the differential diagnosis of colitis	15
Increased epicardial nerves and decreased intramyocardial PVAT in acute myocardial infarction	15
Synovial expression of glucocorticoid receptor parallels fibroblast activation in patients with rheumatoid arthritis	15
Mortality after transvenous lead extraction: A risk prediction model for sustainable care delivery	15
Role of the electrocardiogram in differentiating genetically determined dilated cardiomyopathy from athlete's heart	14
Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades	14
Impact of stroke history on procedural cerebrovascular insult probability and long‐term outcome after TAVI	14
Association between the use of lipid‐lowering drugs and the risk of inflammatory bowel disease	14
Artificial intelligence evaluation of coronary computed tomography angiography for coronary stenosis classification and diagnosis	14
Residual risk prediction in anticoagulated patients with atrial fibrillation using machine learning: A report from the GLORIA‐AF registry phase II/III	14
Open Access Publications is our mission in 2022: perspective from the editors of the European Journal of Clinical Investigation	14
Issue Information	14
A systematic review and meta‐analysis on oncological radiotherapy in patients with a cardiac implantable electronic device: Prevalence and predictors of device malfunction in 3121 patients	13
Hypercholesterolemia and inflammation—Cooperative cardiovascular risk factors	13
PD‐L1 expression pattern as predictive factor of biological behaviour in intracranial meningiomas: A single‐center retrospective study	13
Circulating haematopoietic stem cells and long‐term outcomes of COVID‐19	13
Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization	13
The role of artificial intelligence in cardiovascular research: Fear less and live bolder	13
Nomogram for stratifying patients with lifelong premature ejaculation before using the PHQ‐9: An observational study	13
Respiratory dysfunction in old mice could be related to inflammation and lung fibrosis induced by hyperphosphatemia	12
Total lesion glycolysis is a promising predictor of chemo‐response in pancreatic cancer patients treated with neoadjuvant chemotherapy prior to surgery	12
In‐house editorials and journalistic pieces comprise a massive corpus in the scientific literature that can be improved	12
Advanced biomedical imaging for accurate discrimination and prognostication of mediastinal masses	12
Antithrombotic therapy and clinical outcomes at 1 year in the Spanish cohort of the EORP‐AF Long‐term General Registry	12
Membrane oxygenator longevity was higher in argatroban‐treated patients undergoing vvECMO	12
The effect of subcutaneous dulaglutide on weight loss in patients with Type 2 diabetes mellitus: Systematic review and meta‐analysis of randomized controlled trials	12
Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore	12
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Protective effects of avasopasem manganese (GC4419) against sepsis‐induced acute lung injury: A comprehensive experimental study	12
Abstract	12
Anthropometric measures, predicted visceral adipose tissue and biomarkers of chronic inflammation	12
Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update	12
Issue Information	12
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When less is more: The association between the expression of polymorphic CYPs and AFB1‐induced HCC	12
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Burden of hypertensive heart disease and its attributable risk factors in 204 countries and territories, 1990–2021: Results from the global burden of disease study 2021	12
Clinical outcomes of transcatheter edge‐to‐edge repair in patients with functional mitral regurgitation and pulmonary hypertension	12
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Fatty kidney: A possible future for chronic kidney disease research	12
Issue Information	12
Issue Information	12
Reciprocity between the regulation of the expression and functions of CEACAM	12
Clinical measures in chronic neuropathic pain are related to the Kennedy and endocannabinoid pathways	11
Evidence base for yearly respiratory virus vaccines: Current status and proposed improved strategies	11
Issue Information	11
Prehospital seizures: Short‐term outcomes and risk stratification based in point‐of‐care testing	11
Prognostic impact of abnormal sodium burden in heart failure patients with preserved ejection fraction	11
CHA2DS2‐VASc impact on risk following percutaneous coronary intervention in atrial fibrillation	11
Association of aortic stiffness early post myocardial infarction with left ventricular remodelling	11
Issue Information	11
Shorter periconception maternal telomere length and the risk of congenital cardiac outflow defects in the offspring	11
Impact of prior oral anticoagulation therapies on post‐discharge outcomes after COVID‐19: Results from a global federated health network analysis	11
Issue Information	11
Long‐term risk of delayed postoperative Crohn's disease recurrence in patients with no or mild endoscopic recurrence at first assessment	11
Issue Information	10
Microvascular disease increases the risk of lower limb amputation – A Western Danish cohort study	10
Issue Information	10
Circulation tumour DNA in predicting recurrence and prognosis in operable colorectal cancer patients: A meta‐analysis	10
Machine learning in cardiovascular risk assessment: Towards a precision medicine approach	10
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Risk prediction of atrial fibrillation and its complications in the community using hs troponin I	10
Triglyceride‐glycaemic index: Insights into predicting fetal macrosomia and its interaction with gestational diabetes mellitus: A cohort study of Chinese pregnant women	10
Localization of accessory pathways in Wolff‐Parkinson‐white syndrome using ECG‐based multi‐task deep learning	10
Targeting nicotinamide N‐methyltransferase decreased aggressiveness of osteosarcoma cells	10
The role of microbiota in nonalcoholic fatty liver disease	10
Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients	10

Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux	10
Novel 3D versus traditional transesophageal echocardiography techniques: Defining differences in the diagnosis of infective endocarditis	10
Six‐minute walking distance and desaturation–distance ratio in allogeneic stem cell transplantation	10
Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers—Results from the study of health in Pomerania	9
Abnormal circulating steroids refine risk of progression to heart failure in ischemic heart disease	9
Poor self‐reported sleep is associated with risk factors for cardiovascular disease: A cross‐sectional analysis in half a million adults	9
Issue Information	9
Increased body mass index is associated with sarcopenia and related outcomes	9
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Low triiodothyronine syndrome is associated with stroke‐associated pneumonia	9
Ambulatory central BP and arterial stiffness in patients with and without intradialytic hypertension	9
Sex disparities for patients with atrial fibrillation in the direct oral anticoagulant era	9
The autonomic nervous system and bone health in chronic kidney disease	9
Gender differences on healthcare accessibility and outcomes of a electronic inter‐clinician consultation program at the cardiology department in a Galician Health Area	9
Decompressive surgery in cerebral venous thrombosis: A systematic review and meta‐analysis	9
Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility	9
Recent advances in multimodality imaging‐guided therapy in pericarditis	9
56th Annual Scientific Meeting, 8–10 June 2022, Bari, Italy, “Promoting Biomedical Research, Equal Health and Environment in the post‐COVID Syndemic Era”	9
Preprocedural assessment of coronary artery disease in patients undergoing transcatheter aortic valve implantation: Rationale and design of the EASE‐IT CT registry	9
Sotatercept in pulmonary hypertension and beyond	9
Promising biomarker panel to monitor therapeutic efficacy of neoadjuvant chemotherapy in pancreatic cancer patients	9
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One‐hour post‐load glucose and subclinical left atrial myocardial dysfunction in hypertensive patients	9
First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry	8
Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis	8
Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20–23 September 2024. Würzburg, Germany	8
Zinc finger proteins and ATP‐binding cassette transporter‐dependent multidrug resistance	8
Meta‐analysis of factors associated with antidiabetic drug prescribing for type 2 diabetes mellitus	8
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Impact of oncologic diseases on outcome in patients with severe isolated tricuspid regurgitation	8
LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR‐539‐5p/CXCL1 axis	8
Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019	8
Distant metastasis and prognostic factors in patients with invasive ductal carcinoma of the breast	8
The influence of viral protein R amino acid substitutions on clinical outcomes in people living with HIV: A systematic review	8
Frailty trajectories in community‐dwelling older adults during COVID‐19 pandemic: The PRESTIGE study	8
A Mendelian randomization study on causal effects of leisure sedentary behaviour on the risk of rheumatoid arthritis	8
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Heart failure in patients is associated with downregulation of mitochondrial quality control genes	8
Common misconceptions of randomized controlled trials in oncology	8
ESCI Newsletter	8
Depression in nonalcoholic fatty liver disease and all‐cause/cause‐specific mortality	8
Risk of cardiovascular disease in elderly subjects with obesity and liver fibrosis and the potential benefit of statin treatment	8
Use of rivaroxaban attenuates renal function impairment in patients with atrial fibrillation: insights of the EMIR study	8
The biology of lipoprotein(a): From genetics to molecular mechanisms	8
Liraglutide modulates morpho‐functional and inflammatory gastrointestinal responses in rats	8
Issue Information	8
The definition of long COVID used in interventional studies	8
Cancer and cardiovascular diseases: A deadly combination	8
Issue Information	8
Assessing cardiorespiratory fitness relative to sex improves surgical risk stratification	8
Deep learning for electrocardiogram interpretation: Bench to bedside	8
Effects of NAD+ precursors on blood pressure, C‐reactive protein concentration and carotid intima‐media thickness: A meta‐analysis of randomized controlled trials	8
Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus	7
Issue Information	7
Issue Information	7
Machine learning prediction of moderate‐to‐severe acute kidney injury after ICU admission and cardiac surgery with urine trace elements	7
Serological markers and long COVID—A rapid systematic review	7
Erythrocyte membrane fluidity: A novel biomarker of residual cardiovascular risk in type 2 diabetes	7
Enhanced neutrophil extracellular traps formation in AF patients with dilated left atrium	7
Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study	7
miR‐619‐5p and cardiogenic shock in patients with ST‐segment elevation myocardial infarction	7
Sexual dimorphism in exercise‐induced response on steroid hormones to a 24‐week supervised concurrent training intervention	7
An online nomogram of acute respiratory distress syndrome originating from pulmonary disease	7
‘Obesities’: Position statement on a complex disease entity with multifaceted drivers	7
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Familial hypercholesterolemia is related to cardiovascular disease, heart failure and atrial fibrillation. Results from a population‐based study	7
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Issue Information	7
Corrigendum	7
Fatal attractions that trigger inflammation and drive atherosclerotic disease	7
Major bleeding in patients with pulmonary embolism presenting with syncope	7
Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: The X‐COVID‐19 Randomized Trial	7
Angiotensin converting enzyme 2 level and its significance in COVID‐19 and other diseases patients	7
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Sex‐associated differences in cardiac ageing: Clinical aspects and molecular mechanisms	7
A weekly 4‐methylpyrazole treatment attenuates the development of non‐obese metabolic dysfunction‐associated steatotic liver disease (MASLD) in male mice: Role of JNK	7