European Journal of Clinical Investigation

Article	Citations
The ‘new normality’ in research? What message are we conveying our medical students?	126
Heart and vessels ‘on fire’	94
rFVIII‐Fc in severe haemophilia A: The incentive switch in case of high risk of joint bleedings	91
Circ_0021087 acts as a miR‐184 sponge and represses gastric cancer progression by adsorbing miR‐184 and elevating FOSB expression	78
Preprocedural assessment of coronary artery disease in patients undergoing transcatheter aortic valve implantation: Rationale and design of the EASE‐IT CT registry	75
Suboptimal monitoring and management in patients with unrecorded stage 3 chronic kidney disease in real‐world settings: Insights from REVEAL‐CKD	73
Fructooligosaccharides reverses hepatic vascular dysfunction and dysbiosis in rats with liver cirrhosis and portal hypertension	70
Sotatercept in pulmonary hypertension and beyond	64
A scoping review evaluating the current state of gut microbiota and its metabolites in valvular heart disease physiopathology	46
The autonomic nervous system and bone health in chronic kidney disease	44
Antiangiogenic effect of circulating extracellular vesicles in acute coronary syndrome: Role of miR‐199a‐3p and miR‐125a‐5p	43
Editorial to ‘A score for predicting invasive pulmonary aspergillosis in immunocompetent critically ill patients’	40
From A to E: Uniting vitamins against stroke risk—A systematic review and network meta‐analysis	36
Issue Information	36
De Ritis ratio and long‐term major cardiovascular adverse events in patients undergoing elective percutaneous coronary intervention	36
COVID‐19 illness: Different comorbidities may require different immunological therapeutic targets	35
Routine beta‐blocker therapy after acute coronary syndromes: The end of an era?	33
Impact of vitamin D supplementation on markers of bone turnover: Systematic review and meta‐analysis of randomised controlled trials	33
Effects of pharmacological inhibition of hyaluronic acid synthesis on experimental endometriosis	32
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Issue Information	31
Predictive value of quality of life as measured by KCCQ in heart failure patients: A meta‐analysis	29
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Impact of alcohol consumption on metabolic dysfunction‐associated fatty liver disease development and remission: A longitudinal cohort study	29
The use of the Crohn's disease exclusion diet (CDED) in adults with Crohn's disease: A randomized controlled trial	29

Clustering of blood cell count abnormalities and future risk of death	28
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Serum vaspin levels and carotid intima‐media thickness in predialysis patients	27
Science and the social media: Time for a reset	27
Issue Information	26
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Abstract	25
Prognostic value of haemoglobin drop in patients with acute coronary syndromes	23
Decompressive surgery in cerebral venous thrombosis: A systematic review and meta‐analysis	23
Social determinants of health and cardiovascular outcomes in patients with heart failure	23
Prognostic implications of traditional and non‐traditional cardiovascular risk factor profiles in patients with non‐valvular atrial fibrillation	23
Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion	23
Genome‐wide DNA methylation analysis of body composition in Chinese monozygotic twins	23
Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus	22
56th Annual Scientific Meeting, 8–10 June 2022, Bari, Italy, “Promoting Biomedical Research, Equal Health and Environment in the post‐COVID Syndemic Era”	22
Issue Information	22
Batch‐dependent safety of the BNT162b2 mRNA COVID‐19 vaccine	22
Gender differences on healthcare accessibility and outcomes of a electronic inter‐clinician consultation program at the cardiology department in a Galician Health Area	22
Risk prediction of atrial fibrillation and its complications in the community using hs troponin I	22
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Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease	21
Prevalence and management of tuberculosis infection in Apulian rheumatologic patients treated with biologics: An observational cohort 10‐year study from the BIOPURE registry	21
Interferon lambda 3 in the early phase of coronavirus disease‐19 can predict oxygen requirement	20
Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review	20
ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function	20
Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease	20
Palliative care of COVID‐19 patients with do‐not‐resuscitate status in underrepresented minorities	20
Issue Information	18
Genetic risk score of cerebral infarction in atrial fibrillation genome‐wide association study	18
Optimal antiplatelet and antithrombotic regimen post‐transcatheter aortic valve replacement	18
Causal relationship between sleep apnea and non‐alcoholic fatty liver disease: A Mendelian randomization study	17
Sex disparities for patients with atrial fibrillation in the direct oral anticoagulant era	17
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Ambulatory central BP and arterial stiffness in patients with and without intradialytic hypertension	17
Cooler dialysate temperature for the prevention of intradialytic hypotension: Is it time for a shift in our practice?	16
Trends in home dialysis use differ among age categories in past two decades: A Dutch registry study	16
Progress and challenges in the symbiosis of AI with science and medicine	16
A decrease in peripheral thyroid hormone conversion efficiency in patients treated with immune checkpoint inhibitors and L‐T3 as a possible alternative therapeutic escape option	16
Hydrogen sulphide: Diabetic cardiomyopathy as the paradigm of its pleiotropic function	16
A novel echocardiographic parameter considering left ventricular afterload during V‐A ECMO support	16
Issue Information	16
Issue Information	16
Long‐term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy	16
Ga‐68 EDTA aerosols in evaluation of inhaled‐particle deposition and clearance of obstructive pulmonary diseases: A pilot prospective study compared with Galligas	15
Heart rate variability and cardiovascular diseases: A Mendelian randomization study	15
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus	15
Does natural and hybrid immunity obviate the need for frequent vaccine boosters against SARS‐CoV‐2 in the endemic phase?	15
New insights into Covid‐19 disease. Apo‐A1 antibodies are generated after mRNA Covid‐19 vaccination and after Covid‐19 infection	15
A comprehensive review of adverse events to drugs used in COVID‐19 patients: Recent clinical evidence	15
Liver fibrosis is associated with an increased risk of non‐fatal myocardial infarction	15

Long‐term fasting induces a remodelling of fatty acid composition in erythrocyte membranes	14
Associations of cataract, cataract surgery with dementia risk: A systematic review and meta‐analysis of 448,140 participants	14
Differences in hospitalisation between peritoneal dialysis and haemodialysis patients	14
Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients	14
Effects of glucagon‐like PEPTIDE‐1 receptor agonists on incidence of hepatocellular carcinoma and liver decompensation in patients with diabetes: A systematic review and META‐analysis	14
Human blood metabolites and risk of severe COVID‐19: A Mendelian randomization study	14
Reliable, cheap, fast and few: What is the best study for assessing medical practices? Randomized controlled trials or synthetic control arms?	14
Editorial response to Aimo et al Quality‐of‐life assessment in amyloid transthyretin amyloidosis	14
Increased body mass index is associated with sarcopenia and related outcomes	14
Direct oral anticoagulants in patients with nonvalvular atrial fibrillation and extreme body weight	14
Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease	13
Salivary noncoding RNA in the diagnosis of pancreatic cancer: Systematic review and meta‐analysis	13
Association between insulin‐associated gene polymorphisms and new‐onset diabetes mellitus in statin‐treated patients	13
Integrative bioinformatic analysis of prognostic biomarkers in heart failure: Insights from clinical trials	13
Long‐term safety of macitentan in patients with pulmonary hypertension: A meta‐analysis of randomised controlled trials	13
Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers—Results from the study of health in Pomerania	13
The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma	13
Microvascular disease increases the risk of lower limb amputation – A Western Danish cohort study	13
Does hospitalisation improve oral anticoagulant optimisation in patients with atrial fibrillation?	13
Molecular mechanisms of glucocorticoid resistance	13
Prevalence and clinical outcomes of myocarditis and pericarditis in 718,365 COVID‐19 patients	13
Altered fibrin clot properties and elevated von Willebrand factor are associated with progression to permanent atrial fibrillation: A cohort study	13
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Multimodal strategy to rescue the brain in mild cognitive impairment: Ketogenic oral nutrition supplementation with B vitamins and aerobic exercise	13
A score for predicting invasive pulmonary aspergillosis in immunocompetent critically ill patients	13
Cancer patients with venous thromboembolism: Diagnostic and prognostic value of elevated D‐dimers	13
Prehospital troponin as a predictor of early clinical deterioration	13
TNF‐α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm‐ageing	12
Combination therapy with an SGLT‐2 inhibitor and finerenone in DKD: Are we there yet?	12
Poor self‐reported sleep is associated with risk factors for cardiovascular disease: A cross‐sectional analysis in half a million adults	12
Acetyl‐CoA‐driven respiration in frozen muscle contributes to the diagnosis of mitochondrial disease	12
Respiratory follow‐up after hospitalization for COVID‐19: Who and when?	12
Clinical predictors of late SARS‐CoV‐2 positivity in Italian internal medicine wards	12
The relevance of intestinal barrier dysfunction, antimicrobial proteins and bacterial endotoxin in metabolic dysfunction‐associated steatotic liver disease	12
Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review	12
The use of comics to promote health awareness: A template using nonalcoholic fatty liver disease	12
Treatment and outcomes of patients with chronic lung disease and acute myocardial infarction: Insights from the nationwide AMIS plus registry	11
Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants	11
Age differences of patients treated with wearable cardioverter defibrillator: Data from a multicentre registry	11
The fate and role of the pericytes in myocardial diseases	11
Use of artificial intelligence and radiomics for risk stratification in patients with pulmonary embolism: New tools for an old problem	11
Pulmonary thrombosis associated with COVID‐19 pneumonia: Beyond classical pulmonary thromboembolism	11
Issue Information	11
Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure	11
Elevated factor XIa as a modulator of plasma fibrin clot properties in coronary artery disease	11
Predictive model for atrial fibrillation in hypertensive diabetic patients	11
Imaging‐based risk stratification of patients with pulmonary embolism based on dual‐energy CT‐derived radiomics	11
Abnormal circulating steroids refine risk of progression to heart failure in ischemic heart disease	11
Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression	11
Adrenergic dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia: A systematic review and meta‐analysis	10
Adipocyte maturation impacts daunorubicin disposition and metabolism	10
Effect of addingPCSK9inhibitors to lipid‐lowering interventions on arterial stiffness: A systematic review and meta‐analysis	10
CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression	10
Post COVID‐19 syndrome with impairment of flow‐mediated epicardial vasodilation and flow reserve	10
Correction of Erratum in Czaja AJ, Eur J Clin Invest: 48:e12899	10
Glucagon and glucagon‐like peptide‐1 dual agonist therapy: A possible future towards fatty kidney disease	10
Issue Information	10
Late Breaker Abstract	10
Washed microbiota transplantation improves haemoglobin levels in anaemia of chronic disease	10
Prognostic role of CRP‐independent inflammatory patterns in patients undergoing primary percutaneous interventions	10
Impact of sirolimus on long‐term adverse cardiovascular outcomes in kidney transplant recipients: A nationwide cohort study	10
Dysfunctional antioxidant capacity of high‐density lipoprotein in rheumatoid arthritis	10
Modification, validation and comparison of Naples prognostic score to determine in‐hospital mortality in ST‐segment elevation myocardial infarction	10
Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes	10
A newly developed, easy‐to‐use prehospital drug‐derived score compared with three conventional scores: A prospective multicenter study	10
Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility	10
Adrenocortical dysfunction in rheumatoid arthritis: Α narrative review and future directions	10
Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses	10
Circ_0007142 downregulates miR‐874‐3p‐mediated GDPD5 on colorectal cancer cells	9
Thirteen‐year trends in hospitalization and outcomes of patients with heart failure in Spain	9
Single versus dual antiplatelet therapy following percutaneous left atrial appendage closure—A systematic review and meta‐analysis	9
Promising biomarker panel to monitor therapeutic efficacy of neoadjuvant chemotherapy in pancreatic cancer patients	9
Soluble urokinase plasminogen activator receptor and survival in elective cardiac surgery	9
CHA2DS2‐VASc and R2CHA2DS2‐VASc scores predict mortality in high cardiovascular risk population	9
Mechanical aortic valve prostheses offer a survival benefit in 50–65 year olds: AUTHEARTVISIT study	9
Systemic biomarker associated with poor outcome after futile reperfusion	9
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship	9
New approach to specific Alzheimer's disease diagnosis based on plasma biomarkers in a cognitive disorder cohort	9
Big data and machine learning to tackle diabetes management	9
Association between sleep traits and primary liver cancer: A Mendelian randomization analysis	9

The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections	9
Comparison of pan‐immune‐inflammation value with other inflammation markers of long‐term survival afterST‐segment elevation myocardial infarction	9
Omega‐3 phospholipids and obesity‐associated NAFLD: Potential mechanisms and therapeutic perspectives	9
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study	9
Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin	9
Association of MASLD with the risk of extrahepatic cancers: A systematic review and meta‐analysis of 18 cohort studies	9
Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: Analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK bio	9
Exosomal circEPB41L2 serves as a sponge for miR‐21‐5p and miR‐942‐5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway	9
Clinical utility and prognostic implications of the 4S‐AF scheme: Report from Asia Pacific Heart Rhythm Society Atrial Fibrillation Registry	9
Serum antibody response to BNT162b2 after natural SARS‐CoV‐2 infection	8
The effect of parthenolide on methamphetamine‐induced blood‐brain barrier and astrocyte alterations	8
Off‐label use of PAH‐targeted medications approved for adults and their financial coverage by health insurances are vital for children with pulmonary hypertension	8
Carcinoembryonic antigen‐related cell adhesion molecule 1 in cancer: Blessing or curse?	8
Insights into circulating CEACAM1 in insulin clearance and disease progression: Evidence from the Portuguese PREVADIAB2 study	8
Distant metastasis and prognostic factors in patients with invasive ductal carcinoma of the breast	8
An observational study of the Covid‐19 situation following the first pan‐European mass sports event	8
Improving atrial fibrillation outcomes through interclinician electronic consultation	8
Issue Information	8
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets	8
Low soluble dipeptidyl Peptidase‐4 levels during acute myocardial infarction and decreased endogenous glucagon like Peptide‐1 response are associated with adverse long‐term cardiovascular outcome and	8
Cardiac proteomic profiling suggests that hypertrophic and dilated cardiomyopathy share a common pathogenetic pathway of the calcium signalling pathway	8
Subtyping strokes using blood‐based protein biomarkers: A high‐throughput proteomics and machine learning approach	8
Use of rivaroxaban attenuates renal function impairment in patients with atrial fibrillation: insights of the EMIR study	8
The influence of SARS‐CoV‐2 on male reproduction and men's health	8
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The emerging role of Fusobacteria in carcinogenesis	8
Medication non‐adherence patterns and profiles for patients with incident myocardial infarction: Observations from a large multi‐morbid US population	8
Issue Information	8
Doing better with functional gastrointestinal disorders? Profiling gut microbiota and circulating antibodies to CdtB and vinculin	8
Effects of NAD+ precursors on blood pressure, C‐reactive protein concentration and carotid intima‐media thickness: A meta‐analysis of randomized controlled trials	7
First time ACS in patients with on‐target lipid levels: Inflammation at admission and re‐event rate at follow‐up	7
Issue Information	7
Elevated fasting insulin results in snoring: A view emerged from causal evaluation of glycemic traits and snoring	7
Impaired fibrin clot lysis is associated with increased mortality in patients after coronary artery bypass grafting: A long‐term follow‐up study	7
Insulin action in subjects with type 2 diabetes following biliopancreatic diversion	7
Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta‐analysis	7
Current policies of non‐commercial funders towards transparency in clinical trials	7
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Withdrawal: Circ_0008078 inhibits EC cell tumour properties by miR‐191‐5p‐dependent regulation of ELOVL4	7
Low triiodothyronine syndrome is associated with stroke‐associated pneumonia	7
Short‐ and long‐term risk stratification in acutely ill medical patients by implementing ankle‐brachial index and pulse wave velocity in the emergency setting	7
One‐hour post‐load glucose and subclinical left atrial myocardial dysfunction in hypertensive patients	7
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Issue Information	7
Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors	7
When type II diabetes mellitus meets COVID‐19—Identification of the shared gene signatures and biological mechanism between the two diseases	7
Adiponectin as a biomarker in liver cirrhosis—A systematic review and meta‐analysis	7
Prognostic parameters of in‐hospital mortality in COVID‐19 patients—An Italian experience	7
Long‐term cognitive function changes with non‐vitamin K oral anticoagulants in older patients with atrial fibrillation. A multicenter cohort study	7
Phenotypes of Polish primary care patients using hierarchical clustering: Exploring the risk of mortality in the LIPIDOGEN2015 study cohort	7
The electrocardiogram in athletes with left ventricular dilatation and reduced ejection fraction	7
The association of testosterone with sarcopenia and frailty in chronic liver disease	7
Emerging clinical role of proprotein convertase subtilisin/kexin type 9 inhibition–Part two: Current and emerging concepts in the clinical use of PCSK9 inhibition	7
Exploring omics signature in the cardiovascular response to semaglutide: Mechanistic insights and clinical implications	6
Efficacy and safety of benralizumab in eosinophilic granulomatosis with polyangiitis: A meta‐analysis of eight studies	6
Refining the role of presurgical PET/4D‐CT in a large series of patients with primary hyperparathyroidism undergoing [18F]Fluorocholine PET/CT	6
An obscure myocardial blood flow may illuminate post‐acute sequelae of COVID‐19 cardiovascular syndrome	6
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Assessing cardiorespiratory fitness relative to sex improves surgical risk stratification	6
Meta‐analysis of factors associated with antidiabetic drug prescribing for type 2 diabetes mellitus	6
The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women	6
BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis	6
Reparixin improves survival in critically ill and transplant patients: A meta‐analysis	6
Physical performance and plasma metabolic profile as potential prognostic factors in metastatic lung cancer patients	6
Prehospital Respiratory Early Warning Score for airway management in‐ambulance: A score comparison	6
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Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs	6
Evaluation of heart failure admission as a surrogate for mortality in randomized clinical trials: A meta‐analysis	6
The glucagon‐like peptide‐1 receptor agonist semaglutide in diabetic kidney disease: A new kid on the block to afford maximal kidney protection	6
Sex‐specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress	6
Issue Information	6
Blood CD45+/CD3+ lymphocyte‐released extracellular vesicles and mortality in hospitalized patients with coronavirus disease 2019	6
An international multicentre study of SwiTching from Intravenous to subcutaneous inflixiMab and vEdolizumab in inflammatory bowel diseases: The TIME study	6
The impact of metabolic syndrome on chronic kidney disease development. Insights from a big prospective study	6
Blood pressure measurement for prediction of chronic pressure overload and cardiovascular events	6
Epigenetic changes in the metabolically healthy obese: A case‐control versus a prospective study	6
Clinical relevance of endothelial function, oxidative stress and inflammation after smoking cessation	6
Metrics: Reflections on the 2020s impact factors	6
Mental health conditions and risk of first‐ever ischaemic stroke and death in patients with incident atrial fibrillation: A nationwide cohort study	6
The fibrosis‐4 score is associated with long‐term mortality in different phenotypes of acute heart failure	6