OOIR: Observatory of International Research

Papers

(The median citation count of European Journal of Immunology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Transglutaminase 2 affinity and enzyme‐substrate intermediate stability as determining factors for T‐cell responses to gluten peptides in celiac disease	354
Impressum	80
Impressum	75
Inborn errors of immunity and immunodeficiencies: Antibody‐mediated pathology and autoimmunity as a consequence of impaired immune reactions	74
A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model	68
Integrin activation enables rapid detection of functional Vδ1⁺ and Vδ2⁺ γδ T cells	60
B‐cell modulation with anti‐CD79b antibodies ameliorates experimental autoimmune encephalitis in mice	56
Metabolic dynamics instruct CD8⁺ T‐cell differentiation and functions	55
Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France	54
Cover Story: Eur. J. Immunol. 4'23	46
Intrahepatic plasma cells, but not atypical memory B cells, associate with clinical phases of chronic hepatitis B	45
Bead‐by‐bead normalization of single antigen assays: A necessary step for accurate detection of weak anti‐HLA antibodies	44
Issue Information: Eur. J. Immunol. 10'21	40
Immunomodulation under the lens of real‐time in vivo imaging	40
Staphylococcus aureus‐derived factors promote human Th9 cell polarization and enhance a transcriptional program associated with allergic inflammation	39
Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages	38
Guidelines for mouse and human DC functional assays	38
Dimethyl itaconate selectively targets inflammatory and metabolic pathways in chronic lymphocytic leukemia	38
In memoriam Martin Röllinghoff (1941–2022)	37
Epigenetic Regulation of CD8⁺ Effector T Cell Differentiation by PDCD5	35
Immune signature of patients with cardiovascular disease predicts increased risk for a severe course of COVID‐19	35
Emerging roles of host and microbial bioactive lipids in inflammatory bowel diseases	34
Linking Epitope‐Specific T‐Cell Receptors to IFNγ Secretion Using Nanovial Technology	32
Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cells	32
Fate‐mapping studies in inbred mice: A model for understanding macrophage development and homeostasis?	31

Airway epithelial type‐2 alarmin profiles: Blood eosinophil counts remain in memory	30
Surface CD69‐Negative CD4 and CD8 Bone Marrow‐Resident Human Memory T Cells	30
The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses	30
Four challenges to CAR T cells breaking the glass ceiling	29
The potential of γδ CAR and TRuC T cells: An unearthed treasure	29
Neutrophil subsets in noncancer liver diseases: Cellular crosstalk and therapeutic targets	28
Mast cells in type 2 skin inflammation: Maintenance and function	28
Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages?	27
In this issue	27
Regulatory T cells as a therapeutic approach for inflammatory bowel disease	27
	27
Sustained innate interferon is an essential inducer of tertiary lymphoid structures	27
Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology	27
Fully functional monocytic MDSC generation from the murine HoxB8 cell line	26
The VEGF‐Mediated Cytoprotective Ability of MIF‐Licensed Mesenchymal Stromal Cells in House Dust Mite‐Induced Epithelial Damage	26
BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function	26
AK2‐Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis	26
	25
E‐Cadherin restricts mast cell degranulation in mice	25
LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response	24
Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation	24
Paradoxical immunodeficiencies—When failures of innate immunity cause immunopathology	23
Global k_off‐rates of polyclonal T‐cell populations merge subclonal avidities and predict functionality	23
MHC class I molecules co‐stimulate NK1.1 signaling and enhance Ca²⁺ flux in murine NK cells	23
Enhanced in vitro type 1 conventional dendritic cell generation via the recruitment of hematopoietic stem cells and early progenitors by Kit ligand	22
Czech Young Immunologists: Bound by science, united in purpose	21
T‐cell signature cytokines distinguish pulmonary sarcoidosis from pulmonary tuberculosis	21
The Young Immunologists' Podcast: Immunology and Much More	21
Immunomodulation of neutrophil granulocyte functions by bacterial polyphosphates	21
IQGAP1 Influences Neutrophil Maturation and Its Effector Functions	20
Issue Information: Eur. J. Immunol. 8'23	19
Functional Fc receptors are crucial in antibody‐mediated protection against cytomegalovirus	19
Communication and transparency at EJI: Supporting authors through their publishing experience	19
Researcher Reflections—Inspiring Paths in Academia	18
Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors	18
Issue Information: Eur. J. Immunol. 1'25	18
Key actors in neuropathophysiology: The role of γδ T cells	18
IL‐4, IL‐15, and Type I Interferon Orchestrate the Shaping of the Heterogeneity of Virtual Memory CD8 T Cells	18
TLR9‐Driven S‐Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets	17
Potentiation of the axis involving pentose phosphate pathway/NADPH oxidase/reactive oxygen species drives higher IL‐10 production in monocytes of Sub‐Saharan Africans	17
Cover Story: Eur. J. Immunol. 1'24	17
Innate immunity champions: The diverse functions of macrophages	17
Mouse dendritic cells and other myeloid subtypes in healthy lymph nodes and skin: 26‐Color flow cytometry panel for immune phenotyping	17
Immediate major dynamic changes in the T‐ and NK‐cell subset composition after cardiac transplantation	17
YF17D‐based vaccines – standing on the shoulders of a giant	17
Metabolic reprograming shapes neutrophil functions in severe COVID‐19	17
Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection	16
Acquired immune resistance is associated with interferon signature and modulation of KLF6/c‐MYB transcription factors in myeloid leukemia	16
MicroRNA‐146a deficiency enhances host protection against murine cytomegalovirus	16
The Swiss Young Immunologists Society (SYIS): Empowering the next generation of immunologists	16

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Distinct Tissue‐Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells	16
Novel homozygous CD46 variant with C‐isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome	16
Differential regulation of CD8⁺CD86⁺ Vγ1.1⁺ γδT cell responses in skin barrier tissue protection and homeostatic maintenance	16
PP2A catalytic subunit alpha is critically required for CD8⁺ T‐cell homeostasis and antibacterial responses	16
Langerhans cells orchestrate apoptosis of DNA‐damaged keratinocytes upon high‐dose UVB skin exposure	16
Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes	15
EFIS News	15
Knockout of SLy1 decreases double‐negative thymocyte proliferation and protects mice from p53‐induced tumor formation	15
Microenvironmental signals shaping NK‐cell reactivity in cancer	15
In this issue	15
B Cell Receptor Repertoire Analysis of the CD21^lo B Cell Compartment in Healthy Individuals, Patients With Sjögren's Disease, and Patients With Radiographic Axial Spondyloarthritis	15
Tyrosine kinase inhibitor cabozantinib impacts dendritic and natural killer cells immune response in C38 syngeneic tumor model	15
Nonreplicating synthetic mRNA vaccines: A journey through the European (Journal of Immunology) history	15
Immunology meeting	15
Endogenous secretory leukocyte protease inhibitor inhibits microbial‐induced monocyte activation	14
Journal roundup	14
	14
In this issue	14
Contents: Eur. J. Immunol. 7'22	14
Hyperlipidemia‐induced metabolic changes in regulatory T cells result in altered function	14
Contents: Eur. J. Immunol. 11'22	14
Contents: Eur. J. Immunol. 12'21	14
	14
Dendritic cells generated from induced pluripotent stem cells and by direct reprogramming of somatic cells	14
Impressum	13
Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression	13
The immunosuppressive drug cyclosporin A has an immunostimulatory function in CD8⁺ T cells	13
Expanding our understanding of Guillain–Barré syndrome: Recent advances and clinical implications	13
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Helios is a marker, not a driver, of human Treg stability	13
Impressum	13
Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas–intestinal barrier axis	13
Exploring How Cytoskeleton Dynamics Tunes T Cell Activation at the Immunological Synapse	13
Guidelines for mouse and human DC generation	13
Human cDC1s display constitutive activation of the UPR sensor IRE1	13
Altered increase in STAT1 expression and phosphorylation in severe COVID‐19	13
Release of IL‐1β and IL‐18 in human primary bronchial epithelial cells exposed to cigarette smoke is independent of NLRP3	13
Differential Runx3, Eomes, and T‐bet expression subdivides MS‐associated CD4⁺ T cells with brain‐homing capacity	13
DsbA‐L deletion attenuates LPS‐induced acute kidney injury by modulating macrophage polarization	13
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Lymphotoxins from distinct types of lymphoid cells differentially contribute to neuroinflammation	12
Diversity of regulatory B cells: Markers and functions	12
SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination	12
Bin‐based visualization of cytokine‐co‐expression patterns of IL‐10‐producing CD4 T cell subsets	12
Therapeutic targeting of factor D and MASP3 in complement‐mediated diseases: Lessons learned from mouse studies	12
Resolution of Autoimmune Uveitis Requires CCL20‐Dependent Regulatory T Cells	12
Cover Story: Eur. J. Immunol. 12'23	12
Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct‐acting antivirals	12
ACKR1 favors transcellular over paracellular T‐cell diapedesis across the blood‐brain barrier in neuroinflammation in vitro	12
Methiothepin downregulates SNAP‐23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow‐derived mast cells	12
Actinin‐4 controls survival signaling in B cells by limiting the lateral mobility of B‐cell antigen receptors	12
Human T Cell Responses to Flavivirus Vaccines	12
Georg Friedrich (Fritz) Melchers (27.4.1936–24.2.2025)	12
Issue Information: Eur. J. Immunol. 7'23	12
Acellular Pertussis Vaccines Induce CD8⁺ and CD4⁺ Regulatory T Cells That Suppress Protective Tissue‐Resident Memory CD4⁺ T Cells, in Part via IL‐10	12
Augmented neutralization of SARS‐CoV‐2 Omicron variant by boost vaccination and monoclonal antibodies	12
Correction	12
Cover story: Eur. J. Immunol. 7'22	12
Booster Injection with Birch Pollen Extract Activates B‐Cellular Memory Responses in Patients Having Completed Allergen Immunotherapy	12
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR⁺ cells during antibody‐mediated immune responses	12
Puppet masters of B‐cell progenitor acute lymphoblastic leukemia: The preB cell receptor and the interleukin 7 receptor α	11
In this issue	11
Inhibition of Melanoma Growth by Ex Vivo Expanded Tumor‐Specific CD8+ T Cells Is Dependent on the Configuration of Nanoscale Artificial APCs	11
PDGFRα‐lineage origin directs monocytes to trafficking proficiency to support peripheral immunity	11
TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages	11
CCR4⁺CD8⁺ T cells clonally expand to differentiated effectors in murine psoriasis and in human psoriatic arthritis	11
Interleukin‐2‐induced skin inflammation	11
Portuguese Society of Immunology (SPI): Turning 50, inspired by the past, looking into the future	11
Antibiotic use during pregnancy is linked to offspring gut microbial dysbiosis, barrier disruption, and altered immunity along the gut–lung axis	11
Characterization of SARS‐CoV‐2 and common cold coronavirus‐specific T‐cell responses in MIS‐C and Kawasaki disease children	11
Impressum	11
From simple to complex: Protein‐based biomarker discovery in tuberculosis	11
SIRPα: A key player in innate immunity	11
Molecular and functional in vivo characterisation of murine Dectin‐1 isoforms	11
PIEZO1‐mediated mechanosensing governs NK‐cell killing efficiency and infiltration in three‐dimensional matrices	11
Impressum	11
Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses	10
Regulation of B‐cell function and expression of CD11c, T‐bet, and FcRL5 in response to different activation signals	10
Impressum	10

	10
Retinoic acid‐loaded liposomes induce human mucosal CD103⁺ dendritic cells that inhibit Th17 cells and drive regulatory T‐cell development in vitro	10
The first year of young group of the Spanish Immunology Society: Progress, challenges, and next steps	10
Issue Information: Eur. J. Immunol. 1'23	10
Contents: Eur. J. Immunol. 8'22	10
Detection of dendritic cell subsets in the tumor microenvironment by multiplex immunohistochemistry	10
Characterization of human CD4⁺EOMES⁺GzmK⁺ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities	10
Vitamin A‐treated natural killer cells reduce interferon‐gamma production and support regulatory T‐cell differentiation	10
Front cover story: Eur. J. Immunol. 2'22	10
TLR2 on CD4+ and CD8+ T cells promotes control of Mycobacterium tuberculosis infection	10
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Epigenetic Regulations in Autoimmunity and Cancer: from Basic Science to Translational Medicine	10
Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity	10
Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species	10
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Bystander activation of tissue‐resident memory CD4 T cells: Getting by with a little help from unfamiliar T‐cell friends	10
Upregulation of IL4‐induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties	10
Cover Story: Eur. J. Immunol. 5'24	9
Plasmodium berghei Radiation‐Attenuated Sporozoite‐Immunized Mice Require Infectious Sporozoite Challenge to Maintain Protective Immunity	9
Survival of Human Bone Marrow Plasma Cells In Vitro Depends on the Support of the Stromal Cells, PI3K, and Canonical NF‐kappaB Signaling	9
Crafting an MSCA PhD Masterpiece: Guiding Students on the Verge of Discovery	9
Translational immunology: Applying fundamental discoveries to human health and autoimmune diseases	9
Interleukin 23 receptor: Expression and regulation in immune cells	9
In this issue	9
IL1R2 Acts as a Negative Regulator of Monocyte Recruitment During Inflammation	9
Autoimmunity and SARS‐CoV‐2 infection: Unraveling the link in neurological disorders	9
High Extracellular K⁺ Skews T‐Cell Differentiation Towards Tumour Promoting Th2 and T_reg Subsets	9
Chronic stimulation desensitizes β2‐adrenergic receptor responses in natural killer cells	9
Guidelines for DC preparation and flow cytometry analysis of mouse lymphohematopoietic tissues	9
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Cover Story: Eur. J. Immunol. 4'25	9
Neural Crest‐Derived Mesenchymal Cells Support Thymic Reconstitution After Lethal Irradiation	9
yEFIS with EFIS Lead the Way to ECR Engagement at ECI2024	9
Effects of altered salt intake and diet on cytokines in humans: A 20‐week randomized cross‐over intervention study	9
Cover Story: Eur. J. Immunol. 8'23	9
Impressum	9
Immunogenicity‐Guided Design of an Acinetobacter baumanii Vaccine	9
yEFIS 1^st Symposium: Shaping the future of Immunology in Europe, 10–11 November, 2022, Berlin, Germany	9
PAD2 immunization induces ACPA in wild‐type and HLA‐DR4 humanized mice	8
The complement system: A key player in the host response to infections	8
Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency	8
Dendritic cells Trigger IFN‐γ secretion by NK cells independent of IL‐12 and IL‐18	8
Trametinib Suppresses the Stimulated T Cells Through G1 Arrest and Apoptosis	8
Foxp3⁺ regulatory T cells in the central nervous system and other nonlymphoid tissues	8
Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression	8
PD‐L2 Inhibits Protective Immunity, Th2 Cell Functional Quality, and GATA‐3 Expression During Filarial Nematode Infection	8
Sphingosine‐1‐phosphate receptor type 4 is critically involved in the regulation of peritoneal B‐1 cell trafficking and distribution in vivo	8
Autoantibodies targeting type I interferons: Prevalence, mechanisms of induction, and association with viral disease susceptibility	8
Dynamics of IL‐15/IL‐15R‐α expression in response to HSV‐1 infection reveal a novel mode of viral immune evasion counteracted by iNKT cells	8
	8
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Fine needle aspiration of human lymph nodes reveals cell populations and soluble interactors pivotal to immunological priming	8
Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human macrophages and blunt glycolysis in response to antigenic stimuli	8
Combined Deletion of ZFP36L1 and ZFP36L2 Drives Superior Cytokine Production in T Cells at the Cost of Cell Fitness	8
ICAP‐1 loss impairs CD8⁺ thymocyte development and leads to reduced marginal zone B cells in mice	8
Polymorphism in F pocket affects peptide selection and stability of type 1 diabetes‐associated HLA‐B39 allotypes	8
MicroRNAs targeting TGF‐β signaling exacerbate central nervous system autoimmunity by disrupting regulatory T cell development and function	8
Rational design of polymer‐based particulate vaccine adjuvants	8
Immunity in malignant brain tumors: Tumor entities, role of immunotherapy, and specific contribution of myeloid cells to the brain tumor microenvironment	8
Verteporfin protects against Th17 cell‐mediated EAE independently of YAP inhibition	8
Impressum	8
Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapy	8
T helper cell subsets: diversification of the field	8
Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation	8
	8
Regulation of DC metabolism by nitric oxide in murine GM‐CSF cultures	8
Cover Story: Eur. J. Immunol. 11'23	8
Sensing context: Inhibitory receptors on non‐hematopoietic cells	8
SARS‐CoV‐2 variants of concern elicit divergent early immune responses in hACE2 transgenic mice	8
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Composition of fatty acids in a high‐fat diet affects adipose tissue inflammation by inducing calreticulin on adipocytes and activating group 1 innate lymphoid cells	7
CD95L concatemers highlight different stoichiometries of CD95‐mediated apoptotic and nonapoptotic pathways	7
Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM	7
Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope	7
Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection	7
In this issue	7
Early career immunology: A digital space to support early career investigators	7
	7
Cover Story: Eur. J. Immunol. 4'24	7
TOX Does Not Drive Sepsis‐Induced T‐Cell Exhaustion	7
Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy	7
Deciphering the Human Germinal Center: A Review of Models to Study T–B Cell Interactions	7
Therapeutic tactics for targeting B lymphocytes in autoimmunity and cancer	7
Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights	7
Neutralizing antibodies to SARS‐CoV‐2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects	7
	7
Contents: Eur. J. Immunol. 1'22	7
Cover Story: Eur. J. Immunol. 8'24	7
GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development	7
Identification and Mapping of Human Lymph Node Stromal Cell Subsets by Combining Single‐Cell RNA Sequencing with Spatial Transcriptomics	7
Influence of SLAM Family Receptors in the NK‐Cell‐Mediated Surveillance of Lymphoblastic Acute Leukemia	7
VSIG4‐Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity	7
Bile acid‐activated receptors in innate and adaptive immunity: targeted drugs and biological agents	7