European Journal of Pharmacology

Papers
(The median citation count of European Journal of Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Retraction notice to “Tanshinone IIA protects hypoxia-induced injury by preventing microRNA-28 up-regulation in PC-12 cells” [Eur. J. Pharmacol. 854 (2019) 265–271]261
Natural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice166
Role of 11β-hydroxysteroid dehydrogenase type 1 inhibition in the antiobesity effect of J2H-1702 on adipocytes and a high-fat diet-induced NASH model122
TNF-alpha mediates airway hyperreactivity in silicotic mice: Effect of thalidomide treatment111
Retinal pharmacodynamic and pharmacokinetic profile of cannabidiol in an in vivo model of retinal excitotoxicity107
Students’ perspective on the Dutch National Pharmacotherapy Assessment, a national survey study among final-year medical students98
Sodium Danshensu alleviates bone cancer pain by inhibiting the osteoclast differentiation and CGRP expression96
Metformin reduces inflammatory nociception in mice through a serotonin-dependent mechanism96
Sodium-glucose cotransporter 2 inhibitor empagliflozin enhances autophagy and reverses remodeling in hearts with large, old myocardial infarctions91
Luteolin alleviates diabetic cardiac injury related to inhibiting SHP2/STAT3 pathway87
Corrigendum to “Isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate protects lipopolysaccharide-induced acute lung injury in mice by attenuating pyroptosis” [Eur. J. Pharmacol. 5 (2023) 175545]86
The pathogenesis of depression: Roles of connexin 43-based gap junctions and inflammation84
The Risk of Propofol Infusion Syndrome on Epilepsy Patients :Insights from FAERS Data and Published Case Reports83
Targeting beta-catenin signaling for prevention of colorectal cancer – Nutraceutical, drug, and dietary options75
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway74
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling73
Effects of sacubitril-valsartan on aging-related cardiac dysfunction71
The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A1171
Comprehensive characterization of fatty acid oxidation in triple-negative breast cancer: Focus on biological roles and drug modulation67
MK886 ameliorates Alzheimer's disease by activating the PRKCI/AKT signaling pathway63
Rostral ventromedial medulla astrocytes regulate chronic itch and anxiety-related behaviors63
Matrine alleviates Staphylococcus aureus-induced acute lung injury in mice by inhibiting MLKL and NLRP3-mediated inflammatory activity62
Interleukin-35 mRNA therapy for influenza virus-induced pneumonia in mice61
Modulating mitochondrial dynamics preserves cognitive performance via ameliorating iron-mediated brain toxicity in iron-overload rats59
GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis59
Safety, tolerability and pharmacokinetic profile of the low-impact ampakine CX717 in young healthy male subjects and elderly healthy male and female subjects56
Caveolin-1 attenuates acetaminophen aggravated lipid accumulation in alcoholic fatty liver by activating mitophagy via the Pink-1/Parkin pathway55
Glutamine alleviates intestinal injury in a murine burn sepsis model by maintaining intestinal intraepithelial lymphocyte homeostasis55
“Sigma-1 receptor modulation by clemastine highlights its repurposing as neuroprotective agent against seizures and cognitive deficits in PTZ-kindled rats”55
Comprehensive analysis of MAPK genes in the prognosis, immune characteristics, and drug treatment of renal clear cell carcinoma using bioinformatic analysis and Mendelian randomization54
1, 8-cineole protects against ISO-induced heart failure by inhibiting oxidative stress and ER stress in vitro and in vivo52
Cediranib ameliorates portal hypertensive syndrome via inhibition of VEGFR-2 signaling in cirrhotic rats51
A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress51
Advancing health care via artificial intelligence: From concept to clinic51
Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway50
Spinal dopaminergic D1-and D2-like receptors have a sex-dependent effect in an experimental model of fibromyalgia50
Melanocortin receptor-4 mediates the anorectic effect induced by the nucleus tractus solitarius injection of glucagon-like Peptide-2 in fasted rats50
Aging in chronic lung disease: Will anti-aging therapy be the key to the cure?50
Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study49
Retraction notice to “Ginsenoside Rg3 inhibits growth and epithelial-mesenchymal transition of human oral squamous carcinoma cells by down-regulating miR-221” [Eur. J. Pharmacol. 853 (2019) 353–363]48
Retraction notice to “Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation” [Eur. J. Pharmacol. 483 (1) (2004) 79–93]47
Oridonin, a small molecule inhibitor of cancer stem cell with potent cytotoxicity and differentiation potential47
Curcumin nicotinate increases LDL cholesterol uptake in hepatocytes through IDOL/LDL-R pathway regulation46
Sis-25, a meroditerpenoid derivative with a cyclobutane scaffold, inhibits activated T cell proliferation by targeting GSK3β in vitro and in vivo46
Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs46
Non-coding RNAs and exosomal ncRNAs in multiple myeloma: An emphasis on molecular pathways46
Editorial Board45
Amorphous selenium nanodots alleviate non-alcoholic fatty liver disease via activating VEGF receptor 1 to further inhibit phosphorylation of JNK/p38 MAPK pathways45
Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway45
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Antagonizing interleukin-5 receptor ameliorates dextran sulfate sodium-induced experimental colitis in mice through reducing NLRP3 inflammasome activation43
Sodium butyrate alleviates right ventricular hypertrophy in pulmonary arterial hypertension by inhibiting H19 and affecting the activation of let-7g-5p/IGF1 receptor/ERK43
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Reno-protective potential of sodium glucose cotransporter-2 (SGLT2) inhibitors: Summary evidence from clinical and real-world data39
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Single-cell transcriptome analysis reveals dynamic changes of the preclinical A549 cancer models, and the mechanism of dacomitinib39
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The role of NFAT in the pathogenesis and targeted therapy of hematological malignancies38
Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment38
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Possible involvement of brain hydrogen sulphide in the inhibition of the rat micturition reflex induced by activation of brain alpha7 nicotinic acetylcholine receptors37
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17β-Estradiol promotes angiogenesis of stria vascular in cochlea of C57BL/6J mice37
Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery36
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Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling35
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Effect of mitochondrial complex III inhibitors on the regulation of vascular tone in porcine coronary artery34
Fucoxanthin mitigates valproic acid-induced autistic behavior through modulation of the AKT/GSK-3β signaling pathway34
CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway34
Targeted treprostinil delivery inhibits pulmonary arterial remodeling34
Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytes34
Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars34
Interaction of the preferential D3 agonist (+)PHNO with dopamine D3-D2 receptor heterodimers and diverse classes of monoamine receptor: relevance for PET imaging34
Protocatechuic acid attenuates chronic unpredictable mild stress induced-behavioral and biochemical alterations in mice34
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Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?34
Inhibiting the growth of ovarian cancer cells in vitro and in vivo by a small molecular inhibitor targeting La-RNA interactions33
Hydrogen sulphide protects mice against the mutual aggravation of cerebral ischaemia/reperfusion injury and colitis33
Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study33
Characterisation of bis(4-aminoquinoline)s as α1A adrenoceptor allosteric modulators33
Research progress of phosphatidylinositol 4-kinase and its inhibitors in inflammatory diseases33
Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis33
Deciphering the role of siRNA in anxiety and depression32
Dapagliflozin attenuates fat accumulation and insulin resistance in obese mice with polycystic ovary syndrome32
A novel dual mode-of-action anti-hyperalgesic compound in rats which is neuroprotective and promotes neuroregeneration32
Dendritic cells in Parkinson's disease: Regulatory role and therapeutic potential32
Itaconate prolongs the healthy lifespan by activating UPRmt in Caenorhabditis elegans32
Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension32
Targeting KPNB1 with genkwadaphnin suppresses gastric cancer progression through the Nur77-mediated signaling pathway32
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway32
In vitro pharmacological characterization of growth hormone secretagogue receptor ligands using the dynamic mass redistribution and calcium mobilization assays31
Hydrogen sulfide as a neuromodulator of the vascular tone31
β-caryophyllene blocks reactive oxygen species-mediated hyperlipidemia in isoproterenol-induced myocardial infarcted rats31
In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases31
Efficacy of probiotics on improvement of health outcomes in cirrhotic liver disease patients: A systematic review and meta-analysis of randomised controlled trials31
Investigating the impact of protein S-sulfhydration modification on vascular diseases: A comprehensive review31
Dulaglutide provides protection against sepsis-induced lung injury in mice by inhibiting inflammation and apoptosis31
Licoflavone B, an isoprene flavonoid derived from licorice residue, relieves dextran sodium sulfate-induced ulcerative colitis by rebuilding the gut barrier and regulating intestinal microflora30
The clinical outcomes of dapagliflozin in patients with acute heart failure: A randomized controlled trial (DAPA-RESPONSE-AHF)30
Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice30
Catalpol ameliorates LPS-induced inflammatory response by activating AMPK/mTOR signaling pathway in rat intestinal epithelial cells30
The emerging roles of HDACs and their therapeutic implications in cancer30
Sacubitril/valsartan attenuates myocardial inflammation, hypertrophy, and fibrosis in rats with heart failure with preserved ejection fraction30
Carbon monoxide-releasing molecule-2 ameliorates postresuscitation myocardial dysfunction in rat via mitochondrial-mediated apoptosis pathway and the regulation of mitochondrial dynamics30
MiR-29a inhibits MPP + - Induced cell death and inflammation in Parkinson's disease model in vitro by potential targeting of MAVS30
Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway29
Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing29
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells29
Antioxidant effect of ascorbic acid against cisplatin-induced nephrotoxicity and P-glycoprotein expression in rats29
An 8-aminoquinoline-naphthyl copper complex causes apoptotic cell death by modulating the expression of apoptotic regulatory proteins in breast cancer cells29
Anti-inflammatory effects of theaflavin-3′-gallate during influenza virus infection through regulating the TLR4/MAPK/p38 pathway29
Roflumilast alleviates adenine-induced chronic kidney disease by regulating inflammatory biomarkers29
Glutamic oxaloacetic transaminase 1 as a potential target in human cancer29
Editorial Board28
CB-839 induces reversible dormancy in lung tumor-cells28
Nanomedicine: A great boon for cardiac regenerative medicine28
Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization28
ML218 modulates calcium binding protein, oxidative stress, and inflammation during ischemia-reperfusion brain injury in mice28
Matrix metalloproteinases as the critical regulators of cisplatin response and tumor cell invasion28
The serotonin(5-HT)2A receptor is involved in the hypersensitivity of bladder afferent neurons in cyclophosphamide-induced cystitis28
Repositioning of Ticagrelor: Renoprotection mediated by modulating renin-angiotensin system, inflammation, autophagy and galectin-328
Intravesical combination therapies for non-muscle invasive bladder cancer: Recent advances and future directions28
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Small molecule CGRP receptor antagonists for the preventive treatment of migraine: A review28
Implication of P2Y12 receptor in uc.48+-mediated abnormal sympathoexcitatory reflex via superior cervical ganglia in myocardial ischemic rats28
Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review28
Novel approaches to primary membranous nephropathy: Beyond the KDIGO guidelines28
Peficitinib halts acute kidney injury via JAK/STAT3 and growth factors immunomodulation27
Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice27
Metformin turns 62 in pharmacotherapy: Emergence of non-glycaemic effects and potential novel therapeutic applications27
Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats27
Demotion of canonical/non-canonical inflammasome and pyroptosis alleviates ischemia/reperfusion-induced acute kidney injury: Novel role of the D2/D3 receptor agonist ropinirole27
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway27
Gut microbiota and Alzheimer's disease: Exploring natural product intervention and the Gut–Brain axis for therapeutic strategies27
Resveratrol alleviates acute lung injury through regulating PLSCR-3-mediated mitochondrial dysfunction and mitophagy in a cecal ligation and puncture model27
Resveratrol suppresses the reprogramming of macrophages into an endotoxin-tolerant state through the activation of AMP-activated protein kinase27
β-asarone relieves Parkinson's disease through reducing intracellular Ca2+ in PINK1 mutant Drosophila melanogaster27
Modulation of morphine antinociceptive and rewarding effect by mirtazapine in an animal model of osteoarthritic pain27
Fibroblast growth factor 21 inhibited inflammation and fibrosis after myocardial infarction via EGR127
Therapeutic potential of lipid-lowering probiotics on the atherosclerosis development27
Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats27
Liraglutide chronic treatment prevents development of tolerance to antiseizure effects of diazepam in genetically epilepsy prone rats27
Editorial Board27
Bioengineered exosomes: Cellular membrane-camouflaged biomimetic nanocarriers for Parkinson's disease management27
A comprehensive review of targeting RAF kinase in cancer26
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy26
α7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats26
Retraction notice to “Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation“26
Immunomodulatory effect of protocatechuic acid on cyclophosphamide induced brain injury in rat: Modulation of inflammosomes NLRP3 and SIRT126
Harnessing the neuroprotective effect of oral administration of benfotiamine in MPTP induced Parkinson's disease in rats26
γ-mangostin attenuates amyloid-β42-induced neuroinflammation and oxidative stress in microglia-like BV2 cells via the mitogen-activated protein kinases signaling pathway26
A research update on the therapeutic potential of rhein and its derivatives26
The contributory roles of the CXCL12/CXCR4/CXCR7 axis in normal and malignant hematopoiesis: A possible therapeutic target in hematologic malignancies26
Editorial Board26
MiRNA-138–5p: A strong tumor suppressor targeting PD-L-1 inhibits proliferation and motility of breast cancer cells and induces apoptosis26
The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin25
HSP90: A promising target for NSCLC treatments25
Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration in rats25
Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset25
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy25
The impact of sodium-glucose Cotransporter-2 inhibitors on lipid profile: A meta-analysis of 28 randomized controlled trials25
Effects of chronic mirabegron treatment on metabolic and cardiovascular parameters as well as on atherosclerotic lesions of WHHL rabbits with high-fructose high-fat diet-induced insulin resistance.25
β-caryophyllene modulates B-cell lymphoma gene-2 family genes and inhibits the intrinsic pathway of apoptosis in isoproterenol-induced myocardial infarcted rats; A molecular mechanism25
Levofloxacin alleviates blood-brain barrier disruption following cerebral ischemia and reperfusion via directly inhibiting A-FABP25
Pharmacological characterization of AS2690168, a novel small molecule RANKL signal transduction inhibitor24
3,3′-O-dimethylquercetin: A bi-functional vasodilator isolated from green propolis of the Caatinga Mimosa tenuiflora24
PTH 1–34 reduced apoptosis of MLO-Y4 osteocyte-like cells by activating autophagy and inhibiting ER stress under RPM conditions24
Potent in vitro antitumor activity of B-subunit of Shiga toxin conjugated to the diphtheria toxin against breast cancer24
Apigenin-6-C-glucoside ameliorates MASLD in rodent models via selective agonism of adiponectin receptor 224
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer24
ADAM28 from both endothelium and gastric cancer cleaves von Willebrand Factor to eliminate von Willebrand Factor-induced apoptosis of gastric cancer cells24
Morphine timing-dependent modulation of TRPV1 phosphorylation correlates with differential morphine effects on myocardial ischemia/reperfusion injury24
Inhibition of the Notch signaling pathway attenuates progression of cell motility, metastasis, and epithelial-to-mesenchymal transition-like phenomena induced by low concentrations of cisplatin in ost24
Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity24
The potential of carbonic anhydrase enzymes as a novel target for anti-cancer treatment24
Dopamine agonists versus levodopa monotherapy in early Parkinson's disease for the potential risks of motor complications: A network meta-analysis24
Ghrelin alleviates placental dysfunction by down-regulating NF-κB phosphorylation in LPS-induced rat model of preeclampsia24
Dehydrocostuslactone attenuated oxygen and glucose deprivation/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K/AKT/mTOR pathway24
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis24
Ghrelin attenuates depressive-like behavior, heart failure, and neuroinflammation in postmyocardial infarction rat model24
Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a24
Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries24
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF-κB pathways23
Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stress and protein aggregation23
Low-intensity pulsed ultrasound prevents angiotensin II-induced aortic smooth muscle cell phenotypic switch via hampering miR-17-5p and enhancing PPAR-γ23
Laccase-mediated functionalization of natamycin by gallic acids for the therapeutic effect on Aspergillus fumigatus keratitis23
Role of nitric oxide, bradykinin B2 receptor, and TRPV1 in the airway alterations caused by simvastatin in rats23
Apigenin acts as a partial agonist action at estrogen receptors in vivo23
Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification23
Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes23
Estrogen alleviates liver fibrosis and restores metabolic homeostasis in ovariectomy-induced liver injury and carbon tetrachloride (CCl4) exposure23
Hypoxia promotes the expression of Von Willebrand factor in breast cancer cells by up-regulating the transcription factor YY1 and down-regulating the hsa-miR-42423
IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease23
Multi-omics study on the molecular mechanism of anlotinib in regulating tumor metabolism23
Early growth response 1/Krüppel-like factor 5 pathway inhibitor alleviates lipopolysaccharide-induced lung injury by promoting autophagy23
Peptide identification of hepatocyte growth-promoting factor and its function in cytoprotection and promotion of liver cell proliferation through the JAK2/STAT3/c-MYC pathway23
Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons23
Inhibition of melanoma cell migration and invasion by natural coumarin auraptene through regulating EMT markers and reducing MMP-2 and MMP-9 activity23
Inverse agonism of lysophospholipids with cationic head groups at Gi-coupled receptor GPR8222
Molecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics22
Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway22
Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model22
Astaxanthin alleviates neuropathic pain by inhibiting the MAPKs and NF-κB pathways22
Calycosin-7-O-β-D-glucoside attenuates palmitate-induced lipid accumulation in hepatocytes through AMPK activation22
Captopril alleviates glucocorticoid-induced osteonecrosis of the femoral head by mediating the ACE2/ Ang-(1-7)/Mas receptor cascade22
Repositioning and development of new treatments for neurodegenerative diseases: Focus on neuroinflammation22
Integrative experimental validation of concomitant miRNAs and transcription factors with differentially expressed genes in acute myocardial infarction.22
Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats22
Cyclin-dependent kinase 5 inhibitor attenuates lipopolysaccharide-induced neuroinflammation through metabolic reprogramming21
L-amino acid oxidase from snake venom: Biotransformation and induction of apoptosis in human colon cancer cells21
P2Y14 receptor in trigeminal ganglion contributes to neuropathic pain in mice21
Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway21
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis21
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats21
Antiproliferative effects of LY-2183240 combined with various chemotherapeutic drugs in an isobolographic in vitro model of malignant melanoma21
Modified lipoprotein-induced sFlt1 production in human placental trophoblasts is mediated by protein kinase C21
The protective effect of S-adenosylmethionine on chronic adolescent stress-induced depression-like behaviors by regulating gut microbiota21
Advantages and disadvantages of disulfiram coadministered with popular addictive substances21
Validating the temporal performance of genetic biomarkers in an animal model of recurrence/ non-recurrence myocardial infarction persuades by bioinformatics tools21
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression21
Vitexin-2-O-rhamnoside improves immunosuppression, oxidative stress, and phosphorylation of PI3K/Akt signal pathway in cyclophosphamide treated mice21
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins20
Aloperine protects beta-cells against streptozocin-induced injury to attenuate diabetes by targeting NOS120
Suppression of hippocampal GABAergic transmission impairs memory in rodent models of Alzheimer's disease20
The efficacy and safety of PI3K and AKT inhibitors for patients with cancer: A systematic review and network meta-analysis20
Research progress on the potential novel analgesic BU0802820
Methylglyoxal impairs ATP- and UTP-induced relaxation in the rat carotid arteries20
Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats20
Anti-pneumoconiosis effect of schisantherin A in PMA-induced A549 cells and SiO/TiO nanoparticles-induced acute pulmonary injury in mice20
HnRNPK and lysine specific histone demethylase-1 regulates IP-10 mRNA stability in monocytes20
The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD3920
Involvement of interstitial cells of Cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter20
SCP-7, a germacrane-type sesquiterpene lactone derivative, induces ROS-mediated apoptosis in NSCLC cells in vitro and in vivo20
Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis20
Crosstalk between the liver and kidney in diabetic nephropathy20
Antagonism of N/OFQ attenuates externalization of β1-adrenergic receptor and ventricular arrhythmias in acute myocardial ischemia rat model20
Novel apocynin regulates TRPV1 activity in the trigeminal system and controls pain in a temporomandibular joint neurogenic model20
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