Experimental Eye Research

Article	Citations
Biological functions of tear film	124
Composition, structure and function of the corneal stroma	101
Corneal wound healing	95
Corneal neovascularization	83
Corneal myofibroblasts and fibrosis	66
Inflammatory basis for dry eye disease flares	63
Descemet's membrane development, structure, function and regeneration	57
TGF beta −1, −2 and −3 in the modulation of fibrosis in the cornea and other organs	52
Bowman's layer in the cornea– structure and function and regeneration	52
USH2A-retinopathy: From genetics to therapeutics	52
Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution	51
Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis	49
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342–3p targeting of CASP1 in diabetic retinopathy	45
Systemic diseases and the cornea	45
Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus	42
The role of fungi in fungal keratitis	39
TGFβ1 and TGFβ2 proteins in corneas with and without stromal fibrosis: Delayed regeneration of apical epithelial growth factor barrier and the epithelial basement membrane in corneas with stromal fibr	39
Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients	37
N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells	37
Update on the genetics of keratoconus	37
The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases	36
Corneal epithelial basement membrane: Structure, function and regeneration	35
Inherited cataracts: Genetic mechanisms and pathways new and old	35
Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model	35
A prodrug of epigallocatechin-3-gallate alleviates high glucose-induced pro-angiogenic factor production by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis in retinal Müller cells	35

The biology of Acanthamoeba keratitis	34
A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling	34
Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy	33
Keratocyte biology	33
Candidate pathways for retina to scleral signaling in refractive eye growth	32
GSDMD, an executor of pyroptosis, is involved in IL-1β secretion in Aspergillus fumigatus keratitis	32
Foundational concepts in the biology of bacterial keratitis	32
Protection of retinal ganglion cells in glaucoma: Current status and future	31
Biochemistry of human tear film: A review	30
Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221–3p/PI3K/AKT pathway in age-related cataract	30
Current insights in the pathogenesis of scleritis	30
Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration	30
Corneal epithelial biology: Lessons stemming from old to new	29
The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo	29
Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye	29
Corneal fibroblasts: Function and markers	29
Ectatic diseases	29
Corneal biomechanics: Measurement and structural correlations	29
Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development	28
The biology of corneal cross-linking derived from ultraviolet light and riboflavin	28
FTO regulates ocular angiogenesis via m6A-YTHDF2-dependent mechanism	28
Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls	28
Mechanisms of organelle elimination for lens development and differentiation	28
Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits	27
Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression	27
Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death	26
Topical ocular drug delivery systems: Innovations for an unmet need	26
Alterations in the conjunctival surface bacterial microbiome in bacterial keratitis patients	26
Novel insights into gene therapy in the cornea	26
A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration	26
Topical losartan inhibits corneal scarring fibrosis and collagen type IV deposition after Descemet's membrane-endothelial excision in rabbits	25
Corneal angiogenic privilege and its failure	25
Corneal Nerve Abnormalities in Ocular and Systemic Diseases	25
Connexin43 hemichannel block inhibits NLRP3 inflammasome activation in a human retinal explant model of diabetic retinopathy	25
Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis	25
Melanopsin modulates refractive development and myopia	25
The potential role of m6A RNA methylation in diabetic retinopathy	25
Hallmarks of lens aging and cataractogenesis	25
Single cell RNA sequencing (scRNA-Seq) deciphering pathological alterations in streptozotocin-induced diabetic retinas	24
Resveratrol protects retinal ganglion cell axons through regulation of the SIRT1-JNK pathway	24
3D in vitro corneal models: A review of current technologies	24
Different modes of full-thickness macular hole formation	24
Progress in developing rodent models of age-related macular degeneration (AMD)	24
Leucine-rich α-2-glycoprotein-1 promotes diabetic corneal epithelial wound healing and nerve regeneration via regulation of matrix metalloproteinases	24
Safety of silicone oils as intraocular medical device: An in vitro cytotoxicity study	24
Keratin expression by corneal and limbal stem cells during development	24
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a	23
Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation	23
Dichloroacetate prevents TGFβ-induced epithelial-mesenchymal transition of retinal pigment epithelial cells	23
Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4/Bco2 double knockout mice	23

The limbus: Structure and function	23
Corneal stroma regeneration: Preclinical studies	23
Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study	23
Limbal stem cell diseases	23
Focus on cell therapy to treat corneal endothelial diseases	22
Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome; a review study	22
Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes	22
Efficacy of topotecan nanoparticles for intravitreal chemotherapy of retinoblastoma	22
Pathobiology and treatment of viral keratitis	22
The prognostic landscape of adaptive immune resistance signatures and infiltrating immune cells in the tumor microenvironment of uveal melanoma	22
RNA therapeutics in ophthalmology - translation to clinical trials	22
Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD	22
CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy	21
Glycyrrhizin micelle as a genistein nanocarrier: Synergistically promoting corneal epithelial wound healing through blockage of the HMGB1 signaling pathway in diabetic mice	21
Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis	21
Knockdown of Malat1 alleviates high-glucose-induced angiogenesis through regulating miR-205-5p/VEGF-A axis	21
Descemet's membrane injury and regeneration, and posterior corneal fibrosis, in rabbits	21
Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells	21
Diseases of the corneal endothelium	21
The aqueous humor proteome of primary open angle glaucoma: An extensive review	20
The road to restore vision with photoreceptor regeneration	20
Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways	20
Differentially expressed circular RNAs in orbital adipose/connective tissue from patients with thyroid-associated ophthalmopathy	20
The role of TRPV4 channels in ocular function and pathologies	20
Plasma metabolites in treatment-requiring retinopathy of prematurity: Potential biomarkers identified by metabolomics	20
Biology of keratorefractive surgery- PRK, PTK, LASIK, SMILE, inlays and other refractive procedures	20
Integrin: Basement membrane adhesion by corneal epithelial and endothelial cells	20
Procyanidin B2 and rutin in Ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling	20
12. Endothelial pump and barrier function	20
Overexpression of S100A4 protects retinal ganglion cells against retinal ischemia-reperfusion injury in mice	20
Functional integration of eye tissues and refractive eye development: Mechanisms and pathways	20
Corneal nerves anatomy, function, injury and regeneration	19
The microRNAs miR-302d and miR-93 inhibit TGFB-mediated EMT and VEGFA secretion from ARPE-19 cells	19
Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis	19
Effect of long-term inflammation on viability and function of RPE cells	19
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice	19
Immune regulation of the ocular surface	19
A prospective study of serum metabolomic and lipidomic changes in myopic children and adolescents	19
N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice by inhibiting the ROS/NLRP3/Caspase-1/IL-1β signaling pathway	18
Impact of a high-fat diet on the fatty acid composition of the retina	18
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis	18
AQP5 regulates vimentin expression via miR-124–3p.1 to protect lens transparency	18
Corneal nerves and their role in dry eye pathophysiology	18
Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies	18
Short chain fatty acids inhibit endotoxin-induced uveitis and inflammatory responses of retinal astrocytes	18
Exosomes, extracellular vesicles and the eye	18
Tear and ocular surface disease biomarkers: A diagnostic and clinical perspective for ocular allergies and dry eye disease	18
Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier	17
Development, structure, and bioengineering of the human corneal stroma: A review of collagen-based implants	17
The cornea in keratoconjunctivitis sicca	17
VEGF receptor 2 inhibitor nintedanib completely reverts VEGF-A165-induced disturbances of barriers formed by retinal endothelial cells or long-term cultivated ARPE-19 cells	17
Occurrence of SARS-CoV-2 in the intraocular milieu	17
The gut microbiota in retinal diseases	17
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes	17
Viral delivery of multiple miRNAs promotes retinal ganglion cell survival and functional preservation after optic nerve crush injury	17
Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology	17
Signals for defocus arise from longitudinal chromatic aberration in chick	17
Lutein and zeaxanthin attenuates VEGF-induced neovascularisation in human retinal microvascular endothelial cells through a Nox4-dependent pathway	17
The effect of nerve growth factor on corneal nerve regeneration and dry eye after LASIK	17
Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy	17
LncRNA KCNQ1OT1 knockdown inhibits viability, migration and epithelial-mesenchymal transition in human lens epithelial cells via miR-26a-5p/ITGAV/TGF-beta/Smad3 axis	17
Functional, structural, and molecular identification of lymphatic outflow from subconjunctival blebs	16
Tree shrews do not maintain emmetropia in initially-focused narrow-band cyan light	16
A method to quantify regional axonal transport blockade at the optic nerve head after short term intraocular pressure elevation in mice	16
microRNA profiling in the aqueous humor of highly myopic eyes using next generation sequencing	16
The human Descemet's membrane and lens capsule: Protein composition and biomechanical properties	16
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia–reperfusion rats via the TLR4/NF-κB/NLRP3 pathway	16
Deconstructing aqueous humor outflow – The last 50 years	16
Linezolid shows high safety and efficacy in the treatment of Pythium insidiosum keratitis in a rabbit model	16
Role of radially aligned scleral collagen fibers in optic nerve head biomechanics	16
Impacts of high fat diet on ocular outcomes in rodent models of visual disease	16
Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease	16
circRNA-miRNA-mRNA network in age-related macular degeneration: From construction to identification	15
PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells	15
Kaempferol alleviates corneal transplantation rejection by inhibiting NLRP3 inflammasome activation and macrophage M1 polarization via promoting autophagy	15
Calcitriol inhibits apoptosis via activation of autophagy in hyperosmotic stress stimulated corneal epithelial cells in vivo and in vitro	15
Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study	15
Spectrum-frequency and genotype–phenotype analysis of rhodopsin variants	15
TNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation	15
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration	15

Astaxanthin mediated regulation of VEGF through HIF1α and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model	15
The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies	15
A mouse model of retinal hypoperfusion injury induced by unilateral common carotid artery occlusion	15
Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation	15
Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138–5p/SLC7A5 axis	15
Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands	15
Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK	15
In vivo immune cell dynamics in the human cornea	15
The functional role of decorin in corneal neovascularization in vivo	15
The effects of brief high intensity light on ocular growth in chicks developing myopia vary with time of day	15
Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract	15
Immune cells in lens injury repair and fibrosis	15
Role of small interfering RNA (siRNA) in targeting ocular neovascularization: A review	15
Combined hyperosmolarity and inflammatory conditions in stressed human corneal epithelial cells and macrophages to evaluate osmoprotective agents as potential DED treatments	14
H2O2-induced cataract as a model of age-related cataract: Lessons learned from overexpressing the proteasome activator PA28αβ in mouse eye lens	14
The ocular surface and diabetes, the other 21st Century epidemic	14
Cerium oxide nanoparticles reduce the accumulation of autofluorescent deposits in light-induced retinal degeneration: Insights for age-related macular degeneration	14
Plasma metabolomics study of Vogt-Koyanagi-Harada disease identifies potential diagnostic biomarkers	14
Intravitreal enzyme replacement preserves retinal structure and function in canine CLN2 neuronal ceroid lipofuscinosis	14
A new ophthalmic formulation containing antiseptics and dexpanthenol: In vitro antimicrobial activity and effects on corneal and conjunctival epithelial cells	14
Developmental abnormalities in the cornea of a mouse model for Marfan syndrome	14
Assessment of intraocular lens/capsular bag biomechanical interactions following cataract surgery in a human in vitro graded culture capsular bag model	14
RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells	14
Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma	14
Role of growth factors and internal limiting membrane constituents in müller cell migration	14
Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells	14
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration	14
Interaction of alpha-crystallin with four major phospholipids of eye lens membranes	14
Filtering blue light mitigates the deleterious effects induced by the oxidative stress in human retinal pigment epithelial cells	13
PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage	13
Isolation and Characterization of primary human trabecular meshwork cells from segmental flow regions: New tools for understanding segmental flow	13
Inlays and the cornea	13
Piezo1 plays a role in optic nerve head astrocyte reactivity	13
Keratocyte mechanobiology	13
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure	13
Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells	13
Ocular surface temperature measurement in diabetic retinopathy	13
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells	13
Functional assessment of cryopreserved clinical grade hESC-RPE cells as a qualified cell source for stem cell therapy of retinal degenerative diseases	13
Corneal development: Role of the periocular mesenchyme and bi-directional signaling	13
Redox chemistry of lens crystallins: A system of cysteines	13
Interaction of inflammatorily activated retinal pigment epithelium with retinal microglia and neuronal cells	13
IL-6-induced acetylation of E2F1 aggravates oxidative damage of retinal pigment epithelial cell line	13
Neuroprotective role of sphingolipid rheostat in excitotoxic retinal ganglion cell death	13
Melatonin exerts protective effects on diabetic retinopathy via inhibition of Wnt/β-catenin pathway as revealed by quantitative proteomics	13
Carbonic anhydrase inhibition in X-linked retinoschisis: An eye on the photoreceptors	13
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis	13
PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy	13
Microglia increase tight-junction permeability in coordination with Müller cells under hypoxic condition in an in vitro model of inner blood-retinal barrier	13
Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip	13
Prostaglandin F2α and EP2 agonists, and a ROCK inhibitor modulate the formation of 3D organoids of Grave's orbitopathy related human orbital fibroblasts	13
Fusarium infection alters the m6A-modified transcript landscape in the cornea	13
The role of the inflammasomes in the pathogenesis of uveitis	13
Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy	13
Aerobic exercise delays retinal ganglion cell death after optic nerve injury	13
Pathogenesis of keratoconus: NRF2-antioxidant, extracellular matrix and cellular dysfunctions	12
Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2Akita mouse	12
Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results	12
Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease	12
Pathophysiology of dry eye disease and novel therapeutic targets	12
Piezo1 activation induces fibronectin reduction and PGF2α secretion via arachidonic acid cascade	12
Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo	12
Krüppel-like factor 7 protects retinal ganglion cells and promotes functional preservation via activating the Akt pathway after retinal ischemia-reperfusion injury	12
Modeling the cornea in 3-dimensions: Current and future perspectives	12
Novel variants in PNPLA6 causing syndromic retinal dystrophy	12
Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections	12
Magnesium acetyltaurate protects against endothelin-1 induced RGC loss by reducing neuroinflammation in Sprague dawley rats	12
Niche regulation of limbal epithelial stem cells: HC-HA/PTX3 as surrogate matrix niche	12
Effect of monochromatic light on the circadian clock of cultured chick retinal tissue	12
Expression profiles and potential corneal epithelial wound healing regulation targets of high-mobility group box 1 in diabetic mice	12
Effect of a TSPO ligand on retinal pigment epithelial cholesterol homeostasis in high-fat fed mice, implication for age-related macular degeneration	12
Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway	12
CD63+ extracellular vesicles from retinal pigment epithelial cells participate in crosstalk with macrophages in the innate inflammatory axis	12
IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness	12
Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva	12
α-MSH ameliorates corneal surface dysfunction in scopolamine-induced dry eye rats and human corneal epithelial cells via enhancing EGFR expression	12
JQ1, a selective inhibitor of BRD4, suppresses retinoblastoma cell growth by inducing cell cycle arrest and apoptosis	12
Topical application of dopaminergic compounds can inhibit deprivation myopia in chicks	12
Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo	12
PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration	12
Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases	12
Crystallin gene expression: Insights from studies of transcriptional bursting	12
Effect of prostaglandin analogs: Latanoprost, bimatoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human trabecular meshwork endothelial cells	12
The optic nerve head, lamina cribrosa, and nerve fiber layer in non-myopic and myopic children	12
Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis	12
Interactions of cone abundancies, opsin expression, and environmental lighting with emmetropization in chickens	11
Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes	11
Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma	11
Prolonged use of nitric oxide donor sodium nitroprusside induces ocular hypertension in mice	11
Mutation spectrum and genotype-phenotype correlations in Chinese congenital ectopia lentis patients	11
Assessment of necroptosis in the retina in a repeated primary ocular blast injury mouse model	11
VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions	11
The aging mouse lens transcriptome	11
cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology	11
Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis	11