Immunology

Article	Citations
Editorial: Highlighting early‐career researchers—The future of Immunology	384
Featured Cover	135
New Engineered‐Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E	90
Effectiveness of interleukin‐4 administration or zinc supplementation in improving zinc deficiency–associated thymic atrophy and fatty degeneration and in normalizing T cell maturation process	85
Maternal Carriage of Prevotella copri Is Associated With Increased Thymus Derived Naïve Regulatory T Cells in Cord Blood	81
High common‐γ cytokine receptor levels promote expression of Interleukin‐2/Interleukin‐7 receptor α‐chains with implications on T‐cell differentiation and function	77
The immune response to COVID‐19: Does sex matter?	74
Update on the current knowledge of lymphatic drainage system and its emerging roles in glioma management	67
The hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells	64
Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus	61
Interferon‐α promotes MHC I antigen presentation of islet β cells through STAT1‐IRF7 pathway in type 1 diabetes	59
A new strategy for immunotherapy of microsatellite‐stable (MSS)‐type advanced colorectal cancer: Multi‐pathway combination therapy with PD‐1/PD‐L1 inhibitors	56
Hypoxic tumour‐derived exosomal miR‐1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization	56
What's in a name? Nomenclature in immunology	55
Issue Information	53
Issue Information	49
Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of CoronaVac	48
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Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS‐CoV‐2 spike protein vaccine as a homologous and heterologous booster vaccination: A randomized placebo‐controlled trial	41
Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody	40
DNA methylation trajectories during innate and adaptive immune responses of human B lymphocytes	40
Identification of psoriasis‐associated immune marker G3BP2 through single‐cell RNA sequencing and meta analysis	39
Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma	37
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Idiotopes of antibodies against HIV‐1 CD4‐induced epitope shared with those against microorganisms	34

Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori	31
Caspase‐6 is a key regulator of cross‐talk signal way in PANoptosis in cancer	31
Trispecific antibodies for cancer immunotherapy	31
New‐onset autoimmune phenomena post‐COVID‐19 vaccination	31
Issue Information	30
The alterations of innate immunity and enhanced severity of infections in diabetes mellitus	29
Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level	29
Immunomodulatory Mechanisms of ILC2 in Lung Development: Emerging Insights Into Bronchopulmonary Dysplasia Pathogenesis	29
Dietary human milk oligosaccharides reduce allergic airway inflammation by modulating SCFAs level and ILC2 activity	28
Correlation between antibodies against the pathogenic pHERV‐W envelope protein and the inflammatory phase of multiple sclerosis	27
Expression of RAG and secondary gene rearrangement of BCR in mature peripheral B lymphocytes in Takayasu arteritis	27
Memory CD8+ T cells exhibit tissue imprinting and non‐stable exposure‐dependent reactivation characteristics following blood‐stage Plasmodium berghei ANKA infections	26
Corrigendum	26
T cell maturation is significantly affected by SARS‐CoV‐2 infection	26
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Induction of Regulatory T Cells After Virus Infection and Vaccination	24
CCR5‐Mediated Reprogramming of Regulatory T Cells and Monocytic‐Myeloid‐Derived Suppressor Cells in Young Dyslipidemic Individuals: A Plausible Therapeutic Approach	24
Antibodies to SARS‐CoV‐2 in patients with primary immunodeficiencies treated with nonspecific immunoglobulins	24
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Integration of Immune Responses and Transcriptomic Signatures Reveals the Efficacy of Maternal Genetic Vaccination in a Pregnant Model and Its Neonates	22
Early life vaccination reprograms the metabolism and function of myeloid cells in neonates	22
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A detective story of intermittent fasting effect on immunity	22
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Unravelling the Impact of Outer Membrane Protein, OmpA, From S. Typhimurium on Aberrant AID Expression and IgM to IgA Class Switching in H	21
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Helios—Illuminating the way for lymphocyte self‐control	21
The soluble IL‐2 receptor α/CD25 as a modulator of IL‐2 function	20
A Novel Polymersome Nanocarrier Promotes Anti‐Tumour Immunity by Improved Priming of CD8+ T Cells	20
Lineage Tracking Dissects the Fate of Neonatal iNKT Cells Later in Life	20
Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota	20
Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis	19
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis	19
Activation‐induced marker assays for identification of Trypanosoma cruzi‐specific CD4 or CD8 T cells in chronic Chagas disease patients	19
CD226 deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene‐induced atopic dermatitis	19
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy	19
Peripheral blood MR1 tetramer‐positive mucosal‐associated invariant T‐cell function is modulated by mammalian target of rapamycin complex 1 in patients with active tuberculosis	18
Mucosal‐associated invariant T cells in digestive tract: Local guardians or destroyers?	18
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis	18
6‐Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD‐1 to inhibit PD‐1 signalling and enhance T cell function	18
TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display	18
Dysregulated neutrophil extracellular traps formation in sepsis	18
Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniae	18
Issue Information	17
Diagnostic Significance of Metagenomic Next‐Generation Sequencing in Immunocompromised Patients With Suspected Pulmonary Infection	17
Crosstalk between B cells and neutrophils in rheumatoid arthritis	17
γδT Cells in IBD: Beneficial or Detrimental?	17
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An immunogenetic investigation of 30 autoimmune and autoinflammatory diseases and their links to psychiatric disorders in a nationwide sample	16

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Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour‐Associated Tissue‐Resident Memory T Cells	16
Antibody‐dependent cell‐mediated cytotoxicity using T cells with NK‐like phenotype in combination with avelumab, an anti‐PD‐L1 antibody	15
Pla2g5 contributes to viral‐like‐induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment	15
Helper innate lymphoid cells as cell therapy for cancer	15
Exploration of the efficacy of anti‐immunoglobulin E monoclonal antibodies in the treatment of allergic asthma	15
Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctions	15
The Roles of T Cells in the Development of Metabolic Dysfunction‐Associated Steatohepatitis	14
Issue Information	14
Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies	14
IL‐20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation	14
Ceftazidime reduces cellular Skp2 to promote type‐I interferon activity	14
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TIM3/CEACAM1 pathway involves in myeloid‐derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysp	13
cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases	13
Sphingosine‐1‐Phosphate Signalling Inhibition Suppresses Th1‐Like Treg Generation by Reversing Mitochondrial Uncoupling	13
Augmenting Macrophages Apoptosis Induced by Carnitine Palmitoyl Transferase 1A Inhibition via Acetyl‐CoA‐Associated Protein Acetylation	13
Issue Information	13
IL‐1β promotes IL‐17A production of ILC3s to aggravate neutrophilic airway inflammation in mice	12
Sequential engagement of adhesion molecules and cytokine receptors impacts both piecemeal and anaphylactic degranulation of human basophils	12
Tumour‐associated neutrophils: Potential therapeutic targets in pancreatic cancer immunotherapy	12
IL‐10 indirectly modulates functional activity of CD4+CD28null T‐lymphocytes through LFA‐3 and HLA class II inhi	12
The clinical relevance of epithelial‐mesenchymal transition and its correlations with tumorigenic immune infiltrates in hepatocellular carcinoma	12
Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental autoimmune hepatitis	12
Epigenetics: An opportunity to shape innate and adaptive immune responses	12
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Immune control of Mycobacterium tuberculosis is dependent on both soluble TNFRp55 and soluble TNFRp75	11
Omicron breakthrough infections after triple‐dose inactivated COVID‐19 vaccination: A comprehensive analysis of antibody and T‐cell responses	11
CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2	11
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids	11
Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus‐prone mouse models	11
IBD functions as a double‐edged sword for food allergy in BALB/c mice model	11
The Neurobeachin‐like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells	11
Epstein–Barr Virus‐Induced 3 Attributes to TLR7‐Mediated Splenomegaly	11
Polygenic TB control and the sequence of innate/adaptive immune responses to infection: MHC‐II alleles determine the size of the S100A8/9‐producing neutroph	11
Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin‐1 downregulation	11
Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis	11
Simultaneous Blockade of CD209 and CD209L by Monoclonal Antibody Does Not Provide Sufficient Protection Against Multiple Viral Infections In Vivo	11
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LncRNA00492 is required for marginal zone B‐cell development	10
Myeloid‐derived suppressor cells from tumour‐bearing mice induce the population expansion of CD19hiFcγRIIbhi regulatory B cells via PD‐L1	10
NRP1 downregulation correlates with enhanced ILC2 responses during IL‐33 challenge	10
Acute Plasmodium yoelii17XNL Infection During BCG Vaccination Limits T Cell Responses and Mycobacterial Growth Inhibition	10
Lung adenocarcinoma manifesting as subsolid nodule potentially represents tumour in the equilibrium phase of immunoediting	10
Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?	10
Ectopic endometriotic stromal cells‐derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis	10
K33 only mutant ubiquitin augments bone marrow‐derived dendritic cell‐mediated CTL priming via PI3K‐Akt pathway	10
mTORC2 contributes to systemic autoimmunity	10
Chimerism of avian IgY‐scFv and truncated IgG‐Fc: A novel strategy in cross‐species antibody generation and enhancement	10
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19	9
Staphylococcus aureus biofilm properties and chronic rhinosinusitis severity scores correlate positively with total CD4+ T‐cell frequencies and inversely with its Th1, Th1	9
Issue Information	9
Circadian rhythm regulation in the immune system	9
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Issue Information	9
Retinal microglia: Functions and diseases	9
Correction to “Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell”	9
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Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculos	9
Editorial: Perspectives on the landscape of immunology from Nikhil Joshi	9
Vaccines, adjuvants and key factors for mucosal immune response	9
CD73 Expression by CD4+ T Cells Marks Early Effector Memory T Cells	9
Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8+ T cell immunosenescence signature linked to immunopathology	9
Adoptive transfer of IL‐4 reprogrammed Tc17 cells elicits anti‐tumour immunity through functional plasticity	9
Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment	8
Mast cells contribute to T‐cell accumulation in the bronchoalveolar space in mice with IL‐33‐induced airway inflammation	8
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Regulatory B cells protect against chronic hypoxia‐induced pulmonary hypertension by modulating the Tfh/Tfr immune balance	8
Pellino3 ligase negatively regulates influenza B dependent RIG‐I signalling through downregulation of TRAF3‐mediated induction of the transcription factor IRF3 and	8
Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics	8
Induction of a cytokine storm involves suppression of the Osteopontin‐dependent TH1 response	8
IL‐6 Signalling to Responding T Cells Is Key to Calcitonin Gene‐Related Peptide‐Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen Presentation	8
Mycobacterium potentiates protection from colorectal cancer by gut microbial alterations	8
Role of CD14 in human disease	8
A robust platform for integrative spatial multi‐omics analysis to map immune responses to SARS‐CoV‐2 infection in lung tissues	8
Identification of neoantigens in oesophageal adenocarcinoma	8
SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells	8
Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor	8
The role of HMGB1 in COVID‐19‐induced cytokine storm and its potential therapeutic targets: A review	8
TREM1/DAP12 based novel multiple chain CAR‐T cells targeting DLL3 show robust anti‐tumour efficacy for small cell lung cancer	8

Downregulation of type I interferon signalling pathway by urate in primary human PBMCs	8
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS‐CoV‐2‐Induced Immune Responses	8
Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver	8
Coexistence of IL12Rβ1 and BTK Mutations in a Family	8
βhCG mediates immune suppression through upregulation of CD11b+Gr1+ myeloid derived suppressor cells, CD206+M2 macrophages,	8
The Contribution of Complement System in Multiple Sclerosis: Mechanisms and Therapeutic Potentials	8
CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression	7
Computer Integrated Dominant Epitopes Evoke Protective Immune Response Against Streptococcus pneumoniae	7
Expression of GPR56 reflects a hypoactivated state of circulating B cells and is downregulated in B cell subsets in patients with early‐stage lung adenocarcinoma	7
Issue Information	7
Break down the barriers of auto‐inflammation: How to deal with a monogenic auto‐inflammatory disease and immuno‐haematological features in 2022?	7
How maternal factors shape the immune system of breastfed infants to alleviate food allergy: A systematic and updated review	7
NKG2A‐checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA‐E	7
Neutrophils in secondary lymphoid organs	7
NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway	7
BCG‐mediated protection against M. tuberculosis is sustained post‐malaria infection independent of parasite virulence	7
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CD39 pathway inhibits Th1 cell function in tuberculosis	7
New sights of low dose IL‐2: Restoration of immune homeostasis for viral infection	7
Complement: Functions, location and implications	7
A Review on Biosensors for Quantification of MCP‐1 as a Potential Biomarker in Diseases	7
Interleukin‐35 is a critical regulator of immunity during helminth infections associated with multiple sclerosis	7
Immunoparalysis in critically ill children	7
Critical roles of the E3 ubiquitin ligase FBW7 in B‐cell response and the pathogenesis of experimental autoimmune arthritis	7
PD‐1 expression on tumour‐infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B‐cell lymphoma	7
Endocannabinoids in immune regulation and immunopathologies	7
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sjögren's syndrome	7
SAA1 as a Potential Early Diagnostic Biomarker for Sepsis Through Integrated Proteomics and Metabolomics	7
Clinical C3 Inhibition With AMY‐101 Reveals Novel Insights Into IL‐8‐Driven Inflammation in COVID‐19	7
The Role of Innate Immunity in Healthy Aging Through Antimicrobial Peptides	7
The functional diversity of tissue‐resident natural killer cells against infection	7
Impact of Pre‐Infection COVID‐19 Vaccination on the Incidence and Severity of Long COVID: A Retrospective Case–Control Study	7
Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity	7
Increased CD8dim and Decreased CD8bright T Cells as Immunological Signature for Multibacilary Leprosy Patients	7
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Role of novel protein acylation modifications in immunity and its related diseases	6
NK‐cell exhaustion, B‐cell exhaustion and T‐cell exhaustion—the differences and similarities	6
Icariin Induces Chondrocyte Degeneration via Activation of the NF‐κB Signalling Pathway and Reduces the Inflammation Factor Expression Induced by Lipopolysaccharide	6
Issue Information	6
Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel	6
Effector immune cells in chronic lung allograft dysfunction: A systematic review	6
The turning point of COVID‐19 severity is associated with a unique circulating neutrophil gene signature	6
TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice	6
Involvement of Janus kinase‐dependent Bcl‐xL overexpression in steroid resistance of group 2 innate lymphoid cells in asthma	6
Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3+/CD141+) dendritic cells	6
PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody‐secreting cells from oxidative stress	6
Application and Perspectives of Immunotherapy in Head and Neck Squamous Cell Carcinoma	6
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Eleven‐month longitudinal study of antibodies in SARS‐CoV‐2 exposed and naïve primary health care workers upon COVID‐19 vaccination	6
Elucidation of the signalling pathways for enhanced exosome release from Mycobacterium‐infected macrophages and subsequent induction of differentiation	6
Abrogation and homeostatic restoration of IgE responses by a universal IgE allergy CTL vaccine—The three signal self/non‐self/self (S/NS/S) theor	6
RNA technology and nanocarriers empowering in vivo chimeric antigen receptor therapy	6
Identifying SARS‐CoV‐2 ‘memory’ NK cells from COVID‐19 convalescent donors for adoptive cell therapy	6
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Inhibition of leukotriene‐B4 signalling‐mediated host response to tuberculosis is a potential mode of adjunctive host‐directed therapy	6
Featured Cover	6
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases	6
Unlocking the role of the B7‐H4 polymorphism in psoriasis: Insights into methotrexate treatment outcomes: A prospective cohort study	6
Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease	5
Cellular landscape of tumour microenvironment in prostate cancer	5
Our evolving view of neutrophils in defining the pathology of chronic lung disease	5
USP12 positively regulates M‐MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65	5
B Cells as a Host of Persistent Salmonella Typhimurium	5
Keap1 moderates the transcription of virus induced genes through G9a‐GLP and NFκB p50 recruitment	5
CD57 T cells associated with immunosenescence in adults living with HIV or AIDS	5
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Haemocyte‐mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites	5
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Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection	5
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Loss of ALK3 Ameliorates Acute but Aggravates Chronic Lung Inflammation In Vivo	5
Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects	5
IL‐2 amplifies quantitative TCR signalling inputs to drive Th1 and Th2 differentiation	5
PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN‐γ propensity	5
Pathogenetic role and clinical significance of interleukin‐1β in cancer	5
Mycobacterium vaccae alleviates allergic airway inflammation and airway hyper‐responsiveness in asthmatic mice by altering intestinal microbiota	5
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The dual role of regulatory T cells in hepatitis B virus infection and related hepatocellular carcinoma	5
Upregulated TCF1+ Treg Cells With Stronger Function in Systemic Lupus Erythematosus Through Activation of the Wnt‐β‐Catenin	5
Antibiotic‐Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa	5
Circular RNA ACTR2 activates M2 polarization of macrophages through activating Yes‐associated protein signalling and contributes to renal fibrosis	5
Unravelling CD4+ T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single‐cell sequencing	5
Monocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant STAT signalling	5
Chromatin‐binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation	5
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Blocking Deoxycytidine Kinase in Activated Lymphocytes Depletes Deoxycytidine Triphosphate Pools and Alters Cell Cycle Kinetics to Yield Less Disease in a Mouse Multiple Sclerosis Model	4
Development of novel self‐assembled vaccines based on tumour‐specific antigenic peptide and TLR2 agonist for effective breast cancer immunotherapy via activating CD8+ T cells and enhancing	4
Glycans in melanoma: Drivers of tumour progression but sweet targets to exploit for immunotherapy	4
Editorial: Diverse responses to SARS‐CoV‐2 in the human population	4
Issue Information	4
Dual blockages of a broad and potent neutralizing IgM antibody targeting GH loop of EV‐As	4
HLA‐dependent variation in SARS‐CoV‐2 CD8 + T cell cross‐reactivity with human coronaviruses	4
Leishmania surface molecule lipophosphoglycan‐TLR2 interaction moderates TPL2‐mediated TLR2 signalling for parasite survival	4
Contributions of each of the BAFF receptors to the lymphocyte profiles in C57BL/6 mice	4
MicroRNA‐590‐3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice	4