Journal of Biological Chemistry

Article	Citations
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency	713
The molecular virology of coronaviruses	363
Mechanisms of evolved herbicide resistance	328
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis	310
Ethylene signaling in plants	296
Inhibition of SARS–CoV-2 by type I and type III interferons	210
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template	204
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles	202
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine	183
Brain manganese and the balance between essential roles and neurotoxicity	168
Biosynthesis of the modified tetrapyrroles—the pigments of life	166
Antisense technology: A review	161
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)	146
The essential elements of Alzheimer’s disease	143
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection	141
Zinc transporters and their functional integration in mammalian cells	128
Recent advances in de novo protein design: Principles, methods, and applications	121
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity	120
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs	120
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action	117
Post-translational modifications of Hsp90 and translating the chaperone code	117
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation	105
Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code	103
The emerging role of α-synuclein truncation in aggregation and disease	101
Mechanisms of adhesion G protein–coupled receptor activation	100

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species	98
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development	96
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection	96
Mitochondrial metabolism regulates macrophage biology	94
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)	94
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography	93
Lipopolysaccharide O-antigens—bacterial glycans made to measure	92
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling	91
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria	91
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants	89
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress	88
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis	87
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization	85
1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities	85
A molecular roadmap to the plant immune system	84
Zinc promotes liquid–liquid phase separation of tau protein	84
The importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification	83
Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants	82
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET	81
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles	79
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response	78
Toward the solution of the protein structure prediction problem	75
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling	74
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity	74
Small molecule strategies to harness the unfolded protein response: where do we go from here?	73
From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies	72
Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique	72
Role of host factors in SARS-CoV-2 entry	69
Exploring cellular biochemistry with nanobodies	69
Acidity and nucleophilic reactivity of glutathione persulfide	68
Bacterial iron detoxification at the molecular level	68
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?	67
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action	67
Targeting mitophagy in Parkinson's disease	66
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells	65
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity	65
Regulation and function of the mammalian tricarboxylic acid cycle	65
Iron homeostasis and plant immune responses: Recent insights and translational implications	62
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection	61
Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy	61
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling	60
Molecular mechanisms of telomere biology disorders	60
Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag	60
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206	58
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks	57
Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense	56
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms	56
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity	56
Adaptation of influenza viruses to human airway receptors	56
Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α	56

Flagging fusion: Phosphatidylserine signaling in cell–cell fusion	56
Structural insights into emergent signaling modes of G protein–coupled receptors	55
There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling	55
Truncation of Tau selectively facilitates its pathological activities	54
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism	54
Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity	54
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance	53
The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes	53
Genetic glycoengineering in mammalian cells	52
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades	52
Sialic acid O-acetylation: From biosynthesis to roles in health and disease	52
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2	51
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions	51
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases	51
Survivin in breast cancer–derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis	51
Redesigning plant cell walls for the biomass-based bioeconomy	50
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity	49
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling	49
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation	49
IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism	48
From integrative structural biology to cell biology	48
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice	48
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system	47
GAPDH delivers heme to soluble guanylyl cyclase	47
Malaria parasite plasmepsins: More than just plain old degradative pepsins	47
H2S and reactive sulfur signaling at the host-bacterial pathogen interface	46
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation	46
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication	46
Metabolic regulation of ferroptosis in the tumor microenvironment	46
Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease	45
The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation	45
Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors	45
Templated folding of intrinsically disordered proteins	45
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells	45
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation	45
In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment	44
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators	44
Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity	44
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis	44
The role of the histone H3 variant CENPA in prostate cancer	44
Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library	44
Crystal structure of a human plasma membrane phospholipid flippase	44
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank	43
How repertoire data are changing antibody science	43
Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control	43
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis	43
The detection and functions of RNA modification m6A based on m6A writers and erasers	43
A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes	42
Metabolite sensing and signaling in cancer	42
The scrambled story between hyaluronan and glioblastoma	42
Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana	41
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration	41
Emerging roles of the MAGE protein family in stress response pathways	41
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection	41
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation	41
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy	41
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells	41
A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination	41
The many lives of type IA topoisomerases	40
Major tail proteins of bacteriophages of the order Caudovirales	40
Cardiac myosin contraction and mechanotransduction in health and disease	40
Findings in redox biology: From H2O2 to oxidative stress	40
Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution	40
Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation	40
Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies	40
Phase separation drives decision making in cell division	40
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2	39
Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic	39
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands	39
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy	39
Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli	39
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2	38
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway	38
Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges	38
The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis	38
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2	38
Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones	38
Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro	38
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration	38
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition	38

Translational regulation of environmental adaptation in bacteria	38
Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment	37
Emerging roles of DYRK2 in cancer	37
NSun2 promotes cell migration through methylating autotaxin mRNA	37
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity	37
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress	37
Biochemistry of nicotine metabolism and its relevance to lung cancer	37
Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice	37
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells	37
A flexible network of vimentin intermediate filaments promotes migration of amoeboid cancer cells through confined environments	37
Nuclear receptor phosphorylation in xenobiotic signal transduction	37
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement	36
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein	36
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells	36
The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation	36
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin	36
African swine fever virus cysteine protease pS273R inhibits pyroptosis by noncanonically cleaving gasdermin D	36
Interactions of ferritin with scavenger receptor class A members	36
Genetic diseases of the Kennedy pathways for membrane synthesis	35
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems	35
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1	35
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11	35
Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke	35
Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants	35
Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations	35
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2	35
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes	35
Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity	35
Circadian clock, carcinogenesis, chronochemotherapy connections	35
Sphingosine kills bacteria by binding to cardiolipin	35
Endosomal cAMP production broadly impacts the cellular phosphoproteome	35
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice	34
Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma	34
Inflammation promotes adipocyte lipolysis via IRE1 kinase	34
SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics	34
Moving beyond static snapshots: Protein dynamics and the Protein Data Bank	34
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism	34
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II	34
Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues	34
Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis	34
X-ray–induced photoreduction of heme metal centers rapidly induces active-site perturbations in a protein-independent manner	34
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response	34
The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation	34
Modulating disease-relevant tau oligomeric strains by small molecules	34
Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease	34
Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation	34
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells	33
The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function	33
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes	33
High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)	33
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis	33
5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs	33
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection	33
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?	32
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)	32
Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f	32
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase	32
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau	32
Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa	32
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2	32
Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function	32
Hypoxia drives the assembly of the multienzyme purinosome complex	32
Insulin signaling requires glucose to promote lipid anabolism in adipocytes	32
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation	32
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes	32
AggreCount: an unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially defined manner	32
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation	32
Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles	32
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain	32
Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection	32
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15	32
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay	32
Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer	32
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs	32
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase	32
The transcription factor HAND2 up-regulates transcription of the IL15 gene in human endometrial stromal cells	32
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes	32
Essence determines phenomenon: Assaying the material properties of biological condensates	32
Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid–induced synaptic dysfunction	32
MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase	31
Human ribosomal G-quadruplexes regulate heme bioavailability	31
Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer	31
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development	31
Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F	31
Post-translational control of the long and winding road to cholesterol	31
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide	31
Ligand bias in receptor tyrosine kinase signaling	31
PIP2 regulation of TRPC5 channel activation and desensitization	31
Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species	31
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils	31
The evolution and mechanism of GPCR proton sensing	31
The ubiquitin system affects agronomic plant traits	31
Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase	31
Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation	31
Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling	31