Journal of Cell Biology

Article	Citations
LNCcation: lncRNA localization and function	642
Mitochondrial regulation of ferroptosis	203
Autophagosome biogenesis: From membrane growth to closure	186
Lysosome biogenesis: Regulation and functions	168
The cell biology of synapse formation	151
Mitophagy pathways in health and disease	120
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis	112
Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy	112
SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration	101
Liquid–liquid phase separation in autophagy	101
STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain	94
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine	93
VPS13D bridges the ER to mitochondria and peroxisomes via Miro	89
The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation	87
Cancer cells educate natural killer cells to a metastasis-promoting cell state	86
FUS-dependent liquid–liquid phase separation is important for DNA repair initiation	86
Mechanisms of nonvesicular lipid transport	85
The NLRP3–inflammasome as a sensor of organelle dysfunction	84
Lipid droplets in the nervous system	84
The cell biology of Parkinson’s disease	78
Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids	73
CDK4/6 regulate lysosome biogenesis through TFEB/TFE3	71
Microtubules control cellular shape and coherence in amoeboid migrating cells	70
Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway	70
Who’s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond	69

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells	63
Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms	62
COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers	62
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2	61
Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale	61
Phospholipid ebb and flow makes mitochondria go	61
The proline-rich domain promotes Tau liquid–liquid phase separation in cells	60
A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy	59
Similarities and interplay between senescent cells and macrophages	59
Phase separation of Axin organizes the β-catenin destruction complex	58
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer	57
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy	57
High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate	56
Secretory autophagy maintains proteostasis upon lysosome inhibition	56
Evolving models for assembling and shaping clathrin-coated pits	56
ECM deposition is driven by caveolin-1–dependent regulation of exosomal biogenesis and cargo sorting	55
Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia	53
The long journey to bring a Myc inhibitor to the clinic	52
Time-resolved proteomics profiling of the ciliary Hedgehog response	52
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling	51
Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation	51
High-content imaging-based pooled CRISPR screens in mammalian cells	51
Role of the early secretory pathway in SARS-CoV-2 infection	50
VPS13D promotes peroxisome biogenesis	50
Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner	50
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness	48
Transmembrane phospholipid translocation mediated by Atg9 is involved in autophagosome formation	47
TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes	47
Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes	46
Cytoskeletal organization of axons in vertebrates and invertebrates	45
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome	45
Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion	43
Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration	43
Coupling of translation quality control and mRNA targeting to stress granules	42
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival	42
Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN	42
CRISPR-Cas12a–assisted PCR tagging of mammalian genes	41
Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging	41
CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion	40
Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes	40
High-speed single-molecule imaging reveals signal transduction by induced transbilayer raft phases	40
Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage	40
mTORC1 activity is supported by spatial association with focal adhesions	39
Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling	38
Synaptic activity controls autophagic vacuole motility and function in dendrites	38
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling	38
Structural and biochemical insights into lipid transport by VPS13 proteins	38
Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations	37
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure	37
FIT2 is an acyl–coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis	37

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae	37
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins	37
Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy	37
Quantitative correlative microscopy reveals the ultrastructural distribution of endogenous endosomal proteins	36
DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A	36
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis	35
PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission	35
Analysis of copy number alterations reveals the lncRNA ALAL-1 as a regulator of lung cancer immune evasion	35
The WAVE complex associates with sites of saddle membrane curvature	35
A cryo-ET survey of microtubules and intracellular compartments in mammalian axons	35
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components	35
Tyramide signal amplification mass spectrometry (TSA-MS) ratio identifies nuclear speckle proteins	35
ER as master regulator of membrane trafficking and organelle function	34
HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions	34
Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs	33
Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging	33
MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes	33
A guide to membrane atg8ylation and autophagy with reflections on immunity	32
Intracellular wetting mediates contacts between liquid compartments and membrane-bound organelles	32
Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy	32
Label-retention expansion microscopy	32
XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end	32
Long-lived mitochondrial cristae proteins in mouse heart and brain	32
A non-canonical Hedgehog pathway initiates ciliogenesis and autophagy	32
Alternative splicing of clathrin heavy chain contributes to the switch from coated pits to plaques	32
The cell biology of inflammation: From common traits to remarkable immunological adaptations	32
FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply	32
Lipid droplets and the host–pathogen dynamic: FATal attraction?	32
Cnm1 mediates nucleus–mitochondria contact site formation in response to phospholipid levels	31
Capture and delivery of tail-anchored proteins to the endoplasmic reticulum	31
PLCγ1 promotes phase separation of T cell signaling components	31
High-precision targeting workflow for volume electron microscopy	31
In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen	31
GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles	30
Phosphorylation of SNX27 by MAPK11/14 links cellular stress–signaling pathways with endocytic recycling	30
ANO5 ensures trafficking of annexins in wounded myofibers	30
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites	30
Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER	30
Optogenetic activators of apoptosis, necroptosis, and pyroptosis	30
The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion	30
ER–mitochondria contacts promote mitochondrial-derived compartment biogenesis	30
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination	29
Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis	29
CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export	29
CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity	29
GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation	29
Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation	29
Cargo crowding contributes to sorting stringency in COPII vesicles	29
WASP integrates substrate topology and cell polarity to guide neutrophil migration	28
Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint	28
A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells	28
mRNA localization mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis	28
Induction of spontaneous human neocentromere formation and long-term maturation	28
MICOS subcomplexes assemble independently on the mitochondrial inner membrane in proximity to ER contact sites	28
Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse	28
A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity	28
Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion	28
Angulin-1 seals tricellular contacts independently of tricellulin and claudins	28
Centriole-independent mitotic spindle assembly relies on the PCNT–CDK5RAP2 pericentriolar matrix	28
Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets	27
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development	27
A septin GTPase scaffold of dynein–dynactin motors triggers retrograde lysosome transport	27
Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism	27
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy	27
NBR1: The archetypal selective autophagy receptor	27
Specific KIF1A–adaptor interactions control selective cargo recognition	27
p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen	27
A ciliopathy complex builds distal appendages to initiate ciliogenesis	27
Evidence for anaphase pulling forces during C. elegans meiosis	27
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals	27
Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway	27
Atg39 links and deforms the outer and inner nuclear membranes in selective autophagy of the nucleus	26
A modified lysosomal organelle mediates nonlytic egress of reovirus	26
The UPRmt preserves mitochondrial import to extend lifespan	26
ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER–mitochondria contact sites	26
RIM-binding protein couples synaptic vesicle recruitment to release sites	26
Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy	26
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle	26
Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function	26
Kinetochore-bound Mps1 regulates kinetochore–microtubule attachments via Ndc80 phosphorylation	26

NUCKS1 promotes RAD54 activity in homologous recombination DNA repair	26
C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria	26
An antibody toolbox to track complex I assembly defines AIF’s mitochondrial function	26
Regulating peroxisome–ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β	25
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination	25
Conserved actin machinery drives microtubule-independent motility and phagocytosis in Naegleria	25
VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection	25
Subcellular localization of the J-protein Sis1 regulates the heat shock response	25
Structural insights into G domain dimerization and pathogenic mutation of OPA1	25
Consensus nomenclature for dyneins and associated assembly factors	25
Cell division requires RNA eviction from condensing chromosomes	25
CDKD-dependent activation of CDKA;1 controls microtubule dynamics and cytokinesis during meiosis	25
MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling	24
LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation	24
The +TIP Navigator-1 is an actin–microtubule crosslinker that regulates axonal growth cone motility	24
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition	24
JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport	24
Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization	24
E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened	24
Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain	23
FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins	23
Cell migration orchestrates migrasome formation by shaping retraction fibers	23
Quality control of 40S ribosome head assembly ensures scanning competence	23
ATG9 vesicles comprise the seed membrane of mammalian autophagosomes	23
The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites	23
Object detection networks and augmented reality for cellular detection in fluorescence microscopy	23
Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis	23
Teasing out function from morphology: Similarities between primary cilia and immune synapses	23
Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockouts	23
Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs	23
Retinyl esters form lipid droplets independently of triacylglycerol and seipin	23
Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes	23
Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control	23
ER membrane contact sites support endosomal small GTPase conversion for exosome secretion	23
Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules	23
Mechanical competition alters the cellular interpretation of an endogenous genetic program	22
A loop extrusion–independent mechanism contributes to condensin I–mediated chromosome shaping	22
Regulation of membrane NMDA receptors by dynamics and protein interactions	22
STING controls energy stress-induced autophagy and energy metabolism via STX17	22
An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity	22
Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1–dependent process	22
ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation	22
Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation	22
Tension promotes kinetochore–microtubule release by Aurora B kinase	22
Genetically encoded live-cell sensor for tyrosinated microtubules	22
Live imaging of transcription sites using an elongating RNA polymerase II–specific probe	22
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina	22
SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity	22
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage	21
Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels	21
ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation	21
Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction	21
c entrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis	21
Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation	21
Stress-responsive regulation of extracellular proteostasis	21
Confounding factors from inducible systems for spatiotemporal gene expression regulation	21
Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine	21
Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin	21
Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia	21
Combinatorial multivalent interactions drive cooperative assembly of the COPII coat	21
Myelination generates aberrant ultrastructure that is resolved by microglia	21
The cell biology of fertilization: Gamete attachment and fusion	21
Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly	21
Protein exchange is reduced in calcium-independent epithelial junctions	21
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1	21
Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop	20
Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure	20
Plk4 triggers autonomous de novo centriole biogenesis and maturation	20
Novel phospho-switch function of delta-catenin in dendrite development	20
O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport	20
Detection and quantification of the vacuolar H+ATPase using the Legionella effector protein SidK	20
Superresolution characterization of core centriole architecture	20
Mitochondria on the move: Horizontal mitochondrial transfer in disease and health	20
The deubiquitylase USP9X controls ribosomal stalling	20
The function of GORASPs in Golgi apparatus organization in vivo	20
WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing	20
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway	20
Multivalent interactions make adherens junction–cytoskeletal linkage robust during morphogenesis	20
Lymphocyte egress signal sphingosine-1-phosphate promotes ERM-guided, bleb-based migration	19
Chromosome oscillation promotes Aurora A–dependent Hec1 phosphorylation and mitotic fidelity	19
High-throughput single-cell epigenomic profiling by targeted insertion of promoters (TIP-seq)	19
Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis	19
Aurora A kinase activation: Different means to different ends	19
Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling	19
Per1/Per2–Igf2 axis–mediated circadian regulation of myogenic differentiation	19
Mechanism of p38 MAPK–induced EGFR endocytosis and its crosstalk with ligand-induced pathways	19
A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4	19
Centromeric transcription maintains centromeric cohesion in human cells	19
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality	19
Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens	19
DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair	18
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation	18
Quality assessment in light microscopy for routine use through simple tools and robust metrics	18
Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions	18
Pex30-like proteins function as adaptors at distinct ER membrane contact sites	18