OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Clinical Investigation is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Deployment of convalescent plasma for the prevention and treatment of COVID-19	583
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis	556
Kinetics of viral load and antibody response in relation to COVID-19 severity	460
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent	402
Immune responses to stroke: mechanisms, modulation, and therapeutic potential	359
SARS–CoV-2 infection of the placenta	341
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population	336
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2	298
Early safety indicators of COVID-19 convalescent plasma in 5000 patients	293
Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children	277
Recent endemic coronavirus infection is associated with less-severe COVID-19	256
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells	228
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer	221
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals	206
Baricitinib restrains the immune dysregulation in patients with severe COVID-19	195
Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma	188
Insulin signaling in health and disease	179
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer	174
SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition	173
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization	162
COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes	157
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	148
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	148
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis	143
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis	140

Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	139
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration	136
Herpesvirus latency	132
Hypoxia-inducible factors and obstructive sleep apnea	129
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals	126
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia	122
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis	121
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure	118
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer	116
Immune dysregulation as a driver of idiopathic pulmonary fibrosis	116
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging	114
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury	113
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control	112
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease	112
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation	111
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability	110
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction	109
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	108
IRF4 instructs effector Treg differentiation and immune suppression in human cancer	107
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	107
Hypoxia-inducible factor signaling in pulmonary hypertension	106
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models	105
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo	105
Pharmacological treatment of hyperglycemia in type 2 diabetes	103
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss	102
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	102
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities	101
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer	101
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation	100
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration	99
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium	98
Biomarkers of inflammation and repair in kidney disease progression	97
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin	97
Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists	97
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity	96
Circadian rhythm influences induction of trained immunity by BCG vaccination	96
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection	96
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner	94
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	94
Minimal PD-1 expression in mouse and human NK cells under diverse conditions	93
Lung megakaryocytes are immune modulatory cells	93
Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease	92
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain	91
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis	91
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury	89
Inherited human IFN-γ deficiency underlies mycobacterial disease	89
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis	89
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus	88
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain	88
Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy	88

Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome	86
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing	86
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	85
Hypoxia-inducible factors and innate immunity in liver cancer	85
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging	83
Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms	83
Hypoxia-inducible factors and diabetes	81
Dietary interventions for obesity: clinical and mechanistic findings	81