Journal of Clinical Investigation

Article	Citations
Deployment of convalescent plasma for the prevention and treatment of COVID-19	583
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis	556
Kinetics of viral load and antibody response in relation to COVID-19 severity	460
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent	402
Immune responses to stroke: mechanisms, modulation, and therapeutic potential	359
SARS–CoV-2 infection of the placenta	341
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population	336
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2	298
Early safety indicators of COVID-19 convalescent plasma in 5000 patients	293
Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children	277
Recent endemic coronavirus infection is associated with less-severe COVID-19	256
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells	228
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer	221
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals	206
Baricitinib restrains the immune dysregulation in patients with severe COVID-19	195
Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma	188
Insulin signaling in health and disease	179
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer	174
SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition	173
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization	162
COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes	157
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	148
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	148
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis	143
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis	140

Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	139
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration	136
Herpesvirus latency	132
Hypoxia-inducible factors and obstructive sleep apnea	129
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals	126
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia	122
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis	121
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure	118
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer	116
Immune dysregulation as a driver of idiopathic pulmonary fibrosis	116
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging	114
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury	113
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control	112
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease	112
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation	111
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability	110
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction	109
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	108
IRF4 instructs effector Treg differentiation and immune suppression in human cancer	107
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	107
Hypoxia-inducible factor signaling in pulmonary hypertension	106
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models	105
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo	105
Pharmacological treatment of hyperglycemia in type 2 diabetes	103
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss	102
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	102
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer	101
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities	101
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation	100
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration	99
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium	98
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin	97
Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists	97
Biomarkers of inflammation and repair in kidney disease progression	97
Circadian rhythm influences induction of trained immunity by BCG vaccination	96
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection	96
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity	96
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	94
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner	94
Lung megakaryocytes are immune modulatory cells	93
Minimal PD-1 expression in mouse and human NK cells under diverse conditions	93
Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease	92
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis	91
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain	91
Inherited human IFN-γ deficiency underlies mycobacterial disease	89
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis	89
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury	89
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain	88
Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy	88
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus	88

Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome	86
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing	86
Hypoxia-inducible factors and innate immunity in liver cancer	85
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	85
Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms	83
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging	83
Hypoxia-inducible factors and diabetes	81
Dietary interventions for obesity: clinical and mechanistic findings	81
Clinical trials for COVID-19 should include sex as a variable	80
Monogenic diabetes: a gateway to precision medicine in diabetes	79
Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis	79
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice	78
Overcoming innate immune barriers that impede AAV gene therapy vectors	77
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	77
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix	77
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors	76
DCAF1 regulates Treg senescence via the ROS axis during immunological aging	74
Gastrointestinal motility disorders in neurologic disease	74
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2	74
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217	73
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness	72
Fecal microbiome and metabolome differ in healthy and food-allergic twins	71
Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy	70
Durable SARS-CoV-2 B cell immunity after mild or severe disease	70
Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones	70
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice	70
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma	69
Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum	69
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells	69
The knowns and unknowns of latent Mycobacterium tuberculosis infection	69
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris	68
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates	67
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia	67
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity	66
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency	65
B cell–intrinsic TLR9 expression is protective in murine lupus	64
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons	64
Kidney diseases in the time of COVID-19: major challenges to patient care	64
New York City COVID-19 resident physician exposure during exponential phase of pandemic	64
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity	63
Type 1 diabetes mellitus: much progress, many opportunities	63
LIN28B promotes the development of neuroendocrine prostate cancer	62
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation	62
dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors	62
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	62
IL-36 in chronic inflammation and fibrosis — bridging the gap?	61
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma	61
Correction of muscular dystrophies by CRISPR gene editing	61
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission	61
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production	60
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice	60
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity	60
Bite of the wolf: innate immune responses propagate autoimmunity in lupus	59
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis	59
Stem cell therapy for muscular dystrophies	58
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients	58
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress	57
Defective lysosome reformation during autophagy causes skeletal muscle disease	56
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis	56
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts	56
Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification	56
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis	56
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation	55
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis	55
Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis	55
Immune pathogenesis of COVID-19–related multisystem inflammatory syndrome in children	55
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity	54
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury	54
OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity	54
Neutrophil dynamics in the tumor microenvironment	54
Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders	54
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease	54
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality	54
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes	54
Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling	53
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells	53
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells	53
Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression	53
FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease	52
Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells	52

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication	52
Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance	52
Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function	52
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice	52
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability	51
SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy	50
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response	50
Diagnostic accuracy of 3 urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients	50
The molecular biology and immune control of chronic Toxoplasma gondii infection	50
Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics	49
γ9δ2T cell diversity and the receptor interface with tumor cells	49
The multifaceted nature of HIV latency	49
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia	49
DNA hypermethylation during tuberculosis dampens host immune responsiveness	48
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines	47
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3	47
SARS-CoV-2 variants and convalescent plasma: reality, fallacies, and opportunities	47
Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility	47
Inhibition of IRF5 hyperactivation protects from lupus onset and severity	47
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction	47
Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice	47
COVID-19, microangiopathy, hemostatic activation, and complement	46
Congenital heart disease risk loci identified by genome-wide association study in European patients	46
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes	46
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma	46
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin	46
T follicular regulatory cells and IL-10 promote food antigen–specific IgE	46
β-Glucan–induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies	46
Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis	46
CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia	45
Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10	45
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion	45
Human NK cell deficiency as a result of biallelic mutations in MCM10	45
Arginase impedes the resolution of colitis by altering the microbiome and metabolome	45
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance	45
Metabolic effects of air pollution exposure and reversibility	45
Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome	45
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms	44
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice	44
Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy	44
H. pylori infection alters repair of DNA double-strand breaks via SNHG17	44
PRICKLE3 linked to ATPase biogenesis manifested Leber’s hereditary optic neuropathy	43
Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD	43
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments	43
Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity	43
Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes	42
TET repression and increased DNMT activity synergistically induce aberrant DNA methylation	42
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models	42
Immobilization after injury alters extracellular matrix and stem cell fate	42
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	42
Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization	41
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia	41
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma	41
Mapping mania symptoms based on focal brain damage	41
Krabbe disease successfully treated via monotherapy of intrathecal gene therapy	40
Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection	40
Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma	40
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow	40
Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease	40
Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice	40
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool	40
Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma	40
Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis	40
Nitric oxide modulates bone anabolism through regulation of osteoblast glycolysis and differentiation	39
mTOR-dependent translation amplifies microglia priming in aging mice	39
Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins	39
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors	39
Turning lead into gold: reprogramming retinal cells to cure blindness	39
BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C–deficient mice	39
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection	38
Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients	38
Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection	38
Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias	38
Severe insulin resistance syndromes	38
Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes	38
A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress–induced bone loss	38
COVID-19 vaccine testing in pregnant females is necessary	37
TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm	37
DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas	37
CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis	37
Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling	37
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis	37
Autologous CMV-specific T cells are a safe adjuvant immunotherapy for primary glioblastoma multiforme	37
The discovery of insulin revisited: lessons for the modern era	37
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle	37
Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression	36
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects	36
Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence	36
Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin	36
Donor monocyte–derived macrophages promote human acute graft-versus-host disease	35
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade	35
Tau is not necessary for amyloid-β–induced synaptic and memory impairments	35
Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis	35
Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion	35
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease	35