OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Clinical Investigation is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
Changes in the National Cancer Institute’s R01 workforce: growth, aging, retention, and policy implications	224
Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle	208
CC17 group B Streptococcus exploits integrins for neonatal meningitis development	196
An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides	172
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle	146
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	127
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	119
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity	110
Integrating imaging and RNA-seq improves outcome prediction in cervical cancer	102
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses	101
Identification of SARS-CoV-2–specific immune alterations in acutely ill patients	92
Age-specific effects of vaccine egg adaptation and immune priming on A(H3N2) antibody responses following influenza vaccination	85
VCAM-1: closing the gap between lipotoxicity and endothelial dysfunction in nonalcoholic steatohepatitis	85
Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis	78
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	78
A sobering addition to the literature on COVID-19 and the brain	76
NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis	75
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease	74
Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus	69
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis	68
America’s deadly flirtation with antiscience and the medical freedom movement	67
Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy	66
TorsinA restoration in a mouse model identifies a critical therapeutic window for DYT1 dystonia	65
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation	65
Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy	63

Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	63
A conversation with Robert Lefkowitz	56
Endoplasmic reticulum–associated degradation is required for nephrin maturation and kidney glomerular filtration function	56
UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia	55
Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma	54
The JCI Scholar experience strengthens physician-scientist training	53
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia	52
YAP/TFEB pathway promotes autophagic cell death and hypertrophic cardiomyopathy in lysosomal storage diseases	51
Uridine diphosphate–glucose/P2Y14R axis is a nonchemokine pathway that selectively promotes eosinophil accumulation	51
Benjamin Ebert wins the 2021 ASCI/Stanley J. Korsmeyer Award	50
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases	50
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	46
Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor–mediated lymphangiogenesis	44
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis	41
Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle–mediated trafficking	41
Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans	40
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin	40
Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration	39
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer	39
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	37
Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10	36
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice	36
A tribute to John G. Bartlett, MD (1937–2021)	35
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification	33
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells	33
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons	33
Type 1 diabetes mellitus: much progress, many opportunities	31
Triglyceride lowering by omega-3 fatty acids: a mechanism mediated by N-acyl taurines	31
A clear pathway to tubulointerstitial disease: is an exclusive focus on fibrosis justified?	30
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects	29
APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production	29