Journal of Experimental Medicine

Article	Citations
S1PR1, an endothelial-immune influencer	258
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	223
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	183
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	171
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	134
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	126
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	124
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	118
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	116
The microbial one-hit wonder	113
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	106
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	103
Early innate role for CD8αα+ cells in tuberculosis	98
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	98
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	94
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	85
RORγt eTACs mediate oral tolerance and Treg induction	85
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	84
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	83
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	82
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	81
B cell receptor ligation induces IgE plasma cell elimination	79
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	79
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	77
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	77

ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	77
Dual role of vascular endothelial growth factor-C in post-stroke recovery	71
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	71
pDCs, type 1 IFN, and the female predileXion of SSc	70
Challenges in TB research	69
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	69
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	68
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	68
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	66
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	64
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	63
Correction: ICAM-1 controls development and function of ILC2	63
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	63
Implication of folate deficiency in CYP2U1 loss of function	63
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	62
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	62
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	62
Obesity alters monocyte developmental trajectories to enhance metastasis	62
Systems-level conservation of the proximal TCR signaling network of mice and humans	62
Making memories with Bcl-6	62
Role of adipose tissue macrophages in obesity-related disorders	62
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	61
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin	60
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	60
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	60
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	59
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	59
A twist in the tail: Of T cell subsets and disease	57
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	56
Tingible body macrophages: Gargantuan chameleons of the germinal center	56
Michelle Linterman: We are always learning	56
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	55
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes	55
Spatiotemporal dynamics of fetal liver hematopoietic niches	55
Altered glycosylation in pancreatic cancer and beyond	54
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	54
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	54
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	53
How decreasing T cell signaling unexpectedly results in autoimmunity	52
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	52
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	52
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	51
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	51
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	51
Human autoantibodies underlying infectious diseases	51
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	51
Pleiotrophin drives a prometastatic immune niche in breast cancer	51
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	50
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer	50
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	50

Protective fibroblastic niches in secondary lymphoid organs	49
T2B or not to B: Calming neutrophils offshore	49
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	48
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	48
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	48
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	48
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	48
Tumor-derived OBP2A promotes prostate cancer castration resistance	47
Sara Suliman: Science is better when it’s shared	46
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	46
Immature B cell homing shapes human lymphoid tissue structure and function	45
Correction: Role of affinity in plasma cell development in the germinal center light zone	45
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	45
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	45
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	45
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	44
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	44
Changing behind the scenes	44
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	43
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	43
CTLA4 prohibits T cells from cross-dressing	43
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	43
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	43
Targeting neuroinflammation in neuropathic pain and opioid use	43
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	43
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	42
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	42
CAR-T cell manufacturing: Major process parameters and next-generation strategies	42
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	42
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	42
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	41
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	41
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	41
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	41
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	40
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	40
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	40
Laura Mackay: Don't be afraid to engage	40
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	40
Dominant negative OTULIN-related autoinflammatory syndrome	39
Cigarette smoke components modulate the MR1–MAIT axis	39
Single-cell imaging of T cell immunotherapy responses in vivo	39
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	39
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	39
Competitive fungal commensalism mitigates candidiasis pathology	38
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	38
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	38
A path forward for Staphylococcus aureus vaccine development	38
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	37
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	37
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	37
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	37
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	37
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	36
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	36
Perfecting antigen prediction	36
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	36
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	35
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	35
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	35
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	34
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	34
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	34
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	34
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	34
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	34
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	33
Charting the meningeal lymphatic network	33
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	33
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	33
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	32
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	32
Iron TAMs: The fallen protectors	32
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	32
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza	32
Inhibitory pattern recognition receptors	32
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	31
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	31
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	31
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	31

Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	31
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	31
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire	31
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	30
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	30
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	30
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	29
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	29
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	29
The PML hub: An emerging actor of leukemia therapies	29
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice	29
Eating away T cell responses in lung cancer	29
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF	29
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	29
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress	28
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	28
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	28
Fueling the fire in the gut	28
Th17-to-Tfh plasticity during periodontitis limits disease pathology	28
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	27
Emerging in vivo tools for ILC2 research	27
Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity	27
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	27
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	27
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	27
Macro-clusters: CD301b+ DCs prime Th2 responses	27
The X factor in neurodegeneration	27
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	27
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	27
Identifying genetic errors of immunity due to mosaicism	26
Stopping the fat: Repurposing an antidepressant for cancer treatment	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	26
STAT3 gain of function: Too much of a good thing in the skin!	26
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	26
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	26
The stunning clodronate	26
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	26
Lymph node metastasis: An immunological burden	25
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	25
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	25
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	25
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	25
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	25
Mechanosensing regulates pDC activation in the skin through NRF2 activation	25
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	25
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	24
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells	24
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	24
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	24
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	24
Landscape of mast cell populations across organs in mice and humans	24
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	24
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	24
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	24
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	24
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	24
OTULIN and Muller’s morphs	23
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	23
A half-century of research on tuberculosis: Successes and challenges	23
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	23
Guardians of the oral barriers	23
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	23
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	22
BATF represses BIM to sustain tolerant T cells in the periphery	22
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	22
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	22
Lymphatic transport in anti-tumor immunity and metastasis	22
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	22
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	22
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	22
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	22
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	22
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	22
Five decades of natural killer cell discovery	22
A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies	22
Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance	21
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge	21
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway	21
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation	21
Correction: Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	21
The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination	21
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua	21
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection	21
NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome	21
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration	21
Kids’ noses resist COVID-19	21
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies	21
Sidestepping SHP2 inhibition	20
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes	20
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions	20
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency	20
The Src–ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage	20
Helminths revive to survive	20
Natural rodent model of viral transmission reveals biological features of virus population dynamics	20
Correction: Germinal center–dependent and –independent memory B cells produced throughout the immune response	20