Journal of Experimental Medicine

Article	Citations
SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology	644
Neuroinvasion of SARS-CoV-2 in human and mouse brain	600
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients	548
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses	470
Lipid metabolism and cancer	349
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	320
Ferroptosis in infection, inflammation, and immunity	307
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19	271
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo	256
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection	255
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease	247
Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer	226
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model	224
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1	179
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?	156
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance	149
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells	148
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients	142
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics	138
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling	137
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling	137
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine	130
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	127
Neutrophil phenotypes and functions in cancer: A consensus statement	126
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19	125

Mapping and role of T cell response in SARS-CoV-2–infected mice	125
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice	124
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation	120
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome	119
Tumor-infiltrating dendritic cell states are conserved across solid human cancers	116
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	115
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome	113
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate	113
Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis	109
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion	106
Persistent cellular immunity to SARS-CoV-2 infection	102
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration	101
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer	100
Tissue-resident memory T cells in tumor immunity and immunotherapy	100
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis	99
Activated microglia mitigate Aβ-associated tau seeding and spreading	99
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4	99
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?	97
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions	97
B cells and cancer: To B or not to B?	96
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia	95
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells	95
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS	94
STING agonist promotes CAR T cell trafficking and persistence in breast cancer	93
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function	91
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo	88
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection	84
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis	84
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth	84
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity	80
The SIRPα–CD47 immune checkpoint in NK cells	79
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression	78
Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes	77
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses	77
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	75
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts	72
Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease	72
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	72
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment	72
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool	71
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis	71
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity	71
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	70
Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage	70
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer	70
Germinal center–dependent and –independent memory B cells produced throughout the immune response	68
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	68
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs	67
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	66
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms	65

Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10	65
Necroptosis restricts influenza A virus as a stand-alone cell death mechanism	63
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus	63
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases	60
Human autoantibodies underlying infectious diseases	59
Conserved meningeal lymphatic drainage circuits in mice and humans	59
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	59
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment	59
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	58
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A	58
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection	58
Mechanosensing through YAP controls T cell activation and metabolism	58
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP	57
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	56
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C	56
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes	56
Anti–IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections	55
Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death	54
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia	54
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy	54
The pleiotropic roles of leptin in metabolism, immunity, and cancer	54
Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies	53
High microbiota reactivity of adult human intestinal IgA requires somatic mutations	53
Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function	52
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis	52
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain	52
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions	52
Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21	51
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases	51
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer	51
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9	51
Functional immune cell–astrocyte interactions	51
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading	50
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells	49
Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal	49
α-Synuclein modulates tau spreading in mouse brains	49
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress	48
Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation	48
The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses	47
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer	47
Human marginal zone B cell development from early T2 progenitors	47
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche	47
NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation	47
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses	47
Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life	46
Vi-specific serological correlates of protection for typhoid fever	46
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia	46
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice	46
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue	46
Membrane budding is a major mechanism of in vivo platelet biogenesis	45
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire	45
A robust platform for expansion and genome editing of primary human natural killer cells	44
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them	44
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis	44
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma	43
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria	43
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	43
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy	43
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors	43
SIRT1–NOX4 signaling axis regulates cancer cachexia	42
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	42
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression	42
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention	41
TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells	41
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates	41
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis	41
Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation	40
Neutrophils and COVID-19: Nots, NETs, and knots	40
Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A	40
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS	40
Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM	39
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection	39
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy	39
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway	39
Early type I IFN blockade improves the efficacy of viral vaccines	39
Reversal of emphysema by restoration of pulmonary endothelial cells	39
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling	38
Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism	38
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis	38
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers	38

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	37
Autoantibodies against type I IFNs in patients with critical influenza pneumonia	37
The current landscape of single-cell transcriptomics for cancer immunotherapy	37
Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	37
The metabolism-modulating activity of IL-17 signaling in health and disease	37
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection	37
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	36
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	36
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation	36
Gut microbiota, NLR proteins, and intestinal homeostasis	36
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation	36
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15	36
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis	36
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence	35
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice	35
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation	35
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE	35
Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers	35
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction	34
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers	34
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function	34
C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury	34
Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19	34
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation	33
Role of adipose tissue macrophages in obesity-related disorders	33
Diagnostic blood RNA profiles for human acute spinal cord injury	33
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection	33
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation	33
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic	32
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA	32
Circulating tumor cells: Ready for translation?	32
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma	32
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma	32
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency	32
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education	32
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope	32
Cancer cell CCR2 orchestrates suppression of the adaptive immune response	32
CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response	32
Layilin augments integrin activation to promote antitumor immunity	31
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients	31
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas	31
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival	31
T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome	31
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance	31
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2	31
Circadian immune circuits	31
A partial form of inherited human USP18 deficiency underlies infection and inflammation	31
Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen	31
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells	31
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	31
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	31
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity	30
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells	30
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	30
Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells	30
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican	30
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection	30
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling	30
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma	30
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC	30
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia	30
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection	30
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors	30
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	30
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme	30
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions	30
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants	29
Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity	29
Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis	29
Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection	29
Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease	29
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	29
Adoptive cell therapy: Living drugs against cancer	29
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release	29
The dark side of the gut: Virome–host interactions in intestinal homeostasis and disease	29
Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma	29
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer	29
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome	29
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	29
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes	29
The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression	28
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance	28
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair	28
Immune checkpoint inhibitors	28
The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain	28
Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib	28
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2	28
Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories	28
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion	28
Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome	27
GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection	27
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression	27
Human NLRP1: From the shadows to center stage	27
Immunodominant antibody germlines in COVID-19	27
Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis	27