Journal of Experimental Medicine

Article	Citations
Early innate role for CD8αα+ cells in tuberculosis	294
S1PR1, an endothelial-immune influencer	223
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	158
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	141
Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state	133
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	124
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	114
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2	113
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	107
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	106
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	105
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	104
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	96
B cell receptor ligation induces IgE plasma cell elimination	96
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	96
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	93
RORγt eTACs mediate oral tolerance and Treg induction	90
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	90
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	88
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	87
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	87
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	83
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	83
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	83
T cell engagers emerge as a compelling therapeutic modality	83

Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis	82
Obesity alters monocyte developmental trajectories to enhance metastasis	81
Role of adipose tissue macrophages in obesity-related disorders	80
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	80
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	75
Challenges in TB research	74
pDCs, type 1 IFN, and the female predileXion of SSc	73
Correction: ICAM-1 controls development and function of ILC2	73
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	73
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	72
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	71
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	70
Dual role of vascular endothelial growth factor-C in post-stroke recovery	70
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	69
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	69
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	68
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	68
Michelle Linterman: We are always learning	66
How decreasing T cell signaling unexpectedly results in autoimmunity	66
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	66
A twist in the tail: Of T cell subsets and disease	64
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	63
Tingible body macrophages: Gargantuan chameleons of the germinal center	63
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	63
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	62
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	60
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	58
Rethinking disomy: Autosomal expression bias	58
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	57
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	56
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	55
Pleiotrophin drives a prometastatic immune niche in breast cancer	55
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	54
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	53
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	52
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	52
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	52
Spatiotemporal dynamics of fetal liver hematopoietic niches	52
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance	51
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	51
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	51
Altered glycosylation in pancreatic cancer and beyond	51
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	50
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	50
CTLA4 prohibits T cells from cross-dressing	50
Protective fibroblastic niches in secondary lymphoid organs	50
Sara Suliman: Science is better when it’s shared	50
Tumor-derived OBP2A promotes prostate cancer castration resistance	49
Changing behind the scenes	49
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	49

Immature B cell homing shapes human lymphoid tissue structure and function	49
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	48
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	47
Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis	46
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	45
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	45
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers	45
Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2	45
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	45
Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions	43
Correction: Role of affinity in plasma cell development in the germinal center light zone	43
CD4+ T cell dysfunction in cancer	43
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	43
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	43
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	42
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	42
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	42
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	42
Targeting neuroinflammation in neuropathic pain and opioid use	42
IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens	42
CAR-T cell manufacturing: Major process parameters and next-generation strategies	41
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	41
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	41
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	41
Perfecting antigen prediction	40
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	39
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	39
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	39
Laura Mackay: Don't be afraid to engage	39
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	38
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	38
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself	38
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	38
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	38
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	37
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	37
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	37
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	37
Cigarette smoke components modulate the MR1–MAIT axis	36
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	36
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	35
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	35
MHC one–two punch knocks out cancer	35
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity	35
Competitive fungal commensalism mitigates candidiasis pathology	35
Dominant negative OTULIN-related autoinflammatory syndrome	34
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	34
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	34
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	34
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	34
A path forward for Staphylococcus aureus vaccine development	34
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	33
Iron TAMs: The fallen protectors	33
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	33
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	33
Staying IgD positive in a challenging environment	33
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	33
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	33
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	32
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	32
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	32
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice	32
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation	32
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	32
Charting the meningeal lymphatic network	32
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	32
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	32
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	31
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	31
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	31
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	31
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	31
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	31
Fueling the fire in the gut	30
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	30
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	30
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	30
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	30
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	29
Th17-to-Tfh plasticity during periodontitis limits disease pathology	29

Eating away T cell responses in lung cancer	29
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	29
Macro-clusters: CD301b+ DCs prime Th2 responses	29
Does fever drive the evolution of antiviral genes?	29
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine	29
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	28
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	28
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	28
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine	28
The PML hub: An emerging actor of leukemia therapies	28
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	28
Lymph node metastasis: An immunological burden	27
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	27
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	27
Identifying genetic errors of immunity due to mosaicism	27
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	27
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	27
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	27
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	27
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	27
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	27
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation	26
Mechanosensing regulates pDC activation in the skin through NRF2 activation	26
Myeloid diversity in tumors: Shaped by genes, location, and time	26
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms	26
STAT3 gain of function: Too much of a good thing in the skin!	26
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	26
The X factor in neurodegeneration	26
Stopping the fat: Repurposing an antidepressant for cancer treatment	26
Emerging in vivo tools for ILC2 research	26
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance	26
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	25
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	25
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	25
The stunning clodronate	25
Guardians of the oral barriers	25
Landscape of mast cell populations across organs in mice and humans	25
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	25
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	25
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	24
OTULIN and Muller’s morphs	24
BATF represses BIM to sustain tolerant T cells in the periphery	24
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	24
Next-generation CRISPR screens enable causal systems immunology	24
Lymphatic transport in anti-tumor immunity and metastasis	24
In vivo antibody diversification targeting a conserved coronavirus epitope	24
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	24
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity	24
Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy	24
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	24
A half-century of research on tuberculosis: Successes and challenges	23
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	23
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	23
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	23
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	23
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	23
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	23
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	23
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	23
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	22
Five decades of natural killer cell discovery	22
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway	22
Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency	22
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	22
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	22
Kids’ noses resist COVID-19	22
NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome	22
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	22
The cribriform plate: A dynamic central nervous system–immune hub	22
Correction: Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	22
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions	21
ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype	21
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection	21
Who gets the calories? An endothelial checkpoint for fat expansion	21
Women in STEM becoming independent: Put science and discovery ahead of your ego	21
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies	21
The X in seX-biased immunity and autoimmune rheumatic disease	21
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect	21
MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors	21
Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis	21
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge	21
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain	20
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation	20
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases	20
Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma	20
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua	20
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes	20
Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis	20
Sex biases in infectious diseases research	19
Inhibition of GABAA receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity	19
Correction: Germinal center–dependent and –independent memory B cells produced throughout the immune response	19
The Src–ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage	19
Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s	19
Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	19
INPP4B ensures that ILC1s and NK cells set up a productive home office	19