Journal of Experimental Medicine

Article	Citations
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	237
Early innate role for CD8αα+ cells in tuberculosis	228
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	210
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	200
The microbial one-hit wonder	187
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	179
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	174
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	163
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells	161
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	144
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	137
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	126
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	122
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	121
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	121
B cell receptor ligation induces IgE plasma cell elimination	118
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	110
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	110
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	109
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	106
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	100
RORγt eTACs mediate oral tolerance and Treg induction	96
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	95
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	92
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	84

Implication of folate deficiency in CYP2U1 loss of function	82
Making memories with Bcl-6	82
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	80
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	79
Systems-level conservation of the proximal TCR signaling network of mice and humans	79
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	77
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	77
pDCs, type 1 IFN, and the female predileXion of SSc	76
Challenges in TB research	76
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	75
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	75
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin	75
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	74
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	74
Dual role of vascular endothelial growth factor-C in post-stroke recovery	69
Role of adipose tissue macrophages in obesity-related disorders	67
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	66
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	65
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	65
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	65
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	64
Obesity alters monocyte developmental trajectories to enhance metastasis	64
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	63
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	62
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	62
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses	61
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	60
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	60
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	59
Spatiotemporal dynamics of fetal liver hematopoietic niches	59
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes	58
Tingible body macrophages: Gargantuan chameleons of the germinal center	58
T2B or not to B: Calming neutrophils offshore	57
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	57
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	57
A twist in the tail: Of T cell subsets and disease	57
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	56
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	56
Michelle Linterman: We are always learning	56
How decreasing T cell signaling unexpectedly results in autoimmunity	55
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	54
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	54
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non–small cell lung cancer	53
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer	52
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	52
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	52
Altered glycosylation in pancreatic cancer and beyond	52
Pleiotrophin drives a prometastatic immune niche in breast cancer	51
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	51
Correction: Role of affinity in plasma cell development in the germinal center light zone	50

Protective fibroblastic niches in secondary lymphoid organs	50
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	50
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	50
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	50
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	50
Human autoantibodies underlying infectious diseases	50
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	50
CTLA4 prohibits T cells from cross-dressing	49
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	49
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	49
Sara Suliman: Science is better when it’s shared	49
Immature B cell homing shapes human lymphoid tissue structure and function	48
Changing behind the scenes	48
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	47
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	47
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	47
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	47
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	46
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	46
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	46
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	46
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	46
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	45
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	45
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	45
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	44
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	44
Targeting neuroinflammation in neuropathic pain and opioid use	44
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	44
Tumor-derived OBP2A promotes prostate cancer castration resistance	44
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	43
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	43
CAR-T cell manufacturing: Major process parameters and next-generation strategies	43
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	43
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	42
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	42
Perfecting antigen prediction	42
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	42
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	41
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	41
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	41
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	41
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	41
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	40
Laura Mackay: Don't be afraid to engage	40
A path forward for Staphylococcus aureus vaccine development	40
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	40
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	40
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	40
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	40
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	40
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	40
Dominant negative OTULIN-related autoinflammatory syndrome	39
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	39
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	39
Single-cell imaging of T cell immunotherapy responses in vivo	38
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	38
Iron TAMs: The fallen protectors	37
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	37
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	37
Competitive fungal commensalism mitigates candidiasis pathology	37
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	37
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	37
Cigarette smoke components modulate the MR1–MAIT axis	37
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	36
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	36
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	36
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	35
Charting the meningeal lymphatic network	35
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire	35
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	35
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	35
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	34
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	34
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	34
Inhibitory pattern recognition receptors	34
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	34
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	34
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	34
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza	34

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	34
Macro-clusters: CD301b+ DCs prime Th2 responses	33
Fueling the fire in the gut	33
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	33
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	33
Eating away T cell responses in lung cancer	33
Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity	32
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	32
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	32
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	31
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	31
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	31
Th17-to-Tfh plasticity during periodontitis limits disease pathology	31
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	31
The PML hub: An emerging actor of leukemia therapies	31
Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ	30
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	30
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	30
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	30
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress	30
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	30
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice	30
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	30
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF	30
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	29
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	29
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	29
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	29
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	28
STAT3 gain of function: Too much of a good thing in the skin!	28
The X factor in neurodegeneration	28
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	28
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	27
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	27
Stopping the fat: Repurposing an antidepressant for cancer treatment	27
Identifying genetic errors of immunity due to mosaicism	27
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	27
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	27
Emerging in vivo tools for ILC2 research	27
The stunning clodronate	27
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	27
Mechanosensing regulates pDC activation in the skin through NRF2 activation	27
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	27
Landscape of mast cell populations across organs in mice and humans	26
Guardians of the oral barriers	26
Lymph node metastasis: An immunological burden	26
Analyzing signaling activity and function in hematopoietic cells	26
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	26
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	26
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	26
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	26
A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies	25
Lymphatic transport in anti-tumor immunity and metastasis	25
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	25
OTULIN and Muller’s morphs	25
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells	24
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	24
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	24
BATF represses BIM to sustain tolerant T cells in the periphery	24
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	24
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	24
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	24
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	24
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	24
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	24
Five decades of natural killer cell discovery	23
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	23
MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors	23
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway	23
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	23
A half-century of research on tuberculosis: Successes and challenges	23
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	23
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	23
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation	23
Kids’ noses resist COVID-19	23
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	23
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	23
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	23
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge	23
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases	23
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions	22
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain	22
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies	22
The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination	22
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection	22
Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance	22
The X in seX-biased immunity and autoimmune rheumatic disease	22
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua	22
Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma	22
Toward an understanding of allogeneic conflict in pregnancy and transplantation	22
Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency	22
Correction: Germinal center–dependent and –independent memory B cells produced throughout the immune response	21
INPP4B ensures that ILC1s and NK cells set up a productive home office	21
All eyes on a phosphatase in glioma stem cells	21
Iron out KRAS-driven cancer	21