Journal of Experimental Medicine

Article	Citations
The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity	475
Splicing factor RBM10 loss fuels thyroid cancer metastasis	222
RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs	217
Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice	209
miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease	195
VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival	182
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress	177
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	174
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa	158
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	155
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity	153
GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection	136
ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses	130
HER2 drives lung fibrosis by activating a metastatic cancer signature in invasive lung fibroblasts	127
Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder	122
The effector program of human CD8 T cells supports tissue remodeling	115
Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma	114
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion	114
Type I interferons drive MAIT cell functions against bacterial pneumonia	113
An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment	111
The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer	103
Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella	102
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease	98
KLF family members control expression of genes required for tissue macrophage identities	98
Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation	94

c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs	91
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	86
Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling	85
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	82
Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease	79
Gut microbiota biofilms: From regulatory mechanisms to therapeutic targets	79
Lectin recruits pathogenic bugs	77
Macrophages and bone metastasis	77
Eating away T cell responses in lung cancer	77
γδIL17 under control	74
Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition	74
AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunity	72
Eye on genome editing	71
Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling	71
Thymic mimicry: The art of imitation	71
Oligodendroglia-to-neuron material transfer lights up the mouse CNS	70
B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM	69
SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19	69
The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance	68
Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells	68
Early innate role for CD8αα+ cells in tuberculosis	66
The PML hub: An emerging actor of leukemia therapies	66
Golnaz Vahedi: My environment enables me to achieve impossible goals	63
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	62
A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation	61
Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance	60
Women in STEM becoming independent: Science thrives on diverse perspectives	60
Unraveling the Tcrb interactome	59
Macro-clusters: CD301b+ DCs prime Th2 responses	58
Dural mural cells paint an anti-inflammatory picture	58
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	58
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	58
Sounding the alarm in the lung with TL1A	57
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome	57
γδ T cells: The first line of defense for neonates	57
Rediscovering the human thymus through cutting-edge technologies	57
Locus folding mechanisms determine modes of antigen receptor gene assembly	56
Th17-to-Tfh plasticity during periodontitis limits disease pathology	55
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	54
Transcription of HIV-1 at sites of intact latent provirus integration	54
Hormonal basis of brain fog in cancer treatment	53
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy	53
Send it, receive it, quick erase it: A mouse model to decipher chemokine communication	52
Generation and repair of thymic epithelial cells	52
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells	51
IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation	51
ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses	51
Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	51
Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection	51
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	51

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease	50
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	50
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160	49
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis	49
Bone marrow runs the (bone) show	49
The microbial one-hit wonder	49
Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity	49
JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy	48
Vascular heterogeneity: VEGF receptors make blood vessels special	48
“P2RY8-son” break of tolerance promotes SLE	48
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	48
T-independent antigen induces humoral memory through germinal centers	47
Helminths make themselves at home	47
Avery August: The data are the data	47
Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors	47
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	47
Goldilocks and the three TILs	47
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	47
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	46
Fueling the fire in the gut	46
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function	46
Inherited TNFSF9 deficiency causes broad Epstein–Barr virus infection with EBV+ smooth muscle tumors	46
The brain–eye connection: More than just action potentials	45
Traffic on the TLR expressway	45
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	45
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	45
Bridging the gap between tumor and disease: Innovating cancer and glioma models	45
Judy Lieberman: Stay curious and excited about science	45
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	44
IFITM3 incorporation sensitizes influenza A virus to antibody-mediated neutralization	44
The α glycolipid rules the NKT cell TCR	44
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection	44
CCDC134 controls TLR biogenesis through the ER chaperone Gp96	44
Inflammasome-independent functions of AIM2	43
Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy	43
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation	43
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies	43
Regnase-1 is essential for B cell homeostasis to prevent immunopathology	42
Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript	42
Finding NEMO in the thymus	41
Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)	41
Breaching self-tolerance by targeting the gatekeeper	41
Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer	41
Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ	41
Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs	41
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	41
Highlights from a year in a pandemic	41
ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons	40
Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice	40
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis	40
A partial form of inherited human USP18 deficiency underlies infection and inflammation	39
Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26	39
Correction: Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity	39
Expression of Concern: ACKR4 restrains antitumor immunity by regulating CCL21	38
Correction: TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	38
Correction: Treg–tissue cell interactions in repair and regeneration	38
Correction: Generation and repair of thymic epithelial cells	38
Correction: IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2	38
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice	38
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression	37
Autoantibodies against type I IFNs in patients with critical influenza pneumonia	37
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	37
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	37
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	37
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma	37
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF	36
CTCF mediates CD8+ effector differentiation through dynamic redistribution and genomic reorganization	36
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	36
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway	36
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury	36
The early interferon catches the SARS-CoV-2	35
Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib	35
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair	35
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs	35
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	35
Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation	35
Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV	35
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS	35
Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	34
Neural control of immune cell trafficking	34

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	34
Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis	34
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis	34
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education	34
Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells	34
Modeling human yolk sac hematopoiesis with pluripotent stem cells	33
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice	33
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	33
Viable mutations of mouse midnolin suppress B cell malignancies	33
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	32
Human NLRP1: From the shadows to center stage	32
Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease	32
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity	32
Treg–tissue cell interactions in repair and regeneration	32
Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients	32
Remodeling of colon plasma cell repertoire within ulcerative colitis patients	31
STING trafficking as a new dimension of immune signaling	31
B cell receptor ligation induces IgE plasma cell elimination	31
CSF-to-dura gateways	31
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	31
B cell–intrinsic Myd88 regulates disease progression in murine lupus	31
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	31
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	31
Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs	30
Imatinib augments standard malaria combination therapy without added toxicity	30
Suppression of BRCA1 facilitates kidney regeneration	30
Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease	30
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	30
Mammalian infections with highly pathogenic avian influenza viruses renew concerns of pandemic potential	29
Emerging functions of tissue-resident eosinophils	29
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions	29
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	29
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells	29
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	29
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	29
tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells	28
Challenges in TB research	28
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection	28
Correction: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect	28
pDCs, type 1 IFN, and the female predileXion of SSc	28
NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy	28
Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans	28
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	28
Interleukin-4 receptor signaling modulates neuronal network activity	27
Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development	26
Expression of Concern: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation	26
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	26
Correction: Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome	26
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling	26
The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium	26
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	26
Correction: Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
A “second hit” impacts disease severity in a dominantly inherited genetic skin disorder	26
miR-15/16 clusters restrict effector Treg cell differentiation and function	25
Tregs tame skin bacteria and IFN-γ–associated pathology	25
The RNA binding protein Arid5a drives IL-17–dependent autoantibody-induced glomerulonephritis	25
Cbl-b deficiency prevents functional but not phenotypic T cell anergy	25
Yukiko Gotoh: I am fascinated by the beauty of science	25
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	25
Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation	25
Women in STEM becoming independent: Embracing every experience as part of the learning process	25
TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance	25
STAT3 gain of function: Too much of a good thing in the skin!	25
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	24
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	24
Kazuyo Moro: Building relationships is essential for gaining both speed and opportunities in research	24
Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis	24
FOXP3 snatches transcription factors depending on the context	24
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	24
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	24
Genetic and environmental risks for clonal hematopoiesis and cancer	24
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	24