Journal of Experimental Medicine

Papers
(The TQCC of Journal of Experimental Medicine is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
S1PR1, an endothelial-immune influencer258
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein223
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes183
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration171
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation134
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation126
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees124
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion118
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge116
The microbial one-hit wonder113
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly106
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice103
Early innate role for CD8αα+ cells in tuberculosis98
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C98
Primary tumor–derived systemic nANGPTL4 inhibits metastasis94
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis85
RORγt eTACs mediate oral tolerance and Treg induction85
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL84
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes83
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis82
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection81
B cell receptor ligation induces IgE plasma cell elimination79
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children79
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice77
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion77
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death77
Dual role of vascular endothelial growth factor-C in post-stroke recovery71
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination71
pDCs, type 1 IFN, and the female predileXion of SSc70
Challenges in TB research69
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression69
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy68
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer68
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control66
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma64
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover63
Correction: ICAM-1 controls development and function of ILC263
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host63
Implication of folate deficiency in CYP2U1 loss of function63
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity62
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation62
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy62
Obesity alters monocyte developmental trajectories to enhance metastasis62
Systems-level conservation of the proximal TCR signaling network of mice and humans62
Making memories with Bcl-662
Role of adipose tissue macrophages in obesity-related disorders62
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-1761
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin60
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients60
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses60
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path59
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner59
A twist in the tail: Of T cell subsets and disease57
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons56
Tingible body macrophages: Gargantuan chameleons of the germinal center56
Michelle Linterman: We are always learning56
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation55
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes55
Spatiotemporal dynamics of fetal liver hematopoietic niches55
Altered glycosylation in pancreatic cancer and beyond54
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow54
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy54
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function53
How decreasing T cell signaling unexpectedly results in autoimmunity52
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans52
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils52
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment51
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice51
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer51
Human autoantibodies underlying infectious diseases51
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses51
Pleiotrophin drives a prometastatic immune niche in breast cancer51
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming50
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer50
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease50
Protective fibroblastic niches in secondary lymphoid organs49
T2B or not to B: Calming neutrophils offshore49
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis48
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury48
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery48
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth48
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma48
Tumor-derived OBP2A promotes prostate cancer castration resistance47
Sara Suliman: Science is better when it’s shared46
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis46
Correction: Role of affinity in plasma cell development in the germinal center light zone45
Immature B cell homing shapes human lymphoid tissue structure and function45
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection45
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus45
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement45
Changing behind the scenes44
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling44
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD3944
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis43
Targeting neuroinflammation in neuropathic pain and opioid use43
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus43
The common HAQ STING allele prevents clinical penetrance of COPA syndrome43
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation43
CTLA4 prohibits T cells from cross-dressing43
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation43
CAR-T cell manufacturing: Major process parameters and next-generation strategies42
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes42
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice42
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria42
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition42
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine41
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function41
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile41
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon41
Laura Mackay: Don't be afraid to engage40
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients40
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer40
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier40
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses40
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment39
Dominant negative OTULIN-related autoinflammatory syndrome39
Cigarette smoke components modulate the MR1–MAIT axis39
Single-cell imaging of T cell immunotherapy responses in vivo39
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey39
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling38
A path forward for Staphylococcus aureus vaccine development38
Competitive fungal commensalism mitigates candidiasis pathology38
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients38
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products37
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation37
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration37
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis37
Addendum: Resolvins suppress tumor growth and enhance cancer therapy37
Perfecting antigen prediction36
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation36
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits36
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice36
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design35
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition35
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity35
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas34
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer34
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage34
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype34
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia34
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination34
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response33
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation33
Charting the meningeal lymphatic network33
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control33
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza32
Inhibitory pattern recognition receptors32
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment32
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine32
Iron TAMs: The fallen protectors32
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP132
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response31
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation31
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire31
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model31
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis31
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition31
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity31
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD2530
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT30
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection30
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice29
Eating away T cell responses in lung cancer29
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF29
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis29
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds29
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency29
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies29
The PML hub: An emerging actor of leukemia therapies29
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis28
Fueling the fire in the gut28
Th17-to-Tfh plasticity during periodontitis limits disease pathology28
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress28
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses28
The X factor in neurodegeneration27
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages27
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus27
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease27
Emerging in vivo tools for ILC2 research27
Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity27
KLF2 expression in IgG plasma cells at their induction site regulates the migration program27
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma27
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation27
Macro-clusters: CD301b+ DCs prime Th2 responses27
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis26
The stunning clodronate26
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge26
Identifying genetic errors of immunity due to mosaicism26
Stopping the fat: Repurposing an antidepressant for cancer treatment26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting26
STAT3 gain of function: Too much of a good thing in the skin!26
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis26
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors25
Linda-Gail Bekker: Mentorship is critical for anyone in STEM25
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner25
Mechanosensing regulates pDC activation in the skin through NRF2 activation25
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis25
Lymph node metastasis: An immunological burden25
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum25
Delineating a serotonin 1B receptor circuit for appetite suppression in mice25
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome24
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine24
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans24
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery24
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes24
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth24
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells24
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals24
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas24
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells24
Landscape of mast cell populations across organs in mice and humans24
Guardians of the oral barriers23
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency23
OTULIN and Muller’s morphs23
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans23
A half-century of research on tuberculosis: Successes and challenges23
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs23
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