Journal of Experimental Medicine

Article	Citations
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	333
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	268
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	208
Early innate role for CD8αα+ cells in tuberculosis	200
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	160
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	156
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	132
S1PR1, an endothelial-immune influencer	113
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	113
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2	107
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	104
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	102
B cell receptor ligation induces IgE plasma cell elimination	97
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	93
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	92
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	91
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	88
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	85
RORγt eTACs mediate oral tolerance and Treg induction	85
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	84
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	81
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	80
Correction: ICAM-1 controls development and function of ILC2	78
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	77
Systems-level conservation of the proximal TCR signaling network of mice and humans	75

Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis	75
Challenges in TB research	75
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	74
pDCs, type 1 IFN, and the female predileXion of SSc	74
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	73
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	73
Obesity alters monocyte developmental trajectories to enhance metastasis	72
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	72
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	72
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	70
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	70
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	68
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	68
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	68
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	65
T cell engagers emerge as a compelling therapeutic modality	65
Dual role of vascular endothelial growth factor-C in post-stroke recovery	64
Role of adipose tissue macrophages in obesity-related disorders	64
How decreasing T cell signaling unexpectedly results in autoimmunity	63
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	63
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	62
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	62
Michelle Linterman: We are always learning	62
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	61
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	61
Human autoantibodies underlying infectious diseases	61
A twist in the tail: Of T cell subsets and disease	61
Tingible body macrophages: Gargantuan chameleons of the germinal center	61
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	60
Protective fibroblastic niches in secondary lymphoid organs	59
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	59
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance	58
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	57
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	57
Pleiotrophin drives a prometastatic immune niche in breast cancer	57
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	56
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	56
Spatiotemporal dynamics of fetal liver hematopoietic niches	56
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	56
Altered glycosylation in pancreatic cancer and beyond	55
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	54
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	54
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	54
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	54
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	53
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	53
Sara Suliman: Science is better when it’s shared	51
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	51
Correction: Role of affinity in plasma cell development in the germinal center light zone	51
Changing behind the scenes	50

CTLA4 prohibits T cells from cross-dressing	50
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	49
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	49
Immature B cell homing shapes human lymphoid tissue structure and function	49
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	48
Tumor-derived OBP2A promotes prostate cancer castration resistance	47
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	47
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	46
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	46
Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions	46
CD4+ T cell dysfunction in cancer	45
Targeting neuroinflammation in neuropathic pain and opioid use	45
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	45
Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis	45
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	45
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	44
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	44
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	44
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	44
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	43
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	42
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	42
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	41
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	41
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	41
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	40
CAR-T cell manufacturing: Major process parameters and next-generation strategies	40
Perfecting antigen prediction	40
Laura Mackay: Don't be afraid to engage	40
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	40
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	39
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	39
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	39
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	38
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	38
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	38
Cigarette smoke components modulate the MR1–MAIT axis	37
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	37
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	37
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	37
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	37
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	37
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	37
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	36
A path forward for Staphylococcus aureus vaccine development	36
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	36
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	36
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	36
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	35
Competitive fungal commensalism mitigates candidiasis pathology	35
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	35
Dominant negative OTULIN-related autoinflammatory syndrome	35
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	35
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	35
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice	34
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	33
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	33
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	33
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	33
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	33
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	33
Iron TAMs: The fallen protectors	33
Charting the meningeal lymphatic network	33
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	32
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	32
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	32
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	32
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	32
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	32
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	31
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	31
Does fever drive the evolution of antiviral genes?	31
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	31
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	31
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	31
Macro-clusters: CD301b+ DCs prime Th2 responses	31
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	31
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine	30
Fueling the fire in the gut	30
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	30

No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	30
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	30
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	29
The PML hub: An emerging actor of leukemia therapies	29
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	29
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	29
Eating away T cell responses in lung cancer	29
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	29
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	28
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	28
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	28
Th17-to-Tfh plasticity during periodontitis limits disease pathology	28
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms	28
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	28
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	28
The X factor in neurodegeneration	27
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	27
Emerging in vivo tools for ILC2 research	27
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	27
STAT3 gain of function: Too much of a good thing in the skin!	27
Identifying genetic errors of immunity due to mosaicism	27
Stopping the fat: Repurposing an antidepressant for cancer treatment	26
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	26
Lymph node metastasis: An immunological burden	26
Mechanosensing regulates pDC activation in the skin through NRF2 activation	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	26
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance	26
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	26
The stunning clodronate	26
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	25
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	25
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	25
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	25
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	25
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	25
Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy	25
Guardians of the oral barriers	25
A half-century of research on tuberculosis: Successes and challenges	25
Landscape of mast cell populations across organs in mice and humans	25
In vivo antibody diversification targeting a conserved coronavirus epitope	25
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity	25
OTULIN and Muller’s morphs	25
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	24
Five decades of natural killer cell discovery	24
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	24
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	24
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	24
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	24
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	24
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	24
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	24
BATF represses BIM to sustain tolerant T cells in the periphery	24
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	24
Lymphatic transport in anti-tumor immunity and metastasis	24