Journal of Experimental Medicine

Article	Citations
Early innate role for CD8αα+ cells in tuberculosis	243
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	241
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	218
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	178
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	166
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	130
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	128
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	125
The microbial one-hit wonder	118
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	117
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	114
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	113
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	110
B cell receptor ligation induces IgE plasma cell elimination	104
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	99
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	97
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	93
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	87
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	85
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	84
RORγt eTACs mediate oral tolerance and Treg induction	83
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	83
Making memories with Bcl-6	80
Implication of folate deficiency in CYP2U1 loss of function	80
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	78

Systems-level conservation of the proximal TCR signaling network of mice and humans	77
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	77
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	77
pDCs, type 1 IFN, and the female predileXion of SSc	77
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	75
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	74
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	69
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	68
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	68
Dual role of vascular endothelial growth factor-C in post-stroke recovery	66
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	66
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	65
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin	65
Role of adipose tissue macrophages in obesity-related disorders	65
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	63
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	63
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	61
Obesity alters monocyte developmental trajectories to enhance metastasis	61
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	61
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	61
Correction: ICAM-1 controls development and function of ILC2	61
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	60
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	60
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	60
Challenges in TB research	60
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	59
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	58
Spatiotemporal dynamics of fetal liver hematopoietic niches	58
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	57
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	57
Altered glycosylation in pancreatic cancer and beyond	57
Tingible body macrophages: Gargantuan chameleons of the germinal center	56
A twist in the tail: Of T cell subsets and disease	56
T2B or not to B: Calming neutrophils offshore	56
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	54
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	54
Michelle Linterman: We are always learning	54
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	54
How decreasing T cell signaling unexpectedly results in autoimmunity	53
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	53
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	52
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	52
Pleiotrophin drives a prometastatic immune niche in breast cancer	52
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer	51
Human autoantibodies underlying infectious diseases	51
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	51
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	51
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	51
Protective fibroblastic niches in secondary lymphoid organs	50
Correction: Role of affinity in plasma cell development in the germinal center light zone	50

Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes	50
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	50
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	50
Sara Suliman: Science is better when it’s shared	49
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	48
CTLA4 prohibits T cells from cross-dressing	48
Changing behind the scenes	48
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	48
Immature B cell homing shapes human lymphoid tissue structure and function	48
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	47
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	47
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	47
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	47
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	46
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	46
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	45
Tumor-derived OBP2A promotes prostate cancer castration resistance	45
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	44
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	44
Targeting neuroinflammation in neuropathic pain and opioid use	44
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	44
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	44
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	43
CAR-T cell manufacturing: Major process parameters and next-generation strategies	43
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	43
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	43
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	43
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	42
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	42
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	42
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	42
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	42
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	41
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	41
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	41
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	41
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	40
Single-cell imaging of T cell immunotherapy responses in vivo	40
A path forward for Staphylococcus aureus vaccine development	40
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	40
Dominant negative OTULIN-related autoinflammatory syndrome	40
Laura Mackay: Don't be afraid to engage	40
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	40
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	40
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	40
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	38
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	38
Perfecting antigen prediction	38
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	38
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	38
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	37
Cigarette smoke components modulate the MR1–MAIT axis	37
Competitive fungal commensalism mitigates candidiasis pathology	37
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	37
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	37
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	37
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	37
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	36
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	36
Iron TAMs: The fallen protectors	36
Charting the meningeal lymphatic network	36
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	36
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	36
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	35
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	35
Inhibitory pattern recognition receptors	35
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	35
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	35
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza	35
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire	35
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	34
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	34
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	34
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	33
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	33
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	33
Eating away T cell responses in lung cancer	32
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	32
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	32
Fueling the fire in the gut	32

Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	32
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	31
The PML hub: An emerging actor of leukemia therapies	31
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	31
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	31
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	31
Macro-clusters: CD301b+ DCs prime Th2 responses	31
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	31
Th17-to-Tfh plasticity during periodontitis limits disease pathology	31
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	30
Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity	30
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	30
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	30
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF	30
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	30
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	29
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	29
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	29
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice	29
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	28
STAT3 gain of function: Too much of a good thing in the skin!	28
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	28
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	28
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	28
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress	28
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	28
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	28
Mechanosensing regulates pDC activation in the skin through NRF2 activation	27
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	27
Identifying genetic errors of immunity due to mosaicism	27
The X factor in neurodegeneration	27
Emerging in vivo tools for ILC2 research	27
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	27
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	27
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	26
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	26
The stunning clodronate	26
Landscape of mast cell populations across organs in mice and humans	26
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	26
Lymph node metastasis: An immunological burden	26
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	26
Stopping the fat: Repurposing an antidepressant for cancer treatment	26
OTULIN and Muller’s morphs	25
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	25
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	25
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	25
BATF represses BIM to sustain tolerant T cells in the periphery	25
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	25
Lymphatic transport in anti-tumor immunity and metastasis	25
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	25
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	25
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	25
Guardians of the oral barriers	25
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	24
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	24
A half-century of research on tuberculosis: Successes and challenges	24
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	24
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	24
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	24
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	24
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	24
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	24
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	24