Journal of General Physiology

Article	Citations
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	62
On the molecular mechanism of excitation–transcription coupling in skeletal muscle	55
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	40
The epithelial potassium channel Kir7.1 is stimulated by progesterone	38
Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain	37
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	35
TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs	33
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology	33
Effects of HOCl oxidation on excitation–contraction coupling: Implications for the pathophysiology of Duchenne muscular dystrophy	31
Discovery of new intracellular junctions: The calcium entry units (CEUs)	30
Why make a strong muscle weaker?	29
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	27
Titin–N2A: More than a signaling node?	27
Unraveling the mysteries of the titin–N2A signalosome	26
Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers	26
Further progress in understanding of myofibrillar function in health and disease	24
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator	22
What FXYDs fix	22
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	22
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	21
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	20
Regional differences in arrhythmogenesis	20
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism	19
Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes	19
X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation	19

CaV1.3 L-type Ca2+ channel modulates pancreatic β-cell electrical activity and survival	19
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	18
Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump	18
Interrogating the gating motions of the NaK channel	17
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	17
From α1s splicing to γ1 function: A new twist in subunit modulation of the skeletal muscle L-type Ca2+ channel	17
Directing two-way traffic in the kidney: A tale of two ions	17
Real-time observation of functional specialization among phosphorylation sites in CFTR	16
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	16
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	16
How can AI accelerate advances in physiology?	15
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	15
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	15
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	15
Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation	15
Fifty years of gating currents and channel gating	15
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	14
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	14
Fluorescence labeling strategies for cell surface expression of TRPV1	14
Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse	13
An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities	13
Kv1.1 channels help set the pace	13
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	13
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	13
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	12
Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels	12
Grammotoxin increases its toxic behavior	12
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	11
Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum	11
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	11
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	11
The fast block to polyspermy breaks with convention	11
Cooperative mechanisms underlie differences in myocardial contractile dynamics between large and small mammals	11
Ion channels of cold transduction and transmission	11
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	11
Electro-metabolic signaling	10
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	10
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1	10
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	10
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels	10
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	10
Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents	10
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity	10
The spatial distribution of glycogen and glycogen consumption in muscle cells	10
The surprising difficulty of “simple” equilibrium binding measurements on ligand-gated ion channels	9
Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide	9
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	9
Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model	9
Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression	9
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	9

D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion	9
The physical basis of osmosis	9
Extracellular mechanotransduction	9
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	8
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	8
Modeling cardiac contractile cooperativity across species	8
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	8
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	8
Correction: Longitudinal diffusion barriers imposed by myofilaments and mitochondria in murine cardiac myocytes	8
Calcium has a direct effect on thick filament activation in porcine myocardium	8
Correction: Segregation of Ca2+ signaling in olfactory signal transduction	8
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	8
Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore	8
Correction: Optimization of CFTR gating through the evolution of its extracellular loops	8
Therapeutic effects of novel type 1 ryanodine receptor inhibitor on malignant hyperthermia	8
Mechanistic insights on KATP channel regulation from cryo-EM structures	8
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	8
Direct cardiotoxicity of lead	7
Structural basis of the super- and hyper-relaxed states of myosin II	7
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	7
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	7
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	7
A Kv2 inhibitor traps itself in place	7
CaV1.1 defects in hypokalemic periodic paralysis and harnessing multiple approaches for therapeutic intervention	7
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	7
A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model	7
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	7
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	7
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	7
Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	6
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin	6
Variants of the myosin interacting-heads motif	6
Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms	6
Optimization of CFTR gating through the evolution of its extracellular loops	6
Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels	6
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	6
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	6
Calcium activation through thick and thin?	6
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	6
Reconstituting depolarization-induced calcium release	6
Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure	6
X rays activate T cell calcium signaling	6
Mechanism of external K+ sensitivity of KCNQ1 channels	6
Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging	6
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	6
Ion channel regulation of gut immunity	6
Extracellular histone proteins activate P2XR7 channel current	5
Niclosamide potentiates TMEM16A and induces vasoconstriction	5
Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake	5
Sarcomere length in the beating heart: Synchronicity is optional	5
A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function	5
About hysteresis in Shaker: A note on Cowgill and Chanda	5
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	5
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	5
How PKA helps cardiomyocytes Navigate chronic stress	5
Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles	5
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	5
Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation	5
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	5
Fusion pore flux controls the rise-times of quantal synaptic responses	5
Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects	5
Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport	5
The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation	5
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	5
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	5
cMyBPC phosphorylation alters response to heart failure drug	5
The S1 helix is a VIP in VSP	5
Interactions between selectivity filter and pore helix control filter gating in the MthK channel	5
Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites	5
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	4
Stochastic force generation in an isometric binary mechanical system	4
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	4
In vivo potentiation of post-tetanic twitch across age and sex	4
Catecholamines help snakes have a change of heart	4
Distinct roles for CaV1.1’s voltage-sensing domains	4
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	4
Correction: How could simulations elucidate Nav1.5 channel blockers mechanism?	4
Exercise-activated Ca2+ entry and enhanced risk of heat stroke	4
What happened to the pursuit of truth?	4
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	4

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	4
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel	4
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	4
Sinus node dysfunction in heart failure is characterized by reduced CaMKII signaling	4
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	4
Piezo1 is a mechanosensor channel in CNS capillaries	4
Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response	4
Insect elementary calcium release events measured in honeybee muscle cells	4
Correction: Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle	4
State-dependent inhibition of BK channels by the opioid agonist loperamide	4
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle	4
Targeting late ICaL to close the window to ventricular arrhythmias	4
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	3
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	3
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	3
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	3
About hysteresis in Shaker: Response to note by Villalba-Galea	3
Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate	3
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	3
A TREK inhibitor takes multiple tracks	3
A model for how Gβγ couples Gα to GPCR	3
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	3
Segregation of Ca2+ signaling in olfactory signal transduction	3
JGP in 2023	3
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development	3
Mitochondrial morphology governs ATP production rate	3
Full opening of helix bundle crossing does not lead to NaK channel activation	3
Gap junctions and hemichannels keep the RPE connected	3
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages	3
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	3
Light drives the developmental progression of outer retinal function	3
Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle	3
Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice	3
Inactivation of CaV1 and CaV2 channels	2
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	2
ALLIN: A tool for annotation of a protein alignment combined with structural visualization	2
Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore	2
Molecular mechanism of claudin-15 strand flexibility: A computational study	2
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels	2
Myosin-binding protein-H: Not just filler	2
The molecular evolution of function in the CFTR chloride channel	2
Longitudinal diffusion barriers imposed by myofilaments and mitochondria in murine cardiac myocytes	2
Urea and water are transported through different pathways in the red blood cell membrane	2
The Cranefield Awards 2022	2
Intrinsic adaptive plasticity in mouse and human sensory neurons	2
Sensory transduction in auditory hair cells—PIEZOs can’t touch this	2
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	2
2022	2
Molecular basis of impaired muscle function in a mouse model of congenital myopathy due to compound heterozygous RYR1 mutations	2
A mutation that prevents myosin from overcoming its inhibitions	2
Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle	2
Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band	2
A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice	2
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP	2
Examining the calcium sensitivity of skeletal muscle thick filaments	2
Pivoting to a new view of tropomyosin movement	2
A misstep in the multistep process of fast inactivation	2
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	2
Mechanisms underlying the distinct K+ dependencies of periodic paralysis	2
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	2
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	2
Exercise attenuates juvenile irradiation-induced skeletal muscle decline by improving calcium handling and decreasing mitochondrial stress	2
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	2
On the link between antibiotic resistance, diabetes, and wastewater	2
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	2
Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle	2
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	2
Changing face of contractile activation in striated muscle at physiological temperature	2
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	2
Connecting the dots on connexin function	2
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	2