Journal of General Physiology

Article	Citations
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	67
Unraveling the mysteries of the titin–N2A signalosome	44
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	40
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	38
Interrogating the gating motions of the NaK channel	37
Kv1.1 channels help set the pace	33
Further progress in understanding of myofibrillar function in health and disease	33
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	32
The epithelial potassium channel Kir7.1 is stimulated by progesterone	27
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	26
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	26
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	25
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	23
Mechanism of external K+ sensitivity of KCNQ1 channels	23
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	23
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	22
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	22
Niclosamide potentiates TMEM16A and induces vasoconstriction	21
Reconstituting depolarization-induced calcium release	20
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	20
Stochastic force generation in an isometric binary mechanical system	20
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	20
Variants of the myosin interacting-heads motif	19
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	19
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	18

The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	18
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	17
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	17
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	17
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	16
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	16
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	16
Segregation of Ca2+ signaling in olfactory signal transduction	15
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	15
Myosin-binding protein-H: Not just filler	15
Connecting the dots on connexin function	15
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	15
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	15
About hysteresis in Shaker: Response to note by Villalba-Galea	15
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	14
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	14
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	14
Piezo1 is a mechanosensor channel in CNS capillaries	14
Null method to estimate the maximal PA at subsaturating concentrations of agonist	13
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	13
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	13
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	13
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes	13
A complete set of rate constants for a transporter’s catalytic cycle	13
Mitochondrial morphology governs ATP production rate	13
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	12
Probing function in ligand-gated ion channels without measuring ion transport	12
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	12
Expression of ENaC subunits in epithelia	12
Molecular mechanism of claudin-15 strand flexibility: A computational study	11
Blockade of TRPV channels by intracellular spermine	11
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	11
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	11
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	11
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	11
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	11
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	10
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	10
How a tyrosine primes the pump	10
Worms find PEZO-1’s function easy to swallow	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	10
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	10
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	10
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	10
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	9
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	9
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	9

A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	9
A sodium channel mutant removes fast inactivation with the inactivation particle bound	9
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	9
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	9
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	9
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	9
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	9
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	8
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	8
Directing two-way traffic in the kidney: A tale of two ions	8
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	8
Fusion pore flux controls the rise-times of quantal synaptic responses	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	8
Fifty years of gating currents and channel gating	8
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	8
The S1 helix is a VIP in VSP	8
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	8
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	8
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	8
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	8
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	8
Mechanistic insights on KATP channel regulation from cryo-EM structures	7
The physical basis of osmosis	7
The Cranefield Awards 2022	7
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	7
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	7
Examining the calcium sensitivity of skeletal muscle thick filaments	7
Insect elementary calcium release events measured in honeybee muscle cells	7
State-dependent inhibition of BK channels by the opioid agonist loperamide	7
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	7
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	7
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	7
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	6
2022	6
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	6
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	6
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	6
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	6
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	6
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	6
Phosphoinositide regulation of voltage-gated sodium channels	6
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	6
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	6
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	6
Essential role of Orai1 and SARAF in vascular remodeling	6
How the Blind Watchmaker messed around with potassium channels	5
RyR2 phosphorylation alters dyad architecture	5
Different species, different gap junctions?	5
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	5
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	5
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes	5
How could simulations elucidate Nav1.5 channel blockers mechanism?	5
Sniffing out Ca2+ signaling in olfactory cilia	5
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	5
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	5
A realistic look at rod synapses	5
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells	5
Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	5
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	5
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents	5
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats	5
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion	5
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	5
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins	5
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor	5
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	5
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	5
Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism	5
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	5
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini	4
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy	4
The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating	4
Intercalated disk nanoscale structure regulates cardiac conduction	4
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	4
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias	4
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	4

Structural determinants of acid-sensing ion channel potentiation by single chain lipids	4
Cardiac myosin filaments are directly regulated by calcium	4
Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres	4
Stable oxidative posttranslational modifications alter the gating properties of RyR1	4
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	4
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	4
Electro-metabolic signaling	4
Therapeutic effects of novel type 1 ryanodine receptor inhibitor on malignant hyperthermia	4
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	4
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	4
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2	4
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation	4
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology	4
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	4
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	4
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	4
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	4
Mechanism of acid-sensing ion channel modulation by Hi1a	3
Calcium has a direct effect on thick filament activation in porcine myocardium	3
Correction: Segregation of Ca2+ signaling in olfactory signal transduction	3
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	3
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	3
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	3
Ion channel regulation of gut immunity	3
X rays activate T cell calcium signaling	3
Distinct roles for CaV1.1’s voltage-sensing domains	3
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	3
Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels	3
On the link between antibiotic resistance, diabetes, and wastewater	3
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	3
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	3
Catecholamines help snakes have a change of heart	3
Light drives the developmental progression of outer retinal function	3
SMR transporters meet the challenge of metformin metabolites	3
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2
Ion channels of cold transduction and transmission	2
Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites	2
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	2
Kv1 channel inactivation: Slow and slower	2
Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit	2
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	2
JGP in 2025	2
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	2
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	2
Correction: Urea and water are transported through different pathways in the red blood cell membrane	2
Cryo-EM reveals local and global structural rearrangements in RYR mutants	2
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	2
Discovery of new intracellular junctions: The calcium entry units (CEUs)	2
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	2
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	2
Structural basis for diamide modulation of ryanodine receptor	2
Effect of a sensing charge mutation on the deactivation of KV7.2 channels	2
Preconditioning contractions prevent Ca2+-dependent proteolysis of STAC3 and prolonged force depression after eccentric contractions	2
A scorpion toxin takes the sting out of T cell activation	2
Septin-7 is indispensable in skeletal muscle regeneration	2
Gating and modulation of an inward-rectifier potassium channel	2
JGP in 2024	2
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	2
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease	2
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	2
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	2
The spatial distribution of glycogen and glycogen consumption in muscle cells	2
RYR1-related myopathies: Expanding the spectrum of morphological presentation	2
Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?	2
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	2
Troponin I phosphorylation is essential for cardiac reserve	2
Cardiac muscle disease and therapeutic targets	2
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)	2
Correction: A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	2
Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase	2
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific	2
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels	2