Journal of General Physiology

Article	Citations
Interrogating the gating motions of the NaK channel	65
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	54
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation	51
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	45
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	41
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	36
NALCN/Cch1 channelosome subunits originated in early eukaryotes	33
Investigating the role of the I–II linker in Nav1.5 channel function	33
Reconstituting depolarization-induced calcium release	31
Kv1.1 channels help set the pace	31
Variants of the myosin interacting-heads motif	28
Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction	27
Stochastic force generation in an isometric binary mechanical system	27
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	27
Niclosamide potentiates TMEM16A and induces vasoconstriction	25
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	25
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	24
The relationship between apparent potentiation and the magnitude of the control response	23
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	22
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV	22
Mechanism of external K+ sensitivity of KCNQ1 channels	20
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	20
Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles	20
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	19
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	19

Mitochondrial morphology governs ATP production rate	19
Coincidence detection supported by electrical synapses is shaped by the D-type K+ current	19
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	19
About hysteresis in Shaker: Response to note by Villalba-Galea	19
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	18
Segregation of Ca2+ signaling in olfactory signal transduction	18
Connecting the dots on connexin function	18
Myosin-binding protein-H: Not just filler	18
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	17
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	17
Expression of ENaC subunits in epithelia	16
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	16
Null method to estimate the maximal PA at subsaturating concentrations of agonist	16
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations	16
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	16
Molecular mechanism of claudin-15 strand flexibility: A computational study	16
Kinetic reconstruction of graded membrane excitability in Paramecium	16
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	15
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	15
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	15
Blockade of TRPV channels by intracellular spermine	15
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	14
A complete set of rate constants for a transporter’s catalytic cycle	14
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	14
Variability in reported midpoints of (in)activation of cardiac INa	13
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	13
A sodium channel mutant removes fast inactivation with the inactivation particle bound	13
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	13
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	13
Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue	12
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	12
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains	12
Trouble in store for muscle fibers	12
Directing two-way traffic in the kidney: A tale of two ions	12
Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations	12
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	12
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	12
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	12
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility	12
Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets	12
Fifty years of gating currents and channel gating	11
Molecular dynamics analyses of CLDN15 pore size and charge selectivity	11
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	11
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	11
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	11
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	11
Evaluating sequential and allosteric activation models in I Ks channels with mutated voltage sensors	11
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	11
Mechanistic insights on KATP channel regulation from cryo-EM structures	11
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	11

Subtype-selective targeting of NMDA receptors—A potent new compound emerges	10
Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies?	10
Examining the calcium sensitivity of skeletal muscle thick filaments	10
Fusion pore flux controls the rise-times of quantal synaptic responses	10
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	10
Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit	10
The physical basis of osmosis	10
The S1 helix is a VIP in VSP	10
Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane	10
Mind the midpoints: Rethinking variability in cardiac INa	10
Phosphoinositide regulation of voltage-gated sodium channels	9
The Cranefield Awards 2022	9
Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue	9
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	9
Manganese and intracellular Ca2+ handling	9
Giving structure meaning: Modelling the cellular synapse of excitation–contraction coupling in skeletal muscle	9
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	9
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	8
Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen	8
Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2	8
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	8
Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol	8
A realistic look at rod synapses	8
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	8
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	8
Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement	8
Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944	8
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	8
How the Blind Watchmaker messed around with potassium channels	8
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	8
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	7
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	7
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents	7
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	7
Sniffing out Ca2+ signaling in olfactory cilia	7
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats	7
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells	7
Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity	7
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	7
Correction: The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner	7
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	7
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor	7
Different species, different gap junctions?	6
How could simulations elucidate Nav1.5 channel blockers mechanism?	6
The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating	6
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy	6
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity	6
RyR2 phosphorylation alters dyad architecture	6
Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	6
Cardiac myosin filaments are directly regulated by calcium	6
Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels	6
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	6
Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism	6
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes	6
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation	6
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	6
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini	6
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	5
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	5
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	5
Electro-metabolic signaling	5
Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence	5
Stable oxidative posttranslational modifications alter the gating properties of RyR1	5
GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle	5
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	5
Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere	5
Cortical spreading depression dynamics are altered by topical D2 receptor ligands	5
Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres	5
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	5
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias	5
Ion channel regulation of gut immunity	5
Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation	4
Structural determinants at KCNE4 position 145 govern Kv1.3 channel function	4
Towards a unified gating scheme for the CNBD ion channel family	4
Correction: A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	4
Calcium has a direct effect on thick filament activation in porcine myocardium	4
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	4
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	4
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	4
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	4

Correction: Segregation of Ca2+ signaling in olfactory signal transduction	4
Tirasemtiv enhances submaximal muscle tension in an Acta1 :p.Asp286Gly mouse model of nemaline myopathy	4
On the link between antibiotic resistance, diabetes, and wastewater	4
Light drives the developmental progression of outer retinal function	4
Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry	3
Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels	3
JGP in 2024	3
Gating and modulation of an inward-rectifier potassium channel	3
SMR transporters meet the challenge of metformin metabolites	3
Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels	3
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	3
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease	3
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	3
Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase	3
Mechanism of acid-sensing ion channel modulation by Hi1a	3
Kinetics of aldosterone-dependent ENaC trafficking in the kidney	3
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	3
JGP in 2025	3
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	3
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	3
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	3
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)	3
Correction: Urea and water are transported through different pathways in the red blood cell membrane	3
Longitudinal diffusion barriers imposed by myofilaments and mitochondria in murine cardiac myocytes	2
ALLIN: A tool for annotation of a protein alignment combined with structural visualization	2
Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport	2
Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles	2
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	2
D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion	2
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	2
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	2
An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect	2
Kv1 channel inactivation: Slow and slower	2
Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?	2
Molecular rearrangements in S6 during slow inactivation in Shaker -IR potassium channels	2
A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice	2
Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish	2
Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions	2
Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure	2
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	2
Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue	2
Ion channels of cold transduction and transmission	2
The spatial distribution of glycogen and glycogen consumption in muscle cells	2
Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites	2
Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit	2
Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	2
Urea and water are transported through different pathways in the red blood cell membrane	2
Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band	2
Resolving zone-specific regulation of cardiac myosin	2
Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons	2
Cavβ dances the two-step with VSD II	2
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2
The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation	2
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels	2
Effect of a sensing charge mutation on the deactivation of KV7.2 channels	2
Correction: The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses	2
Dysferlin’s C2A domain supports normal Ca2+ signaling and membrane repair in dysferlin-null myofibers	2
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	2