Journal of General Physiology

Article	Citations
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	74
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation	40
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	39
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	39
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	37
Kv1.1 channels help set the pace	33
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	28
Interrogating the gating motions of the NaK channel	25
NALCN/Cch1 channelosome subunits originated in early eukaryotes	22
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	22
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	22
Investigating the role of the I–II linker in Nav1.5 channel function	21
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	20
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	20
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	19
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	19
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	18
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	18
Mechanism of external K+ sensitivity of KCNQ1 channels	18
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	18
Niclosamide potentiates TMEM16A and induces vasoconstriction	17
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	17
Reconstituting depolarization-induced calcium release	17
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	17
Stochastic force generation in an isometric binary mechanical system	17

Variants of the myosin interacting-heads motif	17
About hysteresis in Shaker: Response to note by Villalba-Galea	16
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	16
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	15
Connecting the dots on connexin function	15
Segregation of Ca2+ signaling in olfactory signal transduction	15
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	15
Piezo1 is a mechanosensor channel in CNS capillaries	15
Myosin-binding protein-H: Not just filler	15
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	14
Mitochondrial morphology governs ATP production rate	14
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	14
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	14
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	14
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	14
Expression of ENaC subunits in epithelia	13
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	13
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	13
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	13
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	13
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	12
A complete set of rate constants for a transporter’s catalytic cycle	12
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	12
Null method to estimate the maximal PA at subsaturating concentrations of agonist	12
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	12
Probing function in ligand-gated ion channels without measuring ion transport	12
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	12
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	11
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	11
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	11
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	11
Blockade of TRPV channels by intracellular spermine	11
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	11
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	11
Molecular mechanism of claudin-15 strand flexibility: A computational study	11
A sodium channel mutant removes fast inactivation with the inactivation particle bound	11
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	11
How a tyrosine primes the pump	10
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	10
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	10
Worms find PEZO-1’s function easy to swallow	10
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	10
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	9
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	9
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	9
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	9
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	9

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	9
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	9
Directing two-way traffic in the kidney: A tale of two ions	9
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	9
Variability in reported midpoints of (in)activation of cardiac INa	9
Trouble in store for muscle fibers	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	9
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	9
Fifty years of gating currents and channel gating	9
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
The S1 helix is a VIP in VSP	8
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	8
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	8
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	8
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	8
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	8
Fusion pore flux controls the rise-times of quantal synaptic responses	8
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
The Cranefield Awards 2022	7
The physical basis of osmosis	7
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	7
Mind the midpoints: Rethinking variability in cardiac INa	7
Mechanistic insights on KATP channel regulation from cryo-EM structures	7
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	7
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	7
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	7
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	7
Insect elementary calcium release events measured in honeybee muscle cells	7
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	6
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	6
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	6
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	6
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	6
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	6
Different species, different gap junctions?	6
2022	6
Examining the calcium sensitivity of skeletal muscle thick filaments	6
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	6
Phosphoinositide regulation of voltage-gated sodium channels	6
A realistic look at rod synapses	6
Sniffing out Ca2+ signaling in olfactory cilia	6
How the Blind Watchmaker messed around with potassium channels	6
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	6
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	6
Essential role of Orai1 and SARAF in vascular remodeling	6
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	6
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	6
How could simulations elucidate Nav1.5 channel blockers mechanism?	6
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity	5
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	5
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents	5
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor	5
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	5
Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres	5
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	5
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes	5
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	5
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells	5
RyR2 phosphorylation alters dyad architecture	5
Stable oxidative posttranslational modifications alter the gating properties of RyR1	5
Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	5
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	5
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	5
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats	5
Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism	5
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2	5
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation	5
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini	4
Electro-metabolic signaling	4
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias	4
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	4
Ion channel regulation of gut immunity	4
GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle	4
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology	4
The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating	4
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	4
Cardiac myosin filaments are directly regulated by calcium	4

Correction: Segregation of Ca2+ signaling in olfactory signal transduction	4
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	4
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy	4
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	4
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	4
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	4
X rays activate T cell calcium signaling	4
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	4
Catecholamines help snakes have a change of heart	3
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	3
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	3
On the link between antibiotic resistance, diabetes, and wastewater	3
Mechanism of acid-sensing ion channel modulation by Hi1a	3
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	3
Therapeutic effects of novel type 1 ryanodine receptor inhibitor on malignant hyperthermia	3
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)	3
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	3
Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels	3
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	3
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	3
Calcium has a direct effect on thick filament activation in porcine myocardium	3
Distinct roles for CaV1.1’s voltage-sensing domains	3
Kinetics of aldosterone-dependent ENaC trafficking in the kidney	3
Light drives the developmental progression of outer retinal function	3
Cardiac muscle disease and therapeutic targets	2
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	2
Correction: A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	2
Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit	2
Cryo-EM reveals local and global structural rearrangements in RYR mutants	2
The spatial distribution of glycogen and glycogen consumption in muscle cells	2
Discovery of new intracellular junctions: The calcium entry units (CEUs)	2
Effect of a sensing charge mutation on the deactivation of KV7.2 channels	2
Septin-7 is indispensable in skeletal muscle regeneration	2
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease	2
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	2
A scorpion toxin takes the sting out of T cell activation	2
JGP in 2025	2
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	2
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	2
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	2
SMR transporters meet the challenge of metformin metabolites	2
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	2
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	2
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	2
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2
Correction: The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses	2
RYR1-related myopathies: Expanding the spectrum of morphological presentation	2
Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites	2
Structural basis for diamide modulation of ryanodine receptor	2
Troponin I phosphorylation is essential for cardiac reserve	2
Correction: Urea and water are transported through different pathways in the red blood cell membrane	2
Kv1 channel inactivation: Slow and slower	2
Gating and modulation of an inward-rectifier potassium channel	2
Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase	2
JGP in 2024	2
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	2
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	2
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels	2
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	2
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	2
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific	2
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	2
Preconditioning contractions prevent Ca2+-dependent proteolysis of STAC3 and prolonged force depression after eccentric contractions	2
Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?	2