Journal of General Physiology

Article	Citations
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	73
Kv1.1 channels help set the pace	39
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	39
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	38
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	36
Interrogating the gating motions of the NaK channel	33
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	27
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	27
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	25
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation	23
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	22
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	22
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	21
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	20
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	20
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	19
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	18
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	18
Mechanism of external K+ sensitivity of KCNQ1 channels	18
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	18
Stochastic force generation in an isometric binary mechanical system	17
Reconstituting depolarization-induced calcium release	17
Variants of the myosin interacting-heads motif	17
Myosin-binding protein-H: Not just filler	16
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	16

Niclosamide potentiates TMEM16A and induces vasoconstriction	16
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	16
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	16
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	16
About hysteresis in Shaker: Response to note by Villalba-Galea	15
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	15
Connecting the dots on connexin function	15
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	15
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	15
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	15
Segregation of Ca2+ signaling in olfactory signal transduction	14
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	14
Piezo1 is a mechanosensor channel in CNS capillaries	14
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	14
Mitochondrial morphology governs ATP production rate	14
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	14
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	13
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	13
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	13
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	12
Probing function in ligand-gated ion channels without measuring ion transport	12
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	12
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	12
A complete set of rate constants for a transporter’s catalytic cycle	12
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	11
Blockade of TRPV channels by intracellular spermine	11
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	11
Expression of ENaC subunits in epithelia	11
Molecular mechanism of claudin-15 strand flexibility: A computational study	11
Null method to estimate the maximal PA at subsaturating concentrations of agonist	11
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	11
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	11
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	10
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	10
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	10
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	10
A sodium channel mutant removes fast inactivation with the inactivation particle bound	10
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	10
Variability in reported midpoints of (in)activation of cardiac INa	9
Trouble in store for muscle fibers	9
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	9
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	9
Worms find PEZO-1’s function easy to swallow	9
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains	9
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9
Directing two-way traffic in the kidney: A tale of two ions	9

Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	9
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	9
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	9
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	9
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	9
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	9
How a tyrosine primes the pump	9
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	8
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	8
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	8
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	8
Fifty years of gating currents and channel gating	8
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	8
The S1 helix is a VIP in VSP	8
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	8
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	8
Fusion pore flux controls the rise-times of quantal synaptic responses	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
The physical basis of osmosis	8
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	7
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	7
Mind the midpoints: Rethinking variability in cardiac INa	7
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	7
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	7
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	7
Examining the calcium sensitivity of skeletal muscle thick filaments	7
Mechanistic insights on KATP channel regulation from cryo-EM structures	7
The Cranefield Awards 2022	7
Insect elementary calcium release events measured in honeybee muscle cells	7
How the Blind Watchmaker messed around with potassium channels	6
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	6
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	6
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	6
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	6
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	6
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	6
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	6
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	6
Phosphoinositide regulation of voltage-gated sodium channels	6
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	6
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	6
2022	6
Essential role of Orai1 and SARAF in vascular remodeling	6
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	6
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	6
A realistic look at rod synapses	6
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells	5
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes	5
How could simulations elucidate Nav1.5 channel blockers mechanism?	5
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation	5
The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating	5
Sniffing out Ca2+ signaling in olfactory cilia	5
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	5
RyR2 phosphorylation alters dyad architecture	5
Different species, different gap junctions?	5
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents	5
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	5
Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres	5
Cardiac myosin filaments are directly regulated by calcium	5
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	5
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	5
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor	5
Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism	5
Stable oxidative posttranslational modifications alter the gating properties of RyR1	5
Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	5
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2	5
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats	5
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	5
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	4
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity	4
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	4
Electro-metabolic signaling	4
Calcium has a direct effect on thick filament activation in porcine myocardium	4
Therapeutic effects of novel type 1 ryanodine receptor inhibitor on malignant hyperthermia	4
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology	4
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy	4
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	4
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	4

Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	4
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	4
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	4
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	4
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini	4
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	4
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias	4
GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle	4
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	4
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	3
Light drives the developmental progression of outer retinal function	3
Correction: Segregation of Ca2+ signaling in olfactory signal transduction	3
Catecholamines help snakes have a change of heart	3
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	3
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	3
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)	3
On the link between antibiotic resistance, diabetes, and wastewater	3
Ion channel regulation of gut immunity	3
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	3
Distinct roles for CaV1.1’s voltage-sensing domains	3
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	3
X rays activate T cell calcium signaling	3
Preconditioning contractions prevent Ca2+-dependent proteolysis of STAC3 and prolonged force depression after eccentric contractions	2
Correction: The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses	2
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	2
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	2
SMR transporters meet the challenge of metformin metabolites	2
Correction: A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	2
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	2
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	2
Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit	2
The spatial distribution of glycogen and glycogen consumption in muscle cells	2
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	2
Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?	2
Cardiac muscle disease and therapeutic targets	2
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	2
Correction: Urea and water are transported through different pathways in the red blood cell membrane	2
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease	2
Septin-7 is indispensable in skeletal muscle regeneration	2
RYR1-related myopathies: Expanding the spectrum of morphological presentation	2
Mechanism of acid-sensing ion channel modulation by Hi1a	2
JGP in 2024	2
Kinetics of aldosterone-dependent ENaC trafficking in the kidney	2
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	2
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels	2
Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites	2
Gating and modulation of an inward-rectifier potassium channel	2
Effect of a sensing charge mutation on the deactivation of KV7.2 channels	2
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	2
A scorpion toxin takes the sting out of T cell activation	2
JGP in 2025	2
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	2
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific	2
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	2
Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase	2
Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels	2
Structural basis for diamide modulation of ryanodine receptor	2
Kv1 channel inactivation: Slow and slower	2
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	2
Discovery of new intracellular junctions: The calcium entry units (CEUs)	2
Troponin I phosphorylation is essential for cardiac reserve	2
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	2
Cryo-EM reveals local and global structural rearrangements in RYR mutants	2