OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters	98
Pseudoreplication in physiology: More means less	48
Structural basis of the super- and hyper-relaxed states of myosin II	47
ATP synthase: Evolution, energetics, and membrane interactions	43
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity	41
Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle	34
Intercalated disk nanoscale structure regulates cardiac conduction	32
Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice	29
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle	28
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion	28
Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle	27
Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine	26
Multiscale modeling of twitch contractions in cardiac trabeculae	26
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins	25
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle	24
Spike frequency–dependent inhibition and excitation of neural activity by high-frequency ultrasound	23
Cardiac myosin filaments are directly regulated by calcium	23
The very low number of calcium-induced permeability transition pores in the single mitochondrion	22
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1	22
Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing	22
Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin	22
FXYD protein isoforms differentially modulate human Na/K pump function	22
Structure versus function: Are new conformations of pannexin 1 yet to be resolved?	21
Physics of mechanotransduction by Piezo ion channels	21
Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration	21

Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation	19
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator	19
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate	19
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development	17
Molecular underpinning of intracellular pH regulation on TMEM16F	17
FXYD proteins and sodium pump regulatory mechanisms	17
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	16
Single-cell temperature mapping with fluorescent thermometer nanosheets	16
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	16
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling	15
The role of molecular diffusion within dendritic spines in synaptic function	15
Novel insights into sarcomere regulatory systems control of cardiac thin filament activation	15
Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation	14
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation	14
Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake	14
Mechanism and potential sites of potassium interaction with glutamate transporters	14
Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation	14
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	14
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	14
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel	14
The N2A region of titin has a unique structural configuration	13
Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor	13
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP	13
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	13
Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner	13
Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses	13
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	13
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts	13
Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms	13
Dynein regulates Kv7.4 channel trafficking from the cell membrane	13
Filament evanescence of myosin II and smooth muscle function	13
Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity	13
The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle	12
Mechanistic insights on KATP channel regulation from cryo-EM structures	12
C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation	12
Detection of Ca2+ transients near ryanodine receptors by targeting fluorescent Ca2+ sensors to the triad	11
In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes	11
Molecular mechanism of claudin-15 strand flexibility: A computational study	11
Large transient capacitive currents in wild-type lysosomal Cl−/H+ antiporter ClC-7 and residual transport activity in the proton glutamate mutant E312A	11
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	11
Mechanism of use-dependent Kv2 channel inhibition by RY785	10
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	10
Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle	10
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state	10
How does flecainide impact RyR2 channel function?	10
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	10
Function of mammalian M-cones depends on the level of CRALBP in Müller cells	10
Multiscale modeling shows that dielectric differences make NaV channels faster than KV channels	10
Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors	10
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart	9

Mechanisms of proton inhibition and sensitization of the cation channel TRPV3	9
Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites	9
The molecular evolution of function in the CFTR chloride channel	9
Dendritic spine morphology regulates calcium-dependent synaptic weight change	9
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	9
E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms	9
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism	9
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243	9
Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle	9
A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin	9
Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel	9
An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization	8
A novel voltage-clamp/dye uptake assay reveals saturable transport of molecules through CALHM1 and connexin channels	8
Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function	8
Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin	8
How hot are single cells?	8
Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel	8
Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation	8
The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size	8
cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation	8
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	8
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	8
Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons	8
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	8
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	8
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy	8
Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans	7
Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity	7
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	7
Variants of the myosin interacting-heads motif	7
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	7
The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs	7
Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle	7
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties	7
Q-cubed mutant cues clues to CLC antiport mechanism	7
Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump	7
Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction	7
PI(4,5)P2 regulates the gating of NaV1.4 channels	7
A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	7
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	7
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	7
The activation gate controls steady-state inactivation and recovery from inactivation in Shaker	7