OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	71
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	39
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	39
Interrogating the gating motions of the NaK channel	37
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	37
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	35
The epithelial potassium channel Kir7.1 is stimulated by progesterone	32
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	27
Kv1.1 channels help set the pace	26
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	25
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	23
Stochastic force generation in an isometric binary mechanical system	22
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	22
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	21
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	21
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	20
Mechanism of external K+ sensitivity of KCNQ1 channels	20
Variants of the myosin interacting-heads motif	19
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	19
Reconstituting depolarization-induced calcium release	18
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	17
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	17
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	17
Niclosamide potentiates TMEM16A and induces vasoconstriction	17
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	17

Myosin-binding protein-H: Not just filler	16
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	16
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	16
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	16
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	16
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	16
Piezo1 is a mechanosensor channel in CNS capillaries	15
Connecting the dots on connexin function	15
Mitochondrial morphology governs ATP production rate	15
Segregation of Ca2+ signaling in olfactory signal transduction	15
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	15
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	15
About hysteresis in Shaker: Response to note by Villalba-Galea	15
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	15
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	14
Molecular mechanism of claudin-15 strand flexibility: A computational study	14
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	14
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	14
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	14
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	14
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	14
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	13
A complete set of rate constants for a transporter’s catalytic cycle	13
Null method to estimate the maximal PA at subsaturating concentrations of agonist	12
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	12
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	12
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	12
Probing function in ligand-gated ion channels without measuring ion transport	12
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	12
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	11
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	11
Expression of ENaC subunits in epithelia	11
Blockade of TRPV channels by intracellular spermine	11
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	11
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	11
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	10
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	10
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	10
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
How a tyrosine primes the pump	10
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	10
A sodium channel mutant removes fast inactivation with the inactivation particle bound	10
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	10
Worms find PEZO-1’s function easy to swallow	10
Trouble in store for muscle fibers	9
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	9
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	9
Fifty years of gating currents and channel gating	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9

Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	9
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	9
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	9
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	9
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	9
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	9
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	9
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	8
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	8
Fusion pore flux controls the rise-times of quantal synaptic responses	8
The S1 helix is a VIP in VSP	8
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	8
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	8
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	8
The physical basis of osmosis	8
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
Directing two-way traffic in the kidney: A tale of two ions	8
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	8
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	8
Mechanistic insights on KATP channel regulation from cryo-EM structures	8
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	8
Insect elementary calcium release events measured in honeybee muscle cells	7
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	7
The Cranefield Awards 2022	7
State-dependent inhibition of BK channels by the opioid agonist loperamide	7
Phosphoinositide regulation of voltage-gated sodium channels	7
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	7
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	7
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	7
How the Blind Watchmaker messed around with potassium channels	7
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	7
Examining the calcium sensitivity of skeletal muscle thick filaments	7