OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	67
Unraveling the mysteries of the titin–N2A signalosome	44
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	40
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	38
Interrogating the gating motions of the NaK channel	37
Further progress in understanding of myofibrillar function in health and disease	33
Kv1.1 channels help set the pace	33
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	32
The epithelial potassium channel Kir7.1 is stimulated by progesterone	27
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	26
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	26
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	25
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	23
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	23
Mechanism of external K+ sensitivity of KCNQ1 channels	23
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	22
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	22
Niclosamide potentiates TMEM16A and induces vasoconstriction	21
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	20
Reconstituting depolarization-induced calcium release	20
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	20
Stochastic force generation in an isometric binary mechanical system	20
Variants of the myosin interacting-heads motif	19
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	19
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	18

The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	18
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	17
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	17
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	17
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	16
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	16
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	16
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	15
About hysteresis in Shaker: Response to note by Villalba-Galea	15
Segregation of Ca2+ signaling in olfactory signal transduction	15
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	15
Myosin-binding protein-H: Not just filler	15
Connecting the dots on connexin function	15
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	15
Piezo1 is a mechanosensor channel in CNS capillaries	14
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	14
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	14
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	14
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes	13
A complete set of rate constants for a transporter’s catalytic cycle	13
Mitochondrial morphology governs ATP production rate	13
Null method to estimate the maximal PA at subsaturating concentrations of agonist	13
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	13
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	13
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	13
Expression of ENaC subunits in epithelia	12
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	12
Probing function in ligand-gated ion channels without measuring ion transport	12
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	12
Molecular mechanism of claudin-15 strand flexibility: A computational study	11
Blockade of TRPV channels by intracellular spermine	11
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	11
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	11
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	11
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	11
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	11
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	10
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	10
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	10
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	10
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	10
How a tyrosine primes the pump	10
Worms find PEZO-1’s function easy to swallow	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	10
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	9
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	9
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9

Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	9
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	9
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	9
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	9
A sodium channel mutant removes fast inactivation with the inactivation particle bound	9
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	9
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	9
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	9
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	8
The S1 helix is a VIP in VSP	8
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	8
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	8
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	8
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	8
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	8
Directing two-way traffic in the kidney: A tale of two ions	8
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	8
Fusion pore flux controls the rise-times of quantal synaptic responses	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	8
Fifty years of gating currents and channel gating	8
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	8
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	8
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	7
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	7
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	7
Mechanistic insights on KATP channel regulation from cryo-EM structures	7
The physical basis of osmosis	7
The Cranefield Awards 2022	7
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	7
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	7
Examining the calcium sensitivity of skeletal muscle thick filaments	7
Insect elementary calcium release events measured in honeybee muscle cells	7
State-dependent inhibition of BK channels by the opioid agonist loperamide	7