Journal of Lipid Research

Article	Citations
Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein	193
Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation	88
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice	77
High cholesterol absorption efficiency increases the risk of the nonfatal and fatal atherosclerotic events	65
Bioorthogonal azido-S1P works as substrate for S1PR1	59
Expression of SREBF2 and HMGCR discriminates the viability of steatotic grafts for human liver transplantation	54
Erratum to: The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases [Journal of Lipid Research 66/1 (2025) 100711]	53
Four-dimensional lipidomics profiling in X-linked adrenoleukodystrophy using trapped ion mobility mass spectrometry	46
A simplified method for preventing postmortem alterations of brain prostanoids for true in situ level quantification	43
The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis	42
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport	38
Functional characterization of 16 variants found in the LDL receptor gene	36
Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates	35
A Gly-β-muricholic acid and FGF15 combination therapy synergistically reduces “humanized” bile acid pool toxicity in cholestasis mice	35
Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease	35
New multiplex LC-MS/MS method for lipid biomarker analysis of inherited neurodegenerative metabolic diseases	32
Specific approaches and limitations in (multi)-omic Mendelian randomization	30
A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors	30
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Nuclear lipid droplets in Caco2 cells originate from nascent precursors and in situ at the nuclear envelope	28
Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species	28
Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin	28
Leaflet-specific effects of charged lipids on a voltage-gated potassium channel	27
Dietary modulation of Lp(a): more questions than answers	27
In memoriam: Ana Jonas, PhD	27

Introduction of a lipidomics scoring system for data quality assessment	25
A fluorogenic substrate for the detection of lipid amidases in intact cells	25
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Lipidomics and mass spectrometry imaging unveil alterations in mice hippocampus lipid composition exposed to hypoxia	24
The adipocyte apolipoprotein M is negatively associated with inflammation	24
Choline kinase inhibition promotes ER-phagy	24
Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection	24
Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders	23
Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment	23
Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits	23
ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice	22
Deep-lipidotyping by mass spectrometry: recent technical advances and applications	22
Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats	22
METTL3-mediated m6A modification of TNFAIP3 promotes endothelial to mesenchymal transition and atherosclerosis via the NF-κB/SNAIL signaling pathway	21
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets	21
The one-key-to-two-doors role of lipidomics: plasma lipidome, cardiovascular risk and statin usage	21
Brown adipose tissue facilitates the fever response following infection with Salmonella enterica serovar Typhimurium in mice	21
Highly tail-asymmetric lipids interdigitate and cause bidirectional ordering	20
The role of high-density lipoproteins in sepsis	20
In Memoriam: Jan B Sjövall, MD, PhD, (1928–2024)	20
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids	20
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The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950, and intralaboratory quality control materials	20
Polyunsaturated fatty acids stimulate immunity and eicosanoid production in Drosophila melanogaster	19
Asprosin as a regulator of hepatic lipogenesis and its association with hepatic steatosis	19
Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis	19
Diet-induced obesity dampens the temporal oscillation of hepatic mitochondrial lipids	19
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content	19
Dissecting cell type–specific impact in lysosomal acid lipase deficiency–associated disorders	19
Fatty acid nitroalkenes regulate intestinal lipid absorption	19
Corrigendum to Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway	19
The role of N-terminal phosphorylation of DGK-θ	19
TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner	18
KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress	18
Saroglitazar is noninferior to fenofibrate in reducing triglyceride levels in hypertriglyceridemic patients in a randomized clinical trial	18
Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry	18
Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis	18
Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation	18
2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis	18
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury	18
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis	18
Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice	17
Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatidyl-, and phosphoglycerol dipeptide lipid families	17
A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification	17
Elevated high-density lipoprotein triglycerides increase atherosclerotic risk	17
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Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats	17
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DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis	17

EBF2 regulates cardiolipin and phosphatidylethanolamine remodeling and mitochondrial dynamics in brown fat	17
Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting	17
Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model	16
In vivo visualization of lipophagy dynamics using the tfLiveDrop reporter mice	16
Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization	16
High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages	16
Repurposing daclatasvir for MASLD Therapy—A promising step forward with challenges ahead	16
Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis	16
Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1	16
Analytical validation of a direct lipoprotein(a)-cholesterol assay	16
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition	16
Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes	16
Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs	16
Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase	16
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Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis	16
Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice	16
Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes	15
Intravital lipid droplet labeling and imaging reveals the phenotypes and functions of individual macrophages in vivo	15
Tripartite motif 38 alleviates the pathological process of NAFLD–NASH by promoting TAB2 degradation	15
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Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters	15
Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway	15
Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomes	15
Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome	15
Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.	15
Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage	15
ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis	15
HBV-miR-3 induces hepatic cholesterol accumulation by targeting ABCA1: Evidence for potential benefits of statin usage	15
GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action	15
An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway	15
Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice	15
Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome	15
Alternative fatty acid desaturation pathways revealed by deep profiling of total fatty acids in RAW 264.7 cell line	14
NEGR1 deficiency disrupts lipid metabolism and steroidogenesis in Leydig cells, linking testosterone to behavior	14
Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia	14
Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain	14
Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain	14
Detecting white adipose tissue browning in mice with in vivo R2∗ mapping at 9.4T MRI	14
Reducing saturated fat intake lowers LDL-C but increases Lp(a) levels in African Americans: the GET-READI feeding trial	14
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis	14
Causal association of blood lipids with all-cause and cause-specific mortality risk: a Mendelian randomization study	14
Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice	14
Lipidation as a post-translational code for protein liquid-liquid phase separation	14
Spatial mapping of PUFA incorporation into phospholipids with bisallylic deuteration	13
Comprehensive mass spectrometry lipidomics of human biofluids and ocular tissues	13
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Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment	13
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Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine	13
A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels	13
Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina	13
Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates	13
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Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue	13
Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype	13
Lipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions	13
The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia	13
Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis	13
De(C1P)hering the role of ceramide-1-phosphate levels in skin wound healing	13
Hormone-sensitive lipase protects adipose triglyceride lipase-deficient mice from lethal lipotoxic cardiomyopathy	13
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma	13
Longitudinal analysis of lipid changes in the sciatic nerve caused by overexpression of PMP22 in murine models of CMT1A	13
Substrate-dependent incorporation of 15-lipoxygenase products in glycerophospholipids: 15-HETE and 15-HEPE in PI, 17-HDHA in plasmalogen PE, and 13-HODE in PC	12
Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder	12
Mitochondria-specific photorelease of ceramide induces apoptosis	12
Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease	12
Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery	12
Strategies for consistent and automated quantification of HDL proteome using data-independent acquisition	12
The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally	12
Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis	12
Characteristic distribution of eicosapentaenoic acid in human abdominal aortic aneurysm wall	12
Sorting through the extensive and confusing roles of sortilin in metabolic disease	12
APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries	12
Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation	12
The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data	12
Targeting to high density lipoprotein cholesterol: new insights for inflammatory bowel disease treatment	12
SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis	11
Brown fat fuels the fire in fever	11
Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency	11

Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate	11
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Vascular lipid droplets formed in response to TNF, hypoxia, or OA: biochemical composition and prostacyclin generation	11
The DNA methyltransferase inhibitor decitabine blunts the response to a high-animal fat and protein diet in mice	11
Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1	11
Global deletion of COX-2 attenuates hepatic inflammation but impairs metabolic homeostasis in diet-induced obesity	11
Unveiling Novel Macrophage-Specific Biomarkers in MASH through Single-Cell Sequencing for Diagnostic Modeling	11
Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis	11
A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis	11
Associations between insulin-like growth factor binding protein-2 and lipoprotein kinetics in men	11
Flavonoids regulate LDLR through different mechanisms tied to their specific structures	11
6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols	11
Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease	11
Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz	11
Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice	11
Pioglitazone alleviates lacrimal gland impairments induced by high-fat diet by suppressing M1 polarization	11
Mining cholesterol genes from thousands of mouse livers identifies aldolase C as a regulator of cholesterol biosynthesis	11
Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2 mice	10
A historical, evidence-based, and narrative review on commonly used dietary supplements in lipid-lowering	10
Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes	10
2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites	10
All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells	10
Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis	10
Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles	10
Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis	10
WITHDRAWN: The Risk of Going Outside: Amino Phospholipids in Rheumatoid Arthritis	10
In Memoriam: G. Stephen (Steve) Tint, PhD (1935–2022)	10
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Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity	10
Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	10
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression	10
Plasma lipidomics and 15-year risk of incident diabetes: a coronary artery risk development in young adults study	10
Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study	10
LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines	10
Specific FAHFAs predict worsening glucose tolerance in non-diabetic relatives of people with Type 2 diabetes	10
Loss of Splicing Factor SRSF3 Impairs Lipophagy Through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes	10
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Lipidomics of phospholipase A2 reveals exquisite specificity in macrophages	10
A novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase	10
The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases	10
Relationship of apolipoprotein(a) isoform size with clearance and production of lipoprotein(a) in a diverse cohort	10
A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling	10
Spatial lipidomics reveals zone-specific hepatic lipid alteration and remodeling in metabolic dysfunction-associated steatohepatitis	10
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Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome	9
Does small HDL’s function improve when lipid-lowering alters its composition?	9
JNK1 mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis	9
Phospholipase A2 products influence the antiplatelet functions of synthetic high-density lipoproteins	9
Elovl4b knockout zebrafish as a model for ocular very-long-chain PUFA deficiency	9
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Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice	9
Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers	9
Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL	9
A high-resolution 13C NMR approach for profiling fatty acid unsaturation in lipid extracts and in live Caenorhabditis elegans	9
Maternal obesogenic diet enhances cholestatic liver disease in offspring	9
Inositol acylation of phosphatidylinositol mannosides: a rapid mass response to membrane fluidization in mycobacteria	9
Total oxylipin concentrations in NIST SRM 1950 plasma compared to fresh and commercially obtained human plasma	9
Effect of type 2 diabetes on the inducible degrader of LDL receptor	9
Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study	9
A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding	9
17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation by inhibiting neutrophil infiltration	9
Hexokinase 2 promotes ISGylation of Acyl-CoA synthetase long-chain family member 4 in sepsis-induced microglia cells	9
Potential causal and temporal relationship between plasma triglyceride levels and circulating leukocyte	9
The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells	9
Peroxisomal ether-glycerophospholipid synthesis is dysregulated after TBI	9
Correction: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	9
Effects of coconut oil, olive oil, and butter on plasma fatty acids and metabolic risk factors: a randomized trial	8
Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation	8
Visualize neuronal membrane cholesterol with split-fluorescent protein tagged YDQA sensor	8
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants	8
S-nitrosylation contributes to ER stress and aggresome formation in secosterol-B-mediated endothelial dysfunction	8
Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS	8
ANGPTL4/8 promotes plasmin-mediated cleavage of LPL inhibitors	8
Unveiling the role of Mfsd2a and LPC-DHA in kidney repair	8
Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH	8
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation	8
Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation	8
Insights into the molecular changes of adipocyte dedifferentiation and its future research opportunities	8
Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans	8
HDL meets triglyceride	8
High Sensitivity and Wide Linearity LC-MS/MS Method for Oxylipin Quantification in Multiple Biological Samples	8
Bioactive lipid mediators in plasma are predictors of preeclampsia irrespective of aspirin therapy	8
Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases	8
Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment	8
Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer	8
Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells	8
Microbe-derived cyclopropane lipids activate host nuclear receptors	8
Deletion of hepatic small heterodimer partner ameliorates development of nonalcoholic steatohepatitis in mice	7
Apolipoprotein A1 deficiency increases macrophage apoptosis and necrotic core development in atherosclerotic plaques in a Bim-dependent manner	7
Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome	7
Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism	7
Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties	7
Glycosylation of ceramide synthase 6 is required for its activity	7
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Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues	7