Journal of Lipid Research

Article	Citations
Bioorthogonal azido-S1P works as substrate for S1PR1	223
Expression of SREBF2 and HMGCR discriminates the viability of steatotic grafts for human liver transplantation	65
Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease	57
A simplified method for preventing postmortem alterations of brain prostanoids for true in situ level quantification	54
High cholesterol absorption efficiency increases the risk of the nonfatal and fatal atherosclerotic events	53
Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates	51
A Gly-β-muricholic acid and FGF15 combination therapy synergistically reduces “humanized” bile acid pool toxicity in cholestasis mice	45
Erratum to: The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases [Journal of Lipid Research 66/1 (2025) 100711]	40
Specific approaches and limitations in (multi)-omic Mendelian randomization	39
Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species	38
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A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors	35
New multiplex LC-MS/MS method for lipid biomarker analysis of inherited neurodegenerative metabolic diseases	34
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice	33
Nuclear lipid droplets in Caco2 cells originate from nascent precursors and in situ at the nuclear envelope	33
Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein	31
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport	30
Four-dimensional lipidomics profiling in X-linked adrenoleukodystrophy using trapped ion mobility mass spectrometry	30
In memoriam: Ana Jonas, PhD	29
Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin	29
The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis	29
Functional characterization of 16 variants found in the LDL receptor gene	29
Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation	29
Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats	28
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Leaflet-specific effects of charged lipids on a voltage-gated potassium channel	26
A fluorogenic substrate for the detection of lipid amidases in intact cells	26
Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection	26
Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders	26
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids	26
The adipocyte apolipoprotein M is negatively associated with inflammation	26
ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice	25
The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950, and intralaboratory quality control materials	25
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets	25
Choline kinase inhibition promotes ER-phagy	24
Brown adipose tissue facilitates the fever response following infection with Salmonella enterica serovar Typhimurium in mice	24
The one-key-to-two-doors role of lipidomics: plasma lipidome, cardiovascular risk and statin usage	24
Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment	24
The role of high-density lipoproteins in sepsis	24
Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits	24
Lipidomics and mass spectrometry imaging unveil alterations in mice hippocampus lipid composition exposed to hypoxia	24
Dietary modulation of Lp(a): more questions than answers	23
A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen	23
Introduction of a lipidomics scoring system for data quality assessment	23
METTL3-mediated m6A modification of TNFAIP3 promotes endothelial to mesenchymal transition and atherosclerosis via the NF-κB/SNAIL signaling pathway	22
Highly tail-asymmetric lipids interdigitate and cause bidirectional ordering	22
In Memoriam: Jan B Sjövall, MD, PhD, (1928–2024)	22
Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis	21
TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner	21
Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry	21
Polyunsaturated fatty acids stimulate immunity and eicosanoid production in Drosophila melanogaster	21
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis	20
Diet-induced obesity dampens the temporal oscillation of hepatic mitochondrial lipids	20
2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis	20
Dissecting cell type–specific impact in lysosomal acid lipase deficiency–associated disorders	20
KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress	20
Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis	20
DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis	20
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content	20
Asprosin as a regulator of hepatic lipogenesis and its association with hepatic steatosis	20
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury	20
The role of N-terminal phosphorylation of DGK-θ	20
Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation	20
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Fatty acid nitroalkenes regulate intestinal lipid absorption	20
Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice	19
Elevated high-density lipoprotein triglycerides increase atherosclerotic risk	19
Carnitine deficiency alters fuel metabolism and voluntary wheel running in mice	19
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EBF2 regulates cardiolipin and phosphatidylethanolamine remodeling and mitochondrial dynamics in brown fat	19
A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification	18
Repurposing daclatasvir for MASLD Therapy—A promising step forward with challenges ahead	18
Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs	18

Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization	18
Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatidyl-, and phosphoglycerol dipeptide lipid families	18
In vivo visualization of lipophagy dynamics using the tfLiveDrop reporter mice	18
Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats	18
Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis	18
Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1	18
Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase	18
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Analytical validation of a direct lipoprotein(a)-cholesterol assay	17
Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway	17
Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model	17
An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway	17
Tripartite motif 38 alleviates the pathological process of NAFLD–NASH by promoting TAB2 degradation	17
Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice	17
Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis	17
Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome	17
Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting	17
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition	16
Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes	16
Characterization of Post-translational Modification in Metabolic Dysfunction-Associated Steatohepatitis: Acetylation, Lactylation, and Phosphorylation	16
GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action	16
HBV-miR-3 induces hepatic cholesterol accumulation by targeting ABCA1: Evidence for potential benefits of statin usage	16
Liver X receptor agonists enhance intestinal repair in neonatal piglets with massive bowel resection	16
ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis	16
High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages	16
Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomes	16
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Detecting white adipose tissue browning in mice with in vivo R2∗ mapping at 9.4T MRI	15
Causal association of blood lipids with all-cause and cause-specific mortality risk: a Mendelian randomization study	15
Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates	15
Reducing saturated fat intake lowers LDL-C but increases Lp(a) levels in African Americans: the GET-READI feeding trial	15
Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia	15
Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice	15
Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters	15
Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain	15
Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis	15
Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain	15
NEGR1 deficiency disrupts lipid metabolism and steroidogenesis in Leydig cells, linking testosterone to behavior	15
Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage	15
Alternative fatty acid desaturation pathways revealed by deep profiling of total fatty acids in RAW 264.7 cell line	15
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis	15
Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype	14
Longitudinal analysis of lipid changes in the sciatic nerve caused by overexpression of PMP22 in murine models of CMT1A	14
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Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment	14
Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina	14
A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels	14
Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice	14
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma	14
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Strategies for consistent and automated quantification of HDL proteome using data-independent acquisition	14
Comprehensive mass spectrometry lipidomics of human biofluids and ocular tissues	14
APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries	14
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine	14
Lipidation as a post-translational code for protein liquid-liquid phase separation	14
Cover	14
Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue	14
Spatial mapping of PUFA incorporation into phospholipids with bisallylic deuteration	14
Sorting through the extensive and confusing roles of sortilin in metabolic disease	13
Lipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions	13
Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate	13
Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease	13
In Memoriam: George H. Rothblat (1935–2026)	13
LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation	13
Substrate-dependent incorporation of 15-lipoxygenase products in glycerophospholipids: 15-HETE and 15-HEPE in PI, 17-HDHA in plasmalogen PE, and 13-HODE in PC	13
Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation	13
Brown fat fuels the fire in fever	13
Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery	13
Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz	13
6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols	13
The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia	13
Characteristic distribution of eicosapentaenoic acid in human abdominal aortic aneurysm wall	13
Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease	13
Mitochondria-specific photorelease of ceramide induces apoptosis	13
Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis	12
Intestinal colonization of germ-free mice with indole-producing E. coli modulates the central and peripheral endocannabinoidome	12
Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1	12
Unveiling novel macrophage-specific biomarkers in MASH through single-cell sequencing for diagnostic modeling	12
Plasma lipid alterations in thrombosis and antiphospholipid syndrome - a differentiating lipid plasma composite score	12
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Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency	12
The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally	12
Global deletion of COX-2 attenuates hepatic inflammation but impairs metabolic homeostasis in diet-induced obesity	12
The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data	12
Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder	12
Targeting to high density lipoprotein cholesterol: new insights for inflammatory bowel disease treatment	12
Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis	12
Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice	11
SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis	11
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Flavonoids regulate LDLR through different mechanisms tied to their specific structures	11
2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites	11
Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes	11
Pioglitazone alleviates lacrimal gland impairments induced by high-fat diet by suppressing M1 polarization	11
Vascular lipid droplets formed in response to TNF, hypoxia, or OA: biochemical composition and prostacyclin generation	11
Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity	11
A historical, evidence-based, and narrative review on commonly used dietary supplements in lipid-lowering	11
In Memoriam: G. Stephen (Steve) Tint, PhD (1935–2022)	11
All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells	11
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The DNA methyltransferase inhibitor decitabine blunts the response to a high-animal fat and protein diet in mice	11
Associations between insulin-like growth factor binding protein-2 and lipoprotein kinetics in men	11
Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice	11
A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis	11
Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	11
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Loss of Splicing Factor SRSF3 Impairs Lipophagy Through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes	11
Mining cholesterol genes from thousands of mouse livers identifies aldolase C as a regulator of cholesterol biosynthesis	11
Plasma lipidomics and 15-year risk of incident diabetes: a coronary artery risk development in young adults study	10
A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling	10
Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis	10
A novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase	10
Ceramide kinase/ceramide 1-phosphate signaling regulates LC3B expression and autophagosome formation	10
17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation by inhibiting neutrophil infiltration	10
Phospholipid remodeling as a key regulator of ferroptosis	10
LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines	10
WITHDRAWN: The Risk of Going Outside: Amino Phospholipids in Rheumatoid Arthritis	10
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression	10
Corrigendum to: ApoB100 remodeling and stiffened cholesteryl ester core raise LDL aggregation in familial hypercholesterolemia patients [Journal of Lipid Research 66/1 (2025) 100703]	10
The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells	10
JNK1 mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis	10
Relationship of apolipoprotein(a) isoform size with clearance and production of lipoprotein(a) in a diverse cohort	10
Specific FAHFAs predict worsening glucose tolerance in non-diabetic relatives of people with Type 2 diabetes	10
Spatial lipidomics reveals zone-specific hepatic lipid alteration and remodeling in metabolic dysfunction-associated steatohepatitis	10
Lipidomics of phospholipase A2 reveals exquisite specificity in macrophages	10
The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases	10
A high-resolution 13C NMR approach for profiling fatty acid unsaturation in lipid extracts and in live Caenorhabditis elegans	10
Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study	10
Reevaluation of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs) as Toll-like receptor 2 (TLR2) agonists	10
Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer	9
P2X receptors and lipids interact to modulate inflammation	9
Potential causal and temporal relationship between plasma triglyceride levels and circulating leukocyte	9
Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers	9
Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL	9
Peroxisomal ether-glycerophospholipid synthesis is dysregulated after TBI	9
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1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells	9
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation	9
Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation	9
Correction: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	9
Microbe-derived cyclopropane lipids activate host nuclear receptors	9
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Hexokinase 2 promotes ISGylation of Acyl-CoA synthetase long-chain family member 4 in sepsis-induced microglia cells	9
A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding	9
Total oxylipin concentrations in NIST SRM 1950 plasma compared to fresh and commercially obtained human plasma	9
Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study	9
ANGPTL4/8 promotes plasmin-mediated cleavage of LPL inhibitors	9
Effect of type 2 diabetes on the inducible degrader of LDL receptor	9
Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment	9
Visualize neuronal membrane cholesterol with split-fluorescent protein tagged YDQA sensor	9
Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice	9
Bioactive lipid mediators in plasma are predictors of preeclampsia irrespective of aspirin therapy	9
Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis	9
Inositol acylation of phosphatidylinositol mannosides: a rapid mass response to membrane fluidization in mycobacteria	9
Phospholipase A2 products influence the antiplatelet functions of synthetic high-density lipoproteins	9
Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome	9
Does small HDL’s function improve when lipid-lowering alters its composition?	9
Elovl4b knockout zebrafish as a model for ocular very-long-chain PUFA deficiency	9
HDL meets triglyceride	9
Effects of coconut oil, olive oil, and butter on plasma fatty acids and metabolic risk factors: a randomized trial	9
S-nitrosylation contributes to ER stress and aggresome formation in secosterol-B-mediated endothelial dysfunction	9
Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans	9
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Resolvin D2/GPR 18 axis ameliorates pressure overload-induced heart failure by inhibiting pro-inflammatory macrophage polarization	8
MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition	8
A fatty acid-ordered plasma membrane environment is critical for Ebola virus matrix protein assembly and budding	8
Isomerization of bis(monoacylglycero)phosphate by acyl migration	8
Corrigendum to: Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay [Journal of Lipid Research 65/1 (2024) 100482]	8
A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome	8
Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties	8
Targeting the ARF6-dependent recycling pathway to alter lipid rafts and reduce inflammation	8
Serum opacity factor normalizes erythrocyte morphology in Scarb1−/− mice in an HDL-free cholesterol-dependent way	8
Ceramide Analysis in Combination With Genetic Testing May Provide a Precise Diagnosis for Self-Healing Collodion Babies	8
Apolipoprotein A1 deficiency increases macrophage apoptosis and necrotic core development in atherosclerotic plaques in a Bim-dependent manner	8
Raman analysis of breast cancer-associated adipocytes: A chemometric pipeline for lipid biochemistry profiling	8