OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Neurochemistry is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
	153
The following article for this Special Issue was previously published and can be found in its respective issue online: “Amyloid processing in COVID‐19‐associated neurological syndromes”	102
ESN‐YMS	94
Issue Information	89
	81
MicroRNA‐29b‐3p degenerates terminally differentiated dopaminergic SH‐SY5Y cells by perturbation of mitochondrial functions	69
Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia	57
Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2‐heterozygous mouse model of Rett syndrome	55
Synaptotagmin‐11 regulates immune functions of microglia in vivo	54
A novel strategy for deliveringNiemann‐Pick typeC2proteins across the blood–brain barrier using the brain endothelial‐specificAAV‐BR1virus	54
Serum amyloid A facilitates expansion of CD4⁺ T cell and CD19⁺ B cell subsets implicated in the severity of myasthenia gravis patients	54
The Impact of Splicing Dysregulation on Neuromuscular Disorders and Current Neuromuscular Genetic Therapies	52
Preface to the Special Issue “Autism Spectrum Disorder: From Genes to Therapies”	45
Dynamics of Neuronal and Astrocytic Energy Molecules in Epilepsy	40
DJ‐1 regulates astrocyte activation through miR‐155/SHP‐1 signaling in cerebral ischemia/reperfusion injury	40
Correlation Analysis Between High‐Density Lipoprotein Cholesterol‐Carried microRNA‐28‐5p and Acute Ischemic Stroke	40
Sex‐dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice	40
The activation of inflammatory responses in the brain is potentiated by over‐expressing acetylcholinesterase in myeloid lineage of transgenic mice	36
Upregulation of FMRP Is Involved in Neuropathic Pain by Regulating GluN2B Activation in Rat Spinal Cord	35
PPARβ/δ Activation Improves Corticosterone‐Induced Oxidative Stress Damage in Astrocytes by Targeting UBR5/ATM Signaling	34
COVID‐19 and the impact on Alzheimer's disease pathology	33
Bioenergetic and excitotoxic determinants of cofilactin rod formation	32
Sex‐specific pleiotropic changes in emotional behavior and alcohol consumption in human α‐synuclein A53T transgenic mice during early adulthood	32
Prenatal Exposure to Vaporized High‐Potency Cannabis Affects Hippocampal Synaptic Remodeling and Efficacy, Axonal Excitability, and Memory in Offspring	32
The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes	31

IL‐1β/IL‐1R1 signaling is involved in the propagation of α‐synuclein pathology of the gastrointestinal tract to the brain	30
From molecules to behavior: Implications for perineuronal net remodeling in learning and memory	29
HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity	27
GluN2B‐Derived Small Interfering Peptide (GluN2B‐Sip) Protects Against Sevoflurane‐Induced Neurotoxicity in Developing Rats	27
Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte‐derived lipid transport	26
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits	26
Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes	26
IL‐17 Stimulates Sensory Neurons and Sensitises Colonic Afferents to Noxious Stimuli in a PI3K Dependent Manner in Male Mice	26
Fundamental Neurochemistry Review: GABA_A receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy	26
Colony‐stimulating factor‐1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model	26
Emerging_Group_Leaders_Symposia	25
Acknowledgement of reviewers	24
	24
Issue Information	24
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	24
Author Index	23
Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke	23
The multifaceted roles of the brain glycogen	23
Exploring the Structural Dynamics of LeuT Using EPR Spectroscopy: A Focus on Transmembrane Helix 10	23
Chronic ecologically relevant stress effects on reverse‐translated touchscreen assays of reward responsivity and attentional processes in male rats: Implications for depression	23
Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis	23
Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model	23
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The sphingosine 1‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus	22
The Evolution of Experimental Rodent Models for Prion Diseases	22
Dysregulation of circadian clock gene expression patterns in a treatment‐resistant animal model of depression	22
Does the inability of CA1 area to respond to ischemia with early rapid adenosine release contribute to hippocampal vulnerability?	22
Colony Stimulating Factor‐1 (CSF‐1) and Interleukin‐34 (IL‐34) Differentially Alter White Matter and Gray Matter Microglia and Oligodendrocyte Progenitor Cells	22
Morphine‐induced kinase activation and localization in the periaqueductal gray of male and female mice	22
Characterisation and automated quantification of induced seizure‐related behaviours in Xenopus laevis tadpoles	21
In memoriam: Frode Fonnum (1937–2023)	21
EDITOR SPOTLIGHT: Interview with Brain Imaging Special Issue guest editors Victor Villemagne and Yulong Li	21
α‐Synuclein induces deficiency in clathrin‐mediated endocytosis through inhibiting synaptojanin1 expression	21
Novel single‐nucleus transcriptomics unravels developmental and functionally controlled principles of mammalian neuromuscular junctions	21
Clinical, molecular, physiologic, and therapeutic feature of patients with CHRNA4 and CHRNB2 deficiency: A systematic review	20
Cerebrospinal fluid levels of L‐glutamate signal central inflammatory neurodegeneration in multiple sclerosis	20
Monitoring conformational changes in the human neurotransmitter transporter homologue LeuT with ¹⁹F‐NMR spectroscopy	20
Roles of metabotropic signaling of nicotine receptors in the development and maintenance of nicotine reward through regulation of dopamine D₃ receptor expression	20
AENK ameliorates cognitive impairment and prevents Tau hyperphosphorylation through inhibiting AEP‐mediated cleavage of SET in rats with ischemic stroke	20
TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia‐reperfusion injury via TAK1‐JNK/p38 pathway	20
Ependymal cells undergo astrocyte‐like reactivity in response to neuroinflammation	20
Tubulin and GTP Are Crucial Elements for Postsynaptic Density Construction and Aggregation	20
Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids	19
The polyphenol EGCG directly targets intracellular amyloid‐β aggregates and promotes their lysosomal degradation	19
Exploring the reduction in aquaporin‐4 and increased expression of ciliary neurotrophic factor with the frontal–striatal gliosis induced by chronic high‐fat dietary stress	19
The relationship between serum neurofilament light chain and glial fibrillary acidic protein with the REM sleep behavior disorder subtype of Parkinson's disease	19
Single‐cell RNA‐seq uncovers novel metabolic functions of Schwann cells beyond myelination	19
Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder	19
Psilocybin as a lead candidate molecule in preclinical therapeutic studies of psychiatric disorders: A systematic review	19

Experimental approaches for altering the expression of Abeta‐degrading enzymes	18
Poster Sessions A	18
Issue Information	18
	18
(Re)building the nervous system: A review of neuron–glia interactions from development to disease	17
Preface to the Special Issue “Matrix Metalloproteinases in Health and Disease”	17
Issue Information	17
Long‐term neurological dysfunction associated with COVID‐19: Lessons from influenza and inflammatory diseases?	17
Altered metabolic function induced by Aβ‐oligomers and PSEN1 mutations in iPSC‐derived astrocytes	17
Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies	17
Association of serum lipidomic profiles with risk of intracranial aneurysm: A Mendelian randomization study	17
The Effects of Exercise‐Associated Factors on Hippocampal Progenitor Cell Dynamics Are Mediated by Cannabinoid Type 2 Receptors	17
Molecular targets of endothelial phosphatidic acid regulating major depressive disorder	16
	16
Demethylase FTO Regulates P2X3R Expression Contributing to the Mechanism of Hyperalgesia in Lumbar Disc Herniation	16
Issue Information	16
Correction to “Constitutive alpha‐secretase cleavage of the beta‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disinte	16
Poster Sessions Wednesday/Thursday	16
Issue Information	16
Presenilin deficiency enhances tau phosphorylation and its secretion	16
Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young‐Onset PLA2G6 Parkinson's Disease iPSCs	16
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Issue Information	16
Phosphacan acts as a repulsive cue in murine and rat cerebellar granule cells in a TAG‐1/GD3 rafts‐dependent manner	15
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation	15
Differential regulation of nucleus accumbens glutamate and GABA in obesity‐prone and obesity‐resistant rats	15
Focal acetylcholinergic modulation of the human midcingulo‐insular network during attention: Meta‐analytic neuroimaging and behavioral evidence	15
Viscerosensory signalling to the nucleus accumbens via the solitary tract nucleus	15
Endonuclease VIII‐like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease	15
Voltage‐gated sodium channels in genetic epilepsy: up and down of excitability	14
Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease	14
Neurotensin and energy balance	14
Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease	14
Reviewer List	14
	14
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging	14
Molecular insights into psychedelic drug action	14
Contribution of ceramides metabolism in psychiatric disorders	14
Embracing the Modern Biochemistry of Brain Metabolism	14
Issue Information	14
Circulating metabolites associated with incident myocardial infarction and stroke: A prospective cohort study of 90 438 participants	14
Towards Better and More Valid Zebrafish Models of Alzheimer's Disease: A Scientific Tribute to Prof. Mikhail I. Aghajanov	14
Diet‐Induced Obesity in the Rat Impairs Sphingolipid Metabolism in the Brain and This Metabolic Dysfunction Is Transmitted to the Offspring via Both the Maternal and the Paternal Lineage	14
GABA‐Producing Levilactobacillus brevis LAB6 Mitigates Pentylenetetrazol‐Induced Gut‐Brain Dysregulation in SD Rats	14
Calcium‐Dependent Signaling in Astrocytes: Downstream Mechanisms and Implications for Cognition	14
α7 nicotinic receptors play a role in regulation of cardiac hemodynamics	14
	14
Book Review: Posttraumatic Epilepsy: Basic and Clinical Aspects (Jonak, Peterson and Binder; Academic Press, 2023)	13
Strain‐dependent role of copper in prion disease through binding to histidine residues in the N‐terminal domain of prion protein	13
Thirty years of BDNF study in central myelination: From biology to therapy	13
The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus	13
A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel‐dependent as well as synaptic functions of α₂δ‐2	13
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Metabolic aspects of genetic ion channel epilepsies	13
Brain‐specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination‐associated astrocyte subtype	13
Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC	13
Up‐regulation of miR‐335 and miR‐674‐3p in the rostral ventrolateral medulla contributes to stress‐induced hypertension	13
Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function	13
Lipidome changes in alcohol‐related brain damage	13
Phase separation of the mammalian prion protein: Physiological and pathological perspectives	13
Gas5 regulates early‐life stress‐induced anxiety and spatial memory	13
Dissecting cell‐type‐specific pathways in medial entorhinal cortical‐hippocampal network for episodic memory	13
Regulation of CNS Lipids by Protease Activated Receptor 1	12
From BBB to PPP: Bioenergetic requirements and challenges for oligodendrocytes in health and disease	12
Omega‐3 polyunsaturated fatty acids and Parkinson's disease: A systematic review of animal studies	12
Issue Information	12
CXCR2 immunomodulatory therapy protects against microstructural white matter injury and gait abnormalities but does not mitigate deficits of cognition in a preclinical model of cerebral pal	12
Amyloid beta 1‐40 and 1‐42 fibril ratios and maturation level cause conformational differences with minimal impact on autophagy and cytotoxicity	12
Circulating medium‐ and long‐chain acylcarnitines are associated with plasma P‐tau181 in cognitively normal older adults	12
Spreading depolarizations pose critical energy challenges in acute brain injury	12
Understanding stress‐induced transmission of peripherally derived factors into the brain and responses in non‐neuronal cells	12
Issue Information	12
Genetically Confirmed Optimal Causal Association of Cerebrospinal Fluid Metabolites With Hemorrhagic Stroke	12
Attenuated responses to attention‐modulating drugs in the neuroligin‐3^R451C mouse model of autism	12
Regulation of Dendrite and Dendritic Spine Formation by TCF20	12
Improving neuropathic pain treatment – by rigorous stratification from bench to bedside	12
Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease	12
	12
TRIM9 Controls Growth Cone Responses to Netrin Through DCC and UNC5C	12
Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases	11

In Vivo Assessment of Cortical Astrocyte Network Dysfunction During Autoimmune Demyelination: Correlation With Disease Severity	11
Preface: Mass spectrometry in Alzheimer disease	11
PARP1 in the intersection of different DNA repair pathways, memory formation, and sleep pressure in neurons	11
Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain	11
Integrative Analysis of DNA Methylation and Gene Expression Reveals Key Molecular Signatures in Spatial Memory Impairment of Sepsis‐Associated Encephalopathy	11
Butyrylcholinesterase in lipid metabolism: A new outlook	11
Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes	11
Toward discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes	11
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Maternal history of Alzheimer's disease predisposes to altered serum cholesterol levels in adult offspring	11
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy	11
Role of palmitoylation on the neuronal glycine transporter GlyT2	11
Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer’s disease research	11
Misprogramming of glucose metabolism impairs recovery of hippocampal slices from neuronal GLT‐1 knockout mice and contributes to excitotoxic injury through mitochondrial superoxide production	11
Preface to the special issue “Neuroimmunology”	11
Selenomethionine mis‐incorporation and redox‐dependent voltage‐gated sodium channel gain of function	11
Critical period of exposure to mercury and the diagnostic of autism spectrum disorder: A systematic review	11
Issue Information	11
Regulatory Dynamics of Nrf2 With Sirtuins in the Brain: Exploring Cellular Metabolism, Synaptic Plasticity, and Defense Mechanisms	11
ESN‐YSLA	11
Neural Metabolic Networks: Key Elements of Healthy Brain Function	11
EXPRESSION OF CONCERN: Antioxidant Compounds Have Potent Anti‐fibrillogenic and Fibril‐destabilizing Effects for α‐synuclein Fibrils In Vitro	10
Disruption of amphetamine sensitization by alteration of dendritic thin spines in the nucleus accumbens core	10
Iron, ferroptosis, and ischemic stroke	10
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SARS‐CoV‐2, aging, and Post‐COVID‐19 neurodegeneration	10
Exploring the Role of Microglial Cells in the Gut–Brain Axis Communication: A Systematic Review	10
Correction to ‘Inhibition of cGMP‐Signalling Rescues Retinal Ganglion Cells From Axotomy‐Induced Degeneration’	10
Cannabidiol Protects Against Neurotoxic Reactive Astrocytes‐Induced Neuronal Death in Mouse Model of Epilepsy	10
FMRP regulation of aggrecan mRNA translation controls perineuronal net development	10
The GTPase Rab21 is required for neuronal development and migration in the cerebral cortex	10
Cell density impacts the susceptibility to ferroptosis by modulating IRP1‐mediated iron homeostasis	10
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Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS	10
Function and regulation of cis P‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies	10
cAMP‐Response Element (CRE)‐Mediated Transcription by CRE‐Binding Protein (CREB) Is Essential for Human Tryptophan Hydroxylase 2 Gene Expression	10
Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains	10
Oxidative Stress Suppresses Trk Signaling While Stimulating JNK‐Mediated Endocytosis and Cleavage of p75^NTR: A Targetable Pathway for Neuroprotection in a Parkinson's	10
Chronic in vivo sequelae of repetitive acute mfb‐DBS on accumbal dopamine and midbrain neuronal activity	10
Plasma C18:0‐ceramide is a novel potential biomarker for disease severity in myasthenia gravis	10
Phospholipid cofactor solubilization inhibits formation of native prions	10
Molecular signatures from multi‐omics of autism spectrum disorders and schizophrenia	10
Spontaneous, transient adenosine release is not enhanced in the CA1 region of hippocampus during severe ischemia models	10
Bioisosteric analogs of MDMA: Improving the pharmacological profile?	10
Zinc induces reactive astrogliosis through ERK‐dependent activation of Stat3 and promotes synaptic degeneration	10
The Blue Light‐Responsive Lateral Pathway of the Retinohypothalamic Tract Promotes Endocannabinoid‐Driven Modulation of Orexin Neurons	10
Self‐Report Alzheimer's Disease Statuses in UK Biobank Distort Downstream Analyses	10
Exosomal miR‐142‐3p from M1‐polarized macrophages suppresses cell growth and immune escape in glioblastoma through regulating HMGB1‐mediated PD‐1/PD	9
Chemical traits of cerebral amyloid angiopathy in familial British‐, Danish‐, and non‐Alzheimerʼs dementias	9
Copper induces neuron‐sparing, ferredoxin 1‐independent astrocyte toxicity mediated by oxidative stress	9
Acknowledgement of reviewers	9
Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning	9
Protein aggregation: A detrimental symptom or an adaptation mechanism?	9
The causal role of circulating amino acids on neurodegenerative disorders: A two‐sample Mendelian randomization study	9
Retraction: Broad DNA repair responses in neural injury are associated with activation of the IL‐6 pathway in cholesterol‐fed rabbits	9
Effects of anti‐tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria	9
Mitophagy suppresses motor neuron necroptotic mitochondrial damage and alleviates necroptosis that converges to SARM1 in acrylamide‐induced dying‐back neuropathy	9
RETRACTION: The oxysterol 27‐hydroxycholesterol regulates α‐synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen recep	9
A common variant in the iron regulatory gene (Hfe) alters the metabolic and transcriptional landscape in brain regions vulnerable to neurodegeneration	9
Multiplexing FSCV and iGluSnFR3 Sensors Reveals Adenosine Transiently Inhibits Stimulated Dopamine and Glutamate Release	9
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The role of the neuronal microenvironment in sensory function and pain pathophysiology	9
SH‐SY5Y cells undergo changes in peroxisomal metabolism when exposed to decanoic acid	9
Glucose as a carbon source to synthesize palmitate de novo in the adult rodent brain: Adding to the carbon recycling story in the brain	9
Variant‐specific in vitro neuronal network phenotypes and drug sensitivity in SCN2A developmental and epileptic encephalopathy	9
Dopamine transporter endocytic trafficking: Neuronal mechanisms and potential impact on DA‐dependent behaviors	9
Tomatidine Ameliorates Diabetes‐Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK‐TFEB Pathway	9
Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats	9
Dissection of Neurochemical Pathways Across Complexity and Scale	9
Relationships between gene expression and behavior in mice in response to systemic modulation of the O‐GlcNAcylation pathway	9
Lipid metabolism in dopaminergic neurons influences light entrainment	9
Cross‐species translational paradigms for assessing positive valence system as defined by the RDoC matrix	9
Loss of the parkinsonism‐associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects	9
Neurochemical correlates of synapse density in a Huntington's disease mouse model	9
Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model mice	8
The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons	8
Equivalence of Plasma and Serum for Clinical Measurement of p‐tau217: Comparative Analyses of Four Blood‐Based Assays	8
Poly (I:C)‐induced maternal immune activation generates impairment of reversal learning performance in offspring	8
Translational validity of neuropsychological tasks of sustained attention between rodents and humans: A systematic review of three rodent tasks	8
Acknowledgement of reviewers	8
Clear‐headed into old age: Resilience and resistance against brain aging—A PET imaging perspective	8
Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation	8
Heme oxygenase‐1: The roles of both good and evil in neurodegenerative diseases	8
A natural small molecule‐mediated inhibition of alpha‐synuclein aggregation leads to neuroprotection in Caenorhabditis elegans	8
Acknowledgements to reviewers	8
Comment on the Editorial “Embracing the Modern Biochemistry of Brain Metabolism”	8
Xanthurenic acid: A role in brain intercellular signaling	8
Association of serum Gasdermin D with anti‐N‐methyl‐D‐aspartate receptor encephalitis	8
Sex‐Specific Distribution of Glycine Transporter 2 in the Central Nervous System of Adult GlyT2‐iCre‐tdTomato Mouse Brain	8
Clearance Pathways for α‐Synuclein in Parkinson's Disease	8
Correction to “The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus”	8
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Associations of circulating metabolites with cerebral white matter hyperintensities	8