Journal of Pathology

Article	Citations
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	104
Issue Information	89
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	87
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	84
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	79
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	78
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	71
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	70
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	61
Clinical outcomes and immune contexture in SMARCA4 ‐deficient gastric cancer patients	58
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	55
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	53
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	50
Artificial intelligence to identify genetic alterations in conventional histopathology	49
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	45
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	44
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	43
Escape from senescence: molecular basis and therapeutic ramifications	43
Pseudobudding: ruptured glands do not represent true tumor buds	42
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	42
CRISPR –Cas9 screening identifies the role of FER as a tumor suppressor	40
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Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	38
Integrating computational pathology and proteomics to address tumor heterogeneity	37
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	35

Identification of actionable targets using DEPArray ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded ti	35
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	35
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	35
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	34
Field cancerization in breast cancer	34
KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers	33
Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	32
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	31
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Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	30
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Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	29
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	28
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	28
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	28
Downregulated BMP –Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithe	28
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	27
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Somatic loss of ATM is a late event in pancreatic tumorigenesis	26
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	25
BMP signalling in colorectal cancer: losing the yin to WNTs yang	25
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Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	24
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	23
Issue Information	23
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	23
PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	23
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	23
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Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	22
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Lineage tracing in human tissues	22
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Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	21
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72 ‐AL	21
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	21
PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	21
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	21
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	21
Issue Information	20
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Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	20
DNA methylation patterns are influenced by Pax3 ::	19
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	19
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	19
Issue Information	19
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	19

Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	18
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	18
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Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	18
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Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	18
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Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	18
Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	18
APC‐related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation	18
Issue Information	18
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	18
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	18
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin re	18
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Unleashing the potential of AI for pathology: challenges and recommendations	17
Mutation profiling in differential diagnosis between TdT ‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma	17
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	17
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	17
Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer	17
Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	16
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	16
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	16
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	16
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	16
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	16
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	16
Issue Information	15
The state of the art for artificial intelligence in lung digital pathology	15
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	15
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	15
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	15
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	14
Issue Information	14
Issue Information	14
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma †	14
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	14
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	14
Issue Information	14
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	13
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	13
Consensus molecular subtype transition during progression of colorectal cancer	13
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	13
Clinical significance of pancreatic ductal metaplasia	13
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	13
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	13
Jeremy Jass Prize for Research Excellence in Pathology 2021	13
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing	13
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	13
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	12
Issue Information	12
Abstracts	12
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	12
Issue Information	12
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
Issue Information	12
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	12
CD27 / CD70 pathway activation in primary cutaneous CD4 + small/med	12
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Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	11
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Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency,	11
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	11
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME ,	11
Extracellular vesicles arising from apoptosis: forms, functions, and applications	11
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	11
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	11
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	11
Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	11
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	11
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Super resolution of pathology images with hierarchical feature integration and local image patterns	10
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	10
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Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	10
Issue Information	10
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	10

Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three en	10
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	10
Cell state dynamics during early stages of serous endometrial carcinoma	10
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	10
Periostin‐IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation	10
Reducing the risks of nuclear war – the role of health professionals	10
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	10
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	10
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	10
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	10
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	10
Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic facto	10
Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	10
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	10
Issue Information	10
TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	9
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	9
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	9
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	9
Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers	9
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	9
Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis	9
List of Reviewers	9
Issue Information	9
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors	9
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Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression	9
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	9
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	9
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	9
Issue Information	9
Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
Reconstructing the epidermal proteolytic cascades in health and disease	8
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Papillary renal cell carcinoma with high‐ ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy	8
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	8
Advancing gastric cancer precision medicine with novel genomic screens†	8
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Utilizing aptamers in targeted protein degradation strategies for disease therapy	8
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions	8
TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
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DNA ‐hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53	7
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Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	7
Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integr	7
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	7
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Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	7
Issue Information	7
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡	7
Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer	7
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	7
Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	7
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	7
Genetic and immune landscape evolution in MMR‐ deficient colorectal cancer	7
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (	7
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	7
STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	7
Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia	7
AI ‐guided histopathology predicts brain metastasis in lung cancer patients	7
Abstracts	7
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	7
Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts †	7
A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression	6
Concerns about pathology expertise and data quality	6
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alter	6
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Partial‐ EMT cell state correlates with single cell pattern of invasion in head and neck SCC kerat	6
Jeremy Jass Prize for Research Excellence in Pathology 2022	6
GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms	6
The significance of PAX5 in Merkel cell carcinoma	6
Spatial analysis of HPV ‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cance	6
Transcriptomic profiling reveals the role of Hedgehog signaling as a biomarker and in the pathogenesis of Ménétrier's disease	6
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	6
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	6
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	6
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	6
Issue Information	6
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	6
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	6
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	6
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	6
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	6
Comprehensive clinicopathological, molecular, and methylation analysis of mesenchymal tumors with NTRK	6
Aberrant TERT expression: linking chronic inflammation to hepatocellular carcinoma†	6
Nondestructive 3D pathology with analysis of nuclear features for prostate cancer risk assessment	6
LINE ‐1 hypomethylation characterizes the inflammatory response in coeliac disease associated‐intestinal mucosa and small bowel adenocarcinomas	5
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia	5
Correction to the ‘14th Joint Meeting of the BDIAP and The Pathological Society, Liverpool Pathology 2023, 27–29 June, 2023’ supplement	5
The case for homebrew AI in diagnostic pathology	5
Fibroblast‐derived neuropilin 1 alleviates renal fibrosis progression	5