Journal of Pathology

Article	Citations
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	88
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Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	78
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	75
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	68
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	64
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	63
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	55
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	55
Probing the tumorigenic potential of genetic interactions reconstituted in murine fallopian tube organoids	53
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type	51
Escape from senescence: molecular basis and therapeutic ramifications	51
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	50
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	50
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	48
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	44
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	43
CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor	42
Artificial intelligence to identify genetic alterations in conventional histopathology	42
Integrating computational pathology and proteomics to address tumor heterogeneity	41
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	41
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	40
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Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	38
Pseudobudding: ruptured glands do not represent true tumor buds	35

Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	35
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	35
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	33
Field cancerization in breast cancer	33
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	31
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Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	31
Characterisation of an enhanced preclinical model of experimental MPO‐ANCA autoimmune vasculitis	30
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	29
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	28
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	28
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	28
Downregulated BMP–Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithelial cells	28
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Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	27
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	27
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	27
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Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	24
Lineage tracing in human tissues	24
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	24
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	24
BMP signalling in colorectal cancer: losing the yin to WNTs yang	24
PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	24
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	24
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	23
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	23
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	23
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS	23
PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	23
Somatic loss ofATMis a late event in pancreatic tumorigenesis	23
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	22
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Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	22
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Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	21
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Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	21
DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered	20
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	20
Genomic analysis and preclinical xenograft model development identify potential therapeutic targets for MYOD1‐mutant soft‐tissue sarcoma of childhood	20
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin resistance	20
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	20
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	20
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	20

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Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	19
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	19
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	19
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Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	18
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	18
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	18
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	18
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	18
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	18
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	17
Unleashing the potential of AI for pathology: challenges and recommendations	17
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	17
SOX9 has distinct roles in the formation and progression of different non‐small cell lung cancer histotypes	17
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	17
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	17
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Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	16
Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	16
The state of the art for artificial intelligence in lung digital pathology	16
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	16
Jeremy Jass Prize for Research Excellence in Pathology 2021	16
Dystrophin deficiency impairs vascular structure and function in the canine model of Duchenne muscular dystrophy	16
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	16
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Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	15
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†	15
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	15
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	15
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	15
Clinical significance of pancreatic ductal metaplasia	15
Consensus molecular subtype transition during progression of colorectal cancer	15
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	14
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	14
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Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	14
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	14
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	14
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	14
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Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	14
Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	14
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	14
Extracellular vesicles arising from apoptosis: forms, functions, and applications	13
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	13
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	13
Brg1 is required to maintain colorectal cancer stem cells	13
CD27/CD70 pathway activation in primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder	13
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Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	13
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice	13
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Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	13
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Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	13
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
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Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	12
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	12
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors	12
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	12
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Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	12
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	12
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer‐rich regions and 38 spliceogenic variants	12
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	12
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FOXL2C134W: much ado about something!†	12
FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?	12
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	11
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value i	11
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	11
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	11
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	11
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	11

NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	11
Reducing the risks of nuclear war – the role of health professionals	10
Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	10
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Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	10
Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	10
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P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	10
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	10
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	10
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Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	9
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TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	9
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List of Reviewers	9
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	9
Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis	9
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Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involveme	9
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	9
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Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma	9
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Advancing gastric cancer precision medicine with novel genomic screens†	8
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	8
Utilizing aptamers in targeted protein degradation strategies for disease therapy	8
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	8
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STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	8
NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions	8
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡	8
Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers	8
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	8
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer	8
TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	8
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning	8
Reconstructing the epidermal proteolytic cascades in health and disease	8
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	8
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	8
Mitochondria govern histone acetylation in colorectal cancer	8
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alterations	7
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	7
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	7
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	7
Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integr	7
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	7
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Abstracts	7
Concerns about pathology expertise and data quality	7
Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	7
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†	7
AI‐guided histopathology predicts brain metastasis in lung cancer patients	7
Genetic and immune landscape evolution in MMR‐deficient colorectal cancer	7
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	7
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	7
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	7
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	7
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Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	7
Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL‐8	7
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis	7
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	6
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	6
Jeremy Jass Prize for Research Excellence in Pathology 2022	6
Aberrant TERT expression: linking chronic inflammation to hepatocellular carcinoma†	6
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	6
The significance of PAX5 in Merkel cell carcinoma	6
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	6
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	6
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The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet‐induced non‐alcoholic steatohepatitis	6
A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alteration	6
‘NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas’	6
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	6
Manchester Pathology 2021. 13th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 6–8 July 2021	6
Nondestructive3Dpathology with analysis of nuclear features for prostate cancer risk assessment	6
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	6
Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy	6
Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2/ERK1/2/HIF‐1α‐dependent signaling pathway	5
Absence of NOTCH1 mutation and presence of CDKN2A deletion predict progression of esophageal lesions	5
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Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in chronic lymphocytic leukemia	5
NMRK2 is an efficient diagnostic indicator for Xp11.2 translocation renal cell carcinoma	5
EBV infection mediated BDNF expression is associated with bladder inflammation in interstitial cystitis/bladder pain syndrome with Hunner's lesion	5
Calcyphosine promotes the proliferation of glioma cells and serves as a potential therapeutic target	5
Genomic analysis of spermatocytic tumors demonstrates recurrent molecular alterations in cases with malignant clinical behavior	5