Journal of Pathology

Article	Citations
Issue Information	115
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	115
Clinical outcomes and immune contexture in SMARCA4 ‐deficient gastric cancer patients	94
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	73
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	64
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	57
Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response	53
Escape from senescence: molecular basis and therapeutic ramifications	51
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	50
Tissue‐level heterogeneity in FECD : Descemet's membrane phenotypes and association with TCF4	49
Tubal ligation exacerbates ovulation‐driven TP53 mutagenesis and p53 signatures by depleting prote	47
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	45
Roles of THBS2 + fibroblasts in malignant transformation of colorec	44
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	44
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	44
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	44
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	43
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Author Index	41
CRISPR –Cas9 screening identifies the role of FER as a tumor suppressor	40
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	40
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Identification of actionable targets using DEPArray ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded ti	35
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	34
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	34

Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	32
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	31
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	30
CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells	29
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	29
Pseudobudding: ruptured glands do not represent true tumor buds	29
Dedifferentiation in endometrial cancer is associated with HLA ‐I silencing that may be restored by IFN	29
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	28
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	27
KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers	27
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Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	25
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Issue Information	25
Downregulated BMP –Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithe	25
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	24
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	24
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Testican‐1‐ MMP axis in tumour extracellular matrix ( ECM ) remodelling: interaction dynamics anal	23
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Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	22
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PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	21
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	21
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	21
Somatic loss of ATM is a late event in pancreatic tumorigenesis	21
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	20
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72 ‐AL	20
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	20
BMP signalling in colorectal cancer: losing the yin to WNTs yang	20
PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	20
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	20
Issue Information	19
Integrating artificial intelligence ( AI ) into colorectal cancer reporting	19
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	19
Exosomal lncRNA PVT1 promotes fibroblast activation and colon cancer progres	19
Immunological mechanisms underlying the clinical heterogeneity of Kikuchi disease: the potential role of atypical memory B cells	19
APC‐related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation	19
Practical considerations for pathologists when selecting digital pathology systems: an ESDIP guide	19
Identifying therapeutic targets in low‐grade serous ovarian carcinomas with no specific molecular profile	19
Issue Information	18
DNA methylation patterns are influenced by Pax3 ::	18
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	18
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	18
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	18

Issue Information	18
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	17
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	17
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	17
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin re	17
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	16
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	16
Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	16
Issue Information	16
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Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	16
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Mutation profiling in differential diagnosis between TdT ‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma	16
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	15
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	15
Unleashing the potential of AI for pathology: challenges and recommendations	15
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	15
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	15
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	15
Genetic analysis of primary lung interdigitating dendritic cell sarcomas	15
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	15
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	15
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	15
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing	14
Issue Information	14
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	14
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP ‐2 or bone marrow‐derived C5	14
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	14
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	14
Consensus molecular subtype transition during progression of colorectal cancer	14
Issue Information	14
Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer	14
Jeremy Jass Prize for Research Excellence in Pathology 2021	13
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	13
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	13
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	13
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	13
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	13
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	13
Transcriptomic comparative study between canalicular adenoma and HMGA2 ::	13
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	13
Issue Information	13
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	13
Immune dysregulation in the prostates of C57BL / 6 Aire	13
FTO ‐mediated m6A modification of protein disulfide‐isomerase activates VEGFA	13
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis	13
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME ,	12
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
Issue Information	12
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Abstracts	12
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	12
CD27 / CD70 pathway activation in primary cutaneous CD4 + small/med	12
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Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	11
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Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	11
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	11
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three en	11
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	11
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	11
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	11
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	11
Super resolution of pathology images with hierarchical feature integration and local image patterns	11
Issue Information	11
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	11
Extracellular vesicles arising from apoptosis: forms, functions, and applications	11
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	11
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	10
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	10
Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	10
Issue Information	10
TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	10
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	10
Exploring adenoid basal carcinoma to squamous cell carcinoma of the uterine cervix transformation using spatial transcriptomics	10
Cell state dynamics during early stages of serous endometrial carcinoma	10
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Periostin‐IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation	10
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	10
Applying flow cytometry‐based isolation of platelet‐derived microparticles to banked human plasma for cellular studies	10
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	10
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	10
Reducing the risks of nuclear war – the role of health professionals	10
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	10
Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic facto	9
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	9
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Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	9
Bronchiolar adenoma‐like lesions with atypical features beyond the classic morphological spectrum: integrating histomorphology and molecular profiles	9
Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression	9
Advancing gastric cancer precision medicine with novel genomic screens†	9
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	9
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Issue Information	8
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions	8
Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia	8
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	8
Utilizing aptamers in targeted protein degradation strategies for disease therapy	8
TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	8
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Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
List of Reviewers	8
Issue Information	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity	8
Papillary renal cell carcinoma with high‐ ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy	8
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An oncogenic role for EBV ‐encoded BILF1 in nasopharyngeal carcinoma	8
DNA ‐hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53	8
List of Reviewers	8
Issue Information	8
Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in	8
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors	8
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	7
Abstracts	7
Transcriptomic profiling reveals the role of Hedgehog signaling as a biomarker and in the pathogenesis of Ménétrier's disease	7
Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts †	7
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alter	7
What practicing pathologists and oncologists should know about the new computational pathology‐based companion diagnostic tools	7
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	7
Multinodular and vacuolating neuronal tumor: molecular genetics and DNA methylation analysis of 12 cases	7
Genetic and immune landscape evolution in MMR‐ deficient colorectal cancer	7
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	7
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Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	7
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	7
Dopamine inhibits retinal pathological neovascularization in the oxygen‐induced retinopathy mouse model	7
Correction to ‘Quantitative proteomics identifies altered O‐ GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's dise	7
Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	7
Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer	7
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (	7
Issue Information	7
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	7
STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	7
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	7
Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness	7
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB	7
Concerns about pathology expertise and data quality	7
Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	7
AI ‐guided histopathology predicts brain metastasis in lung cancer patients	7
The immune‐metabolism interactome in efferocytosis: a new paradigm for the central nervous system diseases revealed by single‐cell sequencing analysis	7
Professor Philip J Coates: an appreciation	7
Neutrophil extracellular traps aggravate lung injury by inducing pyroptosis of alveolar macrophages	7
Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?	6
Nondestructive 3D pathology with analysis of nuclear features for prostate cancer risk assessment	6
Comprehensive clinicopathological, molecular, and methylation analysis of mesenchymal tumors with NTRK	6
Aberrant TERT expression: linking chronic inflammation to hepatocellular carcinoma†	6
Jeremy Jass Prize for Research Excellence in Pathology 2022	6
Mining bulk transcriptomic datasets identifies inflammasome activation and antigen presentation as key novel mechanisms of BK polyomavirus‐associated	6
Integrated morphological, immunohistochemical, and genomic profiling identifies uterine leiomyoma patients with hereditary leiomyomatosis and renal cell cancer syndrome: a comprehensive analysis of 25	6
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Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression	6
Molecular evidence of a clonal relationship of synchronous/multifocal gastric‐type lesions of the female genital tract	6
The significance of PAX5 in Merkel cell carcinoma	6
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A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
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Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	6
Spatial analysis of HPV ‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cance	6
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	6
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	6
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	6
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Partial‐ EMT cell state correlates with single cell pattern of invasion in head and neck SCC kerat	6
Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy	6
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	6
Implications of tumour heterogeneity on cancer evolution and therapy resistance: lessons from breast cancer	5
Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2/ERK1/2/HIF‐1α‐dependent signaling pathway	5
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