Journal of Pathology

Article	Citations
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	100
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	89
Issue Information	82
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	78
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	77
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	74
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	69
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	67
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	66
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	60
Clinical outcomes and immune contexture in SMARCA4 ‐deficient gastric cancer patients	56
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	53
Artificial intelligence to identify genetic alterations in conventional histopathology	52
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	49
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	47
Escape from senescence: molecular basis and therapeutic ramifications	44
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	43
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	42
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CRISPR –Cas9 screening identifies the role of FER as a tumor suppressor	41
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	41
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	39
Identification of actionable targets using DEPArray ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded ti	38
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	37
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	36

Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	35
Integrating computational pathology and proteomics to address tumor heterogeneity	34
Pseudobudding: ruptured glands do not represent true tumor buds	33
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	33
Field cancerization in breast cancer	33
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	32
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Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	32
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Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	29
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	29
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Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	28
Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	28
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	27
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	26
Downregulated BMP –Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithe	26
KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers	26
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	25
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	25
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	25
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	25
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PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	24
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	23
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	23
BMP signalling in colorectal cancer: losing the yin to WNTs yang	23
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	23
Somatic loss of ATM is a late event in pancreatic tumorigenesis	22
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Lineage tracing in human tissues	22
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	21
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	21
PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	21
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72 ‐AL	20
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	20
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C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin re	19
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	19
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Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	19
DNA methylation patterns are influenced by Pax3 ::	19
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	19
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	18

Issue Information	18
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	18
Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	18
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	18
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	18
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Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	18
APC‐related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation	18
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	18
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	18
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Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	17
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Mutation profiling in differential diagnosis between TdT ‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma	17
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	17
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	17
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Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	16
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	16
Unleashing the potential of AI for pathology: challenges and recommendations	16
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	16
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	16
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	16
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	16
The state of the art for artificial intelligence in lung digital pathology	16
Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer	16
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	15
Jeremy Jass Prize for Research Excellence in Pathology 2021	15
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	15
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma †	15
Consensus molecular subtype transition during progression of colorectal cancer	15
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	15
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	15
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	15
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Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	14
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	14
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	14
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Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	14
Clinical significance of pancreatic ductal metaplasia	14
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‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	14
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	13
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	13
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	13
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	13
Issue Information	13
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	13
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing	13
CD27 / CD70 pathway activation in primary cutaneous CD4 + small/med	13
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	13
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UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	13
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Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	12
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	12
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	12
Issue Information	12
Abstracts	12
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	12
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME ,	11
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	11
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three en	11
Cell state dynamics during early stages of serous endometrial carcinoma	11
Issue Information	11
Extracellular vesicles arising from apoptosis: forms, functions, and applications	11
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	11
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NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	11
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	11
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	11
Super resolution of pathology images with hierarchical feature integration and local image patterns	11
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	11
Reducing the risks of nuclear war – the role of health professionals	10
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Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	10
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	10

Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic facto	10
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	10
Periostin‐IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation	10
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	10
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	10
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	10
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	10
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	10
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency,	10
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	10