Journal of Pathology

Article	Citations
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	91
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	80
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	79
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	71
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	68
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Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	63
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	63
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	60
Escape from senescence: molecular basis and therapeutic ramifications	55
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	53
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	53
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	52
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	50
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	48
Artificial intelligence to identify genetic alterations in conventional histopathology	46
CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor	45
Integrating computational pathology and proteomics to address tumor heterogeneity	43
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	42
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	42
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	41
Pseudobudding: ruptured glands do not represent true tumor buds	39
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	38
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Field cancerization in breast cancer	36

In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	34
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	33
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The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	33
Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	32
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	31
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	31
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Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	29
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	29
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	29
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	29
Downregulated BMP–Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithelial cells	29
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	28
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PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	26
PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	26
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	26
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	26
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	25
BMP signalling in colorectal cancer: losing the yin to WNTs yang	25
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	25
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	25
Lineage tracing in human tissues	25
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	25
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS	25
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Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	23
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Somatic loss ofATMis a late event in pancreatic tumorigenesis	23
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	23
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	23
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Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	22
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin resistance	22
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	22
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Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	22
DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered	21
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	21
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	21
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	21
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Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	20
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Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	19
Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	19
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	19
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	19
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	19
Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	18
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	18
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	18
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	18
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	18
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	18
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Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	18
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	18
Jeremy Jass Prize for Research Excellence in Pathology 2021	17
The state of the art for artificial intelligence in lung digital pathology	17
Unleashing the potential of AI for pathology: challenges and recommendations	17
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	17
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	17
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	17
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	16
Consensus molecular subtype transition during progression of colorectal cancer	16
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Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†	16
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	16
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	16
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	16
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	15
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	15
Clinical significance of pancreatic ductal metaplasia	15
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	15
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	15
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	15
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	15
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	14
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	14
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Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	14
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	14
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PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	14
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	14
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME, CDC7 and Ki67	14
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	14
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Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	14
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Extracellular vesicles arising from apoptosis: forms, functions, and applications	14
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	14
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	13
CD27/CD70 pathway activation in primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder	13
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Brg1 is required to maintain colorectal cancer stem cells	13
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice	13
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Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	13
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Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	13
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	12
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	12
FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?	12
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	12
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	12
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	12
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors	12
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	12
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	12
FOXL2C134W: much ado about something!†	12
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	12
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	11
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	11
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Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value i	11
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NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	11
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer‐rich regions and 38 spliceogenic variants	11
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Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression	10

Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	10
Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis	10
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	10
Reducing the risks of nuclear war – the role of health professionals	10
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	10
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Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	10
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	10
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	10
Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	10
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	10
TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	10
Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma	10