Journal of Pathology

Article	Citations
List of Reviewers	156
Issue Information	109
Issue Information	84
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing	76
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	74
Optical mesoscopy, machine learning, and computational microscopy enable high information content diagnostic imaging of blood films	72
Prenatal histological, cellular, and molecular anomalies in trisomy 21 lung	71
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Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	63
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	56
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	54
Renal deposition and clearance of recombinant poly‐IgA complexes in a model of IgA nephropathy	50
Low‐rank fusion convolutional neural network for prediction of remission after stereotactic radiosurgery in patients with acromegaly: a proof‐of‐concept study	50
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	48
Issue Information	45
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†	44
Issue Information	43
Research autopsy programmes in oncology: shared experience from 14 centres across the world	41
Polyketide synthase positive Escherichia coli one‐time measurement in stool is not informative of colorectal cancer risk in a screening setting	40
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	39
Pan‐cancer evaluation of tumor‐infiltrating lymphocytes and programmed cell death protein ligand‐1 in metastatic biopsies and matched primary tumors	38
EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma	38
Markers of cognitive resilience and a framework for investigating clinical heterogeneity in ALS†	38
Progressive stages of dysmetabolism are associated with impaired biological features of human cardiac stromal cells mediated by the oxidative state and autophagy	37
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	37

Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	34
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	34
Anti‐VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis	33
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer	32
Decreased HER2 expression in endometrial cancer following anti‐HER2 therapy	32
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	31
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	30
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	29
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	29
Concerns about pathology expertise and data quality	28
Mutational signature and prognosis in adenocarcinoma of the bladder	27
Molecular characteristics of multifocal esophageal squamous cell carcinomas to discriminate multicentric origin from intramural metastasis	27
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	26
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	26
B7H3 expression and significance in idiopathic pulmonary fibrosis	26
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	26
Jeremy Jass Prize for Research Excellence in Pathology 2021	26
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	26
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	25
Identification and characterization of primary cilia‐positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation	25
Defect in degradation of glycogenin‐exposed residual glycogen in lysosomes is the fundamental pathomechanism of Pompe disease	25
Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma	25
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Targeting the TWEAK–Fn14 pathway prevents dysfunction in cardiac calcium handling after acute kidney injury	24
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function	23
Issue Information	23
Air pollution aggravates renal ischaemia–reperfusion‐induced acute kidney injury	23
Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder†	23
Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer	22
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	22
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	22
Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL‐6/STAT3‐associated immune phenotypes in pancreatic cancer	22
Methylation profile of imprinted genes provides evidence for teratomatous origin of a subset of mucinous ovarian tumours	22
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	22
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	22
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alterations	22
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs	22
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	21
Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue	21
R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer	21
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	21
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	21
The genomic trajectory of ovarian high‐grade serous carcinoma can be observed in STIC lesions	21
Advancing drug discovery using the power of the human genome	20
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	20
Probing the tumorigenic potential of genetic interactions reconstituted in murine fallopian tube organoids	20
A multi‐ethnic analysis of immune‐related gene expression signatures in patients with ovarian clear cell carcinoma	20
Consensus molecular subtype transition during progression of colorectal cancer	20
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†	19
Activin B, a new player in kidney fibrosis?†	19

Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	19
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	19
Correction to ‘Autophagy mediates survival of pancreatic tumour‐initiating cells in a hypoxic microenvironment’	18
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	18
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	17
Issue Information	17
Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen‐activated protein kinase	17
Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	17
Abstracts	17
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	17
Cripto favors chondrocyte hypertrophy via TGF‐β SMAD1/5 signaling during development of osteoarthritis	16
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type	16
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	16
Stroma AReactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes	16
Clinical significance of pancreatic ductal metaplasia	16
Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors	16
Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas	16
FANCD2 deficiency sensitizes SHH medulloblastoma to radiotherapy via ferroptosis	15
Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF‐A/caveolin‐1/PV‐1 signaling pathway	15
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	15
Neutrophil extracellular traps drive epithelial–mesenchymal transition of human colon cancer	15
A comprehensive luminal breast cancer patient‐derived xenografts (PDX) library to capture tumor heterogeneity and explore the mechanisms of resistance to CDK4/6 inhibitors	15
Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology	15
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	15
Automated Ki‐67 labeling index assessment in prostate cancer using artificial intelligence and multiplex fluorescence immunohistochemistry	15
The fifth edition of the WHO classification of mature B‐cell neoplasms: open questions for research	15
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	14
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Artificial intelligence to identify genetic alterations in conventional histopathology	14
Escape from senescence: molecular basis and therapeutic ramifications	14
Spatial analysis of microRNA regulation at defined tumor hypoxia levels reveals biological traits of aggressive prostate cancer	14
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	14
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	14
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	14
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Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis	14
Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet?	14
Issue Information	13
Distinct spatial N‐glycan profiles reveal glioblastoma‐specific signatures	13
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	13
Brg1 is required to maintain colorectal cancer stem cells	13
Abstracts	13
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	13
The significance of PAX5 in Merkel cell carcinoma	13
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	13
Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα‐dependent mechanism	13
Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node	13
A deep‐learning model for predicting tyrosine kinase inhibitor response from histology in gastrointestinal stromal tumor	13
MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation	13
Hedgehog signalling in Foxd1+ embryonic kidney stromal progenitors controls nephron formation via Cxcl12 and Wnt5a	13
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alteration	13
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	12
Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity	12
‘Oncofetal protein glypican‐3 is a biomarker and critical regulator of function for neuroendocrine cells in prostate cancer’	12
Circular RNAs: emerging players in brain aging and neurodegenerative diseases	12
Issue Information	12
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Jeremy Jass Prize for Research Excellence in Pathology 2022	12
Field cancerization in breast cancer	12
‘NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas’	12
Issue Information	12
C/EBPβ isoform‐specific regulation of podocyte pyroptosis in lupus nephritis‐induced renal injury	12
Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers	12
SWI/SNF‐deficient undifferentiated malignancies: where to draw the line†	12
Virtual 4th Joint Winter Meeting of the Pathological Society of Great Britain and Ireland and the Royal Society of Medicine 25th – 26th January 2022	12
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	12
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1‐mutant cells	12
Manchester Pathology 2021. 13th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 6–8 July 2021	12
Cell death induced by NLRP3–palmitate axis impairs pulmonary damage tolerance and aggravates immunopathology during obesity‐tuberculosis comorbidity	12
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Issue Information	11
Issue Information	11
Issue Information	11
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	10
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis	10
Deficiency of inflammation‐sensing protein neuropilin‐2 in myeloid‐derived macrophages exacerbates colitis via NF‐κB activation	10
Mechanisms of carboplatin‐ and paclitaxel‐dependent induction of premature senescence and pro‐cancerogenic conversion of normal peritoneal mesothelium and fibroblasts	10
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	10
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways	10

Targeting the β2‐adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism	10
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	10
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	10
CD27/CD70 pathway activation in primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder	10
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	10
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	10
Integrating computational pathology and proteomics to address tumor heterogeneity	9
Brain‐derived neurotrophic factor knock‐out mice develop non‐alcoholic steatohepatitis	9
Conditional loss ofUbe3din the retinal pigment epithelium accelerates age‐associated alterations in the retina of mice	9
KAT8/SIRT7‐mediated Fascin‐K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma	9
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	9
Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate	9
Role of MIF1/MIF2/CD74 interactions in bladder cancer	9
Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivoLMNA::NTRK1‐rearranged soft‐tissue sarcoma cell model	9
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice	9
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	9
The CCL2–CCR2 axis determines whether glomerular endocapillary hypercellularity or wire‐loop lesions develop through glomerular macrophage and neutrophil infiltration in lupus ne	9