OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Periodontal Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature‐induced periodontitis	82
Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis	69
Impact of periodontitis on gingival crevicular fluid miRNAs profiles associated with cardiovascular disease risk	43
Periodontal disease and quality of life: Umbrella review of systematic reviews	43
Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice	38
Porphyromonasgingivalis survival skills: Immune evasion	36
Mechanisms involved in regulation of periodontal ligament cell production of pro‐inflammatory cytokines: Implications in periodontitis	30
The emerging role of small extracellular vesicles in saliva and gingival crevicular fluid as diagnostics for periodontitis	29
Deep learning in periodontology and oral implantology: A scoping review	29
Metabolomics of gingival crevicular fluid to identify biomarkers for periodontitis: A systematic review with meta‐analysis	28
The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis	28
Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis	27
Metagenomic sequencing provides new insights into the subgingival bacteriome and aetiopathology of periodontitis	26
Curcumin: A review of experimental studies and mechanisms related to periodontitis treatment	25
Local and systemic levels of aMMP‐8 in gingivitis and stage 3 grade C periodontitis	24
Hydrophilic titanium surface modulates early stages of osseointegration in osteoporosis	23
Anti‐inflammatory and macrophage polarization effects of Cranberry Proanthocyanidins (PACs) for periodontal and peri‐implant disease therapy	23
MiR‐153‐3p inhibits osteogenic differentiation of periodontal ligament stem cells through KDM6A‐induced demethylation of H3K27me3	22
Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment	21
Autophagy and its significance in periodontal disease	20
Mesenchymal stem cell‐derived small extracellular vesicles as cell‐free therapy: Perspectives in periodontal regeneration	20
Retrospectively analysed tooth loss in periodontally compromised patients: Long‐term results 10 years after active periodontal therapy—Patient‐related outcomes	19
Heat‐not‐burn tobacco (IQOS), oral fibroblasts and keratinocytes: cytotoxicity, morphological analysis, apoptosis and cellular cycle. An in vitro study	19
Exosomes from dental pulp cells attenuate bone loss in mouse experimental periodontitis	19
Adjunctive systemic antimicrobials in the treatment of chronic periodontitis: A systematic review and network meta‐analysis	18

Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model	17
NCOA4‐mediated ferritinophagy promoted inflammatory responses in periodontitis	17
A deficiency of Dec2 triggers periodontal inflammation and pyroptosis	17
IL‐1B(3954) polymorphism and red complex bacteria increase IL‐1β (GCF) levels in periodontitis	17
Cannabinoid type‐2 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL‐1β stimulated primary human periodontal ligament fibroblasts	16
Association between TNF‐α G‐308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta‐analysis	15
Interruption of regular dental visits during the COVID‐19 pandemic due to concerns regarding dental visits was associated with periodontitis in Japanese office workers	15
Impaired dental implant osseointegration in rat with streptozotocin‐induced diabetes	15
Membrane vesicles from periodontal pathogens and their potential roles in periodontal disease and systemic illnesses	15
Macro and trace elements signature of periodontitis in saliva: A systematic review with quality assessment of ionomics studies	14
Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation	14
Does the use of omega‐3 fatty acids as an adjunct to non‐surgical periodontal therapy provide additional benefits in the treatment of periodontitis? A systematic review and meta‐analysis	14
Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients	14
Microbial and host‐derived biomarker changes during ligature‐induced and spontaneous peri‐implantitis in the Beagle dog	14
Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non‐surgical periodontal treatment: A systematic review	14
Relationship between periodontitis and microangiopathy in type 2 diabetes mellitus: a meta‐analysis	14
Sirtuin 3 deficiency exacerbates age‐related periodontal disease	14
Periodontitis and edentulism as risk indicators for mortality: Results from a prospective cohort study with 20 years of follow‐up	14
Proteoglycans in the periodontium: A review with emphasis on specific distributions, functions, and potential applications	13
Long‐term exposure to cigarette smoke influences characteristics in human gingival fibroblasts	13
PTH/PTHrP in controlled release hydrogel enhances orthodontic tooth movement by regulating periodontal bone remodaling	13
The role of endoplasmic reticulum stress in the pathophysiology of periodontal disease	13
Interdental and subgingival microbiota may affect the tongue microbial ecology and oral malodour in health, gingivitis and periodontitis	13
Ability of matrix metalloproteinase‐8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis	13
Differential regulation of epithelial growth by gingival and periodontal fibroblasts in vitro	13
Oral microbiota and atherothrombotic carotid plaque vulnerability in periodontitis patients. A cross‐sectional study	13
Pro‐inflammatory cytokine interleukin‐6‐induced hepcidin, a key mediator of periodontitis‐related anemia of inflammation	13
Treatment with functionalized designer self‐assembling peptide hydrogels promotes healing of experimental periodontal defects	12
Dual delivery of platelet‐derived growth factor and bone morphogenetic factor‐6 on titanium surface to enhance the early period of implant osseointegration	12
Diagnostic accuracy of active matrix metalloproteinase‐8 point‐of‐care test for the discrimination of periodontal health status: Comparison of saliva and oral rinse samples	12
Cellular ageing of oral fibroblasts differentially modulates extracellular matrix organization	12
The miR‐155‐5p inhibits osteoclast differentiation through targeting CXCR2 in orthodontic root resorption	12
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis	12
The role of vitamin D in periodontal health and disease	12
ZNF718, HOXA4, and ZFP57 are differentially methylated in periodontitis in comparison with periodontal health: Epigenome‐wide DNA methylation pilot study	11
Association between periodontitis and the Mediterranean diet in young Moroccan individuals	11
Potential biomarkers reflecting inflammation in patients with severe periodontitis: Fractalkine (CX3CL1) and its receptor (CX3CR1)	11
The role of strontium ranelate and guided bone regeneration in osteoporotic and healthy conditions	11
Influence of anti‐rheumatic agents on the periodontal condition of patients with rheumatoid arthritis and periodontitis: A systematic review and meta‐analysis	11
Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune‐enzymatic, and gene expression analysis	11
LiCl‐induced immunomodulatory periodontal regeneration via the activation of the Wnt/β‐catenin signaling pathway	11
Association of probable bruxism with periodontal status: A cross‐sectional study in patients seeking periodontal care	11
Long non‐coding RNAs: Emerging roles in periodontitis	11
Wound healing in periodontal disease induces macrophage polarization characterized by different arginine‐metabolizing enzymes	11
Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta‐analysis	11
Pyroptosis may play a crucial role in modifications of the immune microenvironment in periodontitis	11
Simvastatin loaded chitosan guided bone regeneration membranes stimulate bone healing	10
Cross‐sectional comparisons of subgingival microbiome and gingival fluid inflammatory cytokines in periodontally healthy vegetarians versus non‐vegetarians	10
Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss	10
Identification and integrated analysis of differentially expressed long non‐coding RNAs associated with periodontitis in humans	10

Oral inflammatory load: Neutrophils as oral health biomarkers	10
The presence of neutrophils causes RANKL expression in periodontal tissue, giving rise to osteoclast formation	10
Study on the role of pyroptosis in bone resorption induced by occlusal trauma with or without periodontitis	10
Survival rate and potential risk indicators of implant loss in non‐smokers and systemically healthy periodontitis patients: An up to 9‐year retrospective study	9
Porphyromonas gingivalis facilitated the foam cell formation via lysosomal integral membrane protein 2 (LIMP2)	9
Gingival crevicular fluid lipocalin‐2 and semaphorin3A in stage III periodontitis: Non‐surgical periodontal treatment effects	9
Generation of a novel model of bioengineered human oral mucosa with increased vascularization potential	9
An in vitro study into three different PRF preparations for osteogenesis potential	9
Possible function of GDNF and Schwann cells in wound healing of periodontal tissue	9
Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells	9
Comparative proteomic analysis of dental cementum from deciduous and permanent teeth	9
The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy	8
A novel adiponectin receptor agonist (AdipoAI) ameliorates type 2 diabetes‐associated periodontitis by enhancing autophagy in osteoclasts.	8
Functional and cell surface characteristics of periodontal ligament cells (PDLCs) on RGD‐synthetic polypeptide conjugate coatings	8
Regeneration of rat periodontium by cementum protein 1‐derived peptide	8
Is TIMP‐1 a biomarker for periodontal disease? A systematic review and meta‐analysis	8
Association among periodontitis severity, anti‐agalactosyl immunoglobulin G titer, and the disease activity of rheumatoid arthritis	8
Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial	8
Cross‐sectional analysis of the association of periodontitis with carotid intima media thickness and atherosclerotic plaque in the Hamburg City health study	8
LncRNA DCST1‐AS1 inhibits PDLCs’ proliferation in periodontitis and may bind with miR‐21 precursor to upregulate PLAP‐1	8
MZB1 targeted by miR‐185‐5p inhibits the migration of human periodontal ligament cells through NF‐κB signaling and promotes alveolar bone loss	8
Poly(lactic acid/caprolactone) bilayer membrane blocks bacterial penetration	8
Periodontitis links to concurrent systemic comorbidities among ‘self‐perceived health’ individuals	8
Calprotectin levels in gingival crevicular fluid and serum of patients with chronic periodontitis and type 2 diabetes mellitus before and after initial periodontal therapy	8
Abnormal hsa_circ_0003948 expression affects chronic periodontitis development by regulating miR‐144‐3p/NR2F2/PTEN signaling	8
Different applications forms of green tea (Camelliasinensis (L.) Kuntze) for the treatment of periodontitis: a systematic review and meta‐analysis	8
Regular dental visits, periodontitis, tooth loss, and atherosclerosis: The Ohasama study	8
Iron accumulation is associated with periodontal destruction in a mouse model of HFE‐related haemochromatosis	8
Mechanical and structural properties of leukocyte‐ and platelet‐rich fibrin membranes: An in vitro study on the impact of anticoagulant therapy	8
A systematic review on bacterial community changes after periodontal therapy with and without systemic antibiotics: An analysis with a wider lens	8
Gingival tissue autophagy pathway gene expression profiles in periodontitis and aging	8
Protective mechanisms of Taiwanese green propolis toward high glucose‐induced inflammation via NLRP3 inflammasome signaling pathway in human gingival fibroblasts	7
microRNAs in inflammatory alveolar bone defect: A review	7
Optimizing citric acid protocol to control implant‐related infections: Anin vitroandin situstudy	7
CircRNA Lrp6 promotes cementoblast differentiation via miR‐145a‐5p/Zeb2 axis	7
Alcohol use disorders are associated with higher prevalence of periodontitis in a rural area of Brazil	7
Differences in chlorhexidine mouthrinses formulations influence the quantitative and qualitative changes in in‐vitro oral biofilms	7
Effect of vitamin D₃ on the osteogenic differentiation of human periodontal ligament stromal cells under inflammatory conditions	7
IFN‐γ or IL‐4 polarization impacts the response of gingival fibroblasts to oral bacteria	7
Remnant oral biofilm and microorganisms after autoclaving sterilization of retrieved healing abutments	7
Low association between bleeding on probing propensity and the salivary aMMP‐8 levels in adolescents with gingivitis and stage I periodontitis	7
ODAM promotes junctional epithelium‐related gene expression via activation of WNT1 signaling pathway in an ameloblast‐like cell line ALC	7
Polarization of human gingival fibroblasts by Th1‐, Th2‐, Th17‐, and Treg‐derived cytokines	7
TNFα expression by Porphyromonas gingivalis‐stimulated macrophages relies on Sirt1 cleavage	7
Peripheral neutrophil phenotypes during management of periodontitis	7
Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial	7
Phytocannabinoids regulate inflammation in IL‐1β‐stimulated human gingival fibroblasts	7
Lactic acid bacteria prevent both periodontitis and atherosclerosis exacerbated by periodontitis in spontaneously hyperlipidemic mice	6
Melatonin promoted osteogenesis of human periodontal ligament cells by regulating mitochondrial functions through the translocase of the outer mitochondrial membrane 20	6
Salivary histone deacetylase in periodontal disease: A cross‐sectional pilot study	6
The accuracy of probing, ultrasound and cone‐beam CT scans for determining the buccal bone plate dimensions around oral implants – A systematic review	6
Identification of potentially functional circRNAs and prediction of circRNA‐miRNA‐mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs	6
Identification of hub genes related to immune cell infiltration in periodontitis using integrated bioinformatic analysis	6
Mutual promotions between periodontitis and vascular calcification by rat animal model	6
Canonical and noncanonical pyroptosis are both activated in periodontal inflammation and bone resorption	6
Wnt4 regulates bone metabolism through IKK‐NF‐κB and ROCK signaling under occlusal traumatic periodontitis	6
Caspase inhibitor attenuates the shape changes in the alveolar ridge following tooth extraction: A pilot study in rats	6
In vitro evaluation of the effect of the electronic cigarette aerosol, Cannabis smoke, and conventional cigarette smoke on the properties of gingival fibroblasts/gingival mesenchymal stem cells	6
Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population‐based cross‐sectional study: RANTES was associated with periodontitis	6
Antioxidants protect against gingival overgrowth induced by cyclosporine A	6
Periodontal inflammation triggers a site‐specific and wide radius of calcium metabolic effects on alveolar bone	6
A population‐based cross‐sectional study of the association between periodontitis and arterial stiffness among the older Japanese population	6
Pyrophosphate inhibits periodontal ligament stem cell differentiation and mineralization through MAPK signaling pathways	6
Salivary levels of last generation specific pro‐resolving lipid mediators (SPMs) (protectin and maresin) in patients with cardiovascular and periodontal disease: A case‐control study	6
Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis	6
Renal alterations caused by ligature‐induced periodontitis persist after ligature removal in rats	6
Adjunctive Er:YAG laser in non‐surgical periodontal therapy of patients with inadequately controlled type 2 diabetes mellitus: A split‐mouth randomized controlled study	6
Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro	6
Effects of titanium dioxide microparticles and nanoparticles on cytoskeletal organization, cell adhesion, migration, and proliferation in human gingival fibroblasts in the presence of lipopolysacchari	6
Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats	6
Increased levels of interleukin‐32 isoforms alpha, beta, gamma, and delta in the gingival crevicular fluid and plasma of the patients with periodontitis	6
Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross‐sectional study	6
Obesity influences the proteome of periodontal ligament tissues following periodontitis induction in rats	6