OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacy and Pharmacology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Tilianin obtained from Agastache mexicana inhibits monoamine oxidase and modifies depressive behavior in rats	68
Photoactivation of pheophorbide-a utilizing 670 nm LEDs elicits cancer suppressive effects in androgen-independent prostate cancer cellular models	58
The application of natural compounds in uveal melanoma drug discovery	56
Study on the targeted regulation of Scutellaria baicalensis leaf on glutamine–glutamate metabolism and glutathione synthesis in the liver of d-gal ageing rats	49
A comprehensive review of traditional uses, phytochemistry and pharmacology of Reynoutria genus	47
Δ(9)-tetrahydrocannabinol protects cardiac tissue against endoplasmic reticulum and oxidative stresses, apoptosis, and inflammation in rats with hyperinsulinemia	41
GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition	39
Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger	35
3-Demethyl-2-geranyl-4-prenylbellidifoline, a natural xanthone with diuretic and kidney protective properties	33
Design and optimization of 3D-bioprinted scaffold framework based on a new natural polymeric bioink	33
Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects	32
Doxorubicin alters the disposition of phenytoin by reducing its metabolic elimination and binding affinity to serum albumin in rats	31
Preparation, characteristic, biological activities, and application of polysaccharide from Lilii Bulbus: a review	31
Serum autotaxin level: a promising diagnostic biomarker in differentiating Graves’ disease and thyroiditis	28
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion	27
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats	25
Thyme extract could overcome diabetes-induced reproductive dysfunction by inhibiting oxidative damage and increasing the expression of insulin receptor substrate and pyruvate kinase in the rat sperm	25
Erythrocyte membrane-camouflaged mesoporous silica composite nanoparticles for loading and controlled release of the hepatoprotective agent silibinin: A-synthesis and physicochemical characterization	25
Ending nuclear weapons, before they end us	24
Eleutheroside E functions as anti-cervical cancer drug by inhibiting the phosphatidylinositol 3-kinase pathway and reprogramming the metabolic responses	24
The pleiotropic effects of statins in rheumatoid arthritis	24
Ling-Gui-Zhu-Gan decoction protects against doxorubicin-induced myocardial injury by downregulating ferroptosis	24
The therapeutic potential of curculigoside in poststroke depression: a focus on hippocampal neurogenesis and mitochondrial function	24
Roles of pigment epithelium-derived factor in cardiomyocytes: implications for use as a cardioprotective therapeutic	23
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss	23

Production of mRNA lipid nanoparticles using advanced crossflow micromixing	23
Ginsenoside Rb1 ameliorates hippocampal neuroinflammation in rats after intracerebral hemorrhage by inactivating the TLR4/NF-kB pathway	23
Rhamnetin: a review of its pharmacology and toxicity	23
Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action	22
p-Coumaric acid mitigates lipopolysaccharide induced brain damage via alleviating oxidative stress, inflammation and apoptosis	22
Dexmedetomidine affects the NOX4/Nrf2 pathway to improve renal antioxidant capacity	22
The effect of patient’s body weight, infusion connection point, and infusion pump position on intravenous multi-infusion drug delivery at low infusion rates suitable for premature neonates	22
LINC01572 promotes the malignant progression of lung adenocarcinoma by modulating p53 mediated by miRNA-338-5p/TTK axis	21
Validating the antidiabetic potential of Nakima (Tupistra clarkei Hook.f.), a traditional food from eastern Himalayan region, through network pharmacology and in vivo experimentation	21
Repurposing the familiar: Future treatment options against chronic kidney disease	21
The traditional uses, phytochemistry, pharmacology and toxicology of Dictamnus dasycarpus: a review	21
N(Omega)-nitro-l-arginine methyl ester potentiates lidocaine analgesic and anaesthetic effect in rats	20
Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative st	19
Short overview on the relevance of microRNA–reactive oxygen species (ROS) interactions and lipid peroxidation for modulation of oxidative stress-mediated signalling pathways in cancer treatment	19
Corrigendum to: Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A	19
Phytochemical study and immunomodulatory activity of Fraxinus excelsior L.	19
Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review	19
Icariside II: natural occurrence, biotransformation, pharmacological activity, synthetic modification, pharmacokinetics, and bioavailability	19
Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin	18
Circular RNA hsa_circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion via the miR-590-5p/PDCD4 axis	18
In vitro assessment of P-glycoprotein-mediated antiseizure medications efflux in a blood–brain barrier cell model	18
Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1	17
Therapeutically important bioactive compounds of the genus Polygonum L. and their possible interventions in clinical medicine	16
Scopoletin stimulates the secretion of insulin via a KATP channel-dependent pathway in INS-1 pancreatic β cells	16
Function and inhibition of Haspin kinase: targeting multiple cancer therapies by antimitosis	16
Correction to: FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption	16
Thymol suppressed tumor growth in vitro and in vivo through inducing calcium overload in colorectal cancer	16
The potential applications of nanocomposites in 3D-printed drug delivery systems	15
Molecular mechanisms of endoplasmic reticulum stress-mediated acute kidney injury in juvenile rats and the protective role of mesencephalic astrocyte-derived neurotrophic factor	15
Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer’s disease rat models	15
The genus Oxytropis DC: application, phytochemistry, pharmacology, and toxicity	15
Investigation of the effect of Acai berry on the pharmacokinetics of Atorvastatin, Alogliptin and Empagliflozin: a herb–drug interaction study	15
Exploring the combined therapeutic efficacy of bexarotene and icariin in type 2 diabetic rats	15
Amelioration of cyclophosphamide toxicity via modulation of metabolizing enzymes by avocado (Persea americana) extract	15
Call for emergency action to limit global temperature increases, restore biodiversity and protect health	15
Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review	14
An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins	14
Shaoyao Gancao decoction, an Ancient Classical Prescription: a review on its chemical composition, pharmacology, pharmacokinetics, clinical applications, and toxicology	14
Systems pharmacology-based drug discovery from Amaryllidaceae alkaloids and investigation of mechanisms of action in treatment of Alzheimer’s disease	14
Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis	14
Itrifal-e-Aftimoon potentiates imatinib-induced anti-leukemic effect by influencing FAK/STAT/Akt/ERK signalling pathways against chronic myeloid leukaemia in vitro	14
Research progress on pharmacological effects of isoalantolactone	14
Natural product mitigation of ferroptosis in platinum-based chemotherapy toxicity: targeting the underpinning oxidative signaling pathways	14
Platycarya strobilacea Sieb. et Zucc.: a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology	14
HDAC9 exacerbates myocardial infarction via inactivating Nrf2 pathways	14
Three-dimensional printed personalized drug devices with anatomical fit: a review	14
Correction to: 1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson’s disease	14
Vanillic acid–Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity	14
Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling	13
Euterpe oleracea Mart. (Açai) seed extract improves physical performance in old rats by restoring vascular function and oxidative status and activating mitochondrial muscle biogenesis	13

Corrigendum to: The role of lncRNA ANRIL in the progression of hepatocellular carcinoma	13
Andrographolide attenuates oxidative stress and apoptosis in osteoporosis rats via MEK/ERK and Beclin-1/ATG-5-mediated autophagy pathway	13
Rhus coriaria L., a new candidate for controlling metabolic syndrome: a systematic review	13
Nutritional benefits, ethnomedicinal uses, phytochemistry, pharmacological properties and toxicity of Spondias mombin Linn: a comprehensive review	13
Sanshimao formula inhibits the hypoxia-induced pro-angiogenesis of hepatocellular carcinoma cells partly through regulating MKK6/p38 signaling pathway	13
Ethnobotanical study of Zhuang medicinal herbs of Ardisia: variety systematization, traditional uses, phytochemistry, pharmacology, clinical application, and toxicity	13
Corrigendum to: Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy	13
Activation of 5-HT 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and TLR-4 pathway in the brain of scopolamine-induced dementia in rat	12
A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications	12
Research progress of pharmacological effects of Siraitia grosvenorii extract	12
The combination of astragaloside IV and Panax notoginseng saponins attenuates cerebral ischaemia–reperfusion injury in rats through ferroptosis and inflammation inhibition via activating Nrf2	12
Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis	12
Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease	12
Genus Lupinus (Fabaceae): a review of ethnobotanical, phytochemical and biological studies	12
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis	12
Effects of dietary supplementation with arboreal medicinal mushrooms on stress coping strategies, depressive and anxiety-like behavior of rats	12
Gegen Qinlian Decoction protects kidney in diabetic rats by improving intestinal barrier and regulating intestinal microbiota	12
Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats	12
Psidium guajava leaves extract alters colonic microbiome composition and reduces intestinal sodium absorption in rats exposed to a high-sodium diet	12
Three-dimensional printed dosage forms based on disease-focussed perspectives	12
Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway	11
Role of the integrin-linked kinase/TGF-β/SMAD pathway in sitagliptin-mediated cardioprotective effects in a rat model of diabetic cardiomyopathy	11
Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain	11
An application of p-sulfonatocalix[6]arenes to attenuate cardiotoxicity of mitoxantrone in vitro: preparation, characterization and evaluation	11
Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats	11
Abrogation of STAT3 activation cascade by Ginkgolide C mitigates tumourigenesis in lung cancer preclinical model	11
Mechanistic insights of methylcinnamate in improving oxidative stress and inflammation in acetaminophen-induced hepatotoxic mice by upregulating Nrf2 pathway	11
Brusatol’s anticancer activity and its molecular mechanism: a research update	11
Menthol-based self microemulsifying drug delivery system for augmented intestinal absorption of edoxaban	11
Gap junction is essential for the antidepressant effects of fluoxetine	11
Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways	11
Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling	11
Azithromycin concentration in rabbits’ plasma and posterior segment of the eyes following oral drug administration: a dose-finding study for the application in ocular toxoplasmosis	11
Potential interactions between triazole antifungal agents and lorlatinib based on ultra-performance liquid chromatography-tandem mass spectrometry in rat plasma	10
Research progress on the pharmacy of tetramethylpyrazine and its pharmacological activity in cardiovascular and cerebrovascular diseases	10
Ginsenoside Rg3 inhibits renal cell carcinoma cell migration, invasion, colony formation, and tube formation and enhances apoptosis through promoting the DNA demethylation and histone acetylation	10
Development of benznidazole orally disintegrating tablets for paediatric patients	10
A review on the ethnopharmacology, phytochemistry and pharmacology of Polygonum hydropiper Linn.	10
Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway	10
Ginkgo biloba extracts (GBE) protect human RPE cells from t-BHP-induced oxidative stress and necrosis by activating the Nrf2-mediated antioxidant defence	10
Dendrobium officinale Kimura et Migo: traditional uses, agricultural technology, processing, chemical composition, pharmacological mechanisms, toxicology, and applications	10
Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer	10
Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration	10
Dietary supplements and medicinal plants in urolithiasis: diet, prevention, and cure	10
Risk stratification of AUC upward deviation in patients with low serum creatinine levels treated with vancomycin: a multicenter retrospective study	9
Novel peptide calcitonin gene-related peptide antagonists for migraine therapy	9
Pharmacological properties and derivatives of saikosaponins—a review of recent studies	9
Inhaled exogenous thymosin beta 4 suppresses bleomycin-induced pulmonary fibrosis in mice via TGF-β1 signalling pathway	9
Effect of carvedilol on pharmacokinetics of sofosbuvir and its metabolite GS-331007: role of P-glycoprotein	9
Wedelolactone suppresses breast cancer growth and metastasis via regulating TGF-β1/Smad signaling pathway	9
Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden	9
Ambroxol mitigates renal ischemia/reperfusion-induced cardiac and renal injury via Nrf2/HO-1 activation and TLR4 pathway inhibition	9
Shaoyao Gancao Decoction protects against dextran sulfate sodium-induced ulcerative colitis by down-regulating ferroptosis	9
Hepatoprotective effect of Spirulina platensis against carbon tetrachloride-induced liver injury in male rats	9
Propolis prevents vascular endothelial dysfunction by attenuating inflammation and oxidative damage in the chronic unpredictable stress model of depression in rats	9
Development and characterization of natural phenolics-rich extracts and formulations based on Putoria calabrica leaf for wound healing applications	9
Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition	9
Chalcone-rich extracts from Lonchocarpus cultratus roots present in vitro leishmanicidal and immunomodulatory activity	9
Potential of syringol and guaiacol in mitigating hyperglycemia associated dicarbonyl stress in rats subjected to high-fat high-fructose diet	9
Correction to: Curcumin solid dispersion-loaded in situ hydrogels for local treatment of injured vaginal bacterial infection and improvement of vaginal wound healing	9
Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding p	9
Isolation, phytochemistry, characterization, biological activity, and application of Morinda officinalis How oligosaccharide: a review	8
Monotropein alleviates sepsis-elicited acute lung injury via the NF-κB pathway	8
The state and trends of cinnamaldehyde research over the past three decades: a bibliometric and visualized analysis	8
VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy	8
Imperatorin derivative OW1, a new vasoactive compound, attenuates cell proliferation and migration by inhibiting Nox1-mediated oxidative stress	8
Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin–nicotinamide-induced diabetes in rats	8
Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review	8
Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway	8
3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats	8
Explore the anti-inflammation mechanism of safflower total flavonoids in the treatment of endometritis based on celluar transcriptomics	8
Advances in inhaler therapy for asthma and chronic obstructive pulmonary disease: a comprehensive review of Fostair™ and Trimbow™	8
Corrigendum to: An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury	8
Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress	8
Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32	8
Development and characterization of quetiapine-loaded microneedles-based transdermal patches for improved drug delivery	8
Indolocarbazole alkaloid Loonamycin A inhibits triple-negative breast cancer cell stemness and Notch signalling	8
Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts	8
PD15, a steroidal saponin, induces apoptosis of HCT116 colorectal cancer cells via suppressing the Akt/GSK3β pathway	8