Journal of Physiology-London

Article	Citations
Issue Information	143
The sloppy relationship between neural circuit structure and function	85
An obesogenic diet impairs uncoupled substrate oxidation and promotes whitening of the brown adipose tissue in rats	75
New insights into heart failure during this challenging time	69
Issue Information	66
Cardiorespiratory and autonomic adjustments to exercise with healthy ageing: considerations with extreme heat exposure and hydration	64
In Memoriam: Ann Silver	55
	53
Swift energy shift: Acute exercise reduces cerebral glucose metabolism in cognitively healthy older adults and individuals with Alzheimer's disease	52
Retraction: Grabauskas, G., Wu, X., Lu, Y., Heldsinger, A., Song, I., Zhou, S.‐Y., & Owyang, C. (2015). KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin. The Journal o	51
Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats	49
Small peptides: could they have a big role in metabolism and the response to exercise?	49
Molecular permeation through large pore channels: computational approaches and insights	48
Parkin: a potential target to promote healthy ageing	45
Biogenesis and reformation of synaptic vesicles	44
MC3R signalling in the medial hypothalamus: new insights on energy rheostasis and implications for obesity therapies	42
Brainstem astrocytes control homeostatic regulation of caloric intake	41
Dynamic encoding of saccade sequences in primate frontal eye field	40
Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion	40
Conserved mammalian muscle mechanics during eccentric contractions	39
Diagnostic and prognostic biomarkers for tubulointerstitial fibrosis	39
Logarithmically scaled, gamma distributed neuronal spiking	38
Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids	38
Issue Information	37
Issue Information	36

Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?	35
Diversity of cells and signals in the cardiovascular system	35
	35
Anticipatory stress: a model to study cardiovascular and sympathetic responses to mental stress?	34
Carbohydrate improves exercise capacity but does not affect subcellular lipid droplet morphology, AMPK and p53 signalling in human skeletal muscle	34
The 70‐year search for the voltage‐sensing mechanism of ion channels	34
Improving skeletal muscle insulin sensitivity via beta2‐agonist administration: a promising strategy to counteract metabolic disease and muscle loss	33
GABAB‐ and GABAA‐receptor‐mediated regulation of Up and Down states across development	33
Histone‐mediated skeletal muscle adaptations to exercise: insights into a new era of epigenome‐based personalized medicine	32
The muscle clock: how does muscle physiology change in 24 h in response to exercise?	31
A more holistic view could contribute to our understanding of ‘silent hypoxaemia’ in Covid‐19 patients	31
When fat meets the engine: implications of dietary rumenic acid on myosin‐targeting therapies in heart failure	30
Issue Information	29
Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega‐7,9 trans‐fat rumenic acid	29
Are Hodgkin cycles everywhere?	28
Maternal obesity: influencing the heart right from the start	28
The significance of the loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait	28
Two epilepsy‐associated variants in KCNA2 (KV1.2) at position H310 oppositely affect channel functional expression	28
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SIRT1 induction in the skeletal muscle of male mice partially preserves limb muscle mass but not contractile force in response to androgen deprivation	28
Regulation of PKD2 channel by TACAN: how does it link to cystogenesis in autosomal dominant polycystic kidney disease?	28
Tail of two fishies: age and afferents influence zebrafish lateral‐line hair cell regeneration	28
The PoWeR of exercise: Exploring the anti‐ageing effects of exercise through epigenetic modifications to skeletal muscle	27
Prescribing reduced physical activity following volumetric muscle loss not really a good idea	27
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Issue Information	26
Corticomotor pathway function and recovery after stroke: a look back and a way forward	26
Soleus responses to Achilles tendon stimuli are suppressed by heel and enhanced by metatarsal cutaneous stimuli during standing	26
The complementary dominance hypothesis: a model for remediating the ‘good’ hand in stroke survivors	26
Can lizards become alligators? Muscle fibre type and other factors that may influence (or not) hypertrophy responsiveness after resistance training	26
Chasing the hunger‐suppressive signals of human exercise	26
Distinct mechanisms of CB1 and GABAB receptor presynaptic modulation of striatal indirect pathway projections to mouse globus pallidus	25
Intermittent hypoxia and motor learning: new information and new questions	25
Age and low intensity resistance exercise on exosome‐like vesicle and skeletal muscle microRNA profiles	25
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity	25
Energetic cost of gestation and prenatal growth in humpback whales	25
Issue Information	24
Identification of protein kinase A signalling molecules in renal collecting ducts	24
Elucidation of a proposed cardiorespiratory circadian rhythm impacting survival in SUDEP	23
Death by hypoxia: what were they thinking?	23
Co‐activation of GPCRs facilitate GIRK‐dependent current	23
The missing ‘link’? β‐Catenin's role in skeletal muscle glucose uptake during exercise and contraction	23
Issue Information	23
	23
Myo‐inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism	23
Insight on novel mechanisms mediating the generation of inflammatory pain in somatosensory neurons	23
Ketone body oxidation: glycogen‐sparing yet glucose‐dependent?	23
Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults	23
The endocrine kidney: tampering with oxygen sensors may change your character	23
Passive muscle heating attenuates the decline in vascular function caused by limb disuse	22

CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	22
Ocular surface information seen from the somatosensory thalamus and cortex	22
Issue Information	22
Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins	21
Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues	21
How long is too long? No added benefit with prolonged ventilation with intact cord in preterm infants	21
Activation of LH GABAergic inputs counteracts fasting‐induced changes in tVTA/RMTG neurons	21
Somatostatin modulation of initial fusion pores in Ca2+‐triggered exocytosis from mouse chromaffin cells	21
Issue Information	21
Functional reserve and sex differences during exercise to exhaustion revealed by post‐exercise ischaemia and repeated supramaximal exercise	21
Implications of a patent foramen ovale for environmental physiology and pathophysiology: do we know the ‘hole’ story?	21
Human performance augmentation: the importance of integrative physiological quantification	21
CRAC channel inhibitors in pancreatic pathologies	21
Squeezing viscous blood through narrow pipes, and other problems of high‐altitude polycythaemia	21
Regulation of cerebral blood flow by arterial PCO2 independent of metabolic acidosis at 5050 m	21
Seventy years later: the legacy of the Hodgkin and Huxley model in computational neuroscience	20
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation	20
Putting the HYPE in hypertension: peripheral chemoreflex constraint of skeletal muscle blood flow	20
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Excitatory action of low frequency depolarizing GABA/glycine synaptic inputs is prevalent in prenatal spinal SOD1G93A motoneurons	20
KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction	20
Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties	20
Transcranial direct current stimulation to enhance athletic performance: Are we there yet? Will we ever get there?	20
Does COVID‐19 influence the sympathetic regulation of blood pressure?	20
Direct intraoperative measurement of isometric contractile properties in living human muscle	20
Divergent effects of initial ventilation with delayed cord clamping on systemic and pulmonary arterial flows in the birth transition of preterm lambs	20
Use of a physiological profile to document upper limb motor impairment in ageing and in neurological conditions	19
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Issue Information	19
Closing in on the heat‐activation mechanisms of TRPV channels	19
Why you should pay more attention to your cells’ sex	19
Physiology in Central and South America and hope for better times	19
Issue Information	19
Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness	19
Is the exercise pressor reflex under pressure?	19
Combination of chemotherapy and antioxidants: promising therapeutic strategies for muscle atrophy during cancer treatment	19
Blunted cerebrovascular CO2 reactivity to satisfy the hungry heat stressed brain	19
‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments	19
Has the importance of GABAA presynaptic inhibition been overestimated in human motor control?	18
Probing the interstitial calcium compartment	18
A no brainer: intervening early to protect against perinatal brain injury	18
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How high can the lactate phoenix rise?	18
Opening the door to physiological impacts underlying opioid‐induced respiratory depression and therapeutic strategies: focus on fentanyl	18
Lack of compensatory mitophagy in skeletal muscles during sepsis	18
Regulation of Orai channels by intracellular pH: one step closer to understanding CRAC channel biology?	18
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Issue Information	18
Issue Information	18
Understanding the role of sirtuin 1 in muscle physiology during androgen deprivation	18
Chemoreceptor mechanisms regulating CO2‐induced arousal from sleep	18
Effect of vitamin C infusion on altitude‐related vasodilatory dysfunction	18
Ion channels and transporters keep ideas flowing	18
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Muscle glycogen depletion: a weak‐link rendering muscle cells prone to potassium‐induced fatigue?	17
Morphine‐induced mechanical hypersensitivity in mice requires δ receptors, β‐arrestin2, and c‐Src activity	17
Regional associations between inspiratory tongue dilatory movement and genioglossus activity during wakefulness in people with obstructive sleep apnoea	17
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Distinguishing pathophysiological features of heart failure with reduced and preserved ejection fraction: A comparative analysis of two mouse models	17
Axonal excitability changes in children with spinal muscular atrophy treated with nusinersen	17
THRIFTY: a novel high‐throughput method for rapid fibre type identification of isolated skeletal muscle fibres	17
The potassium–glycogen interaction on force and excitability in mouse skeletal muscle: implications for fatigue	17
Convergent escape behaviour from distinct visual processing of impending collision in fish and grasshoppers	17
Fast A‐type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the neuropeptide Y Y1 receptor	17
Melanin‐concentrating hormone‐producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure	17
EPOtential target for endurance performance: the effect of exogenous ketone supplementation on circulating erythropoietin levels	17
Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance	17
Acute oral digoxin in healthy adults hastens fatigue and increases plasma K+ during intense exercise, despite preserved skeletal muscle Na+,K+‐ATPase	16
Visual placebo and nocebo effects	16
Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)	16
Orbitofrontal control of the olfactory cortex regulates olfactory discrimination learning	16
Late‐gestation maternal undernutrition induces circulatory redistribution while preserving uteroplacental function independent of fetal glycaemic state	16
Blockage of aquaporin‐3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration	16
EXPRESSION OF CONCERN: Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response‐dependent insulin resistance as a cause of obesity‐associated overactive bladde	16
Brief response to Terrar	16
Past the limits of pain: placebo and nocebo effects in visual processing reveal novel behavioural and brain markers of the twin phenomena	16
The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation	15
The impact of 60 days of ‐6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics	15
Current limitations and future opportunities of tracer studies of muscle ageing	15
Rigour and reproducibility redux	15

Madness or progress? The dilemma of standardizing exercise physiology thresholds	15
TRPV1 in arteries enables a rapid myogenic tone	15
Neuroimmune modulation for targeting organ damage in hypertension and atherosclerosis	15
A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization	15
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years	15
Conjunctive processing of spatial border and locomotion in retrosplenial cortex during spatial navigation	15
Correction to ‘Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching’	15
Jun‐activated SOCS1 enhances ubiquitination and degradation of CCAAT/enhancer‐binding protein β to ameliorate cerebral ischaemia/reperfusion injury	15
In Memoriam: Marcello Costa (1940–2024) – a pioneer of the enteric nervous system	15
Is it time to expand the scope of the autonomic nervous system?	15
Regulation of metabolic health by dietary histidine in mice	15
Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells	15
Aquaporin‐4 deletion leads to reduced infarct volume and increased peri‐infarct astrocyte reactivity in a mouse model of cortical stroke	15
A new sympathetic understanding of exercise blood flow regulation in heart failure with preserved ejection fraction	15
The gut–muscle axis shapes exercise performance	15
Role of CFTR in diabetes‐induced pancreatic ductal fluid and HCO3− secretion	14
Action potentials in postganglionic sympathetic nerves depend on NaV1.7	14
The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency	14
Unravelling vagal hypersensitivity in chronic cough: A distinct disease	14
Contribution of transient receptor potential vanilloid 1 (TRPV1) channel to cholinergic contraction of rat bladder smooth muscle	14
Regulation of presynaptic homeostatic plasticity by glial signalling in Alzheimer's disease	14
Sowing the seeds of stress: maternal exposure to synthetic glucocorticoids impacts sperm miRNA for generations	14
Untangling webs of divergent neuroimmune circuits	14
Mitochondrial respiration is lower in the intrauterine growth‐restricted fetal sheep heart	14
cAMP reduces action potential amplitude and conduction velocity over long axonal distance	14
The neurobiological response to intermittent hypoxia: insights into adaptation and resilience	14
The art of blinding in human physiological research: unmasking the hidden hero in scientific inquiry	14
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The susceptibility of the rat pulmonary and caval vein myocardium to the catecholamine‐induced ectopy changes oppositely in postnatal development	14
Rebuttal from Nickole Moon, Christopher Morgan and Tracy L. Bale	14
Physiological determinants of mechanical efficiency during advanced ageing and disuse	14
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Optimized design of an arterial network model reproduces characteristic central and peripheral haemodynamic waveform features of young adults	14
Reflections on reflected waves in ‘YoungAdult’	14
Optogenetic approaches to therapy for inherited retinal degenerations	14
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Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling	14
Capillary module haemodynamics and mechanisms of blood flow regulation in skeletal muscle capillary networks: Experimental and computational analysis	14
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle	14
Harnessing pericytes to aid muscle recovery after immobilization	14
Mitochondria dysfunction in the failing right heart: what is the potential therapeutic target?	13
Correlation networks of spinal motor neurons that innervate lower limb muscles during a multi‐joint isometric task	13
HFrEF and HFpEF: are mitochondria at the heart of the matter?	13
CaM‐dependent modulation of human CaV1.3 whole‐cell and single‐channel currents by C‐terminal CaMKII phosphorylation site S1475	13
Early resistance training‐mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle‐aged adults	13
Ageing attenuates exercise‐enhanced motor cortical plasticity	13
Multiple layers of diversity govern the cell type specificity of GABAergic input received by mouse subicular pyramidal neurons	13
All‐optical monitoring of excitation–secretion coupling demonstrates that SV2A functions downstream of evoked Ca2+ entry	13
Non‐invasive estimation of muscle fibre size from high‐density electromyography	13
Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication	13
A proline‐tyrosine motif, endocytosis and low salt – how to link protein functions to organ physiology	13
Suppression of inflammatory macrophages reduces atherosclerosis	13
On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: which came first, the chicken or the egg?	12
The role of ganglionic plexi neurons in atrial fibrillation following spinal cord injury	12
Functional characterization of PIEZO1 in distinct macrophage populations	12
Avalanche burial pathophysiology – a unique combination of hypoxia, hypercapnia and hypothermia	12
Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease	12
Acid‐sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension	12
Time‐dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation‐induced disuse	12
Short‐term ketone monoester supplementation improves cerebral blood flow and cognition in obesity: A randomized cross‐over trial	12
Regulation of ClC‐K/barttin by endocytosis influences distal convoluted tubule hyperplasia	12
Testosterone and androgen receptors in females: what is possible with resistance training?	12
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Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep	12
Mechanisms of pacemaking in mammalian neurons	12
Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise	12
A tribute to Dr Frederick Sachs	12
Issue Information	12
Sex differences in lipid metabolism may explain disparities in cardiometabolic disease prevalence with sleep apnoea	12
5‐HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity	12
Increased maximal oxygen uptake after sprint‐interval training is mediated by central haemodynamic factors as determined by right heart catheterization	12
Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain‐processing neurons across sex in rats and humans	11
Incretin hormones and obesity	11
Response to a Letter to the Editor: An alternative mechanism for slow pacemaking	11
Resistance artery vasodilator pathways involved in the antihypertensive effects of cocoa shell extract in rats exposed to fetal undernutrition	11
Reply to ‘Reevaluating central versus peripheral contributions to maximal oxygen uptake: the role of muscle diffusive capacity’	11
Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial	11
Augmenting workload drives T‐tubule assembly in developing cardiomyocytes	11
Correction to ‘Pre‐intervention myocardial stress is a good predictor of aortic valvuloplasty outcome for fetal critical aortic stenosis and evolving HLHS’	11
Corrigendum	11
Food for thought: implications of exercise‐induced changes to cerebral glucose metabolism in ageing and Alzheimer's disease	11
Tic‐tac‐mito: The relationship between the biological clock with mitochondria dynamics and skeletal muscle function in humans	11
Rise and shine, it's exercising to improve metabolic syndrome time	11
Stem cell‐derived cardiomyocyte heterogeneity confounds electrophysiological insights	11
Inhibiting aquaporin‐3 to prevent melanoma progression: The potential of organogold	11
Regulation of cardiomyocyte t‐tubule structure by preload and afterload: Roles in cardiac compensation and decompensation	11
The Bayliss–Starling Prize Lecture: The developmental physiology of spinal cord and cortical nociceptive circuits	11
Correction to ‘Fasting for 20 h does not affect exercise‐induced increases in circulating BDNF in humans’	11
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function	11
Editorial: aquaporins in health and disease	11
Glycogen pools and utilization during exercise: future implication on glucose regulation	11
What time of the day should I exercise?	11
Impacts of time‐restricted feeding on middle‐aged and old mice with obesity	11
Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments	11
House dust mite allergens, store‐operated Ca2+ channels and asthma	11