OOIR: Observatory of International Research

Papers

(The H4-Index of Life Sciences is 55. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Metacaspase (Pf MCA-1) as antimalarial drug target: An in silico approach and their biological validation	321
4-Methylumbelliferone induces antitumor effects independently of hyaluronan synthesis inhibition in human acute leukemia cell lines	312
Insights into the development of insulin-producing cells: Precursors correlated involvement of microRNA panels	293
Behavioural disruption in diabetic mice: Neurobiological correlates and influences of dietary α-linolenic acid	204
The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus	200
Skp2-mediated Zeb1 expression facilitates cancer migration by a ubiquitination-independent pathway	187
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer	173
Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy	153
The combination of mesenchymal stem cell- and hepatocyte-derived exosomes, along with imipenem, ameliorates inflammatory responses and liver damage in a sepsis mouse model	147
Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion	135
Exploring Lin28 proteins: Unravelling structure and functions with emphasis on nervous system malignancies	134
The N6-methyladenosine modification in pathologic angiogenesis	131
Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats	127
Ivabradine restores tonic cardiovascular autonomic control and reduces tachycardia, hypertension and left ventricular inflammation in post-weaning protein malnourished rats	125
Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma	123
Pancreastatin inhibitor PSTi8 prevents free fatty acid-induced oxidative stress and insulin resistance by modulating JNK pathway: In vitro and in vivo findings	119
The proteomic landscape of ovarian cancer cells in response to melatonin	119
The inhibition of autophagy by spautin boosts the anticancer activity of fingolimod in multidrug-resistant hepatocellular carcinoma	93
Physical health, behavioral and emotional functioning in children of gulf war veterans	92
Optimal intervention time of ADSCs for hepatic ischemia-reperfusion combined with partial resection injury in rats	90
Mitochondrial transfer in the progression and treatment of cardiac disease	86
Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway	86
Gulf War Illness Clinical Trials and Interventions Consortium (GWICTIC): A collaborative research infrastructure for intervention and implementation	86
The anxiolytic sertraline reduces the impact of psychological stress on bladder function in mice	85
Carboxyaminotriazole: A bone savior in collagen-induced arthritis—Halting osteoclastogenesis via interleukin-1β downregulation	83

Characterizing COPD phenotypes with a targeted signaling lipids metabolomics approach	82
Hyperglycemia influences the cell proliferation and death of the rat endocrine pancreas in the neonatal period	81
Editorial Board	81
Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia	81
The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibition	80
The combined therapy of mesenchymal stem cell transplantation and resveratrol for diabetes: Future applications and challenges	75
The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts	74
Retraction notice to “Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib” [Life Sci. 259 (2020) 118150]	70
Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk	70
Unleashing the pathological imprinting of cancer in autoimmunity: Is ZEB1 the answer?	69
Progesterone signaling in uterine fibroids: Molecular mechanisms and therapeutic opportunities	68
Liraglutide attenuates intestinal ischemia/reperfusion injury via NF-κB and PI3K/Akt pathways in mice	67
Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer	67
γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress	63
Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy	62
Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency	62
Targeting HMG-CoA synthase 2 suppresses tamoxifen-resistant breast cancer growth by augmenting mitochondrial oxidative stress-mediated cell death	61
Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?	61
In vitro assessment of anti-fibrotic drug activity does not predict in vivo efficacy in murine models of Duchenne muscular dystrophy	60
Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway	60
Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice	60
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury	59
Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research	59
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3	58
Preclinical metabolic characterization of mefunidone, a novel anti-renal fibrosis drug	58
Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model	58
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia	56
Lung cancer vaccination from concept to reality: A critical review of clinical trials and latest advances	56
Repurposing therapeutics for malignant pleural mesothelioma (MPM) – Updates on clinical translations and future outlook	55
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma	55
Renal protective effects and mechanisms of the angiotensin receptor-neprilysin inhibitor LCZ696 in mice with cardiorenal syndrome	55
Application of f-FeNC@GOx cascade enzyme nanomaterials in the healing of infected wounds	55