OOIR: Observatory of International Research

Papers

(The H4-Index of Life Sciences is 56. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Unleashing the pathological imprinting of cancer in autoimmunity: Is ZEB1 the answer?	386
Characterizing COPD phenotypes with a targeted signaling lipids metabolomics approach	371
Carboxyaminotriazole: A bone savior in collagen-induced arthritis—Halting osteoclastogenesis via interleukin-1β downregulation	241
Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma	226
Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion	182
A detailed insight into macrophages' role in shaping lung carcinogenesis	175
Editorial Board	163
Retraction notice to “Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib” [Life Sci. 259 (2020) 118150]	159
The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts	155
Hyperglycemia influences the cell proliferation and death of the rat endocrine pancreas in the neonatal period	153
Combined effects of high fat diet and exercise on autophagy in white adipose tissue of mice	134
Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy	133
Ivabradine restores tonic cardiovascular autonomic control and reduces tachycardia, hypertension and left ventricular inflammation in post-weaning protein malnourished rats	116
Regulation of metabolism by circadian rhythms: Support from time-restricted eating, intestinal microbiota & omics analysis	102
Metabolomics profiling and chemoresistance mechanisms in ovarian cancer cell lines: Implications for targeting glutathione pathway	98
Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence	89
Photothermal therapy-mediated autophagy in breast cancer treatment: Progress and trends	86
Insights into the development of insulin-producing cells: Precursors correlated involvement of microRNA panels	86
Gold nanoparticles show potential in vitro antiviral and anticancer activity	85
Emerging therapeutic landscape: Incretin agonists in chronic kidney disease management	85
Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1	79
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3	78
The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibition	77
Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7	75
Copper homeostasis and cuproptosis in mitochondria	75

Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy	73
Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway	73
Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-Ι diabetic rats	72
Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis	72
Human gestational diabetes mellitus–derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets	71
The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells	70
Pancreastatin inhibitor PSTi8 prevents free fatty acid-induced oxidative stress and insulin resistance by modulating JNK pathway: In vitro and in vivo findings	70
Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation	70
Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-	69
6-NitroDopamine is an endogenous modulator of rat heart chronotropism	69
Molecular insights into the causal role of TG/IDL in rheumatoid arthritis: Integrating Mendelian randomization and single-cell RNA sequencing	68
Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice	68
Tuberous sclerosis complex 2 deficiency in cardiomyocytes exacerbates cardiac remodeling in diabetic mice	67
Identification of specific gut microbes and their therapeutic potential in ameliorating systemic lupus erythematosus in a mouse model	66
Augmented nephroprotective effect of liraglutide and rabeprazole via inhibition of OCT2 transporter in cisplatin-induced nephrotoxicity in rats	66
Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets	63
Metacaspase (Pf MCA-1) as antimalarial drug target: An in silico approach and their biological validation	62
Behavioural disruption in diabetic mice: Neurobiological correlates and influences of dietary α-linolenic acid	62
Exploring Lin28 proteins: Unravelling structure and functions with emphasis on nervous system malignancies	61
The N6-methyladenosine modification in pathologic angiogenesis	60
4-Methylumbelliferone induces antitumor effects independently of hyaluronan synthesis inhibition in human acute leukemia cell lines	60
Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency	60
Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk	59
Optimal intervention time of ADSCs for hepatic ischemia-reperfusion combined with partial resection injury in rats	59
The proteomic landscape of ovarian cancer cells in response to melatonin	59
Antioxidant therapy reverses sympathetic dysfunction, oxidative stress, and hypertension in male hyperadipose rats	58
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer	58
Progesterone signaling in uterine fibroids: Molecular mechanisms and therapeutic opportunities	57
Lung cancer vaccination from concept to reality: A critical review of clinical trials and latest advances	56
Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer	56
Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research	56