Molecular Pharmacology

Article	Citations
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling	60
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist	35
Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan	34
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor	31
Fat traffic control: S-acylation in axonal transport	31
Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K+-Dependent Phosphatase Activity of Na+/K+-ATPase with Chromogenic pNPP Substrate	28
Current Understanding of Membrane Transporters as Regulators or Targets for Cisplatin-Induced Hearing Loss	27
CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals	27
Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism	26
Editorial Board	26
Table of Contents	24
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment	21
Editorial Board	21
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists	20
Lysine Demethylase 6B Regulates Prostate Cancer Cell Proliferation by Controlling c-MYC Expression	20
Isoprenaline shows unique kinase dependencies in stimulating β1AR–β-arrestin2 interaction compared to endogenous catecholamines	20
Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline	19
Chrysosplenol-C Increases Contraction by Augmentation of Sarcoplasmic Reticulum Ca2+ Loading and Release via Protein Kinase C in Rat Ventricular Myocytes	18
Corrigendum to “Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism	18
Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker	18
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2–Induced Inflammation	18
The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels	18
Editorial Board	18
Table of Contents	17
Table of Contents	17

6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a superagonist for the intermediate-conductance Ca2+-activated K+ channel KCa3.1	16
Selection and Characterization of FD164, a High-Affinity Signal Regulatory Protein α Variant with Balanced Safety and Effectiveness, from a Targeted Epitope Mammalian Cell-Displayed Antibody Library	16
Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors	15
Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay	15
St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content	15
Research approaches for exploring the hidden conversations of G protein-coupled receptor transactivation	14
GPR83 Engages Endogenous Peptides from Two Distinct Precursors to Elicit Differential Signaling	14
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells	13
Englerin A Inhibits T-Type Voltage-Gated Calcium Channels at Low Micromolar Concentrations	13
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Compl	13
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes	13
Editorial Board	12
Table of Contents	12
Editorial Board	12
Correction to “High-Throughput Screening of Transient Receptor Potential Channel 1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique”	12
Table of Contents	11
Cholesterol Inhibition of Slo1 Channels Is Calcium-Dependent and Can Be Mediated by Either High-Affinity Calcium-Sensing Site in the Slo1 Cytosolic Tail	11
Correction to “Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells”	11
Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”	11
Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaque	11
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity	11
Modulation of Kv7 Channel Currents by Echinocystic Acid	11
Commentary on the fourth Transatlantic G Protein-Coupled Receptor Symposium for early-career investigators	11
The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State	11
A brief history of nerve action potentials after 1600	11
Table of Contents	11
The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors	11
Expression of concern: “Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling” [Molecular Pharmacology, Volume 76, Issue 5, November 2009, Pages 1082-10	10
Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5	10
Gα Protein Signaling Bias at Serotonin 1A Receptor	10
Editorial Board	10
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins	10
Functional Interaction between Transient Receptor Potential V4 Channel and Neuronal Calcium Sensor 1 and the Effects of Paclitaxel	10
Contents	10
Editorial Board	10
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor	10
Table of Contents	10
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer	9
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?	9
Editorial Board	9
G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation	9
Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins	9
Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1	9
Table of Contents	9
Editorial Board	9
Corrigendum to “Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial- Mesenchymal Transi	9
Editorial Board	9
Editorial Board	9
Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4	8
Corrigendum to “Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2- Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesio	8

Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor	8
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels	8
Corrigendum to “The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation”	8
The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families	8
Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis	8
A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction	8
β2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2	8
Table of Contents	8
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane	8
Roles of Receptor Phosphorylation and Rab Proteins in G Protein-Coupled Receptor Function and Trafficking	8
Editorial Board	8
Upregulating vascular endothelial KCa2.3 channels alleviates pulmonary hypertension in mice	8
CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling	7
Fluorizoline Blocks the Interaction between Prohibitin-2 and γ-Glutamylcyclotransferase and Induces p21 Expression in MCF7 Breast Cancer Cells	7
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3	7
Aryl Hydrocarbon Receptor as a Therapeutical Target of Environmentally Induced Skin Conditions	7
Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?	7
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration	7
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release	7
Molecular determinants of 2-APB-sensitivity of TRPV2 - unexpected differences between two rodent orthologues	7
Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier	7
Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors	7
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells	7
Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone	7
Multipathway In Vitro Pharmacological Characterization of Specialized Proresolving G Protein-Coupled Receptors	6
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor	6
Editorial Board	6
Editorial Board	6
Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease	6
Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood–Brain Barrier Endothelium	6
HDAC6 inhibition ameliorates sensory hypersensitivity and reduces immune cell signatures in the dorsal root ganglia in murine chronic pain models	6
Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism	6
The Common LncRNAs of Neuroinflammation-Related Diseases	6
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates	6
Multiomics Analyses Identify Proline Endopeptidase–Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer’s Disease Pathogenesis	6
Screening and Identification of a Novel Anti–Siglec-15 Human Antibody 3F1 and Relevant Antitumor Activity	5
Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors	5
Table of Contents	5
A Sentimental Segue	5
Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor	5
Editorial Board	5
Table of Contents	5
ADP Ribosylation Factor 6 Promotes Contraction and Proliferation, Suppresses Apoptosis and Is Specifically Inhibited by NAV2729 in Prostate Stromal Cells	5
Upacicalcet Is a Novel Secondary Hyperparathyroidism Drug that Targets the Amino Acid Binding Site of Calcium-Sensing Receptor	5
Coassembly of Warm Temperature–Sensitive Transient Receptor Potential Vanilloid (TRPV) 3 and TRPV4 Channel Complexes with Distinct Functional Properties	5
Editorial Board	5
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology	5
Multiwalled carbon nanotubes activate the NLRP3 inflammasome-dependent pyroptosis in macrophages	5
Table of Contents	5
Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance	5
Correction to “Tacrine Induces Endoplasmic Reticulum–Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells”	5
State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548	5
Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β)	5
Membrane-Mediated Activity of Local Anesthetics	5
Table of Contents	5
Evaluation of allosteric N-methyl-d-aspartate receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling	5
Correction to “Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo”	5
Editorial Board	5
Corrigendum to “Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation”	5
Editorial Board	4
Response to Comments on “Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites”	4
Alkannin Attenuates Amyloid β Aggregation and Alzheimer’s Disease Pathology	4
The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain	4
Atypical Chemokine Receptor 3 “Senses” CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation	4
Molecular and cellular effects of hydroxy-1,4 naphthoquinones used in dermatological and cosmetic applications on human protein tyrosine phosphatase PTP1B in human keratinocytes	4
Agonists of the Nuclear Receptor PPARγ Can Produce Biased Signaling	4
Cyclovirobuxine inhibits ferroptosis to mitigate Alzheimer disease in glutamate-induced SH-SY5Y cell: the role of the liquid-liquid phase separation of FTH1	4
Table of Contents	4
The Synthetic Cannabinoid WIN55,212-2 Can Disrupt the Golgi Apparatus Independent of Cannabinoid Receptor-1	4
Corrigendum to “Functional Interaction between Transient Receptor Potential V4 Channel and Neuronal Calcium Sensor 1 and the Effects of Paclitaxel”	4
Contents	4
Transcriptional Regulation, Signaling Pathways, and Subcellular Localization of Corticotropin-Releasing Factor Receptors in the Central Nervous System	4
Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1	4
Extrachromosomal Circular DNAs, Amplified Oncogenes, and CRISPR-Cas9 System	4
Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7	4
Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites	3
Passive Immunotherapies Targeting Amyloid-β in Alzheimer’s Disease: A Quantitative Systems Pharmacology Perspective	3
Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer	3
Decoding Cinnabarinic Acid–Specific Stanniocalcin 2 Induction by Aryl Hydrocarbon Receptor	3
Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders	3

Table of Contents	3
Ketamine and Major Ketamine Metabolites Function as Allosteric Modulators of Opioid Receptors	3
Dynamic Expression of Transient Receptor Potential Vanilloid-3 and Integrated Signaling with Growth Factor Pathways during Lung Epithelial Wound Repair following Wood Smoke Particle and Other Forms of	3
Nuclear Ceramide Is Associated with Ataxia Telangiectasia Mutated Activation in the Neocarzinostatin-Induced Apoptosis of Lymphoblastoid Cells	3
Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking	3
Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake	3
Voltage sensors	3
Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator	3
TP53 Null Mutations Identify Lung Cancer Cell Lines with Highest Sensitivity to the Nontaxane Microtubule Inhibitor Eribulin	3
G protein-coupled receptor–targeted proteolysis-targeting chimeras in cancer therapeutics	3
Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5	3
The peroxisome proliferator-activated receptors (PPARs) α/β/γ agonist NCPC-626 from microbial metabolites alleviates metabolic dysfunction-associated steatohepatitis in mice	3
Chemokine receptors – Exemplifying functional divergence in G protein-coupled receptors	3
Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor	3
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors	3
Differential Effects of Remdesivir and Lumacaftor on Homomeric and Heteromeric hERG Channels	2
Receptor Determinants for β-Arrestin Functional Specificity at C-X-C Chemokine Receptor 5	2
Correction to “Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase”	2
Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H1 Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine	2
Table of Contents	2
mTOR Regulation of AGC Kinases: New Twist to an Old Tail	2
Coexpressed δ-, μ-, and κ-Opioid Receptors Modulate Voltage-Gated Ca2+ Channels in Gastric-Projecting Vagal Afferent Neurons	2
A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance	2
Comparative evaluation of the biological characteristics of a novel retinoid X receptor agonist and bexarotene	2
Editorial Board	2
Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State	2
Deorphanization of G Protein Coupled Receptors: A Historical Perspective	2
Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway	2
Special Section on Therapeutic Implications for Sphingolipids in Health and Disease—Editorial	2
Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin	2
Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor	2
Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects	2
Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors	2
High-Throughput Screening of TRPV1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique	2
Effects of Small Molecule Ligands on ACKR3 Receptors	2
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action	2
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice	2
Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells	2
Correction to “A Novel Semisynthetic Inhibitor of the FRB Domain of Mammalian Target of Rapamycin Blocks Proliferation and Triggers Apoptosis in Chemoresistant Prostate Cancer Cells”	2
Bioengineered miR-7-5p modulates non–small cell lung cancer cell metabolism to improve therapy	2