OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pharmacology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling	64
Fat traffic control: S-acylation in axonal transport	37
Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K+-Dependent Phosphatase Activity of Na+/K+-ATPase with Chromogenic pNPP Substrate	36
Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan	35
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor	34
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist	34
Editorial Board	30
Table of Contents	29
Editorial Board	26
Isoprenaline shows unique kinase dependencies in stimulating β1AR–β-arrestin2 interaction compared to endogenous catecholamines	25
Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism	25
Lysine Demethylase 6B Regulates Prostate Cancer Cell Proliferation by Controlling c-MYC Expression	24
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment	23
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists	23
Chrysosplenol-C Increases Contraction by Augmentation of Sarcoplasmic Reticulum Ca2+ Loading and Release via Protein Kinase C in Rat Ventricular Myocytes	22
Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker	20
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2–Induced Inflammation	20
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells	19
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes	19
Corrigendum to “Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism	18
Editorial Board	17
Table of Contents	16
Table of Contents	16
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor	15
Research approaches for exploring the hidden conversations of G protein-coupled receptor transactivation	15

The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels	15
6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a superagonist for the intermediate-conductance Ca2+-activated K+ channel KCa3.1	15
Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors	14
Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay	14
GPR83 Engages Endogenous Peptides from Two Distinct Precursors to Elicit Differential Signaling	14
Editorial Board	13
Englerin A Inhibits T-Type Voltage-Gated Calcium Channels at Low Micromolar Concentrations	13
St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content	13
Editorial Board	13
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Compl	12
Table of Contents	12
Emerging roles of ubiquitin-specific proteases in the cardiovascular system	12
Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid	11
Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaque	11
Rational design of biased GPCR agonists	11
Commentary on the fourth Transatlantic G Protein-Coupled Receptor Symposium for early-career investigators	11
A brief history of nerve action potentials after 1600	11
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity	11
Modulation of Kv7 Channel Currents by Echinocystic Acid	11
Table of Contents	11
Cholesterol Inhibition of Slo1 Channels Is Calcium-Dependent and Can Be Mediated by Either High-Affinity Calcium-Sensing Site in the Slo1 Cytosolic Tail	11
The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State	11
Correction to “Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells”	11
Expression of concern: “Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling” [Molecular Pharmacology, Volume 76, Issue 5, November 2009, Pages 1082-10	10
Editorial Board	10
The effects of hippocampal miR-34c-5p on the age-related discrepancies in susceptibility to traumatic stress in the PTSD mice model	10
Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”	10
Gα Protein Signaling Bias at Serotonin 1A Receptor	10
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins	10
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer	10
G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation	10
The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors	10
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor	10
Editorial Board	10
Corrigendum to “Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial- Mesenchymal Transi	10
Contents	10
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex	10
Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5	10
Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway	9
Table of Contents	9
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane	9
Editorial Board	9
Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor	9
Table of Contents	9
The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families	9
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?	9
Editorial Board	9
A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction	9
Roles of Receptor Phosphorylation and Rab Proteins in G Protein-Coupled Receptor Function and Trafficking	8
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels	8

GRK2 and GRK5 – the two critical kinases in cardiac pathophysiology	8
Corrigendum to “Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2- Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesio	8
Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis	8
Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1	8
Corrigendum to “The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation”	8
Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4	8
Editorial Board	8
CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling	7
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release	7
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration	7
Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors	7
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells	7
Activation of TRPV3 channels in bladder cancer cells stimulates ATP release	7
Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier	7
Upregulating vascular endothelial KCa2.3 channels alleviates pulmonary hypertension in mice	7
Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone	6
The Common LncRNAs of Neuroinflammation-Related Diseases	6
Editorial Board	6
Elucidating Molecular Mechanisms Governing TNF-Alpha-Mediated Regulation of Amyloid Beta 42 Uptake in Blood-Brain Barrier Endothelial Cells	6
Molecular determinants of 2-aminoethoxydiphenyl borate sensitivity of transient receptor potential vanilloid 2-unexpected differences between 2 rodent orthologs	6
Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077	6
Fluorizoline Blocks the Interaction between Prohibitin-2 and γ-Glutamylcyclotransferase and Induces p21 Expression in MCF7 Breast Cancer Cells	6
Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?	6
Aryl Hydrocarbon Receptor as a Therapeutical Target of Environmentally Induced Skin Conditions	6
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3	6