Proceedings of the National Academy of Sciences of the United States o

Article	Citations
A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression	949
Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia	634
Revealing the structure of snowflakes using acoustic levitation	509
Kinetic pathways of solid–solid phase transitions dictated by short-range interactions	423
Yeast centrosomes act as organizing centers to promote Polo kinase–mediated adaptation to persistent DNA damage	423
Indigenous territories and protected areas are crucial for ecosystem connectivity in the Amazon basin	421
Semantic change in adults is not primarily a generational phenomenon	417
The power of coalescent methods for inferring recent and ancient gene flow in endangered Bactrian camels	403
Functional redundancy in the toxic pathway of Bt protein Cry1Ab, but not Cry1Fa, against the Asian corn borer	398
Empowering genome-wide association studies via a visualizable test based on the regional association score	393
Roughness-dependent scaling of the contact area and separation gap with pressure for glassy polymers	374
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises	363
False discovery rate control in genome-wide association studies with population structure	352
Stomatal patchiness and cellular computing	350
Retraction for Li et al., Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells	313
Early life lead exposure from private well water increases juvenile delinquency risk among US teens	305
The gender gap in the ownership of promising land	300
A forward modeling approach to analyzing galaxy clustering with S im BIG	288
Rapid shear zone weakening during subduction initiation	279
Modeling DNA methyltransferase function to predict epigenetic correlation patterns in healthy and cancer cells	279
Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization	272
Sound-mediated nucleation and growth of amyloid fibrils	258
Ru-P pair sites boost charge transport in hematite photoanodes for exceeding 1% efficient solar water splitting	249
Circadian clock control of interactions between eIF2α kinase CPC-3 and GCN1 with ribosomes regulates rhythmic translation initiation	249
Individuals benefit individual out-group members rather than harm in-group members	248

Local O 2 concentrating boosts the electro-Fenton process for energy-efficient water remediation	243
Mercury’s complex legacy	238
Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting	237
Water striders are impervious to raindrop collision forces and submerged by collapsing craters	235
Endurance athletes hiding in plain sight in the high Andes	231
Correction for Magesh et al., Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species	226
Insurance and climate risks: Policy lessons from three bounding scenarios	223
Tetrapod species–area relationships across the Cretaceous–Paleogene mass extinction	221
Temperature-dependent fold-switching mechanism of the circadian clock protein KaiB	219
Glucuronic acid confers colonization advantage to enteric pathogens	207
The origin of color categories	206
Aberrant neuronal hyperactivation causes an age-dependent behavioral decline in Caenorhabditis elegans	205
Correction to Supporting Information for Ikeda et al., Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics	204
A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection	203
Data-driven classification of ligand unbinding pathways	202
Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopy	201
Ciliary localization of a light-activated neuronal GPCR shapes behavior	201
Emergent time scales of epistasis in protein evolution	197
Untangling the CD4 T cell response to the microbiota	197
Late Cretaceous community structure changed before the asteroid	193
Phase separation in mitochondrial fate and mitochondrial diseases	191
Thermodynamic consistency of autocatalytic cycles	189
Impression management in research reporting: When effects are not really as pronounced as claimed	189
A conserved ARF–DNA interface underlies auxin-triggered transcriptional response	188
Weakening AMOC reduces ocean carbon uptake and increases the social cost of carbon	188
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52	188
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7	188
Programmable heterogeneous lamellar lattice architecture for dual mechanical protection	185
Deep silicification–assisted long-term preservation of structural and genomic information across biospecies: From micro to macro	183
Bacterial lifestyle shapes pangenomes	182
Unproctored online exams provide meaningful assessment of student learning	179
Maple samaras recover autorotation following raindrop collisions	178
Directional water navigation and reallocation in Tillandsia capitata	178
Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2− breast tumor cells	177
An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis	177
Correction for Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments	176
Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage	174
Parameters of clustered suboptimal miRNA biogenesis	174
Modeling blood metabolite homeostatic levels reduces sample heterogeneity across cohorts	174
Photoreduction of mercuric bromides in polar ice	168
Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes	168
Correction to Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro	167
Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning	163
Integrating life history and behavioral aging in the wild	162
State-dependent motion of a genetically encoded fluorescent biosensor	161
Methodological and conceptual considerations of the TCM evolution	160
Clocking out and letting go to unleash green biotech applications in a photosynthetic host	159
Resilience of deep aquifer microbial communities to seasonal hydrological fluctuations	157
Industrial-era decline in Arctic methanesulfonic acid is offset by increased biogenic sulfate aerosol	156
TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice	156

Promoting C–F bond activation via proton donor for CF 4 decomposition	156
Adaptive DNA amplification of synthetic gene circuit opens a way to overcome cancer chemoresistance	155
Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia	155
GPCR–MAPK signaling pathways underpin fitness trade-offs in whitefly	155
Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform	154
Indigenous Knowledge as a sole data source in habitat selection functions	154
Controlling laser-dressed resonance line shape using attosecond extreme-ultraviolet pulse with a spectral minimum	153
Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex	151
How defective mitochondrial electrical activity leads to inherited blindness	151
Competing gauge fields and entropically driven spin liquid to spin liquid transition in non-Kramers pyrochlores	150
Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics	149
Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization	149
Dual membrane-spanning anti-sigma factors regulate vesiculation in Bacteroides thetaiotaomicron	149
Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure	147
Healthy sleep durations appear to vary across cultures	146
Predictive phage therapy for Escherichia coli urinary tract infections: Cocktail selection for therapy based on machine learning models	146
Contraception ends the genetic maintenance of human same-sex sexual behavior	145
Graphene nanoripples enable unexpected catalytic reactivity	145
Climate warming drives population trajectories of freshwater fish	145
Prolonged exertion of self-control causes increased sleep-like frontal brain activity and changes in aggressivity and punishment	144
Thermo-photo catalytic anode process for carbonate-superstructured solid fuel cells	143
Long-term employment and health effects of active labor market programs	142
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease	142
DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8	141
Accounting for spatial sampling patterns in Bayesian phylogeography	140
Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana	140
In This Issue	140
Proactive or reactive? Neural oscillatory insight into the leader–follower dynamics of early infant–caregiver interaction	139
Sm complex assembly and 5′ cap trimethylation promote selective processing of snRNAs by the 3′ exonuclease TOE1	138
Genetic ablation of the TET family in retinal progenitor cells impairs photoreceptor development and leads to blindness	136
Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations	135
Pinning down a perpetrator in postsurgical eye pain	134
Theory and observations of the interaction between magnetohydrodynamic waves and shocks	134
BRD9 functions as an HIV-1 latency regulatory factor	134
The making of an AI news anchor—and its implications	133
A randomized trial of behavioral interventions yielding sustained reductions in distracted driving	133
Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche	132
Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist	132
Lateral olivocochlear neurons modulate cochlear responses to noise exposure	131
AlphaFold2-based prediction of the co-condensation propensity of proteins	131
Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae	130
Correction for Ahituv et al., Starch-rich plant foods 780,000 y ago: Evidence from Acheulian percussive stone tools	130
Polymorphic transposable elements contribute to variation in recombination landscapes	129
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells	129
Breaking the mobility–stability dichotomy in organic semiconductors through adaptive surface doping	129
Cytoplasmic stirring by active carpets	128
Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity	128
Touching the classical scaling in penetrative convection	128
Hidden in plain sight: (Re)definition of a key lepidopteran color patterning gene	128
Using neuroimaging genomics to investigate the evolution of human brain structure	127
Molecular patterns of matrix protein 1 (M1): A strong predictor of adaptive evolution in H9N2 avian influenza viruses	127
Independent transitions to fully planktonic life cycles shaped the global distribution of medusozoans in the epipelagic zone	127
Sharing of misinformation is habitual, not just lazy or biased	127
Bottlenose dolphin mothers modify signature whistles in the presence of their own calves	127
Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain	126
Atmospheric variability contributes to increasing wildfire weather but not as much as global warming	126
Biodiversity mitigates drought effects in the decomposer system across biomes	125
The importance of elders: Extending Hamilton’s force of selection to include intergenerational transfers	125
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells	125
Extremal structures with embedded prefailure indicators	123
Vulnerability to natural disasters and sustainable consumption: Unraveling political and regional differences	123
High-impact rare genetic variants in severe schizophrenia	123
Identifying regulation with adversarial surrogates	123
LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition	123
IL-1 receptor antagonism reveals a yin-yang relationship between NFκB and interferon signaling in chronic lymphocytic leukemia	122
β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells	122
The Titanic question in TB control: Should we worry about the bummock?	122
Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+ -activated large-conductance K + channels and motor coordination	122
Persistent deep water anoxia in the eastern South Atlantic during the last ice age	121
Oligopoly competition between satellite constellations will reduce economic welfare from orbit use	121
Designing the stripe-ordered cuprate phase diagram through uniaxial-stress	121
A sodium-dependent trehalose transporter contributes to anhydrobiosis in insect cell line, Pv11	120
Gap junction–transported cAMP from the niche controls stem cell progeny differentiation	119
Repeated occurrences of marine anoxia under high atmospheric O 2 and icehouse conditions	119
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy	118
Tsg101 mimicry of canonical E2 enzymes underlies its role in ubiquitin signaling	117
Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson’s disease and essential tremor	117
Phylogenomics of the tetraploid Hawaiian lobeliads: Implications for their origin, dispersal history, and adaptive radiation	117
Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors	117
The global biogeography and environmental drivers of fairy circles	117

Thermoelectricity, metallic liquidity, and magnetohydrodynamics	117
Transcranial magnetic stimulation to frontal but not occipital cortex disrupts endogenous attention	116
Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature	115
Emergent behaviors of buckling-driven elasto-active structures	115
CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation	113
Modeling the population-level impact of a third dose of MMR vaccine on a mumps outbreak at the University of Iowa	113
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse	113
Synergetic collision and space separation in microfluidic chip for efficient affinity-discriminated molecular selection	113
Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent	113
Ancient Maya reservoirs, constructed wetlands, and future water needs	112
The James Webb Space Telescope prompts a rethink of how galaxies form	112
CoRa—A general approach for quantifying biological feedback control	112
A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation	112
Revealing land control dynamics in emerging agricultural frontiers	112
Part of the gender gap in voting for Democrats arises because a higher proportion of women than men voters are Black	111
A law of data separation in deep learning	111
Balance and imbalance in biogeochemical cycles reflect the operation of closed, exchange, and open sets	110
Arabidopsis protein S -acyl transferases positively mediate BR signaling through S -acylation of BSK1	110
Observing heroic behavior and its influencing factors in immersive virtual environments	110
The decade-long growth of government-authored news media in China under Xi Jinping	109
Dynamic early recruitment of GAK–Hsc70 regulates coated pit maturation	109
Consistently estimating network statistics using aggregated relational data	109
Band gap opening of metallic single-walled carbon nanotubes via noncovalent symmetry breaking	108
The importance of geography in forecasting future fire patterns under climate change	108
High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma	108
Laser-driven noncontact bubble transfer printing via a hydrogel composite stamp	107
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family	106
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology	105
Topography affects not only interhemispheric asymmetry of westerly winds and thus storminess but also ocean circulation	105
The retrotransposon R2 maintains Drosophila ribosomal DNA repeats	104
NURR1 expression regulates retinal pigment epithelial–mesenchymal transition and age-related macular degeneration phenotypes	104
Cas9-mediated gene-editing frequency in microalgae is doubled by harnessing the interaction between importin α and phytopathogenic NLSs	104
MBD2a–NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression	104
Reversal of an existing hearing loss by gene activation in Spns2 mutant mice	103
The structural origin of the efficient photochromism in natural minerals	103
Malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification	102
Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance	102
Reply to Apanovich and Weeks: Exceptions exist, as recognized in the paper, but are too rare to challenge the original findings	102
Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy	101
On the microstructural origin of brain white matter hydraulic permeability	101
Low-cost solar power enables a sustainable energy industry system	101
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease	101
Tumor–neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression	100
Simulating institutional heterogeneity in sustainability science	100
Green ammonia could produce climate-friendly ways to store energy and fertilize farms	100
Interacting pest control and pollination services in coffee systems	100
Slope classicality in higher Coleman theory via highest weight vectors in completed cohomology	99
Ride-hailing technology mitigates effects of driver racial discrimination, but effects of residential segregation persist	99
Strong connectivity in real directed networks	99
Global monitoring of the impact of the COVID-19 pandemic through online surveys sampled from the Facebook user base	98
On peer review—then, now, and soon to be?	98
Rab3 mediates a pathway for endocytic sorting and plasma membrane recycling of ordered microdomains	97
Facile self-assembly of colloidal diamond from tetrahedral patchy particles via ring selection	97
GmEID1 modulates light signaling through the Evening Complex to control flowering time and yield in soybean	97
Alternative cGAS signaling promotes herpes simplex encephalitis	96
TNF plays a crucial role in inflammation by signaling via T cell TNFR2	96
Temporal and spatial distribution of health, labor, and crop benefits of climate change mitigation in the United States	96
Engineered bacteria that self-assemble bioglass polysilicate coatings display enhanced light focusing	96
Correction to Supporting Information for Ahuja et al., Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease	95
The visuomotor transformations underlying target-directed behavior	95
Are Americans less likely to reply to emails from Black people relative to White people?	95
Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy	95
Kids adopt different ways of coping in wake of the pandemic	95
Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy	95
Neuronal sensorimotor integration guiding salt concentration navigation in Caenorhabditis elegans	95
Simple, fast, and flexible framework for matrix completion with infinite width neural networks	95
Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na v 1.5	94
In vitro investigation of protein assembly by combined microscopy and infrared spectroscopy at the nanometer scale	94
In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse	94
An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation	94
Longevity, demographic characteristics, and socio-economic status are linked to triiodothyronine levels in the general population	94
Antiprion systems in yeast cooperate to cure or prevent the generation of nearly all [ PSI + ] and [URE3] prions	94
Modeling for COVID-19 college reopening decisions: Cornell, a case study	94
Climate change and the nonlinear impact of precipitation anomalies on income inequality	94
National religiosity eases the psychological burden of poverty	93
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability	93
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic	93
Engineered CaM2 modulates nuclear calcium oscillation and enhances legume root nodule symbiosis	93
Proprioceptive feedback amplification restores effective locomotion in a neuromechanical model of lampreys with spinal injuries	93
Conservation management strategy impacts inbreeding and mutation load in scimitar-horned oryx	93
TGM2-mediated histone transglutamination is dictated by steric accessibility	92
A heritable iron memory enables decision-making in Escherichia coli	92
Defective myelination in an RNA polymerase III mutant leukodystrophic mouse	92
The new W family reconstructs the evolution of MHC genes	92
Wandering mastodons reveal the complexity of Ice Age extinctions	92
Structural basis of higher order oligomerization of KSHV inhibitor of cGAS	92
From the laboratory to the consumer: Innovation, supply chain, and adoption with applications to natural resources	92
Dynamical differential covariance recovers directional network structure in multiscale neural systems	91
Cell–matrix feedback controls stretch-induced cellular memory and fibroblast activation	91
Protein dynamics underlies strong temperature dependence of heat receptors	91
Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae	91
Crosslinguistic word order variation reflects evolutionary pressures of dependency and information locality	91
Correction for Dar et al., Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma	91
Correction for Li et al., SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes	91
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family	90