Proceedings of the National Academy of Sciences of the United States o

Article	Citations
Cell entry mechanisms of SARS-CoV-2	2569
Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences	1021
Insect decline in the Anthropocene: Death by a thousand cuts	896
Identifying airborne transmission as the dominant route for the spread of COVID-19	875
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development	859
The impact of COVID-19 on small business outcomes and expectations	832
The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission	810
An evidence review of face masks against COVID-19	802
Learning loss due to school closures during the COVID-19 pandemic	686
Economic and social consequences of human mobility restrictions under COVID-19	679
Land use and climate change impacts on global soil erosion by water (2015-2070)	639
COVID-19 lockdowns cause global air pollution declines	577
The echo chamber effect on social media	569
Pharmaceutical pollution of the world’s rivers	529
Gender differences in COVID-19 attitudes and behavior: Panel evidence from eight countries	514
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates	479
RCP8.5 tracks cumulative CO 2 emissions	467
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis	439
Vertebrates on the brink as indicators of biological annihilation and the sixth mass extinction	437
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling	418
Physician–patient racial concordance and disparities in birthing mortality for newborns	407
Future of the human climate niche	392
The implications of silent transmission for the control of COVID-19 outbreaks	391
The challenges of modeling and forecasting the spread of COVID-19	382
People have shaped most of terrestrial nature for at least 12,000 years	382

Machine learning–accelerated computational fluid dynamics	363
Lifestyle and mental health disruptions during COVID-19	355
On instabilities of deep learning in image reconstruction and the potential costs of AI	353
Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis	334
BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)	333
Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats	333
Agricultural intensification and climate change are rapidly decreasing insect biodiversity	332
Biodiversity impacts and conservation implications of urban land expansion projected to 2050	325
Large stocks of peatland carbon and nitrogen are vulnerable to permafrost thaw	323
The impact of COVID-19 nonpharmaceutical interventions on the future dynamics of endemic infections	322
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury	316
Political partisanship influences behavioral responses to governors’ recommendations for COVID-19 prevention in the United States	310
Observation of non-Hermitian topology and its bulk–edge correspondence in an active mechanical metamaterial	310
Social distancing responses to COVID-19 emergency declarations strongly differentiated by income	309
ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment	308
A guideline to limit indoor airborne transmission of COVID-19	304
Rapid isothermal amplification and portable detection system for SARS-CoV-2	299
Reductions in 2020 US life expectancy due to COVID-19 and the disproportionate impact on the Black and Latino populations	298
The frontier of simulation-based inference	298
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles	297
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor	289
Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions	282
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients	281
A digital media literacy intervention increases discernment between mainstream and false news in the United States and India	280
Characterization and engineering of a two-enzyme system for plastics depolymerization	279
Global increase in major tropical cyclone exceedance probability over the past four decades	275
The persistent threat of emerging plant disease pandemics to global food security	273
Gender imbalance in medical imaging datasets produces biased classifiers for computer-aided diagnosis	271
Biologically inspired flexible photonic films for efficient passive radiative cooling	271
Plastic waste release caused by COVID-19 and its fate in the global ocean	269
Face masks considerably reduce COVID-19 cases in Germany	263
The changing risk and burden of wildfire in the United States	258
COVID-19 lockdown induces disease-mitigating structural changes in mobility networks	253
Critical period regulation across multiple timescales	253
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease	248
In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment	248
Insects and recent climate change	245
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι	242
Constraining the atmospheric limb of the plastic cycle	240
In the wake of COVID-19, academia needs new solutions to ensure gender equity	237
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation	235
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity	232
Intensity and frequency of extreme novel epidemics	232
Mobile device data reveal the dynamics in a positive relationship between human mobility and COVID-19 infections	232
Systemic signaling during abiotic stress combination in plants	231
Using gross ecosystem product (GEP) to value nature in decision making	230
The inflated significance of neutral genetic diversity in conservation genetics	226
Superhydrophobic photothermal icephobic surfaces based on candle soot	226
The effectiveness of nudging: A meta-analysis of choice architecture interventions across behavioral domains	225
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections	225

Energy storage emerging: A perspective from the Joint Center for Energy Storage Research	223
Climate Endgame: Exploring catastrophic climate change scenarios	220
Tracking the reach of COVID-19 kin loss with a bereavement multiplier applied to the United States	218
Global urban population exposure to extreme heat	217
Instant tough bioadhesive with triggerable benign detachment	217
How cholesterol stiffens unsaturated lipid membranes	216
Pandemic precarity: COVID-19 is exposing and exacerbating inequalities in the American heartland	214
Impacts of the COVID-19 pandemic on rural America	214
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome	213
Electric field-driven microfluidics for rapid CRISPR-based diagnostics and its application to detection of SARS-CoV-2	210
Evidence from internet search data shows information-seeking responses to news of local COVID-19 cases	207
Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer	207
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2	207
Deep learning and computer vision will transform entomology	206
Defining and quantifying the core microbiome: Challenges and prospects	205
Economic hardship and mental health complaints during COVID-19	205
Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior	205
The crucial role of genome-wide genetic variation in conservation	204
SARS-CoV-2 detection using isothermal amplification and a rapid, inexpensive protocol for sample inactivation and purification	203
Social and behavioral consequences of mask policies during the COVID-19 pandemic	201
Collectivism predicts mask use during COVID-19	200
Role of inner solvation sheath within salt–solvent complexes in tailoring electrode/electrolyte interphases for lithium metal batteries	199
Historic Yangtze flooding of 2020 tied to extreme Indian Ocean conditions	196
SARS-CoV-2 exposure in wild white-tailed deer ( Odocoileus virginianus )	195
Network medicine framework for identifying drug-repurposing opportunities for COVID-19	193
The decline of butterflies in Europe: Problems, significance, and possible solutions	193
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing ofAngptl3	192
Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection	188
First-principles experimental demonstration of ferroelectricity in a thermotropic nematic liquid crystal: Polar domains and striking electro-optics	187
The carbon footprint of household energy use in the United States	187
Seasonality and uncertainty in global COVID-19 growth rates	186
A new malaria vector in Africa: Predicting the expansion range of Anopheles stephensi and identifying the urban populations at risk	186
CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages	186
Heat stress destabilizes symbiotic nutrient cycling in corals	185
Ongoing global and regional adaptive evolution of SARS-CoV-2	185
Widespread occurrence of the droplet state of proteins in the human proteome	184
NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING	184
A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants	182
Bioinspired conductive cellulose liquid-crystal hydrogels as multifunctional electrical skins	182
The neural architecture of language: Integrative modeling converges on predictive processing	182
Predicting long-term dynamics of soil salinity and sodicity on a global scale	181
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion	181
Most invasive species largely conserve their climatic niche	180
Global diversity of microbial communities in marine sediment	180
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort	179
Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice	179
Quantifying asymptomatic infection and transmission of COVID-19 in New York City using observed cases, serology, and testing capacity	178
Demographic perspectives on the mortality of COVID-19 and other epidemics	178
Split-TurboID enables contact-dependent proximity labeling in cells	178
Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses	177
Untethered control of functional origami microrobots with distributed actuation	176
Understanding the role of individual units in a deep neural network	175
Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution	174
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein	172
Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines	172
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components	171
Land-use intensity alters networks between biodiversity, ecosystem functions, and services	170
Mitochondria-lysosome contacts regulate mitochondrial Ca 2+ dynamics via lysosomal TRPML1	169
Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs	169
A high-coverage Neandertal genome from Chagyrskaya Cave	169
Coxiella burnetii inhibits host immunity by a protein phosphatase adapted from glycolysis	169
Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin	168
Unsupervised neural network models of the ventral visual stream	168
Characterizing superspreading events and age-specific infectiousness of SARS-CoV-2 transmission in Georgia, USA	167
The total number and mass of SARS-CoV-2 virions	166
Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19	166
Influence of a COVID-19 vaccine’s effectiveness and safety profile on vaccination acceptance	165
Overweight, obesity, and risk of hospitalization for COVID-19: A community-based cohort study of adults in the United Kingdom	165
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis	165
Comparative roles of charge, π , and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins	165
Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes	164
Ten facts about land systems for sustainability	164
Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype	164
Out-group animosity drives engagement on social media	164
Post-2020 biodiversity targets need to embrace climate change	163
Speech can produce jet-like transport relevant to asymptomatic spreading of virus	162
SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma	162
Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance	161
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues	161
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells	158

Stretchable origami robotic arm with omnidirectional bending and twisting	158
Untangling the sequence of events during the S 2 → S 3 transition in photosystem II and implications for the water oxidation mecha	158
High-amplitude cofluctuations in cortical activity drive functional connectivity	156
Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer	155
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease	155
Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae	153
Reduced microbial stability in the active layer is associated with carbon loss under alpine permafrost degradation	153
Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties	153
Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation	153
Exhaled aerosol increases with COVID-19 infection, age, and obesity	152
Strong sequentially bridged MXene sheets	152
A megastudy of text-based nudges encouraging patients to get vaccinated at an upcoming doctor’s appointment	151
Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain	151
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals	151
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response	150
Data integration enables global biodiversity synthesis	150
Reversed-engineered human alveolar lung-on-a-chip model	147
Mechanistic transmission modeling of COVID-19 on the Diamond Princess cruise ship demonstrates the importance of aerosol transmission	146
A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis	146
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases	146
Reconfigurable multifunctional ferrofluid droplet robots	145
Predicting personality from patterns of behavior collected with smartphones	145
Hierarchical dynamics as a macroscopic organizing principle of the human brain	144
Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria	144
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1	144
Effects of fluorinated solvents on electrolyte solvation structures and electrode/electrolyte interphases for lithium metal batteries	143
Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation	143
Phase transition of RNA−protein complexes into ordered hollow condensates	143
Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia	143
Precious metal recovery from electronic waste by a porous porphyrin polymer	142
Identification of Fenton-like active Cu sites by heteroatom modulation of electronic density	142
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2	142
A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases	142
Room-temperature autonomous self-healing glassy polymers with hyperbranched structure	141
Ozone pollution in the North China Plain spreading into the late-winter haze season	140
Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing	140
Structure of the dimeric ATP synthase from bovine mitochondria	140
Improvement in municipal wastewater treatment alters lake nitrogen to phosphorus ratios in populated regions	140
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome	139
Overstated carbon emission reductions from voluntary REDD+ projects in the Brazilian Amazon	139
Direct lysosome-based autophagy of lipid droplets in hepatocytes	139
Ranking the risk of animal-to-human spillover for newly discovered viruses	138
Machine learning uncovers the most robust self-report predictors of relationship quality across 43 longitudinal couples studies	138
Tree planting has the potential to increase carbon sequestration capacity of forests in the United States	138
Climate change and the aridification of North America	138
Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade	137
Root angle modifications by the DRO1 homolog improve rice yields in saline paddy fields	137
Estimating maximal microbial growth rates from cultures, metagenomes, and single cells via codon usage patterns	136
Explaining the homogeneous diffusion of COVID-19 nonpharmaceutical interventions across heterogeneous countries	136
Impacts of biodiversity and biodiversity loss on zoonotic diseases	136
Communication-efficient federated learning	136
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein	135
Evaluation of individual and ensemble probabilistic forecasts of COVID-19 mortality in the United States	135
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP	135
Global warming is causing a more pronounced dip in marine species richness around the equator	135
African burned area and fire carbon emissions are strongly impacted by small fires undetected by coarse resolution satellite data	134
Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary	134
Functional analysis of the OsNPF4.5 nitrate transporter reveals a conserved mycorrhizal pathway of nitrogen acquisition in plants	134
Layer and rhythm specificity for predictive routing	134
SARS-CoV-2 spreads through cell-to-cell transmission	133
TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation	132
Global declines in coral reef calcium carbonate production under ocean acidification and warming	132
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection	131
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol	131
The Earth BioGenome Project 2020: Starting the clock	131
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes	131
Human influence has intensified extreme precipitation in North America	131
Stewardship of global collective behavior	130
Dynamic prioritization of COVID-19 vaccines when social distancing is limited for essential workers	130
Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation	130
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response	130
Provisional COVID-19 infrastructure induces large, rapid increases in cycling	130
Robust wrinkled MoS 2 /N-C bifunctional electrocatalysts interfaced with single Fe atoms for wearable zinc-air batteries	129
Membrane bending by protein phase separation	129
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2	129
Studies on the mechanism of general anesthesia	129
Lower socioeconomic status and the acceleration of aging: An outcome-wide analysis	129
Plant stem-cell organization and differentiation at single-cell resolution	129
Stem water cryogenic extraction biases estimation in deuterium isotope composition of plant source water	128
Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2	128
Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress	127
Sequence locally, think globally: The Darwin Tree of Life Project	126
Indigenous knowledge and the shackles of wilderness	125
Anthropogenic climate change is worsening North American pollen seasons	125
The impact of a poverty reduction intervention on infant brain activity	125
Quantum approximate optimization of the long-range Ising model with a trapped-ion quantum simulator	124
Calibrating the coevolution of Ediacaran life and environment	124
Slowed canonical progress in large fields of science	124
A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis	124
Detected climatic change in global distribution of tropical cyclones	123
Nitrogen deposition accelerates soil carbon sequestration in tropical forests	123
Collagen microarchitecture mechanically controls myofibroblast differentiation	123
Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos	122
Nipah virus dynamics in bats and implications for spillover to humans	122
Misinformation in and about science	122