Proceedings of the National Academy of Sciences of the United States o

Article	Citations
Greener skies? The quest for sustainable flying	731
Profile of Johannes Lehmann	527
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises	435
Industrial-era decline in Arctic methanesulfonic acid is offset by increased biogenic sulfate aerosol	404
Probing the connection between chirality and spin through time-resolved EPR spectroscopy	394
Optimal transitions between nonequilibrium steady states	376
Yeast centrosomes act as organizing centers to promote Polo kinase–mediated adaptation to persistent DNA damage	368
Thermoelectricity, metallic liquidity, and magnetohydrodynamics	354
Reply to Apanovich and Weeks: Exceptions exist, as recognized in the paper, but are too rare to challenge the original findings	348
Slope classicality in higher Coleman theory via highest weight vectors in completed cohomology	347
Kids adopt different ways of coping in wake of the pandemic	325
Reply to Kodner et al.: Fundamental misunderstanding of both model and methods	324
The tumor suppressor RASSF8: A WAVE interaction partner controlling migration and cohesion of invasive border cells in Drosophila	295
In This Issue	294
In This Issue	294
How can we reform the STEM tenure system for the 21st Century?	294
High-throughput measurement of elastic moduli of microfibers by rope coiling	287
Wandering mastodons reveal the complexity of Ice Age extinctions	274
Modeling blood metabolite homeostatic levels reduces sample heterogeneity across cohorts	264
Pinning down a perpetrator in postsurgical eye pain	263
Individuals benefit individual out-group members rather than harm in-group members	256
Mercury’s complex legacy	252
Endurance athletes hiding in plain sight in the high Andes	249
Late Cretaceous community structure changed before the asteroid	237
Impression management in research reporting: When effects are not really as pronounced as claimed	237

SARS-CoV-2-derived RNA replicons as safe and effective vaccines	230
Adaptive cooling strategy via human hair: High optothermal conversion efficiency of solar radiation into thermal dissipation	228
Oligopoly competition between satellite constellations will reduce economic welfare from orbit use	224
In This Issue	223
Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization	220
Cytosolic and mitochondrial ribosomal proteins mediate the locust phase transition via divergence of translational profiles	217
High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma	213
How defective mitochondrial electrical activity leads to inherited blindness	213
Towards CRISPR-based editing of the mitochondrial genome in yeast	210
An accurate cellular assay to determine pathogenicity of coding and noncoding variants in Lynch syndrome genes	207
The Titanic question in TB control: Should we worry about the bummock?	199
The intracellular Ca2+channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis	199
Keystone predator and keystone intransitivity and the rescue of a competitively subdominant species	198
Phantom sinks and missing pollution: Legacies of a hardened number	194
A molecular probe for detecting cholinesterase activity in MRI	193
Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia	192
Circadian clock control of interactions between eIF2α kinase CPC-3 and GCN1 with ribosomes regulates rhythmic translation initiation	188
Phylogenetic evidence clarifies the history of the extrusion of Indochina	185
Probing both sides of the story	182
Advancing stochastic 3-SAT solvers by dissipating oversatisfied constraints	182
Testing whether connectivity stabilizes metacommunities and rescues declining diversity in a 25-y grassland study	182
Nitrogen-fixing microbes gain genes in diverse types of living environments	178
The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells	176
Stochastically evolving graphs via edit semigroups	176
Antiprion systems in yeast cooperate to cure or prevent the generation of nearly all [ PSI + ] and [URE3] prions	175
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases	175
Revealing the structure of snowflakes using acoustic levitation	174
A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression	172
Proprioceptive feedback amplification restores effective locomotion in a neuromechanical model of lampreys with spinal injuries	171
Contraception ends the genetic maintenance of human same-sex sexual behavior	169
Multispecies sensory networks and social foraging strategies: Implications for population decline in procellariiform seabirds	168
Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling	167
Emergent behaviors of buckling-driven elasto-active structures	166
Ru-P pair sites boost charge transport in hematite photoanodes for exceeding 1% efficient solar water splitting	158
Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage	157
Engineered bacteria that self-assemble bioglass polysilicate coatings display enhanced light focusing	157
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency	157
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology	156
GmEID1 modulates light signaling through the Evening Complex to control flowering time and yield in soybean	155
The decade-long growth of government-authored news media in China under Xi Jinping	149
Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing	149
Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy	149
Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study	148
The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics	147
RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation	147
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells	146
Photomolecular effect: Visible light interaction with air–water interface	146
Symmetry and asymmetry in biological structures	144
Climate warming drives population trajectories of freshwater fish	143
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses	142

Parameters of clustered suboptimal miRNA biogenesis	141
Theory and observations of the interaction between magnetohydrodynamic waves and shocks	141
Polymorphic transposable elements contribute to variation in recombination landscapes	140
Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression	140
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain	139
Unproctored online exams provide meaningful assessment of student learning	139
ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice	139
Chronic infection perturbs the affinity hierarchy of antiviral B cells	138
Spirocyclic β-lactone secondary metabolites modulate spliceosome function	138
Promoting C–F bond activation via proton donor for CF 4 decomposition	136
Glucuronic acid confers colonization advantage to enteric pathogens	135
β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells	135
Detecting chirality-induced spin selectivity in chromophore-linked DNA hairpins using photogenerated radical pairs	135
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis	134
Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex	133
Microfluidics guided by deep learning for cancer immunotherapy screening	133
Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+breast cancer by ceramide-loaded nanoparticles	132
Band gap opening of metallic single-walled carbon nanotubes via noncovalent symmetry breaking	132
The gender gap in the ownership of promising land	130
Touching the classical scaling in penetrative convection	129
LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway	129
Repeated occurrences of marine anoxia under high atmospheric O 2 and icehouse conditions	129
Functional near-infrared spectroscopy reveals brain activity on the move	129
Model evidence for distinct origins of glacial–interglacial and millennial signals in Greenland dust	129
Topography affects not only interhemispheric asymmetry of westerly winds and thus storminess but also ocean circulation	128
Modulating metal-centered dimerization of a lanthanide chaperone protein for separation of light lanthanides	128
The global biogeography and environmental drivers of fairy circles	128
Identifying regulation with adversarial surrogates	127
Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis	125
Tsg101 mimicry of canonical E2 enzymes underlies its role in ubiquitin signaling	125
Conservation management strategy impacts inbreeding and mutation load in scimitar-horned oryx	125
Centuries of compounding human influence on Amazonian forests	125
RNA m 6 A demethylase ALKBH5 regulates the development of γδ T cells	124
MBD2a–NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression	124
Architecture-driven quantitative nanoscopy maps cytoskeleton remodeling	123
Deep silicification–assisted long-term preservation of structural and genomic information across biospecies: From micro to macro	122
Strong connectivity in real directed networks	122
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth	122
Genome-wide detection of human variants that disrupt intronic branchpoints	122
Dynamics of memory B cells and plasmablasts in healthy individuals	121
Three common assumptions about inflammation, aging, and health that are probably wrong	121
Bottlenose dolphin mothers modify signature whistles in the presence of their own calves	121
Symmetries and synchronization from whole-neural activity in the Caenorhabditis elegans connectome: Integration of functional and structural networks	121
Molecular patterns of matrix protein 1 (M1): A strong predictor of adaptive evolution in H9N2 avian influenza viruses	120
Single hormone or synthetic agonist induces Gs/Gicoupling selectivity of EP receptors via distinct binding modes and propagating paths	120
Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice	120
DNA methylation shapes transcription factor binding beyond canonical CpG contexts	119
Resilience of deep aquifer microbial communities to seasonal hydrological fluctuations	119
Self-consistent dispersal puts tight constraints on the spatiotemporal organization of species-rich metacommunities	119
Dimerization-activated PP2C-D2 and D5 phosphatases negatively regulate brassinosteroid signaling by antagonizing BRI1	119
Lysosome-related organelles orchestrate guanine crystal formation in pigment cells	119
Wild food portfolios: Access to diverse foods stabilizes harvest in wild food systems	118
Pathogen dilution, resource partitioning, and precipitation generate productivity benefits from plant diversity	118
Acclimation to high and low diurnal light is flexible in Chlamydomonas reinhardtii	118
Simulating COVID-19 classroom transmission on a university campus	117
Designing the stripe-ordered cuprate phase diagram through uniaxial-stress	117
Correction for Andreasson et al., Crowdsourced RNA design discovers diverse, reversible, efficient, self-contained molecular switches	116
Retraction for Li et al., Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells	116
Correction for Dar et al., Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma	116
Correction to Gaffney et al., Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein	115
Structural stability and thermodynamics of artistic composition	115
Correction for Li et al., SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes	115
Correction for Magesh et al., Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species	114
Correction for Ahituv et al., Starch-rich plant foods 780,000 y ago: Evidence from Acheulian percussive stone tools	114
Correction to Supporting Information for Ikeda et al., Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics	113
Correction to Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro	113
Correction for Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments	113
Retraction for Goswami et al., A bifunctional tRNA import receptor from Leishmania mitochondria	112
Correction for Wurman et al., Supercell tornadoes are much stronger and wider than damage-based ratings indicate	111
Correction for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility	111
Untangling the CD4 T cell response to the microbiota	110
Correction for Dong et al., Hybridoma-inspired strategy crafts tailored multifunctional exosomes for precision therapy	110
Correction for Mittal et al., Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A)	110
Cell numbers contribute to cell fate during Ciona cardiopharyngeal mesoderm specification	109
Host–microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation	109
In This Issue	108
Bioresponsive immunomodulator nanocomplex for selective immunoengineering in metastatic lymph nodes	108
Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure	108
Directional water navigation and reallocation in Tillandsia capitata	107
Correlated substitutions reveal SARS-like coronaviruses recombine frequently with a diverse set of structured gene pools	107

Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance	107
Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting	106
Vulnerability to natural disasters and sustainable consumption: Unraveling political and regional differences	106
Kinetic pathways of solid–solid phase transitions dictated by short-range interactions	106
Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations	106
Identification of KU-55933 as an anti-atherosclerosis compound by using a hemodynamic-based high-throughput drug screening platform	106
Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis	106
Ancient Maya reservoirs, constructed wetlands, and future water needs	105
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7	105
Cytoplasmic stirring by active carpets	105
Coherent detection of hidden spin–lattice coupling in a van der Waals antiferromagnet	105
Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform	105
Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2	105
Part of the gender gap in voting for Democrats arises because a higher proportion of women than men voters are Black	105
Grazer exclusion is associated with higher fast-cycling carbon pools but lower slow-cycling mineral-associated carbon across grasslands	105
Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice–Earth interactions in Greenland	103
From relaxation to buckling: A continuum elastic framework connecting surface instabilities of highly compressed lipid thin films	102
The James Webb Space Telescope prompts a rethink of how galaxies form	102
Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities	102
Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization	102
IL-1 receptor antagonism reveals a yin-yang relationship between NFκB and interferon signaling in chronic lymphocytic leukemia	101
A neuron–astrocyte signaling axis in the ACC sustains diabetic neuropathic pain	101
PTP1B inhibition promotes microglial phagocytosis in Alzheimer’s disease models by enhancing SYK signaling	101
A multilocus perspective on the evolutionary dynamics of multistrain pathogens	100
Modeling the population-level impact of a third dose of MMR vaccine on a mumps outbreak at the University of Iowa	100
Regulation of the immune CD155–CD226–TIGIT axis by cyclin D-CDK4/6	100
Human ERG oncoprotein represses a Drosophila LIM domain binding protein–coding gene Chip	100
Explaining happiness trends in Europe	100
Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors	100
Using neuroimaging genomics to investigate the evolution of human brain structure	100
Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia	99
Maple samaras recover autorotation following raindrop collisions	99
A randomized trial of behavioral interventions yielding sustained reductions in distracted driving	99
Exploring the associations between discrimination, coping, skin tone, and the psychosocial health of young adults of color	99
Distinct impact of PI(4)P flux on PI(4,5)P 2 steady states and oscillations	99
Thermo-photo catalytic anode process for carbonate-superstructured solid fuel cells	99
Computationally efficient whole-genome quantile regression at biobank scale	99
Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor	98
Measurement of cellular traction forces during confined migration	98
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability	98
Dominance of felsic continental crust on Earth after 3 billion years ago is recorded by vanadium isotopes	98
The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain	98
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders	98
Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26	97
Wolves fear humans but learn quickly about us	97
Tungsten is utilized for lactate consumption and SCFA production by a dominant human gut microbe Eubacterium limosum	97
Memory’s gatekeeper: The role of PFC in the encoding of congruent events	97
Ride-hailing technology mitigates effects of driver racial discrimination, but effects of residential segregation persist	96
Hidden in plain sight: (Re)definition of a key lepidopteran color patterning gene	96
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model	96
CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation	96
Diets, dominance hierarchies, and kleptoparasitism drive asymmetrical interactions between wolves and cougars	96
Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast	96
The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation	96
Skillful heat-related mortality forecasting during recent deadly European summers	96
CoRa—A general approach for quantifying biological feedback control	96
The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis–mediated inflammation to exacerbate kidney injury	95
Structural basis of higher order oligomerization of KSHV inhibitor of cGAS	95
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis	95
On peer review—then, now, and soon to be?	94
The power of coalescent methods for inferring recent and ancient gene flow in endangered Bactrian camels	94
Decoding antibody response to MERS-CoV in wild dromedary camels	93
Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity	93
In vitro investigation of protein assembly by combined microscopy and infrared spectroscopy at the nanometer scale	93
Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling	93
More social interactions, more polarization? The evidence is not there	93
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52	93
Croquemort elicits activation of the immune deficiency pathway in ticks	93
The importance of elders: Extending Hamilton’s force of selection to include intergenerational transfers	93
Revealing land control dynamics in emerging agricultural frontiers	93
Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist	93
ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration	93
Pressure pushes tRNA Lys3 into excited conformational states	92
Water striders are impervious to raindrop collision forces and submerged by collapsing craters	92
Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae	92
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic	92
Proactive or reactive? Neural oscillatory insight into the leader–follower dynamics of early infant–caregiver interaction	92
A metabolic cell death program downstream of SARM1 couples NAD + depletion to BAX activation and APAF1 degradation	92
Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopy	92
Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics	92
An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis	92
The quorum-sensing peptidic inhibitor rescues host immune system eradication: A novel infectivity mechanism	91
Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2− breast tumor cells	91
Thermodynamic consistency of autocatalytic cycles	90
Sound-mediated nucleation and growth of amyloid fibrils	90
Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak–Keller–Segel chemotaxis model	90
Independent transitions to fully planktonic life cycles shaped the global distribution of medusozoans in the epipelagic zone	90
Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in Pseudomonas aeruginosa PAO1 microcolonies	90
A heritable iron memory enables decision-making in Escherichia coli	90
Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex	90
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse	90
Dynamical differential covariance recovers directional network structure in multiscale neural systems	89
Alternative cGAS signaling promotes herpes simplex encephalitis	89
A bipartite interaction with the processivity clamp potentiates Pol IV-mediated TLS	89
Malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification	89