OOIR: Observatory of International Research

Papers

(The TQCC of New England Journal of Medicine is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Exclusion of Elective Care from Hospital Financial Assistance Policies — Arresting a Troubling Development	3587
Screening for Prostate Cancer	2912
Spontaneous Intracranial Hypotension	2230
Primaquine and Plasmodium vivax Malaria Recurrence in Brazil	2038
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia	1971
Alteplase and Thrombectomy — Not a Bridge to Dismantle	1930
Malnutrition in Adults	1907
SENIOR-RITA — Is It All about Angiography?	1862
Cerebral Embolic Protection during TAVI	1684
Transformative Research in Cystic Fibrosis	1674
Hiding in Plain Sight	1674
Early Active Mobilization during Mechanical Ventilation in the ICU	1584
Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid	1569
Out of Pocket Getting Out of Hand — Reducing the Financial Toxicity of Rapidly Approved Drugs	1419
Audio Interview: Dissecting the Host Response to SARS-CoV-2	1296
Automatic Insurance Policies — Important Tools for Preventing Coverage Loss	1290
Receipt of mRNA Vaccine against Covid-19 and Myocarditis	1233
Overcoming Resistance — Omission of Radiotherapy for Low-Risk Breast Cancer	1182
Gantenerumab in Early Alzheimer’s Disease	1172
Listening and Responding to Community Voices — The Community Wellness HUB	1172
Automated Insulin Pump in Type 2 Diabetes	1100
Measurable Residual Disease–Guided Therapy for Chronic Lymphocytic Leukemia	1042
Reteplase versus Alteplase for Acute Ischemic Stroke	978
Periprosthetic Joint Infection	927
Implanted System for Orthostatic Hypotension in Multiple-System Atrophy	917

Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk	908
Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR	890
Lung Transplantation for Covid-19–Related Respiratory Failure in the United States	877
Threatening the Future of Global Health — NIH Policy Changes on International Research Collaborations	867
Striking a Balance — Advancing Physician Collective-Bargaining Rights and Patient Protections	819
Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure	810
BCMA-Targeted T-Cell Engager for Autoimmune Hemolytic Anemia after CD19 CAR T-Cell Therapy	808
Debating Race and the Diagnosis of Anemia — How Medicine Moved Away from Race-Based Standards	789
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Anemia in CKD	776
Case 18-2025: A 63-Year-Old Woman with Dyspnea on Exertion	774
Paget’s Disease of the Breast	734
Virotherapy for Brain Tumors — Defining the Path to Success	731
Use of Wastewater for Mpox Outbreak Surveillance in California	721
Turning CMS into a Health Technology Assessment Organization	720
A Modern Therapy for an Ancient Disease	716
Modifiable Risk Factors and Cardiovascular Outcomes	711
A Swell Diagnosis	709
Perioperative Durvalumab in Bladder Cancer	701
Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam	693
Asciminib in Newly Diagnosed Chronic Myeloid Leukemia	678
Targeting CSF1R in Chronic GVHD — Lessons in Translation	673
Postacute Sequelae of SARS-CoV-2 Infection in Several Eras	673
Race-Based Diagnosis, Part 1 — ITT Episode 33	661
Investigating Injustices in the Journal ’s History, Part 2	656
Hemotympanum with a Basilar Skull Fracture	650
Secondary Hypertrophic Osteoarthropathy	644
Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors	637
Psychosocial Functioning in Transgender Youth after 2 Years of Hormones	634
Testing for Arginine Vasopressin Deficiency	631
U.S. Law and Discrimination in Health Care	627
Case 40-2022: A 38-Year-Old Man with Exertional Chest Discomfort	627
The Muffin Question	625
Bilothorax	614
Audio Interview: Assessing Bivalent Vaccines against Covid-19	613
Nonketotic Hyperglycemic Hemichorea	602
Gingival Infiltration in Acute Monocytic Leukemia	600
Hyperpigmentation in Vitamin B ₁₂ Deficiency	599
Ménétrier’s Disease	598
Nationwide, Couple-Based Genetic Carrier Screening	582
Rethinking Shadowing for Aspiring Physicians	582
Poet as Patient	577
Navigating and Communicating about Serious Illness and End of Life	572
Preparing for the Next Pandemic — Expanding and Coordinating Global Regulatory Capacity	565
Liver Transplantation for Mahvash Disease, an Inborn Error of Metabolism	563
Adrenal Involvement in Disseminated Histoplasmosis	550
Multicentric Reticulohistiocytosis	549
Zilebesiran for Hypertension	547
Black Dot Tinea Capitis	545
Timing Is Everything — Evidence for When to Perform Complete Revascularization in STEMI	533
Convalescent Rash of Dengue	532

Redefining Lung Cancer Therapy — A Long-Awaited Shift in Strategy	530
Bismuth Subsalicylate Poisoning	529
Covid-19 Infections in Vaccinated Health Care Workers	527
Early Treatment with Sotrovimab for Covid-19	527
Bumps in the Road	526
Foreign-Body Aspiration in a Child	525
Maintenance or Discontinuation of Antidepressants in Primary Care	523
Catching Up on REMs	523
Prolonging Cellular Life after Hypoxic Death	522
Middle Meningeal Artery Embolization for Subdural Hematoma	518
Cholelithiasis, Cholecystitis, and Choledocholithiasis	517
Gazing into a Crystal Ball	511
Breaking the Sacred Promise	504
Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial	503
A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes	503
Nutritional Support for Moderate-to-Late–Preterm Infants — A Randomized Trial	502
Mucosal IgA against SARS-CoV-2 Omicron Infection	499
Designing Cures 2.0 — From Corridors to Cornerstones	498
Optical Coherence Tomography and Eye Care	492
Sacituzumab Govitecan in Untreated, Advanced Triple-Negative Breast Cancer	487
Hypothermia or Machine Perfusion in Kidney Donors	481
Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD	480
Ten Years of Incidental, Secondary, and Actionable Findings	477
From the Eyeball Test to the Algorithm — Quality of Life, Disability Status, and Clinical Decision Making in Surgery	470
Childhood Risk Factors and Adult Cardiovascular Events	464
Tenecteplase for Stroke — Opening the Window?	454
Permethrin-Treated Baby Wraps for the Prevention of Malaria	454
How Can We Fully Realize SNAP’s Health Benefits?	446
Evidence-Based Work Design — Bridging the Divide	440
Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma	435
Empagliflozin in Heart Failure with a Preserved Ejection Fraction	435
Bronchiectasis — A Clinical Review	434
Navigating and Communicating about Serious Illness and End of Life	433
New Horizons in the Treatment of Osteosarcoma	427
Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer	417
Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B	411
Haloperidol for the Treatment of Delirium in ICU Patients	410
Monoclonal Antibodies for Malaria	409
Fever of Unknown Origin	405
Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction	401
Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer	401
Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts	399
First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia	398
Targeting HER2 -Mutant NSCLC — The Light Is On	393
Audio Interview: The Omicron Variant of SARS-CoV-2	393
Ultraprocessed Food on an Ultrafast Track	393
Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype	393
A Tale of Two Diseases	392
Hospital Problems	391
Ondansetron after ED Visits in Children with Gastroenteritis	388
Making Long-Term Oxygen Therapy Less Burdensome	387
Invasive Strategy for Older Patients with MI	384
What’s in a Number? Breaking Down the Residency Match Rate	383
Guidance on Energy and Macronutrients across the Life Span	383
Extending Cancer Survival with Exercise — Time for Oncology to Act	381
The IARC Perspective on Cervical Cancer Screening	378
New Perioperative Strategy in Gastric Cancer	377
Cholesterol Pericarditis	376
SGLT2 Inhibitors and False Positive Toxicology Tests	373
Crinecerfont in Adult Congenital Adrenal Hyperplasia	371
Case 38-2024: A 22-Year-Old Woman with Headache, Fever, and Respiratory Failure	371
Case 5-2023: A 67-Year-Old Man with Interstitial Lung Disease, Fever, and Myalgias	370
Personality Disorders	369
Audio Interview: Rolling Out New Covid-19 Vaccines	368
Atrial Fibrillation — What Is It and How Is It Treated?	364
HIV Prevention and the 340B Drug Pricing Program	363
Academic Freedom in America — In Support of Institutional Voices	362
Benefits and Risks of Iron Interventions in Infants in Bangladesh	362
Japanese Spotted Fever	362
Medication for Gastroesophageal Reflux Disease in Infants	361
Vocal-Cord Polyp Causing Airway Obstruction	360
Chylothorax	359
Broken Both Ways	358
Convalescent Plasma for Covid-19–Induced ARDS	355
A Physician Attack on the FDA — Will the Supreme Court Reduce Access to Mifepristone?	354
What We Don’t Know about School Shooter Drills	352
Public Health’s Role in a Post- Dobbs World — The New York City Abortion Access Hub	347
Case 21-2023: A 61-Year-Old Man with Eyelid Swelling	347
Intravenous Amino Acids and Kidney Protection	344
NEJM at AHA — Routine Spironolactone in Acute Myocardial Infarction	344

The Death of an Unlikable Man	344
Felzartamab in Antibody-Mediated Rejection	341
Routine Removal of Inferior Vena Cava Filters	339
Case 26-2022: A 48-Year-Old Woman with Cystic Lung Disease	335
Diagnostic Aspirations	332
Audio Interview: Ending the Covid-19 Public Health Emergency	330
End of a Declared Public Health Emergency — Implications for U.S. Emergency Use Authorizations	329
Covid-19 Surveillance Testing in Nursing Homes	329
Guilty	322
PD-1 and PD-L1 Blockade plus Chemotherapy in Endometrial Cancer	321
Water-Based and Waterless Surgical Scrub Techniques	321
Case 39-2023: A 43-Year-Old Woman with Chronic Diarrhea, Hair Loss, and Nail and Skin Changes	319
Genital Herpes Zoster	317
Expect With Me — Group Prenatal Care to Reduce Disparities	316
Tuberculous Meningitis — New Approaches Needed	315
Increasing Firearm-Related Deaths among U.S. Black Rural Youths	314
Laryngeal Candidiasis	313
Neurovascular Complications of Iatrogenic Fusarium solani Meningitis	312
“Putting America First” — Undermining Health for Populations at Home and Abroad	311
Gastric Syphilis	310
Helicobacter pylori , Homologous-Recombination Genes, and Gastric Cancer	310
Postherpetic Abdominal Pseudohernia	306
Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia	306
Transfusion Strategy in Myocardial Infarction and Anemia	306
The Increasing Incidence of Early-Onset Colorectal Cancer	302
Moving the Needle on Alzheimer’s Disease with an Anti-Oligomer Antibody	302
In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6	301
Mycoplasma-Induced Rash and Mucositis	301
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation	299
Focused Cardiac Ultrasonography for Right Ventricular Size and Systolic Function	299
Trials for Managing Acute Pain — A Clinically Meaningful Small Effect Size?	298
Criminalizing Homelessness — The Grants Pass, Oregon, Supreme Court Case	298
Safety and Efficacy of Denosumab for Fibrous Dysplasia of Bone	296
Gustatory Hyperhidrosis after Parotid Surgery	296
Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction	295
Autoantibodies Targeting Nephrin in Podocytopathies	290
Transforming Management of Opioid Use Disorder with Universal Treatment	289
Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy	287
Risks and Benefits of Janus Kinase Inhibitors in Rheumatoid Arthritis — Past, Present, and Future	286
Advanced HIV as a Neglected Disease	285
Small Step or Giant Leap? Expanding the Acute Stroke Thrombolysis Window to 24 Hours	280
FINEARTS-HF — The Latest Masterpiece for MRAs in Heart Failure	279
Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction	278
Compared with What? Measuring AI against the Health Care We Have	276
Chronic Traumatic Encephalopathy in the Brains of Military Personnel	276
Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases	276
Pegylated Interferon Lambda for Covid-19	274
Occupational Health and Safety on the Chopping Block — What’s at Stake?	274
Medication-Associated Diethylene Glycol Mass Poisoning — A Preventable Cause of Illness and Death	270
Fulminant Viral Myocarditis Associated with Thogotovirus	270
Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial	270
Can AI Solve Primary Care?	269
A Dual-Chamber Leadless Pacemaker	267
A Preview of the Dangerous Future of Abortion Bans — Texas Senate Bill 8	267
Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer	266
The Risks of Normalizing Parental Vaccine Hesitancy	265
Cardiac Implantable Electronic Devices	264
Emodepside for Trichuris trichiura and Hookworm Infection	264
Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation	263
Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B	263
Early Outpatient Treatment for Covid-19 with Convalescent Plasma	262
Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis	262
Behçet’s Syndrome	261
Betibeglogene Autotemcel Gene Therapy for Non–β ⁰ /β ⁰ Genotype β-Thalassemia	259
Artificial Intelligence in Medicine	256
Bivalent Covid-19 Vaccines — A Cautionary Tale	254
Audio Interview: Ending the Covid-19 Emergency	252
Disappearing Data at the U.S. Federal Government	251
Targeting Lipoprotein(a) — the Next Frontier in Cardiovascular Disease	249
Acute Myeloid Leukemia Case after Gene Therapy for Sickle Cell Disease	248
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma	248
Resistance Mutations in SARS-CoV-2 Delta Variant after Sotrovimab Use	247
Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial	247
A Zoonotic Henipavirus in Febrile Patients in China	247
Association between Covid-19 Vaccination and Influenza Vaccination Rates	246
Pretomanid in the Treatment of Patients with Tuberculosis in the United States	246
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer	246
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma	245
A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis	243
Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes	243
Autoantibodies Targeting Nephrin in Podocytopathies	242
Immune Checkpoint Inhibitors — The Need for Innovation	240
Booster Doses and Prioritizing Lives Saved	240
Monkeypox	239
Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension	239
Waning Immunity after the BNT162b2 Vaccine in Israel	239
Transcatheter Valve Replacement in Severe Tricuspid Regurgitation	237
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction	237
Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas	237
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity	235
Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults	234
Aspiration Thrombectomy for Coronary Stent Thrombosis	234
Health Care in an Evolving Immigration Landscape — Providing Care while Upholding the Law	233
Daily Urinary Sodium and Potassium Excretion and Cardiovascular Risk	232
Dietary Sodium Restriction in Patients with Heart Failure	231